2,3,4-Trimethoxybenzaldehyde supplier

Name
2,3,4-Trimethoxybenzaldehyde
EINECS 218-271-0
CAS No. 2103-57-3
Article Data48
CAS DataBase
Density 1.133 g/cm³
Solubility methanol: 0.1 g/mL, clear
Melting Point 38-40 °C(lit.)
Formula C₁₀H₁₂O₄
Boiling Point 312 °C at 760 mmHg
Molecular Weight 196.203
Flash Point 137.1 °C
Transport Information
Appearance white to light yellow crystals or cryst. powder
Safety 22-24/25-45-36/37/39-27-26
Risk Codes 36/37/38-34
Molecular Structure
Hazard Symbols Xi,C
Synonyms Benzaldehyde, 2,3,4-trimethoxy-;AI3-36670;
PSA 44.76000
LogP 1.52490

Synthetic route

: 2144-08-3
2,3,4-trihydroxybenzylaldehyde

: 74-88-4
methyl iodide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 24h;	97.2%
With potassium carbonate In acetone at 80℃; for 12h; Inert atmosphere; Schlenk technique;	89%
With potassium carbonate In acetone

: 71989-96-3
2,3,4-trimethoxybenzylalcohol

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [CuNi(-OAc)(μ-OH)(μ-OH2)(bpy)2](ClO4)2; dihydrogen peroxide In water at 70℃; for 2h;	97%
With oxygen; Nafion polymer anchored ruthenium oxide pyrochlore composite In acetone at 20℃; under 760.051 Torr; for 7.5h;	95%
With dihydrogen peroxide at 20 - 70℃; for 3.5h; Catalytic behavior;	94%

: 50-00-0
formaldehyd

: 634-36-6
1,2,3-trimethoxybenzene

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate; magnesium chloride for 5h; Concentration; Reflux;	82.9%

: acetic acid acetoxy-(2,3,4-trimethoxy-phenyl)-methyl ester

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
β‐cyclodextrin In methanol; water at 60℃; for 8h; Product distribution;	80%

: 121336-22-9
1,2,3-Trimethoxy-4-phenethyloxymethyl-benzene

A: 60-12-8
2-phenylethanol

B: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃; for 0.5h;	A 60% B 75%

: 634-36-6
1,2,3-trimethoxybenzene

: 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 70 - 80℃; for 10h;	74%

: 634-36-6
1,2,3-trimethoxybenzene

: 1535-67-7
difluoromethyl phenyl sulfide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 1,2,3-trimethoxybenzene; difluoromethyl phenyl sulfide With tin(IV) chloride In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water; dimethyl sulfoxide at 20℃; for 2h;	72%

: 2,3,4-trimethoxy-benzaldehyde oxime

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With zeolyte H-Y supported KMnO4 In 1,2-dichloro-ethane for 0.5h; Ambient temperature;	68%

: 90704-71-5
2,3,4-trimethoxy-N,N-dimethylbenzylamine

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-2,3,4-trimethoxybenzylamine With iodine; sodium carbonate In 1,4-dioxane at 20℃; for 12h; Stage #2: With water In 1,4-dioxane for 3h;	64%

: 33257-15-7
1,2,3-trimethoxy-4-methylbenzene

: Mangantriacetat

A: 2,3,4-trimethoxybenzyl aceteate

B: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With *5H2O; lithium chloride In acetic acid at 100℃; for 3.4h;	A 34% B 26%

...Expand

: 33257-15-7
1,2,3-trimethoxy-4-methylbenzene

A: 2,3,4-trimethoxybenzyl aceteate

B: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With *5H2O; lithium chloride In acetic acid at 100℃; for 3.4h;	A 34% B 26%

: 634-36-6
1,2,3-trimethoxybenzene

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With acetic acid In tetrahydrofuran; N-methyl-acetamide; hexane	24%

: 141-82-2
malonic acid

: 634-36-6
1,2,3-trimethoxybenzene

A: 573-11-5
2,3,4-Trimethoxy-benzoic acid

B: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With manganese triacetate In acetic acid for 0.0166667h; Heating; Yields of byproduct given;	A 9% B n/a

...Expand

: 74-90-8
hydrogen cyanide

: 634-36-6
1,2,3-trimethoxybenzene

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With hydrogenchloride; aluminium trichloride; benzene anschliessend Erhitzen mit Wasser;
With hydrogenchloride; aluminium trichloride; benzene at 0 - 40℃; und nachfolgenden Zersetzen mit Eis;

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 77-78-1
dimethyl sulfate

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With alkaline solution

: 634-36-6
1,2,3-trimethoxybenzene

: 93-61-8
N-methyl-N-phenylformamide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With trichlorophosphate

: 4055-69-0
2,3-dihydroxy-4-methoxybenzaldehyde

: 74-88-4
methyl iodide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate; acetone

: 77-78-1
dimethyl sulfate

2.3.4-trioxy-benzaldehyde: 2.3.4-trioxy-benzaldehyde

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydroxide anschliessend in einer Wasserstoff-Atmosphaere;

: 5150-42-5
2,3-dimethoxyphenol

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl; ZnCl2; diethyl ether / Erhitzen des Reaktionsprodukts mit Wasser 2: aqueous alkaline solution View Scheme

: 4885-02-3
Dichloromethyl methyl ether

: 634-36-6
1,2,3-trimethoxybenzene

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With titanium tetrachloride In dichloromethane at 0 - 20℃; Inert atmosphere;
With titanium tetrachloride In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;	52.7 g

: 2144-08-3
2,3,4-trihydroxybenzylaldehyde

: 77-78-1
dimethyl sulfate

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2,3,4-trihydroxybenzylaldehyde With potassium carbonate In acetone at 20℃; for 0.25h; Stage #2: dimethyl sulfate In acetone for 8h; Reflux;

: 1111086-84-0
C11H15NO6

A: C11H15NO6

B: C11H15NO6

C: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With hydroxynitrile lyase from Arabidopsis thaliana In aq. phosphate buffer; (2)H8-toluene at 30℃; for 3h; Resolution of racemate; Enzymatic reaction; enantioselective reaction;	A n/a B n/a C n/a

...Expand

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 19283-70-6
3,4-dimethoxysalicylaldehyde

Conditions

Conditions	Yield
With aluminium trichloride In benzene for 3h; Heating;	100%
With aluminum (III) chloride In dichloromethane at -5 - 25℃;	92%
With aluminium trichloride In benzene 1.) RT, 5 min, 2.) 70-80 deg C, 6 h;	90.5%

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 52978-83-3
2,3,4-trimethoxy-6-nitrobenzaldehyde

Conditions

Conditions	Yield
With nitric acid; acetic acid at 0℃; for 0.5h;	100%
With nitric acid; acetic acid at 20℃; for 0.166667h;	100%
With nitric acid; acetic acid at 0℃; for 1.5h; Inert atmosphere;	80%

: 762-04-9
phosphonic acid diethyl ester

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 181178-75-6
[Hydroxy-(2,3,4-trimethoxy-phenyl)-methyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With aluminum oxide for 48h; Ambient temperature;	100%

: 22483-09-6
2,2-dimethoxyethylamine

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 54879-68-4
(2,3,4-trimethoxybenzylidene)-(2,2-dimethoxyethyl)amine

Conditions

Conditions	Yield
In benzene for 4h; Heating;	100%

: 558-13-4
carbon tetrabromide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 849186-15-8
1-(2,2-dibromovinyl)-2,3,4-trimethoxybenzene

Conditions

Conditions	Yield
With triphenylphosphine In dichloromethane	100%

: 5003-71-4
3-bromopropylamine hydrochloride

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 2,3,4-trimethoxybenzylidene-(3-bromo-1-propylamine)

Conditions

Conditions	Yield
Stage #1: 3-bromopropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: 2,3,4-trimethoxybenzaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	100%

: 62-53-3
aniline

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 31434-97-6
N-(2,3,4-trimethoxybenzylidene)aniline

Conditions

Conditions	Yield
at 80℃; under 15.0015 Torr; for 3h;	100%

: 41580-73-8
2'-(propargyloxy)acetophenone

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1227420-53-2
1-(2-prop-2-ynyloxy-phenyl)-3-(2,3,4-trimethoxy-phenyl)-propenone

Conditions

Conditions	Yield
Stage #1: 2'-(propargyloxy)acetophenone With sodium hydroxide In methanol at 25℃; for 0.5h; Claisen-Schmidt condensation; Stage #2: 2,3,4-trimethoxybenzaldehyde In methanol at 25℃; Claisen-Schmidt condensation;	100%

: 141-82-2
malonic acid

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 116406-19-0
trans-2,3,4-trimethoxycinnamic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 6h; Reflux;	99%
With piperidine
With piperidine; pyridine
With pyridine at 90℃; Knoevenagel Condensation;

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 4055-69-0
2,3-dihydroxy-4-methoxybenzaldehyde

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at 0℃; Inert atmosphere;	99%
With boron trichloride In dichloromethane at 0℃; for 48h; Inert atmosphere;	99%
With boron trichloride In dichloromethane at 0℃; Inert atmosphere;	96%

: 870-46-2
t-butoxycarbonylhydrazine

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: N'-[1-(2,3,4-Trimethoxy-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	99%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: (E)-1-(4-methoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: 1-(4-methoxyphenyl)ethanone With sodium hydroxide In ethanol; water at 20℃; for 0.0833333h; Claisen-Schmidt Condensation; Stage #2: 2,3,4-trimethoxybenzaldehyde at 20℃; Claisen-Schmidt Condensation;	99%

: 50838-22-7
1-crotonoylpiperidine

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: (2E,4E)-1-(piperidin-1-yl)-5-(2,3,4-trimethoxyphenyl)penta-2,4-dien-1-one

Conditions

Conditions	Yield
With potassium hydroxide In water; dimethyl sulfoxide at 20℃; for 8h;	99%

: 544-97-8
dimethyl zinc(II)

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: (S)-1-(2,3,4-trimethoxyphenyl)ethan-1-ol

Conditions

Conditions	Yield
Stage #1: dimethyl zinc(II) With C41H42N2O3 In hexane; toluene at 0 - 40℃; for 0.5h; Inert atmosphere; Schlenk technique; Stage #2: 2,3,4-trimethoxybenzaldehyde In hexane; toluene at 0 - 30℃; Inert atmosphere; Schlenk technique; enantioselective reaction;	99%

: 3626-69-5
N-crotonoylpiperidine

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: (2E,4E)-1-(piperidin-1-yl)-5-(2,3,4-trimethoxyphenyl)penta-2,4-dien-1-one

Conditions

Conditions	Yield
With potassium hydroxide In water; dimethyl sulfoxide at 20℃; for 8h;	99%

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 19676-64-3
2,3,4-trimethoxyphenol

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane	98%
With dihydrogen peroxide; sulfuric acid In methanol for 1h; Ambient temperature;	97%
With sulfuric acid; dihydrogen peroxide In methanol Inert atmosphere;	97%

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 71989-96-3
2,3,4-trimethoxybenzylalcohol

Conditions

Conditions	Yield
With water; nickel dichloride; zinc In N,N-dimethyl-formamide for 2h; Ambient temperature;	98%
With cobalt(II) chloride; zinc In water; N,N-dimethyl-formamide for 1.5h; Ambient temperature;	98%
With sodium tetrahydroborate In methanol; hexane; ethyl acetate at 0℃; for 0.5h;	98%

: 75-08-1
ethanethiol

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1073536-41-0
1-(bis(ethylthio)methyl)-2,3,4-trimethoxybenzene

Conditions

Conditions	Yield
With hafnium(IV) trifluoromethanesulfonate In dichloromethane at 20℃; for 0.166667h;	98%
With silica gel-supported phosphorus pentoxide at 20℃; Neat (no solvent);	92%

: 126-81-8
dimedone

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 3,3,6,6-tetramethyl-9-(2,3,4-trimethoxyphenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium Tetrafluoroborate at 20℃; for 1h; Reagent/catalyst; Green chemistry;	98%
With tungsten(VI) oxide In neat (no solvent) at 70℃; for 2h; Green chemistry;	80%

: 51673-84-8
dimethoxyacetaldehyde

: 104-94-9
4-methoxy-aniline

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: N-(2,2-dimethoxyethyl)-4-methoxy-N-(3,4,5-trimethoxybenzyl)aniline

Conditions

Conditions	Yield
Stage #1: 4-methoxy-aniline; 2,3,4-trimethoxybenzaldehyde With sodium diacetoxy(acetyl)boranuide In chloroform at 20℃; for 1h; Stage #2: dimethoxyacetaldehyde In chloroform at 20℃; for 8h;	98%

...Expand

: 95-84-1
3-amino-4-hydroxytoluene

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 5-Methyl-2-{[1-(2,3,4-trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-phenol

Conditions

Conditions	Yield
	97%

: 36901-75-4
(2-bromobenzyl)triphenylphosphonium bromide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1,2,3-trimethoxy-4-[2-(2-bromophenyl)vinyl]benzene

Conditions

Conditions	Yield
Stage #1: (2-bromobenzyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 2,3,4-trimethoxybenzaldehyde In tetrahydrofuran at 20℃; for 16h; Further stages.;	97%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 39240-15-8
1,2,3-trimethoxy-4-vinylbenzene

Conditions

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In diethyl ether at 0℃; for 0.25h; Inert atmosphere; Stage #2: 2,3,4-trimethoxybenzaldehyde In diethyl ether at 0℃; Inert atmosphere;	97%
Stage #1: Methyltriphenylphosphonium bromide With sodium amide In diethyl ether at 20℃; for 10h; Inert atmosphere; Stage #2: 2,3,4-trimethoxybenzaldehyde In diethyl ether at -10 - 20℃; Wittig reaction; Inert atmosphere;	58%

: 134-81-6
benzil

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 169155-38-8
4,5-diphenyl-2-(2,3,4-trimethoxyphenyl)-1H-imidazole

Conditions

Conditions	Yield
With ammonium acetate In neat (no solvent) at 100℃; for 0.5h; Irradiation; Green chemistry;	96%
With ammonium acetate; acetic acid for 5h; Condensation; Heating;	65%

: 75-04-7
ethylamine

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: Ethyl-[1-(2,3,4-trimethoxy-phenyl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In chloroform at 80℃; sealed tube;	96%

: 504-17-6
4,6-dihydroxy-2-mercaptopyrimidine

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 301351-66-6
2-thioxo-5-(2,3,4-trimethoxybenzylidene)hexahydropyrimidine-4,6-dione

Conditions

Conditions	Yield
With benzyltrimethylammonium chloride In water at 90℃; for 4 - 5h; Knoevenagel condensation;	96%

: 769-42-6
1,3-dimethylbarbituric acid

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1,3-dimethyl-5-(2,3,4-trimethoxybenzylidene)-hexahydropyrimidine-2,4,6-trione

Conditions

Conditions	Yield
With benzyltrimethylammonium chloride In water at 90℃; for 4 - 5h; Knoevenagel condensation;	96%
In water at 20℃; Knoevenagel Condensation;

: 455-14-1
4-trifluoromethylphenylamine

: 7677-24-9
trimethylsilyl cyanide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1529776-74-6
2-{[4-(trifluoromethyl)phenyl]amino}-2-(2,3,4-trimethoxyphenyl)acetonitrile

Conditions

Conditions	Yield
In neat (no solvent) at 90℃; Microwave irradiation;	96%

...Expand

2,3,4-Trimethoxybenzaldehyde Standards and Recommendations

Assay: 99.0%Min.
Sulfated Ash: 0.02%Max
Heavy Metals: 15ppm Max
Moisture: 0.5%Max

2,3,4-Trimethoxybenzaldehyde Specification

The 2,3,4-Trimethoxybenzaldehyde, with the CAS registry number 2103-57-3,is also known as Benzaldehyde,2,3,4-trimethoxy-. It belongs to the product categories of (intermediate of trimetazidine.);Aldehydes;C10 to C21;Carbonyl Compounds. This chemical's molecular formula is C₁₀H₁₂O₄ and molecular weight is196.20. Its EINECS number is 218-271-0.What's more,Its systematic name is 2,3,4-Trimethoxybenzaldehyde.It is a white to light yellow crystals or cryst. powder.And it is used as chemical intermediate to synthesis target molecules of pharmaceuticals, pesticides, stabilizer, antioxidant, colorants, perfumes, photoinitiators, and other organic compounds.

Physical properties about 2,6-Diaminotoluene are:
(1)ACD/LogP: 1.26; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.26; (4)ACD/LogD (pH 7.4): 1.26; (5)ACD/BCF (pH 5.5): 5.34; (6)ACD/BCF (pH 7.4): 5.34; (7)ACD/KOC (pH 5.5): 115.49; (8)ACD/KOC (pH 7.4): 115.49; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.525; (13)Molar Refractivity: 53.041 cm3; (14)Molar Volume: 173.106 cm3; (15) Surface Tension: 35.431999206543 dyne/cm; (16)Density: 1.133 g/cm3; (17)Flash Point: 137.116 °C; (18)Enthalpy of Vaporization: 55.293 kJ/mol; (19) Boiling Point: 311.969 °C at 760 mmHg; (20)Vapour Pressure: 0.00100000004749745 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O=Cc1c(OC)c(OC)c(OC)cc1;
(2)Std. InChI:InChI=1S/C10H12O4/c1-12-8-5-4-7(6-11)9(13-2)10(8)14-3/h4-6H,1-3H3;
(3)Std. InChIKey:UCTUXUGXIFRVGX-UHFFFAOYSA-N.

Safety Information of 2,3,4-Trimethoxybenzaldehyde:
The 2,3,4-Trimethoxybenzaldehyde is irritating to eyes, respiratory system and skin. And it can causes burns. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.),and take off immediately all contaminated clothing .When you use it ,wear suitable protective clothing, gloves and eye/face protection,avoid contact with skin and eyes,and do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Name

2,3,4-Trimethoxybenzaldehyde

Synthetic route

2,3,4-Trimethoxybenzaldehyde Standards and Recommendations

2,3,4-Trimethoxybenzaldehyde Specification

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