2,2'-Dithiobis(benzothiazole) supplier

Name
2,2'-Dithiobis(benzothiazole)
EINECS 204-424-9
CAS No. 120-78-5
Article Data95
CAS DataBase
Density 1.57 g/cm³
Solubility <0.01 g/100 mL at 21 °C in water
Melting Point 177-180 °C(lit.)
Formula C₁₄H₈N₂S₄
Boiling Point 532.5 °C at 760 mmHg
Molecular Weight 332.495
Flash Point 275.8 °C
Transport Information UN 3077 9/PG 3
Appearance yellow amorphous powder
Safety 36/37-60-61
Risk Codes 31-43-50/53
Molecular Structure
Hazard Symbols Xi,N
Synonyms Vulcanization accelerator DM (MBTS);2,2'-Benzothiazolyl disulfide;2-Benzothiazyldisulfide;2-Mercaptobenzothiazole disulfide;AcceleratorDM;Altax;Benzothiazolyl disulfide;Benzothiazyldisulfide;Bis(2-benzothiazolyl) disulfide;Bis(benzothiazol-2-yl)disulfide;2,2'-Dithiobis(benzothiazole);1,2-Bis(2-benzothiazolyl)disulfide;
PSA 132.86000
LogP 5.70540

Synthetic route

: 149-30-4
2-Mercaptobenzothiazole

: 120-78-5
di(benzothiazol-2-yl)disulfide

Conditions

Conditions	Yield
With bis(2,2'-bipyridyl) copper(II) permanganate In dichloromethane for 0.166667h;	100%
With tris paraperiodate In benzene for 0.5h; Heating;	100%
With dihydrogen peroxide In water	100%

: 333-20-0
potassium thioacyanate

: 71355-12-9, 95835-16-8
p-nitrobenzyl <(R)-4-(2-benzothiazol-2-yldithio)-2-oxo-1-azetidinyl>isopropenylacetate

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 112110-51-7
(2S,3R)-3-Methyl-7-oxo-3-thiocyanatomethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

Conditions

Conditions	Yield
In dichloromethane; sulfuric acid; water for 12h; Ambient temperature; electrolysis procedure;	A 99% B 97%

...Expand

: 2492-26-4
sodium 2-mercaptobenzothiazole

: 120-78-5
di(benzothiazol-2-yl)disulfide

Conditions

Conditions	Yield
With bromonitromethane In methanol	98%
With water; chlorine; ammonium chloride
With sulfuric acid; water; dihydrogen peroxide

: 80756-85-0
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

: 120-78-5
di(benzothiazol-2-yl)disulfide

Conditions

Conditions	Yield
With tetrabutylammomium bromide; ozone In methanol at 44℃; for 1.5h; Concentration; Temperature; Large scale;	97.5%

: 41475-98-3
S-(benzo[d]thiazol-2-yl) benzenesulfonothioate

: 57562-33-1, 68128-75-6
2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid benzyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

: 91939-45-6, 106138-52-7
4-phenylsulfonylthio-3-phenoxyacetamido-1-(1-benzyloxycarbonyl-2-methyl-2-propenyl)-2-azetidinone

Conditions

Conditions	Yield
sodium benzenesulfonate In water; acetone for 3.5h; Ambient temperature;	A 96% B 91%

...Expand

: 72844-42-9
2-(Benzothiazol-2-ylsulfanyl)-2-(3-methyl-but-2-enyl)-hexanedioic acid dimethyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 72844-50-9
2-(3-Methyl-but-2-enyl)-hexanedioic acid dimethyl ester

Conditions

Conditions	Yield
In methanol; sulfuric acid Ambient temperature; Electrochemical reduction;	A 96% B 74%

: 149-30-4
2-thioxo-3H-1,3-benzothiazole

: 120-78-5
di(benzothiazol-2-yl)disulfide

Conditions

Conditions	Yield
With 3,3-dimethyldioxirane In dichloromethane; acetone at 25℃;	95%
With dilauryl peroxide In 1,2-dichloro-ethane for 1h; Reflux;	90%
With potassium dichromate; acetic acid

: (R)-2-[2-(Benzothiazol-2-yldisulfanyl)-3,3-dibromo-4-oxo-azetidin-1-yl]-3-methyl-but-3-enoic acid benzyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: benzhydryl 6,6-dibromo-2β-chloromethyl-2α-methylpenam-3α-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In dichloromethane; water at 0℃; for 5h;	A n/a B 95%

: 67-56-1
methanol

: 70203-06-4
2-benzothiazol-2-ylsulfanyl-octanoic acid methyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 74391-99-4
2,2-Dimethoxy-octanoic acid methyl ester

Conditions

Conditions	Yield
With sulfuric acid; copper dichloride Ambient temperature; electrosynthesis;	A 58% B 94%
With tetraethylammonium perchlorate; copper dichloride for 2.4h; Product distribution; Ambient temperature; electrosynthesis; further electrolytes, further α-sulfenylalkanoates; also without CuCl2;	A 80% B 83%

...Expand

: 667-20-9
N,N'-bis(phenylsulfonyl)sulfur diimide

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 81955-02-4
N,N'-bis(phenylsulfonyl)sulfoxylic diamide

Conditions

Conditions	Yield
With 2-Mercaptobenzothiazole In benzene for 8h; Heating;	A 94% B 90%

: (R)-2-[2-(Benzothiazol-2-yldisulfanyl)-3,3-dibromo-4-oxo-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-methoxy-benzyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: p-methoxybenzyl 6,6-dibromo-2β-chloromethyl-2α-methylpenam-3α-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In dichloromethane; water at 0℃; for 5h;	A n/a B 93%

: 41475-98-3
S-(benzo[d]thiazol-2-yl) benzenesulfonothioate

: 98231-55-1
2-[(2R,3R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-methoxy-benzyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

: 93788-86-4, 106247-27-2
4-phenylsulfonylthio-3-phenylacetamido-1-(1-(p-methoxybenzyloxycarbonyl)-2-methyl-2-propenyl)-2-azetidinone

Conditions

Conditions	Yield
sodium 2-mercaptobenzothiazole In water; acetone for 1.5h; Ambient temperature;	A n/a B 92%

...Expand

: 85573-72-4, 87579-79-1
(R)-2-[2-(benzothiazol-2-yldisulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyl-3-enoic acid benzhydryl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 85573-73-5, 115546-67-3
2β-chloromethyl-2α-methylpenicillin-3α-carboxylic acid diphenylmethyl ester

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In dichloromethane; water at 0℃; for 2h;	A n/a B 92%

: 118331-41-2
(R)-2-[2-(Benzothiazol-2-yldisulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-methoxy-benzyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: p-methoxybenzyl 2β-chloromethyl-2α-methylpenam-3α-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In dichloromethane; water at 0℃; for 2h;	A n/a B 92%

: 71355-12-9, 95835-16-8
p-nitrobenzyl <(R)-4-(2-benzothiazol-2-yldithio)-2-oxo-1-azetidinyl>isopropenylacetate

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 89051-52-5
p-nitrobenzyl 2β-(chloromethyl)-2α-methylpenam-3α-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In dichloromethane at 0℃; for 2h; Product distribution; Mechanism; reactions of derivatives with HCl and HBr;	A n/a B 91%
With hydrogenchloride; sodium nitrite In dichloromethane; water at 0℃; for 2h;	A n/a B 91%

: 95122-89-7, 126577-33-1
2-(2-benzothiazolyldithio)-3-bromo-α-(1-methylethylidene)-4-oxo-1-azetidineacetic acid β-nitrobenzyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: p-nitrobenzyl 6α-bromo-2β-chloromethyl-2α-methylpenam-3α-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In dichloromethane; water at 0℃; for 3h;	A n/a B 91%

: 84734-39-4, 91176-99-7, 93132-97-9
(R)-2-[(R)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-3-methyl-but-3-enoic acid benzyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: benzyl 2β-chloromethyl-2α-methyl-6β-(phenylacetamido)-penam-3α-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In dichloromethane; water at 0℃; for 2h;	A n/a B 91%

: 149-30-4
2-Mercaptobenzothiazole

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 4845-58-3
2-mercapto-6-nitrobenzothiazole

Conditions

Conditions	Yield
In sulfuric acid	A 90% B n/a

: 41475-98-3
S-(benzo[d]thiazol-2-yl) benzenesulfonothioate

: 873-55-2
sodium benzenesulfonate

A: 93788-86-4
p-methoxybenzyl 2-(3-phenylacetamido-4-benzenesulfonylthio-2-azetidinon-1-yl)-3-methyl-3-butenoate

B: 120-78-5
di(benzothiazol-2-yl)disulfide

Conditions

Conditions	Yield
In acetone	A 90% B n/a

...Expand

: 75-15-0
carbon disulfide

: 615-43-0
2-iodophenylamine

: 120-78-5
di(benzothiazol-2-yl)disulfide

Conditions

Conditions	Yield
With copper(l) iodide; oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene In dimethyl sulfoxide at 110℃; for 6h; Mechanism; Sealed tube;	89%

: 67-56-1
methanol

: 70203-07-5
2-benzothiazol-2-ylsulfanyl-hexanedioic acid dimethyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 74400-47-8
2,2-Dimethoxy-hexanedioic acid dimethyl ester

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; copper dichloride Ambient temperature; electrosynthesis;	A 88% B 57%

...Expand

: 70203-07-5
2-benzothiazol-2-ylsulfanyl-hexanedioic acid dimethyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 74400-47-8
2,2-Dimethoxy-hexanedioic acid dimethyl ester

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; copper dichloride In methanol Ambient temperature; electrosynthesis;	A 88% B 57%

: 72844-40-7
dimethyl 2-n-pentyl-(2-benzothiazolylthio)adipate

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 72844-48-5
2-Pentyl-hexanedioic acid dimethyl ester

C: 149-30-4
2-Mercaptobenzothiazole

Conditions

Conditions	Yield
In methanol; sulfuric acid Ambient temperature; Electrochemical reduction;	A 31% B 87% C 53%

...Expand

: 72844-45-2
2-(Benzothiazol-2-ylsulfanyl)-2-(3-methyl-but-2-enyl)-octanoic acid methyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 72844-53-2
2-(3-Methyl-but-2-enyl)-octanoic acid methyl ester

C: 149-30-4
2-Mercaptobenzothiazole

Conditions

Conditions	Yield
In methanol; sulfuric acid Ambient temperature; Electrochemical reduction;	A 63% B 84% C 24%

...Expand

: 67-56-1
methanol

: 74391-97-2
2-(Benzothiazol-2-ylsulfanyl)-4-methoxy-butyric acid methyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 74392-00-0
2,2,4-Trimethoxy-butyric acid methyl ester

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; copper dichloride Ambient temperature; electrosynthesis;	A 83% B 70%

...Expand

: 70203-06-4
2-benzothiazol-2-ylsulfanyl-octanoic acid methyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 74391-99-4
2,2-Dimethoxy-octanoic acid methyl ester

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; copper dichloride In methanol for 2.4h; Ambient temperature; electrosynthesis;	A 80% B 83%

: 74391-97-2
2-(Benzothiazol-2-ylsulfanyl)-4-methoxy-butyric acid methyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 74392-00-0
2,2,4-Trimethoxy-butyric acid methyl ester

Conditions

Conditions	Yield
With tetraethylammonium perchlorate; copper dichloride In methanol Ambient temperature; electrosynthesis;	A 83% B 70%

: 149-30-4
2-thioxo-3H-1,3-benzothiazole

A: 95-16-9
1,3-Benzothiazole

B: 120-78-5
di(benzothiazol-2-yl)disulfide

Conditions

Conditions	Yield
With ozone In methanol; dichloromethane at 25℃;	A 11% B 83%
With ozone In dichloromethane at 25℃; Product distribution; other 2-mercaptoheterazoles at different reaction conditions;	A 5% B 75%
With dihydrogen peroxide; acetic acid at 25℃; for 0.0833333h;	A 35% B 43%

: 72844-41-8
dimethyl 2-(2-pentynyl)-2-(2-benzothiazolylthio)adipate

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 72844-49-6
2-Pent-2-ynyl-hexanedioic acid dimethyl ester

C: 149-30-4
2-Mercaptobenzothiazole

Conditions

Conditions	Yield
In methanol; sulfuric acid Ambient temperature; Electrochemical reduction;	A 50% B 82% C 22%

...Expand

: 70905-82-7
2-benzothiazol-2-ylsulfanyl-2-(3-oxo-butyl)-octanoic acid methyl ester

A: 120-78-5
di(benzothiazol-2-yl)disulfide

B: 72844-54-3
2-(3-Oxo-butyl)-octanoic acid methyl ester

C: 149-30-4
2-Mercaptobenzothiazole

Conditions

Conditions	Yield
In methanol; sulfuric acid Ambient temperature; Electrochemical reduction;	A 33% B 80% C 25%

...Expand

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 316123-88-3
(5-Amino-[1,2,4]thiadiazol-3-yl)-[(Z)-1-ethyl-propoxyimino]-acetic acid

: 316123-90-7
(5-amino-[1,2,4]thiadiazol-3-yl)-(1-ethyl-propoxyimino)-thioacetic acid S-benzothiazol-2-yl ester

Conditions

Conditions	Yield
With tributyl-amine; triethyl phosphite In acetonitrile at -10℃;	100%

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 108-91-8
cyclohexylamine

: 95-33-0
N-(cyclohexyl)benzothiazole-2-sulfenamide

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene	100%

: 110-91-8
morpholine

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 102-77-2
4-(benzothiazole-2-sulfenyl)-morpholine

Conditions

Conditions	Yield
With sodium hydroxide In toluene	99.5%
With tetraethylammonium perchlorate In N,N-dimethyl-formamide for 16h; (electrolysis);

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 75-64-9
tert-butylamine

: 95-31-8
N-(tert-butyl)benzothiazole-2-sulfenamide

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 40 - 85℃; for 2.5h; Reagent/catalyst; Solvent; Large scale;	99.5%
Stage #1: di(benzothiazol-2-yl)disulfide In water at 20℃; for 0.5h; Reflux; Stage #2: tert-butylamine In water at 30 - 50℃; for 3h; Stage #3: With sodium hydroxide In water at 80 - 85℃; for 1h; Reagent/catalyst;	98.5%
With tetrabutylammonium tetrafluoroborate In acetonitrile at 30℃; for 2h; Sealed tube; Electrochemical reaction;	95%
With oxygen In water at 60℃; under 2250.23 Torr; for 4h; Reagent/catalyst;	76%
With tetraethylammonium perchlorate In N,N-dimethyl-formamide at 15 - 22℃; for 8h; (electrolysis);

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 143-15-7
1-dodecylbromide

: 106184-47-8
2-(dodecylthio)benzo[d]thiazole

Conditions

Conditions	Yield
With RhCl(PPh3)3; hydrogen; triethylamine In tetrahydrofuran at 50℃; under 760 Torr; for 24h;	99%

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 86299-47-0
(Z)-2-(2-aminothiazol-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxy)iminoacetic acid

: 89604-92-2
2-benzothiazolyl 2-(2-aminothiazol-4-yl)-2-<<1-(tert-butoxycarbonyl)-1-methylethoxy>imino>thioacetate

Conditions

Conditions	Yield
With pyridine; N,N-dimethyl-aniline; triethyl phosphite In acetonitrile; benzene at 18 - 25℃; for 0.5h; Reagent/catalyst; Microwave irradiation; Green chemistry;	98.5%

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 75-66-1
2-methylpropan-2-thiol

: 27657-22-3
2-(tert-butyldisulfanyl)benzo[d]thiazole

Conditions

Conditions	Yield
With palladium dichloride In dimethyl sulfoxide at 80℃; for 2h; Schlenk technique; Inert atmosphere;	98%
In chloroform for 6h; Ambient temperature;	88%
With methanol; tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 4h; Electrochemical reaction; Inert atmosphere;	65%

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 2-Methyl-3-(trityl-amino)-propan-1-ol

: 219126-59-7
[3-(Benzothiazol-2-ylsulfanyl)-2-methyl-propyl]-trityl-amine

Conditions

Conditions	Yield
With tributylphosphine In tetrahydrofuran	98%

: 60-80-0
antipyrine

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 4-(benzo[d]thiazol-2-ylthio)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; potassium iodide In acetonitrile at 60℃; for 16h;	97%
With 1,4-diaza-bicyclo[2.2.2]octane; silver(I) acetate In methanol at 20℃; for 2h; Sealed tube;	84%

: 91868-79-0
2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 94088-75-2
2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one

Conditions

Conditions	Yield
With pyridine; triethylamine; triethyl phosphite In dichloromethane; acetonitrile at 16.5 - 23℃; for 2h; Temperature; Reagent/catalyst;	97%
Stage #1: 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid With N,N-dimethyl acetamide; triethylamine In dichloromethane; acetonitrile for 1.5h; Stage #2: di(benzothiazol-2-yl)disulfide With phosphonic Acid; triethyl phosphite In dichloromethane; acetonitrile at 31℃; for 2h; Reagent/catalyst; Temperature;	92.74%

: 110-91-8
morpholine

dibenzolthiazolyl disulphide: dibenzolthiazolyl disulphide

N-Cyclohexyl-2-benzothiazole sulphene amide: N-Cyclohexyl-2-benzothiazole sulphene amide

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 102-77-2
4-(benzothiazole-2-sulfenyl)-morpholine

Conditions

Conditions	Yield
In ethanol	96.5%

...Expand

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 169956-70-1
(5-Amino-[1,2,4]thiadiazol-3-yl)-[(Z)-3,3-dimethyl-cyclobutoxyimino]-acetic acid

: 169956-71-2
(5-amino-[1,2,4]thiadiazol-3-yl)-(3,3-dimethyl-cyclobutoxyimino)-thioacetic acid S-benzothiazol-2-yl ester

Conditions

Conditions	Yield
With tributyl-amine; triethyl phosphite In acetonitrile at -10℃;	96%

: 909025-52-1
tridec-1-ene-3-thiol

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 909025-34-9
2-(2-(tridec-1-en-3-yl)disulfanyl)benzo[d]thiazole

Conditions

Conditions	Yield
In chloroform at 20℃;	96%
In chloroform	96%

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 620973-40-2
benzothiazolyl-2-sulfur trifluoride

Conditions

Conditions	Yield
With potassium fluoride; chlorine In acetonitrile at 20℃; for 4h;	95.5%
With potassium fluoride; chlorine In acetonitrile at 20℃;

: 629-45-8
dibutyl disulfide

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 2-(butyldisulfanyl)benzo[d]thiazole

Conditions

Conditions	Yield
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate In dichloromethane at 80℃; for 3h;	95%

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 179162-55-1
4-{5-[4-(pentyloxy)phenyl]-1,2-oxazol-3-yl}benzoic acid

: 1426839-84-0
PPIB-MBT

Conditions

Conditions	Yield
With triphenylphosphine In N,N-dimethyl-formamide at 20℃; for 2h;	95%
With triphenylphosphine In N,N-dimethyl-formamide at 20℃; for 2h;	95%

: 108-86-1
bromobenzene

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 4276-60-2
2-(phenylthio)benzothiazole

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide In water; N,N-dimethyl-formamide at 80℃; for 0.166667h; Microwave irradiation;	95%

: 490-64-2
asaronic acid

: 120-78-5
di(benzothiazol-2-yl)disulfide

: C17H15NO4S2

Conditions

Conditions	Yield
Stage #1: di(benzothiazol-2-yl)disulfide With triphenylphosphine In dichloromethane at 5℃; for 1h; Inert atmosphere; Stage #2: asaronic acid In dichloromethane at 5℃; for 1h;	94.4%

: 120-78-5
di(benzothiazol-2-yl)disulfide

: 119-53-9
2-hydroxy-2-phenylacetophenone

: 109275-18-5
2-[(1,3-benzothiazol-2-yl)sulfanyl]-1,2-diphenylethanone

Conditions

Conditions	Yield
With tributylphosphine In toluene for 8h; Heating;	94%

: 503614-92-4
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid

: 120-78-5
di(benzothiazol-2-yl)disulfide

: C32H27N5O4S2

Conditions

Conditions	Yield
Stage #1: di(benzothiazol-2-yl)disulfide With triphenylphosphine In dichloromethane at 20℃; for 1.5h; Stage #2: 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid In dichloromethane at 20℃; for 1h;	94%

2,2'-Dithiobis(benzothiazole) Chemical Properties

Molecular Structure of 2,2'-Dithiobis(benzothiazole) (CAS NO.120-78-5):

IUPAC Name: 2-(1,3-benzothiazol-2-yldisulfanyl)-1,3-benzothiazole
Empirical Formula: C₁₄H₈N₂S₄
Molecular Weight: 332.4867
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 132.86Å²
Index of Refraction: 1.848
Molar Refractivity: 94.48 cm³
Molar Volume: 211.7 cm³
Surface Tension: 90.3 dyne/cm
Density: 1.57 g/cm³
Flash Point: 275.8 °C
Enthalpy of Vaporization: 77.79 kJ/mol
Boiling Point: 532.5 °C at 760 mmHg
Vapour Pressure: 6.97E-11 mmHg at 25°C
Water Solubility: <0.01 g/100 mL at 21 ºC
Merck: 3370
Melting point: 177-180 °C(lit.)
EINECS: 204-424-9
Product Categories: Rubber Chemicals; Industrial/Fine Chemicals; Xanthones; Organics; Carumonam; Cefixime; Spirapril; Building Blocks; Heterocyclic Building Blocks; Thiazoles

2,2'-Dithiobis(benzothiazole) Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)	National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	180mg/kg (180mg/kg)	U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02251,
mouse	LD50	oral	7gm/kg (7000mg/kg)	International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
rabbit	LD50	skin	> 7940mg/kg (7940mg/kg)	United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1190-0987S,
rat	LD50	intraperitoneal	2600mg/kg (2600mg/kg)	International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
rat	LD50	oral	> 12gm/kg (12000mg/kg)	National Technical Information Service. Vol. AD755-358,

2,2'-Dithiobis(benzothiazole) Consensus Reports

Reported in EPA TSCA Inventory.

2,2'-Dithiobis(benzothiazole) Safety Profile

Poison by intravenous and intraperitoneal routes. Slightly toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x and NO_x. See also SULFIDES.
Hazard Codes: Irritant Xi, Dangerous N
Risk Statements: 31-43-50/53
R31 :Contact with acids liberates toxic gas.
R43:May cause sensitization by skin contact.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 36/37-60-61
S36/37:Wear suitable protective clothing and gloves.
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077 9/PG 3
WGK Germany: 2

2,2'-Dithiobis(benzothiazole) Specification

2,2'-Dithiobis(benzothiazole) , with CAS number of 120-78-5, can be called 1,2-Bis(2-benzothiazolyl)disulfide ; 2,2'-Benzothiazolyl disulfide ; 2,2'-Benzothiazyl disulfide ; 2,2'-Dibenzothiazole disulfide ; 2,2'-Dibenzothiazolyl disulfide ; 2,2'-Dithiobis ; 2-Benzothiazolyl disulfide ; 2-Mercaptobenzothiazole disulfide ; Bis(2-benzothiazolyl) disulfide ; Bis(benzothiazol-2-yl)disulfide ; Dibenzothiophene disulfide . It is a yellow amorphous powder. 2,2'-Dithiobis(benzothiazole) (CAS NO.120-78-5) is used as universal promoting agents like the natural rubber, synthetic rubber, reclaimed rubber. 2,2'-Dithiobis(benzothiazole) (CAS NO.120-78-5) is mainly used in the manufacture of tires, tire tube, rubber belt, rubber overshoes and general industrial products. High purity Benzothiazole disulfide (pharmaceutical grade) is the important manufacturing cephalosporin antiphlogistics pharmaceutical intermediates.

Product Name

2,2'-Dithiobis(benzothiazole)

Synthetic route

2,2'-Dithiobis(benzothiazole) Chemical Properties

2,2'-Dithiobis(benzothiazole) Toxicity Data With Reference

2,2'-Dithiobis(benzothiazole) Consensus Reports

2,2'-Dithiobis(benzothiazole) Safety Profile

2,2'-Dithiobis(benzothiazole) Specification

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