trimethylsilyl 2-[2-(2-ethoxyethoxy)ethoxy]-2,3,3,3-tetrafluoropropionate
A
ethoxyethoxyethanol
B
Carbitol-trimethylsilylaether
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water for 1h; Ambient temperature; | A n/a B n/a C 95% |
Conditions | Yield |
---|---|
With tungsten(VI) oxide at 90 - 95℃; unter Druck; | |
With sulfur dioxide at 75 - 80℃; |
Conditions | Yield |
---|---|
With sulfuric acid at 100 - 130℃; im Autoklaven; | |
With toluene-4-sulfonic acid at 100 - 130℃; | |
With 2,3-Dimethylaniline at 100 - 130℃; | |
With sulfuric acid at 80 - 100℃; | |
With metal oxide at 100 - 130℃; |
Conditions | Yield |
---|---|
(i) Na, (ii) /BRN= 1209224/; Multistep reaction; |
chloro-trimethyl-silane
2-[2-(2-Ethoxy-ethoxy)-ethoxy]-2,3,3,3-tetrafluoro-propionic acid 2-(2-ethoxy-ethoxy)-ethyl ester
A
ethoxyethoxyethanol
B
Carbitol-trimethylsilylaether
C
trimethylsilyl 2-[2-(2-ethoxyethoxy)ethoxy]-2,3,3,3-tetrafluoropropionate
Conditions | Yield |
---|---|
With sodium hydroxide; sodium hydride 1.) H2O, THF, 40 deg C, 3 h, 2.) Et2O, room temp., 3 h; Multistep reaction. Yields of byproduct given; | |
With sodium hydroxide; sodium hydride 1.) H2O, THF, 40 deg C, 3 h, 2.) Et2O, room temp., 3 h; Yield given. Multistep reaction; |
2-[2-(2-Ethoxy-ethoxy)-ethoxy]-2,3,3,3-tetrafluoro-propionic acid 2-(2-ethoxy-ethoxy)-ethyl ester
A
ethoxyethoxyethanol
Conditions | Yield |
---|---|
With sodium hydroxide 1.) THF, H2O, 40 deg C, 3 h, 2.) 200 deg C; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
at 90 - 95℃; under 7355.08 - 8826.09 Torr; |
diethylene glycol monoethyl ether acetate
A
ethoxyethoxyethanol
B
acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water at 30 - 49.8℃; Kinetics; |
ethoxyethoxyethanol
p-toluenesulfonyl chloride
2-(2-ethoxyethoxy)ethyl tosylate
Conditions | Yield |
---|---|
With pyridine at 5℃; | 100% |
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 2h; Inert atmosphere; | 98% |
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 1.16667h; Inert atmosphere; | 95.8% |
ethoxyethoxyethanol
methyl (E)-m-fluorocinnamate
Conditions | Yield |
---|---|
Stage #1: ethoxyethoxyethanol With N-methyl-N-nitrosotoluene-p-sulfonamide; potassium hydroxide In diethyl ether; water at 65℃; Stage #2: methyl (E)-m-fluorocinnamate; palladium diacetate In diethyl ether; dichloromethane; water at 0 - 20℃; for 2.5h; | 100% |
With potassium hydroxide; palladium diacetate In dichloromethane; water |
Conditions | Yield |
---|---|
at 120℃; for 3h; | 99% |
at 120℃; for 3h; | 82% |
at 110 - 120℃; for 3h; Yield given; |
ethoxyethoxyethanol
1,2-dibromomethane
1,13-diethoxy-3,6,8,11-tetraoxa-tridecane
Conditions | Yield |
---|---|
With potassium hydroxide; tetrabutylammomium bromide In water; chlorobenzene at 50℃; for 0.5h; | 98.58% |
Conditions | Yield |
---|---|
With sodium borohydrid In 5,5-dimethyl-1,3-cyclohexadiene | 97% |
3-benzyl-6-bromo-2-chloro-quinoline
ethoxyethoxyethanol
C22H24BrNO3
Conditions | Yield |
---|---|
Stage #1: ethoxyethoxyethanol With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: 3-benzyl-6-bromo-2-chloro-quinoline In tetrahydrofuran at 0℃; for 18h; Heating / reflux; | 97% |
4,4'-dibromo-2,2'-bipyridine
ethoxyethoxyethanol
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide for 2h; Inert atmosphere; Reflux; | 97% |
Conditions | Yield |
---|---|
In toluene at -20 - 20℃; for 8h; Temperature; Schlenk technique; | 97% |
benzoic acid methyl ester
ethoxyethoxyethanol
2-(2-ethoxyethoxy)ethyl benzoate
Conditions | Yield |
---|---|
With N-methyl-N,N,N-trioctylammonium methylcarbonate In hexane for 3h; Molecular sieve; Reflux; Green chemistry; | 96% |
ethoxyethoxyethanol
methanesulfonyl chloride
2-(2-ethoxyethoxy)ethyl methanesulfonate
Conditions | Yield |
---|---|
Stage #1: ethoxyethoxyethanol With triethylamine In dichloromethane for 0.0833333h; Inert atmosphere; Cooling with ice; Stage #2: methanesulfonyl chloride In dichloromethane at 0 - 20℃; Inert atmosphere; | 95% |
With triethylamine In dichloromethane at 0 - 20℃; for 72h; Inert atmosphere; |
ethoxyethoxyethanol
1-[2-(ethoxy)ethoxy]-2-chloroethane
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide | 94% |
With pyridine; thionyl chloride | |
With thionyl chloride; pyrographite for 14h; Heating; |
Conditions | Yield |
---|---|
With thionyl chloride 2 h, room t., 90 min, reflux; | 93% |
ethoxyethoxyethanol
3-chloro-3-(p-nitrophenyl)diazirine
A
2-chloroethyl ethyl ether
B
2-(4-nitrophenyl)-1,3-dioxolane
C
1-dichloromethyl-4-nitrobenzene
Conditions | Yield |
---|---|
at 80℃; for 6h; | A n/a B 93% C n/a |
poly(methacrylic acid)
ethoxyethoxyethanol
di(ethylene glycol) ethyl ether methacrylate
Conditions | Yield |
---|---|
With 10H-phenothiazine In toluene at 155℃; Temperature; | 92.49% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 1.5h; thioacetylation; | 91% |
ethoxyethoxyethanol
cyanoacetic acid
diethylene glycol ethyl ether cyanoacetate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 2h; | 90% |
With sulfuric acid In toluene | |
With toluene-4-sulfonic acid In toluene at 20℃; Reflux; |
ethoxyethoxyethanol
1,2-Diiodobenzene
1,2-bis(2-(2-ethylethoxy)ethoxy)benzene
Conditions | Yield |
---|---|
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene for 20h; Reflux; Inert atmosphere; | 90% |
ethoxyethoxyethanol
carbonochloridic acid 1-chloro-ethyl ester
1-chloroethyl (2-(2-ethoxyethoxy)ethyl) carbonate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at -78℃; for 3h; | 89% |
With pyridine In dichloromethane at -78℃; for 3h; | 89% |
ethoxyethoxyethanol
2-Bromoacetyl bromide
2-(2-ethoxyethoxy)ethyl 2-bromoacetate
Conditions | Yield |
---|---|
With aluminum oxide at 0 - 20℃; for 1h; Product distribution / selectivity; | 88% |
With triethylamine In dichloromethane at -78℃; for 3h; Product distribution / selectivity; | 71% |
With triethylamine In dichloromethane at -78℃; Inert atmosphere; | 61% |
Conditions | Yield |
---|---|
With tellurium tetrachloride In dichloromethane at 0 - 20℃; for 0.333333h; Ferrier Carbohydrate Rearrangement; Inert atmosphere; diastereoselective reaction; | A 88% B n/a |
Conditions | Yield |
---|---|
With phosphoric acid In acetonitrile for 24h; Reflux; | 88% |
ethoxyethoxyethanol
1-bromo-2-(2-ethoxyethoxy)ethane
Conditions | Yield |
---|---|
With carbon tetrabromide; triphenylphosphine In tetrahydrofuran at 0 - 20℃; | 87% |
With carbon tetrabromide; triphenylphosphine In tetrahydrofuran at 20℃; for 12h; | 87% |
With pyridine; phosphorus tribromide In benzene for 56h; | 65% |
With pyridine; phosphorus tribromide |
Conditions | Yield |
---|---|
With thionyl chloride at 50℃; for 5h; | 87% |
0.90 g (53%) |
Conditions | Yield |
---|---|
Stage #1: ethoxyethoxyethanol With sodium hydride In tetrahydrofuran at 0℃; for 2h; Stage #2: 4-Vinylbenzyl chloride In tetrahydrofuran for 24h; Reflux; | 87% |
ethoxyethoxyethanol
5-ethyl-8-oxo-5,8-dihydro-[1,3]-dioxolo[4,5-g]quinoline-7-carbonyl chloride
5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 2-(2-ethoxy-ethoxy)-ethyl ester
Conditions | Yield |
---|---|
With pyridine In dichloromethane for 3h; | 85% |
6-amino-7-methoxy-4-(3'-methylanilino)quinazoline
ethoxyethoxyethanol
2-Amino-4-chlorobenzoic acid
7-chloro-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With formamide | 85% |
6-nitro-7-chloro-4-(3-methylanilino)quinazoline
ethoxyethoxyethanol
2-Amino-4-chlorobenzoic acid
7-chloroquinazolin-4(1H)-one
Conditions | Yield |
---|---|
With formamide | 85% |
With formamide | 85% |
6-amino-7-methoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline
ethoxyethoxyethanol
2-Amino-4-chlorobenzoic acid
7-chloroquinazolin-4(1H)-one
Conditions | Yield |
---|---|
With formamide | 85% |
4,7-dichloroquinazoline
ethoxyethoxyethanol
2-Amino-4-chlorobenzoic acid
7-chloroquinazolin-4(1H)-one
Conditions | Yield |
---|---|
With formamide | 85% |
Carbitol Cellosolve (CAS NO.111-90-0) is reported in EPA TSCA Inventory. Glycol ether compounds are on the Community Right-To-Know List.
1. Introduction of 2-(2-Ethoxyethoxy)ethanol
2-(2-Ethoxyethoxy)ethanol, is an industrial solvent. It is a clear, colorless, hygroscopic liquid. Structurally it is an alcohol and an ether, a triethylene glycol with missing one hydroxyl group with formula CH3CH2OCH2CH2OCH2CH2OH. At direct contact it causes drying of skin by leaching fats, and is mildly irritating to the eyes. It is flammable.
2. Properties of 2-(2-Ethoxyethoxy)ethanol
MW: 134.17
EINECS: 203-919-7
Melting point: -80 °C
Index of Refraction: 1.419
Surface Tension: 31.6 dyne/cm
Density: 0.973 g/cm3
Flash Point: 96.1 °C
Enthalpy of Vaporization: 50.98 kJ/mol
Boiling Point: 202 °C at 760 mmHg
Vapour Pressure: 0.0733 mmHg at 25 °C
Water Solubility: Miscible
Sensitive: Hygroscopic
Merck: 14,1800
BRN: 1736441
Appearance Carbitol Cellosolve: colourless liquid
3. Toxicity of 2-(2-Ethoxyethoxy)ethanol
1. | skn-rbt 500 mg/24H MLD | JPETAB Journal of Pharmacology and Experimental Therapeutics. 82 (1944),377. | ||
2. | eye-rbt 500 mg MOD | UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/22 ,1968. | ||
3. | eye-rbt 125 mg MLD | ADSYAF Archives of Dermatology and Syphilology. 45 (1942),553. | ||
4. | mmo-sat 986 mg/plate | BCFAAI Bollettino Chimico Farmaceutico. 125 (1986),401. | ||
5. | orl-rat LD50:5500 mg/kg | JIDHAN Journal of Industrial Hygiene. 21 (1939),173. | ||
6. | skn-rat LD50:6000 mg/kg | JIHTAB Journal of Industrial Hygiene and Toxicology. 29 (1947),190. |
Hazard Codes:Xn,Xi
Risk Statements:36-20-36/37/38
R36:Irritating to eyes.
R20:Harmful by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-39-26-36
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S39:Wear eye / face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 1
RTECS: KK8750000
HS Code: 29094400
Moderately toxic by ingestion, intravenous, intraperitoneal, and possibly other routes. Mildly toxic by skin contact. A skin and eye irritant. Experimental reproductive effects. Mutation data reported. Combustible when exposed to heat; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
5. Use of 2-(2-Ethoxyethoxy)ethanol
2-(2-Ethoxyethoxy)ethanol can be used to make soaps, dyes, and other chemicals.
6. Other details of 2-(2-Ethoxyethoxy)ethanol
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, exposure to moist air or water.
Incompatibilities with Other Materials Strong oxidizing agents, strong acids, acid chlorides, anhydrides.
Hazardous Decomposition Products Carbon monoxide, carbon dioxide, peroxides.
Hazardous Polymerization Will not occur.
1、Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
2、Handling and Storage
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container. Store under nitrogen.
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