2,2,3,3-Tetrafluoro-1-propanol supplier

Name
Tetrafluoro-1-propanol
EINECS 200-955-5
CAS No. 76-37-9
Article Data18
CAS DataBase
Density 1.35 g/cm³
Solubility Soluble in water.
Melting Point -15 °C
Formula C₃H₄F₄O
Boiling Point 109.5 °C at 760 mmHg
Molecular Weight 132.058
Flash Point 31 °C
Transport Information UN 1986 3/PG 3
Appearance colourless liquid
Safety 26-37/39-16-36/37-36
Risk Codes 10-20-36-36/37/38
Molecular Structure
Hazard Symbols Xn, F, Xi
Synonyms 1,1,3-Trihydroperfluoro-1-propanol;2,2,3,3-Tetrafluoropropyl alcohol;2,2,3,3-tetrafluoro-porpanol;1-Propanol, 2,2,3,3-tetrafluoro-;2,2,3,3-Tetrafluoropropanol-1;1,1, 3-Trihydroperfluoro-1-propanol;Tetrafluoropropyl alcohol;4-01-00-01438 (Beilstein Handbook Reference);2,2,3,3-Tetrafluoropropan-1-ol;2, 2,3,3-Tetrafluoropropyl alcohol;2,2,3,3-Tetrafluoro-1-propanol (TFP);1H,1H,3H-Tetrafluoro-1-propanol;2,2,3,3-tetrafluoro-1-propanol;;Tetrafluoropropanol;Trans-4-ethyl Hexahydrobenzoic Acid;2,2,3,3-Tetrafluoro-Propanol;2,2,3,3-Tetrafluoro-1-Propanol(Tfp);
PSA 20.23000
LogP 0.87910

Synthetic route

: 65611-25-8
phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester

: 121-44-8
triethylamine

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: triethylammonium hydrogen 1H,1H,3H-tetrafluoropropyl phosphite

Conditions

Conditions	Yield
With water for 1h; Ambient temperature;	A 96.4% B 88.6%

...Expand

: 3,5-Bis-(1,1,2,2-tetrafluoro-ethyl)-2,2,2-tris-(2,2,3,3-tetrafluoro-propoxy)-2λ5-[1,4,2]dioxaphospholane

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 756-04-7
2,2,3,3-tetrafluoropropionaldehyde

C: (2,2,3,3-Tetrafluoro-1-hydroxy-propyl)-phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester

Conditions

Conditions	Yield
With water In acetone at 20℃; for 20h;	A n/a B n/a C 95%

...Expand

: 302-17-0
chloral hydrate

: 87651-42-1
di(1,1,3-trihydrotetrafluoropropyl)phenyl phosphonite

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 1235818-80-0
(1,1,3-trihydrotetrafluoropropyl) (1-hydroxy-2,2,2-trichloroethyl)phenylphosphinate

Conditions

Conditions	Yield
In benzene at 30 - 40℃; for 12h; Abramov reaction; Inert atmosphere;	A n/a B 95%

...Expand

: 2648-47-7
2,2,3,3,4,4,5,5-octafluorovaleraldehyde

: 2241-68-1
tris(2,2,3,3-tetrafluoropropyl)phosphite

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: bis(2,2,3,3-tetrafluoropropyl) (1H,5H-octafluoro-1-hydroxypentyl)phosphonate

Conditions

Conditions	Yield
In benzene at 20 - 25℃; for 2h;	A n/a B 92%

...Expand

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 106-54-7
p-Chlorothiophenol

A: 563-10-0
phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester)

B: 76-37-9
2,2,3,3-tetrafluoropropanol

C: 1-Chloro-4-(2,2,3,3-tetrafluoro-propylsulfanyl)-benzene

Conditions

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 72%

...Expand

: 302-17-0
chloral hydrate

: C7H9F8O2P

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 111257-11-5
O-(1,1,3-trihydrotetrafluoropropyl)-(1-hydroxy-2,2,2-trichloroethyl)methylphosphinate

C: (1-hydroxy-2,2,2-trichloroethyl)methylphosphinic acid

Conditions

Conditions	Yield
In benzene for 12h; Heating;	A n/a B 70% C n/a

...Expand

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 106-53-6
para-bromobenzenethiol

A: 563-10-0
phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester)

B: 76-37-9
2,2,3,3-tetrafluoropropanol

C: 1-Bromo-4-(2,2,3,3-tetrafluoro-propylsulfanyl)-benzene

Conditions

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 70%

...Expand

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 108-98-5
thiophenol

A: 563-10-0
phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester)

B: 76-37-9
2,2,3,3-tetrafluoropropanol

C: 2,2,3,3-tetrafluoropropylphenyl sulfide

Conditions

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 63.5%

...Expand

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 106-45-6
para-thiocresol

A: 563-10-0
phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester)

B: 76-37-9
2,2,3,3-tetrafluoropropanol

C: 1-Methyl-4-(2,2,3,3-tetrafluoro-propylsulfanyl)-benzene

Conditions

Conditions	Yield
at 150℃; for 4h;	A n/a B n/a C 60%

...Expand

: 2,2,2-Tris-(2,2,3,3-tetrafluoro-propoxy)-3,5-bis-trifluoromethyl-2λ5-[1,4,2]dioxaphospholane

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 75-90-1
2,2,2-Trifluoroacetaldehyde

C: 88332-81-4
(2,2,2-Trifluoro-1-hydroxy-ethyl)-phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester

Conditions

Conditions	Yield
With water In acetone at 20℃; for 20h;	A n/a B n/a C 56%

...Expand

: 1137575-85-9
2[(3,3,2,2-tetrafluoropropoxy)methyl]thiirane

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 681-68-5
3-(2,2,3,3-tetrafluoropropoxy)-1-propene

C: C6H8F4O

Conditions

Conditions	Yield
at 210 - 215℃;	A n/a B 51% C n/a

...Expand

: 67-56-1
methanol

: 116-14-3
polytetrafluoroethylene

: 76-37-9
2,2,3,3-tetrafluoropropanol

Conditions

Conditions	Yield
With di-tert-butyl peroxide
With di-tert-butyl peroxide at 125℃; for 15.5h; Product distribution / selectivity;
With di-tert-butyl peroxide; calcium oxide at 125℃; for 20h; Product distribution / selectivity;

: 67-56-1
methanol

: 116-14-3
polytetrafluoroethylene

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 355-80-6
2,2,3,3,4,4,5,5-octafluoropentan-1-ol

Conditions

Conditions	Yield
With dibenzoyl peroxide at -30℃; for 6h; Yields of byproduct given;	A 12.3 g B n/a
With dibenzoyl peroxide at -30℃; for 6h; Yield given;	A 12.3 g B n/a

...Expand

: 358-33-8
bis(1,1,3-trihydroperfluoropropyl) hydrogen phosphate

A: 563-10-0
phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester)

B: 76-37-9
2,2,3,3-tetrafluoropropanol

Conditions

Conditions	Yield
Heating;	A 3.4 g B 0.7 g

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 108-98-5
thiophenol

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 80587-03-7
C18H17F16O4PS

...Expand

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 106-53-6
para-bromobenzenethiol

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: C18H16BrF16O4PS

...Expand

: 85878-21-3
C12H12F16O4Te

: 76-37-9
2,2,3,3-tetrafluoropropanol

Conditions

Conditions	Yield
With hydrogenchloride In hexane; benzene

: C20H25F20NO5P(1-)*C5H11N*H(1+)

A: 563-10-0
phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester)

B: 76-37-9
2,2,3,3-tetrafluoropropanol

C: bis(2,2,3,3-tetrafluoropropyl) piperidinophosphonate

D: 91461-54-0
1-(2,2,3,3-tetrafluoropropyl)piperidine

Conditions

Conditions	Yield
at 150℃; for 15h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
at 150℃; for 15h; Yield given. Yields of byproduct given;

...Expand

: C19H23F20NO6P(1-)*C4H9NO*H(1+)

A: 110-91-8
morpholine

B: 71878-96-1
bis(2,2,3,3-tetrafluoropropyl) morpholinophosphonate

C: 76-37-9
2,2,3,3-tetrafluoropropanol

D: 343331-58-8
4-(2,2,3,3-tetrafluoropropyl)morpholine

Conditions

Conditions	Yield
at 150℃; for 15h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
at 150℃; for 15h; Yield given. Yields of byproduct given;

...Expand

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 106-45-6
para-thiocresol

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: C19H19F16O4PS

...Expand

: 71879-02-2
pentakis(2,2,3,3-tetrafluoropropoxy)phosphorane

: 106-54-7
p-Chlorothiophenol

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: C18H16ClF16O4PS

...Expand

: 116-14-3
polytetrafluoroethylene

carbon monoxide: carbon monoxide

: 76-37-9
2,2,3,3-tetrafluoropropanol

Conditions

Conditions	Yield
With dicobalt octacarbonyl; hydrogen at 150℃; under 110326 Torr;

: C3H3F4O2N

: 76-37-9
2,2,3,3-tetrafluoropropanol

Conditions

Conditions	Yield
With nitric acid Kinetics; Equilibrium constant; Further Variations:; Temperatures; Pressures;

: 1-(2,2,3,3-tetrafluoropropoxy)-perfluoroindan-1-yl cation

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 1736-47-6
perfluoroindane

C: 58161-61-8
octafluoro-1-indanone

Conditions

Conditions	Yield
With hydrogenchloride

...Expand

: 116-14-3
polytetrafluoroethylene

: 76-37-9
2,2,3,3-tetrafluoropropanol

Conditions

Conditions	Yield
With di-tert-butyl peroxide In methanol

: 302-17-0
chloral hydrate

: 2241-68-1
tris(2,2,3,3-tetrafluoropropyl)phosphite

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 65611-19-0
(2,2,2-trichloro-1-hydroxy-ethyl)-phosphonic acid bis-(2,2,3,3-tetrafluoro-propyl) ester

Conditions

Conditions	Yield
Abramov reaction;

...Expand

: 302-17-0
chloral hydrate

: C7H9F8O2P

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 111257-11-5
O-(1,1,3-trihydrotetrafluoropropyl)-(1-hydroxy-2,2,2-trichloroethyl)methylphosphinate

Conditions

Conditions	Yield
Abramov reaction;

...Expand

: 1893-38-5
methyl 2,2,3,3-tetrafluoropropionate

A: 76-37-9
2,2,3,3-tetrafluoropropanol

B: 2,2,3,3-Tetrafluoro-1-methoxy-propan-1-ol

Conditions

Conditions	Yield
With C28H29ClNOP2Ru; hydrogen; sodium methylate In methanol at 36℃; under 3750.38 Torr; Autoclave;

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 97108-40-2
2-chloro-2,2-diphenyl-3,5-bis(1,1,2,2-tetrafluoroethyl)-1,4,2-dioxaphospholane

: 2,2-Diphenyl-3,5-bis-(1,1,2,2-tetrafluoro-ethyl)-2-(2,2,3,3-tetrafluoro-propoxy)-2λ5-[1,4,2]dioxaphospholane

Conditions

Conditions	Yield
With triethylamine In diethyl ether for 1h;	100%

: α-isocyanatomethylmethyldimethoxysilane

: 76-37-9
2,2,3,3-tetrafluoropropanol

: N-[dimethoxy(methyl)silylmethyl]carbamic acid-2,2,3,3-tetrafluoropropyl ester

Conditions

Conditions	Yield
With dibutyltin dilaurate at 50 - 70℃; for 0.5h;	100%

: 55717-45-8
6-bromo-pyridin-3-ol

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1609098-11-4
2-bromo-5-(2,2,3,3-tetrafluoropropoxy)pyridine

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 1h;	100%

: 116-15-4
perfluoropropylene

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 65064-78-0
1,1,1,2,3,3-hexafluoro-3-(2,2,3,3-tetrafluoropropoxy)propane

Conditions

Conditions	Yield
With potassium hydroxide In water at 50 - 60℃; under 3000.3 - 3750.38 Torr; Inert atmosphere; Autoclave;	99.8%
With potassium hydroxide at 20 - 40℃;	87%
With potassium hydroxide
With potassium hydroxide In acetonitrile cooling;

: 75-38-7
Vinylidene fluoride

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1201897-09-7
C5H6F6O

Conditions

Conditions	Yield
With potassium hydroxide In water at 75 - 80℃; under 6000.6 Torr; Inert atmosphere; Autoclave;	99.8%

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 616-38-6
carbonic acid dimethyl ester

: 1422-70-4
bis(2,2,3,3-tetrafluoropropyl) carbonate

Conditions

Conditions	Yield
With sodium carbonate at 60 - 100℃; for 4h;	99.2%

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 124842-01-9
(1,2,3,4,5,6-Hexachloro-2,3,4,5,6-pentafluoro-cyclohexyl)-[2-(2,2,3,3-tetrafluoro-propoxy)-2λ5-benzo[1,3,2]dioxaphosphol-2-ylidene]-amine

: 140476-65-9
2,2-bis(2,2,3,3-tetrafluoropropoxy)-2-(2,3,4,5,6-pentachloro-2,3,4,5,6-pentafluorocyclohexylideneamino)-1,3,2-benzodioxaphosphole

Conditions

Conditions	Yield
With triethylamine In diethyl ether for 20h;	99%

: 116-16-5
1,1,1,3,3,3-hexachloro-propan-2-one

: 76-37-9
2,2,3,3-tetrafluoropropanol

A: 67-66-3
chloroform

B: 1422-70-4
bis(2,2,3,3-tetrafluoropropyl) carbonate

Conditions

Conditions	Yield
With potassium fluoride; zirconium(IV) oxide at 140℃; for 10h; Product distribution / selectivity; pressure tight reactor;	A 99% B 99%

...Expand

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 87992-83-4
O,O-bis(1,1,3-trihydroperfluoropropyl) hydrogen dithiophosphate

Conditions

Conditions	Yield
With tetraphosphorus decasulfide at 150 - 170℃; for 45h;	98.7%
With tetraphosphorus decasulfide; triethylamine for 2h; Heating;	57%

: 116-14-3
polytetrafluoroethylene

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 16627-68-2
1,1,2,2-tetrafluoro-3-(1,1,2,2-tetrafluoroethoxy)propane

Conditions

Conditions	Yield
With potassium hydroxide In water at 75 - 95℃; under 5625.56 - 6000.6 Torr; for 8.5h; Product distribution / selectivity; Inert atmosphere; Autoclave;	98.5%
With sodium In 1,4-dioxane
With potassium hydroxide In N,N-dimethyl-formamide
With potassium hydroxide In water at 20 - 95℃; under 750.075 - 6000.6 Torr; Product distribution / selectivity; Inert atmosphere; Industry scale; Autoclave;

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 79-38-9
Chlorotrifluoroethylene

: 65064-83-7
3-(2-Chloro-1,1,2-trifluoro-ethoxy)-1,1,2,2-tetrafluoro-propane

Conditions

Conditions	Yield
With potassium hydroxide In water at 75 - 85℃; under 3000.3 Torr; Inert atmosphere; Autoclave;	98%
With potassium hydroxide In N,N-dimethyl-formamide

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 85233-01-8
4,5-benzo-1,3,2-dioxaphosphol-2-yl 2,2,2-trifluoroacetate

A: 88399-68-2
2-(2,2,3,3-tetrafluoropropoxy)-4,5-benzo-1,3,2-dioxaphospholane

B: 76-05-1
trifluoroacetic acid

Conditions

Conditions	Yield
	A 98% B n/a

...Expand

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 2241-68-1
tris(2,2,3,3-tetrafluoropropyl)phosphite

: 931-59-9
benzenesulfenyl chloride

: 80587-03-7
C18H17F16O4PS

Conditions

Conditions	Yield
With triethylamine In diethyl ether; dichloromethane at -50 - 20℃; for 1h;	98%

...Expand

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 110920-07-5
3-[(chlorosulfinyl)oxy]-1,1,2,2-tetrafluoropropane

: 1,1,2,2-tetrafluoro-3-(2,2,3,3-tetrafluoropropoxy)propane

Conditions

Conditions	Yield
With N,N-dimethyl-formamide In chloroform at -10 - 20℃;	98%
With N,N-dimethyl-formamide at 25℃; Kinetics; Temperature;

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 201230-82-2
carbon monoxide

: 112-13-0
n-decanoyl chloride

: C17H24F8O4

Conditions

Conditions	Yield
Stage #1: carbon monoxide; n-decanoyl chloride With 2AlBr3*CBr4 at -20℃; under 735.576 Torr; for 1.45h; Stage #2: 2,2,3,3-tetrafluoropropanol at -20℃; under 735.576 Torr; for 2h; regioselective reaction;	98%

...Expand

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 98-59-9
p-toluenesulfonyl chloride

: 786-31-2
p-toluenesulfonic acid-2,2,3,3-tetrafluoropropyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 3h; Ambient temperature;	97%
With triethylamine at 20℃; for 7h;	94%
With potassium hydroxide In benzene at 80℃; for 1h;	87%

: 116-16-5
1,1,1,3,3,3-hexachloro-propan-2-one

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1422-70-4
bis(2,2,3,3-tetrafluoropropyl) carbonate

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluoropropanol With Tetraethylene glycol dimethyl ether; potassium carbonate at 10 - 30℃; Stage #2: 1,1,1,3,3,3-hexachloro-propan-2-one at 30 - 70℃; Reagent/catalyst;	97%
With potassium fluoride at 100℃; for 10h;	100 g

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1-dimethylosiloxy-3,5,7,9,11,13,15-heptacyclohexylpentacyclo[9.5.113,9.15,15.17,13]octasiloxane

: 1-(dimethyl(2,2,3,3-tetrafluoropropoxy)siloxy)-3,5,7,9,11,13,15-hepta(isobutyl)pentacyclo[9.5.1.13,9.15,15.17,13]octasiloxane

Conditions

Conditions	Yield
With palladium on activated charcoal In tetrahydrofuran at 65℃; for 48h; Schlenk technique; Inert atmosphere;	97%

: 3265-14-3
3-diazo-1-methyl-1,3-dihydro-indol-2-one

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1-methyl-3-(2,2,3,3-tetrafluoropropoxy)indolin-2-one

Conditions

Conditions	Yield
In dichloromethane at 25℃; for 24h; Irradiation;	97%

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 563-10-0
phosphoric acid tris-(2,2,3,3-tetrafluoro-propyl ester)

Conditions

Conditions	Yield
With magnesium sulfate; trichlorophosphate at 60 - 120℃;	96%
With lithium chloride; trichlorophosphate for 2.5h; bath temperature 160 deg C;	91.6%
With phosphorus pentachloride at 20℃; for 12h;	66%

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 183006-17-9
bis[(2,2,3,3-tetrafluoropropoxy)sulfonyl]amine

Conditions

Conditions	Yield
With bis(chlorosulfonyl)amine In benzene for 2h; Heating;	96%

: 2402-77-9
2,3-dichloro-pyridine

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1355067-32-1
3-chloro-2-(2,2,3,3-tetrafluoropropyl)pyridine

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Stage #2: 2,3-dichloro-pyridine In tetrahydrofuran; mineral oil for 16h; Reflux;	96%
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h; Stage #2: 2,3-dichloro-pyridine In tetrahydrofuran; mineral oil for 16h; Reflux;	96%

: 764-85-2
Nonanoyl chloride

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 201230-82-2
carbon monoxide

: C16H22F8O4

Conditions

Conditions	Yield
Stage #1: Nonanoyl chloride; carbon monoxide With 2AlBr3*CBr4 at -20℃; under 735.576 Torr; for 1.45h; Stage #2: 2,2,3,3-tetrafluoropropanol at -20℃; under 735.576 Torr; regioselective reaction;	96%

...Expand

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 644-97-3
Dichlorophenylphosphine

: 87651-42-1
di(1,1,3-trihydrotetrafluoropropyl)phenyl phosphonite

Conditions

Conditions	Yield
at 20 - 25℃;	95%
In pyridine

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 127054-68-6
2-bromo-2,2-bis(2,2,3,3-tetrafluorpropoxy)-4,5-benzo-1,3,2-dioxaphospholane

: 127054-63-1
2-(2,2,3,3-tetrafluoropropoxy)-2-oxobenzo-1,3,2λ5-dioxaphosphole

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -40℃; for 0.5h;	94%

: 106-39-8
bromochlorobenzene

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 1-chloro-4-(2,2,3,3-tetrafluoropropoxy)benzene

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluoropropanol With sodium In 1,4-dioxane Stage #2: bromochlorobenzene With N,N-dimethyl-formamide; copper(I) bromide In 1,4-dioxane at 110℃; for 6h; Sealed tube;	94%

: 76-37-9
2,2,3,3-tetrafluoropropanol

: 649-76-3
bis(1,1,3-trihydroperfluoropropyl) sulfite

Conditions

Conditions	Yield
With HCF2CF2OCF2CF2SO2N=S=O for 1h; -20 deg C up to 25 deg C;	93%
With thionyl chloride; iron(III) chloride at 60℃; for 4h;	80%
With pyridine; thionyl chloride In diethyl ether at -20℃;

2,2,3,3-Tetrafluoro-1-propanol Consensus Reports

Reported in EPA TSCA Inventory.

2,2,3,3-Tetrafluoro-1-propanol Specification

The 2,2,3,3-Tetrafluoro-1-propanol, with the cas registry number 76-37-9, has the systematic name of 2,2,3,3-tetrafluoropropan-1-ol. This is a kind of stable chemical, and it is incompatible with strong oxidizing agents, strong bases, sodium, potassium, acid chlorides, acid anhydrides. Its product categories are various, including industrial/fine chemicals; small molecule; organic fluorides; alcohols; c2 to c6; oxygen compounds.

The characteristics of this chemical are as follows: (1)#H bond acceptors: 1; (2)#H bond donors: 1; (3)#Freely Rotating Bonds: 3; (4)Polar Surface Area: 20.23; (5)Index of Refraction: 1.296; (6)Molar Refractivity: 18.06 cm³; (7)Molar Volume: 97.7 cm³; (8)Polarizability: 7.16 ×10^-24 cm³; (9)Surface Tension: 17 dyne/cm; (10)Density: 1.35 g/cm³; (11)Flash Point: 31 °C; (12)Enthalpy of Vaporization: 40.59 kJ/mol; (13)Boiling Point: 109.5 °C at 760 mmHg; (14)Vapour Pressure: 13.1 mmHg at 25°C; (15)Exact Mass: 132.019828; (16)MonoIsotopic Mass: 132.019828; (17)Topological Polar Surface Area: 20.2; (18)Heavy Atom Count: 8; (19)Complexity: 71.7.

Use of 2,2,3,3-Tetrafluoro-1-propanol is as below: 2,2,3,3-Tetrafluoro-1-propanol could react to produce 3-chloro-1,1,2,2-tetrafluoro-propane, with the following condition: reagent: (2-chloro-1,1,2-trifluoro-ethyl)-diethyl-amin; reaction temp.: 170 ℃.

As to its usage, it is widely applied in many ways. It is usually used in pharmaceutics, intermediate for pesticide, light disk paint solvent, and cleaning agent.

When dealing with this chemical, you should be cautious and then take some measures to protect yourself. For one thing, it is irritant. This chemical is irritating to eyes, respiratory system and skin. For another thing, it is harmful, and may cause damage to health. In addition, it is highly flammable. It may catch fire in contact with air, only needing brief contact with an ignition source, and it has a very low flash point or evolve highly flammable gases in contact with water. Therefore, you should take the following instructions. Wear suitable clothing, gloves and eye/face protection, and keep away from sources of ignition - No smoking. If in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Additionally, the following data information could be converted into the molecular structure:
(1)SMILES:FC(F)C(F)(F)CO
(2)InChI:InChI=1/C3H4F4O/c4-2(5)3(6,7)1-8/h2,8H,1H2
(3)InChIKey:NBUKAOOFKZFCGD-UHFFFAOYAL

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	8600mg/m3/2H (8600mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 109, 1982.
rat	LCLo	inhalation	2000ppm/4H (2000ppm)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS	Journal of Occupational Medicine. Vol. 4, Pg. 262, 1962.
rat	LDLo	oral	3400mg/kg (3400mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES	Journal of Occupational Medicine. Vol. 4, Pg. 262, 1962

Product Name

Tetrafluoro-1-propanol

Synthetic route

2,2,3,3-Tetrafluoro-1-propanol Consensus Reports

2,2,3,3-Tetrafluoro-1-propanol Specification

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