• Name

  2,2-Diethoxyethanol

• EINECS 210-697-5
• CAS No. 621-63-6
• Article Data21
• CAS DataBase
• Density 0.97 g/cm³
• Solubility Miscible with water, chloroform and ethyl acetate.
• Melting Point 209 - 211oC
• Formula C₆H₁₄O₃
• Boiling Point 167 °C at 760 mmHg
• Molecular Weight 134.175
• Flash Point 68.4 °C
• Transport Information
• Appearance Colorless pure liquid
• Safety 23-24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Glycolaldehyde,diethyl acetal (6CI,8CI);2-Hydroxyacetaldehyde diethylacetal;Hydroxyacetaldehyde diethyl acetal;NSC 9255;
• PSA 38.69000
• LogP 0.37780

Synthetic route

5344-23-0

diethoxyacetaldehyde

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol 1.) 2 h, 0 deg C; 2.) r.t., 1 h;	100%

60468-85-1

acetoxyacetaldehyde diethylacetate

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 0℃;	97%

103410-71-5

acetoxy-1 triethoxy-1,2,2 ethane

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 2h; Heating;	94%

64-17-5

ethanol

141-46-8

Glycolaldehyde

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
With sodium hydroxide at 20℃; for 0.25h;	91%

6065-82-3

Ethyl diethoxyacetate

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
With sodium tetrahydroborate In dimethoxyethane, 1,2; ethanol at 50℃; for 7h; Heating / reflux;	88.7%

67-56-1

methanol

sucrose

A

530-26-7

D-Mannose

B

27871-49-4

(S)-Methyl lactate

C

1663-35-0

2-methoxyethyl vinyl ether

D

5837-73-0

methyl 2-hydroxybut-3-enoate

E

1186-47-6

1,1-dihydroxyacetone

F

56-82-6

Glyceraldehyde

G

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
With potassium carbonate at 160℃; for 16h; Reagent/catalyst; Flow reactor;	A n/a B 72% C n/a D n/a E n/a F n/a G n/a

...Expand

66090-23-1

2,5-diethoxy-[1,4]dioxane

7647-01-0

hydrogenchloride

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
at 100℃;

2.5-diethoxy-1.4-dioxane

2.5-diethoxy-1.4-dioxane

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
With hydrogenchloride at 100℃;

2032-35-1

Bromoacetaldehyde diethyl acetal

alcoholic KOH

alcoholic KOH

A

141-78-6

ethyl acetate

B

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
at 130℃;

...Expand

5344-23-0

diethoxyacetaldehyde

A

621-63-6

glycoaldehyde diethyl acetal

B

glyoxylic acid diethylacetal

glyoxylic acid diethylacetal

Conditions

Conditions	Yield
With potassium hydroxide at 95℃;

51806-20-3

1,1-diethoxy-2-iodoethane

alcoholic KOH

alcoholic KOH

A

141-78-6

ethyl acetate

B

78-39-7

Triethyl orthoacetate

C

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
at 100℃;

...Expand

5344-23-0

diethoxyacetaldehyde

KOH

KOH

A

621-63-6

glycoaldehyde diethyl acetal

B

glyoxylic acid diethylacetal

glyoxylic acid diethylacetal

Conditions

Conditions	Yield
at 95℃; im Rohr;

...Expand

3975-14-2

1,1,2,2-tetraethoxyethane

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 65 percent / ZnCl2 / 3 h / 90 °C 2: 94 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme

3054-95-3

acrylaldehyde diethyl acetal

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: durch Oxydation 3: n-KOH / 95 °C View Scheme
Multi-step reaction with 3 steps 2: durch Oxydation 3: KOH / 95 °C View Scheme

105-57-7

diethyl acetal

621-63-6

glycoaldehyde diethyl acetal

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine 2: alcoholic KOH-solution View Scheme
Multi-step reaction with 2 steps 1: durch Bromierung 2: alcoholic KOH-solution View Scheme

100-07-2

4-methoxy-benzoyl chloride

621-63-6

glycoaldehyde diethyl acetal

547752-15-8

4-methoxy-benzoic acid 2,2-diethoxy-ethyl ester

Conditions

Conditions	Yield
With dmap; triethylamine at 20℃; for 16h;	100%

18162-48-6

tert-butyldimethylsilyl chloride

621-63-6

glycoaldehyde diethyl acetal

956317-82-1

1-(tert-butyldimethylsiloxy)-2,2-diethoxyethane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 14h;	100%

100-07-2

4-methoxy-benzoyl chloride

621-63-6

glycoaldehyde diethyl acetal

4-methoxy-benzoic acid 2,2-diethoxy-ethyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In ethyl acetate at 0 - 20℃; for 16h;	100%
With dmap; triethylamine In tert-butyl methyl ether at 0 - 20℃; for 16h;	100%

463-56-9

thiocyanic acid

621-63-6

glycoaldehyde diethyl acetal

32091-51-3

2-mercapto-1,3-oxazole

Conditions

Conditions	Yield
In acetonitrile for 4h; Heating;	100%

75-08-1

ethanethiol

621-63-6

glycoaldehyde diethyl acetal

A

67210-05-3

glycolaldehyde diethyl dithioacetal

B

7038-14-4

1,1,2-tris-ethylsulfanyl-ethane

Conditions

Conditions	Yield
With hydrogenchloride for 0.5h; Ambient temperature;	A 98.6% B 0.73%

...Expand

C18H18N2O2

621-63-6

glycoaldehyde diethyl acetal

C24H30N2O4

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran	98%

98-88-4

benzoyl chloride

621-63-6

glycoaldehyde diethyl acetal

101268-52-4

(benzoyloxy)acetaldehyde diethyl acetal

Conditions

Conditions	Yield
In pyridine at -20 - 30℃; for 167.833h;	96.4%
With N-ethyl-N,N-diisopropylamine In pyridine 0 deg C, 1 h; r.t., 1.5 h;	90%
With pyridine at 0 - 20℃; for 16h; Inert atmosphere;	87%
With potassium hydroxide

58479-61-1

tert-butylchlorodiphenylsilane

621-63-6

glycoaldehyde diethyl acetal

139220-27-2

tert-Butyl-(2,2-diethoxy-ethoxy)-diphenyl-silane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide	95%

32779-36-5

5-Bromo-2-chloropyrimidine

621-63-6

glycoaldehyde diethyl acetal

864757-98-2

5-bromo-2-(2,2-diethoxyethoxy)pyrimidine

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;	94%

107-03-9

1-thiopropane

621-63-6

glycoaldehyde diethyl acetal

A

81712-70-1

glycolaldehyde dipropyl dithioacetal

B

79414-77-0

1,1,2-tris(propylthio)ethane

Conditions

Conditions	Yield
With hydrogenchloride for 0.5h; Ambient temperature;	A 90.3% B 0.76%

...Expand

621-63-6

glycoaldehyde diethyl acetal

563-47-3

3-Chloro-2-methylpropene

251942-44-6

1,1-diethoxyethyl methallyl ether

Conditions

Conditions	Yield
Stage #1: glycoaldehyde diethyl acetal With sodium hydride In tetrahydrofuran at 20℃; for 1h; Stage #2: 3-Chloro-2-methylpropene In tetrahydrofuran Heating; Further stages.;	90%

2,2-Diethoxyethanol Chemical Properties

The molecular formula of 2,2-Diethoxyethanol(621-63-6) is C₆H₁₄O₃ and its formula weight is 134.17.
The density of 2,2-Diethoxyethanol(621-63-6) is 0.97 g/cm³  and it has a boiling point of 167 °C at 760 mmHg. The refractive index is about  1.418 . Its flash point is  68.4 °C .
The chemical synonyms of 2,2-Diethoxyethanol(621-63-6) are 2,2-DIETHOXYETHANOL;GLYCOLALDEHYDE DIETHYL ACETAL;2,2-Diethoxyethanol~Hydroxyacetaldehyde diethyl acetal;2,2-DIETHOXY ALCOHOL;hydroxyacetaldehyde diethyl acetal
The molecular structure of 2,2-Diethoxyethanol(621-63-6):

2,2-Diethoxyethanol Safety Profile

2,2-Diethoxyethanol Specification