2,3-Dimethoxybenzaldehyde supplier

Name
2,3-Dimethoxybenzaldehyde
EINECS 201-677-7
CAS No. 86-51-1
Article Data79
CAS DataBase
Density 1.114 g/cm³
Solubility
Melting Point 48-52 °C(lit.)
Formula C₉H₁₀O₃
Boiling Point 266.7 °C at 760 mmHg
Molecular Weight 166.177
Flash Point 105.8 °C
Transport Information
Appearance white to brown crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms o-Veratraldehyde(6CI,7CI,8CI);Benzaldehyde,2,3-dimethoxy-;5,6-Dimethoxybenzaldehyde;NSC403661;NSC 51953;NSC 6314;
PSA 35.53000
LogP 1.51630

Synthetic route

: 5653-67-8
2,3-dimethoxybenzyl alcohol

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; 1-decyl-4-aza-1-azoniabicyclo[2.2.2]octane chlorochromate In acetonitrile for 1.4h; Heating;	99%
With benzyltriphenylphosphonium dichromate In acetonitrile for 0.333333h; Oxidation; Heating;	98%
With benzyltriphenylphosphonium chlorochromate In dichloromethane for 0.0333333h; Oxidation; microwave irradiation;	98%

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 74-88-4
methyl iodide

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 45℃; for 42h;	99%
Stage #1: 3-methoxy-2-hydroxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃;
Stage #1: 3-methoxy-2-hydroxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃;
Stage #1: 3-methoxy-2-hydroxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃;

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 77-78-1
dimethyl sulfate

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In benzene	98.7%
With potassium carbonate In methanol for 2.5h; Heating;	93%
With potassium carbonate In benzene for 26h; Heating;	89%

: 50-00-0
formaldehyd

: 91-16-7
1,2-dimethoxybenzene

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With triethylamine; magnesium chloride In 5,5-dimethyl-1,3-cyclohexadiene at 100℃; for 6h;	94.4%

: 1-(bis-ethylsulfanyl-methyl)-2,3-dimethoxy-benzene

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In dichloromethane; water at 20℃; for 0.166667h;	90%

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 77-78-1
dimethyl sulfate

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2,3-dihydroxybenzaldehyde With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: dimethyl sulfate In acetone at 20℃; for 5h;	89%
With sodium hydroxide In water for 1h; Heating;	68%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 213479-69-7
2,3-dimethoxyphenyl triflate

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium acetate In acetonitrile at 25℃; for 16h; Schlenk technique; Inert atmosphere;	83%
With triethylsilane; potassium acetate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene at 50℃; for 12h; Schlenk technique; Inert atmosphere; Molecular sieve;	72%

: 64-18-6
formic acid

: 25245-33-4
1-iodo-2,3-dimethoxybenzene

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; for 4h; Sealed tube;	82%

: 121336-26-3
1,2-Dimethoxy-3-phenethyloxymethyl-benzene

A: 60-12-8
2-phenylethanol

B: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water at 20℃; for 12.5h;	A 75% B 73%

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 74-88-4
methyl iodide

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	73%

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 74-88-4
methyl iodide

A: 66495-88-3
3-hydroxy-2-methoxybenzaldehyde

B: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2,3-dihydroxybenzaldehyde With potassium hydrogencarbonate In N,N-dimethyl-formamide for 0.5h; Inert atmosphere; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 28h; Inert atmosphere;	A 72% B n/a
Stage #1: 2,3-dihydroxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 18h;	A 57% B 19%
Stage #1: 2,3-dihydroxybenzaldehyde With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 18h;	A 57% B 19%
With sodium hydride In dimethyl sulfoxide at 25℃; for 17h; NaH : pyrocatechlol 1.1; Yields of byproduct given;	A 52% B n/a

...Expand

: 1-((2,3-dimethoxybenzyl)oxy)-1H-benzo[d][1,2,3]triazole

: 24067-17-2
4-nitrophenylboronic acid

A: C15H15NO4

B: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With potassium phosphate; water; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether In toluene at 100℃; for 18h;	A 67% B n/a

...Expand

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 74-88-4
methyl iodide

A: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

B: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide at 25℃; for 17h; NaH : pyrocatechlol 2.2; Yields of byproduct given;	A 58% B n/a

...Expand

: 99060-42-1
2-(2,3-dimethoxyphenyl)-2-hydroxyacetonitrile

A: 74-90-8
hydrogen cyanide

B: 86-51-1
2,3-dimethyoxybenzaldehyde

: 167774-23-4
1,2-dimethoxy-3-((1E)-prop-1-en-1-yl)benzene

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With potassium dichromate; sulfuric acid; 4-aminobenzene sulfonic acid
With potassium dichromate; sulfuric acid
With ozone; ethyl acetate at -20℃; und Erhitzen des Reaktionsgemisches mit Wasserdampf;

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 77-78-1
dimethyl sulfate

A: 59276-32-3
2,3-dimethoxybenzaldehyde dimethylacetal

B: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With potassium hydroxide

...Expand

: 7169-06-4
2,3-dimethoxybenzoyl chloride

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With Pd-BaSO4; xylene at 140℃; Hydrogenation;

: 100-83-4
meta-hydroxybenzaldehyde

: 77-78-1
dimethyl sulfate

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With oxygen; copper; sodium carbonate; copper(I) chloride 1.) CH3CN; Multistep reaction;

: 1521-38-6
2,3-dimethoxybenzoic acid

A: 5653-67-8
2,3-dimethoxybenzyl alcohol

B: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With chloro-trimethyl-silane; diisobutylaluminium hydride; triethylamine 1.) CH2Cl2, 0 deg C; 2.) CH2Cl2, -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;

: 7647-01-0
hydrogenchloride

: (2-benzo[1,3]dioxol-5-yl-ethyl)-(2,3-dimethoxy-benzyliden)-amine

A: 1653-64-1
homopiperonylamine hydrochloride

B: 86-51-1
2,3-dimethyoxybenzaldehyde

...Expand

: 77-78-1
dimethyl sulfate

alkali salt of 2-oxy-3-methoxy-benzaldehyde: alkali salt of 2-oxy-3-methoxy-benzaldehyde

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With alkaline solution

: 56-23-5
tetrachloromethane

: 7169-06-4
2,3-dimethoxybenzoyl chloride

palladium-barium sulfate: palladium-barium sulfate

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
at 140℃; Hydrogenation;

...Expand

: 77-78-1
dimethyl sulfate

sodium salt of 2-oxy-3-methoxy-benzaldehyde: sodium salt of 2-oxy-3-methoxy-benzaldehyde

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
With benzene

: 91106-58-0
2-cyano-3t-(2,3-dimethoxy-phenyl)-acrylic acid

KOH-solution: KOH-solution

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 919112-52-0
2-benzyl-3-(2,3-dimethoxyphenyl)-5-propylcarbamoyl-2,3-dihydroisoxazole-4-carboxylic acid methyl ester

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
In tetrahydrofuran Heating;

: 868775-52-4, 919112-38-2
C-(2,3-dimethoxyphenyl)-N-benzyl-nitrone

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 73 percent / benzene / 22 h / 20 °C 2: 37 percent / methanol / 3 h / 20 °C 3: tetrahydrofuran / Heating View Scheme

: 919112-44-0
2-benzyl-3-(2,3-dimethoxyphenyl)-2,3-dihydroisoxazole-4,5-dicarboxylic acid dimethyl ester

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 37 percent / methanol / 3 h / 20 °C 2: tetrahydrofuran / Heating View Scheme

: 492-88-6
3-ethoxysalicylaldehyde

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 86 percent / BBr3 / CHCl3 / 1. 0 deg C, 2.5 h; 2. room temperature, overnight 2: 68 percent / NaOH / H2O / 1 h / Heating View Scheme

: 1521-38-6
2,3-dimethoxybenzoic acid

: 86-51-1
2,3-dimethyoxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chloroform; phosphorus pentachloride 2: palladium-barium sulfate; xylene / 140 °C / Hydrogenation View Scheme

: 74-89-5
methylamine

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 722495-95-6
(2,3-dimethoxy-benzylidene)-methyl-amine

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In ethanol at 0 - 40℃;	90%
With benzene zuletzt unter Erwaermen und Entfernen des gebildeten Wassers;
In benzene for 2h; Reflux;
In ethanol; water

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 5653-67-8
2,3-dimethoxybenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 0.166667h;	100%
With sodium tetrahydroborate In ethanol for 20h; Ambient temperature;	99%
With sodium tetrahydroborate In methanol at 20℃; for 1h;	99%

: 112-71-0
1-Bromotetradecane

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 33597-07-8
(+/-)-1-hydroxy-1-(2.3-dimethoxy-phenyl)-pentadecane

Conditions

Conditions	Yield
Stage #1: 1-Bromotetradecane With iodine; magnesium In diethyl ether Stage #2: 2,3-dimethyoxybenzaldehyde In diethyl ether for 4h; Reflux;	100%
With lithium In tetrahydrofuran at 0℃;	63%

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 64-19-7
acetic acid

: 107-11-9
1-amino-2-propene

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 956093-06-4
2-(acetylallylamino)-N-tert-butyl-2-(2,3-dimethoxyphenyl)acetamide

Conditions

Conditions	Yield
In methanol at 20℃; for 6h; Ugi reaction;	100%

...Expand

: 10277-74-4, 34698-41-4, 61341-86-4, 61949-83-5
(S)-1-Aminoindane

: 86-51-1
2,3-dimethyoxybenzaldehyde

: C18H19NO2

Conditions

Conditions	Yield
In neat (no solvent, solid phase) Milling;	100%

: 10277-74-4
(R)-1-Aminoindane

: 86-51-1
2,3-dimethyoxybenzaldehyde

: C18H19NO2

Conditions

Conditions	Yield
In neat (no solvent, solid phase) Milling;	100%

: 23357-52-0
(S)-1,2,3,4-tetrahydronapht-1-yl-amine

: 86-51-1
2,3-dimethyoxybenzaldehyde

: C19H21NO2

Conditions

Conditions	Yield
In neat (no solvent, solid phase) Milling;	100%

: 23357-46-2
(R)-1,2,3,4-Tetrahydro-1-naphthylamine

: 86-51-1
2,3-dimethyoxybenzaldehyde

: C19H21NO2

Conditions

Conditions	Yield
In neat (no solvent, solid phase) Milling;	100%

: 75-52-5
nitromethane

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 37630-20-9
1,2-Dimethoxy-3-((E)-2-nitro-vinyl)-benzene

Conditions

Conditions	Yield
With ammonium acetate; acetic acid at 22℃; for 3h; ultrasound;	99%
	81%
With sodium hydroxide In methanol; water for 0.5h; Cooling with ice;	46%

: (2-iodo-4,5-dimethoxybenzyl)triphenylphosphonium bromide

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 1-(2-(2,3-dimethoxyphenyl)-1-ethenyl)-2-iodo-4,5-dimethoxybenzene

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 16h; Wittig reaction;	99%
Stage #1: (2-iodo-4,5-dimethoxybenzyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; Stage #2: 2,3-dimethyoxybenzaldehyde In tetrahydrofuran at 20℃; Wittig reaction; Further stages.;	99%

: 5003-71-4
3-bromopropylamine hydrochloride

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 2,3-dimethoxybenzylidene-(3-bromo-1-propylamine)

Conditions

Conditions	Yield
Stage #1: 3-bromopropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: 2,3-dimethyoxybenzaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	99%

: 10141-46-5
N-(4-aminophenyl)-N'-phenylurea

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 1173493-02-1
1-[4-(2,3-dimethoxy-benzylamino)phenyl]-3-phenylurea

Conditions

Conditions	Yield
With sodium cyanoborohydride In methanol Reflux; Inert atmosphere;	99%

: 32368-82-4
α,α-difluoromethyl p-tolyl sulfoxide

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 1-(2,3-dimethoxyphenyl)-2,2-difluoro-2-(p-tolylsulfinyl)ethan-1-ol

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -30℃; for 0.666667h; Inert atmosphere; diastereoselective reaction;	99%

: 141-82-2
malonic acid

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 7345-82-6
trans-2,3-dimethoxycinnamic acid

Conditions

Conditions	Yield
piperidine In pyridine Heating;	98%
With piperidine; pyridine at 120 - 130℃; Knoevenagel condensation;	89%
Stage #1: malonic acid; 2,3-dimethyoxybenzaldehyde With pyridine at 50℃; Inert atmosphere; Stage #2: With piperidine at 80 - 115℃; for 4h; Inert atmosphere; Stage #3: With hydrogenchloride In water	84%

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 4463-33-6
1,2-dimethoxy-3-methylbenzene

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal In methanol at 20℃; under 760.051 Torr; for 0.75h;	98%
With potassium hydroxide; hydrazine In diethylene glycol at 90 - 100℃; for 1.5h;	81%
With hydrogenchloride; amalgamated zinc; ethanol

: 14642-79-6
benzyloxy-trimethylsilane

: 143446-41-7
(2R,3R)-(E)-Methyl 2-acetoxy-3-(dimethylphenylsilyl)-hex-4-enoate

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 143446-40-6, 147060-58-0
(E)-(2S,5S,6R)-Methyl 2-acetoxy-6-(benzyloxy)-6-(2,3-dimethoxyphenyl)-5-methylhex-3-enoate

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -78℃; for 10h;	98%
trimethylsilyl trifluoromethanesulfonate In dichloromethane at -78℃; for 18h;	97%

...Expand

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

Conditions

Conditions	Yield
With lithium chloride In N,N-dimethyl-formamide for 22h; Heating;	98%
With aluminum (III) chloride In dichloromethane at -5 - 25℃;	94%
With cerium(III) chloride; sodium iodide In acetonitrile for 7h; dealkylation; Heating;	89%
With magnesium iodide for 10h; neat (no solvent);	80%
With n-butyllithium; lithium 4-methylpiperazin-1-ide In toluene 1.) 15 deg C, 20 min, 2.) 65-70 deg C;	55%

: 61-82-5
3(5)-amino-1,2,4-triazole

: 126-81-8
dimedone

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 9-(2,3-dimethoxyphenyl)-6,6-dimethyl-5,6,7,9-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one

Conditions

Conditions	Yield
With acetic acid at 60℃; for 0.333333h; Green chemistry;	98%
With nano-AlPO4(SO3H) In acetonitrile at 50℃; for 0.25h;	89%

...Expand

: diethyl 3-(allyloxy)-5-methoxybenzylphosphonate

: 86-51-1
2,3-dimethyoxybenzaldehyde

: trans-3-(allyloxy)-2',3',5-trimethoxystilbene

Conditions

Conditions	Yield
Stage #1: diethyl 3-(allyloxy)-5-methoxybenzylphosphonate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Horner-Wadsworth-Emmons Olefination; Stage #2: 2,3-dimethyoxybenzaldehyde In tetrahydrofuran at 0℃; Reflux;	98%

: 7520-94-7
5-acetyl-4-methyl-2-phenylthiazole

: 86-51-1
2,3-dimethyoxybenzaldehyde

: (3E)-(2,3-dimethoxy-phenyl)-1-(4-methyl-2-phenyl-thiazol-5-yl)propenone

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 20℃; Claisen-Schmidt Condensation;	98%

: 63909-57-9
3-fluoro-1-diethylphosphonomethyl-benzene

: 86-51-1
2,3-dimethyoxybenzaldehyde

: (E)-1-(3-fluorostyryl)-2,3-dimethoxybenzene

Conditions

Conditions	Yield
Stage #1: 3-fluoro-1-diethylphosphonomethyl-benzene With sodium hydride In tetrahydrofuran at 0 - 5℃; for 0.5h; Horner-Wadsworth-Emmons Olefination; Stage #2: 2,3-dimethyoxybenzaldehyde In tetrahydrofuran at 0 - 20℃; for 20h; Horner-Wadsworth-Emmons Olefination;	98%

: 83-72-7
2-Hydroxy-1,4-naphthoquinone

: 105-34-0
methyl 2-cyanoacetate

: 86-51-1
2,3-dimethyoxybenzaldehyde

: methyl 2-amino-4-(2,3-dimethoxyphenyl)-5,10-dioxo-5,10-dihydro-4H-benzo[g]chromene-3-carboxylate

Conditions

Conditions	Yield
With ammonium acetate In ethanol; water at 20℃; for 0.116667h; Sonication;	98%

...Expand

: 32151-02-3
(1S,2S)-trans-2-amino-1-indanol

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 94077-04-0
(+)-(1S,2S)-2-(2,3-dimethoxybenzylideneamino)indan-1-ol

Conditions

Conditions	Yield
In benzene for 10h;	97.1%

: 110-91-8
morpholine

: 533-31-3
Sesamol

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 102616-64-8
6-((2,3-dimethoxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol

Conditions

Conditions	Yield
In methanol Heating;	97%
In neat (no solvent) at 125℃; for 0.166667h; Solvent; Reagent/catalyst; Microwave irradiation;	87%
In ethanol Reflux;	57%

...Expand

: 1779-49-3
Methyltriphenylphosphonium bromide

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 17055-36-6
1-ethenyl-2,3-dimethoxybenzene

Conditions

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With sodium amide In diethyl ether at 20℃; for 10h; Inert atmosphere; Stage #2: 2,3-dimethyoxybenzaldehyde In diethyl ether at -10 - 20℃; Wittig reaction; Inert atmosphere;	97%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at -30℃; for 1h; Wittig Olefination; Stage #2: 2,3-dimethyoxybenzaldehyde In tetrahydrofuran at -5 - 20℃; Wittig Olefination;	91%
With Amberlite IR-400 In N,N-dimethyl-formamide at 95℃; for 10h; Inert atmosphere;	86%
Stage #1: Methyltriphenylphosphonium bromide With potassium hexamethylsilazane In tetrahydrofuran at 20℃; for 3h; Wittig Olefination; Inert atmosphere; Stage #2: 2,3-dimethyoxybenzaldehyde In tetrahydrofuran for 18h; Wittig Olefination; Inert atmosphere; Reflux;	72%
Stage #1: Methyltriphenylphosphonium bromide In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Alkaline conditions; Stage #2: 2,3-dimethyoxybenzaldehyde In tetrahydrofuran at 0℃; for 12h; Inert atmosphere;

: 269726-49-0
2-amino-1-tert-butyl-4-cyanopyrrole

: 126-81-8
dimedone

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 1380775-97-2
C26H31N3O3

Conditions

Conditions	Yield
With L-proline In ethanol for 6h; Reflux;	97%

...Expand

: 1275601-94-9
3-aminoethyl-2-[(p-trifluoromethoxy)anilino]quinazolin-4(3H)-one

: 86-51-1
2,3-dimethyoxybenzaldehyde

: 1461736-82-2
C26H23F3N4O4

Conditions

Conditions	Yield
In ethanol at 75℃; for 3h;	97%

2,3-Dimethoxybenzaldehyde Chemical Properties

Structure of 2,3-Dimethoxybenzaldehyde (CAS NO.86-51-1):

IUPAC Name: 2,3-Dimethoxybenzaldehyde
Molecular Formula: C₉H₁₀O₃
Molar mass: 166.1739 g/mol
Density: 1.114 g/cm³
Melting Point: 48-52 °C(lit.)
Flash Point: 105.8 °C
Boiling Point: 266.7 °C at 760 mmHg
Sensitive: air sensitive
Index of Refraction: 1.534
Molar Refractivity: 46.36 cm³
Molar Volume: 149.1 cm³
Surface Tension: 36.1 dyne/cm
Vapour Pressure: 0.00849 mmHg at 25 °C
XLogP3: 1.1
H-Bond Acceptor: 3
Rotatable Bond Count: 3
Exact Mass: 166.062994
MonoIsotopic Mass: 166.062994
Topological Polar Surface Area: 35.5
Heavy Atom Count: 12
Canonical SMILES: COC1=CC=CC(=C1OC)C=O
InChI: InChI=1S/C9H10O3/c1-11-8-5-3-4-7(6-10)9(8)12-2/h3-6H,1-2H3
InChIKey: JIVGSHFYXPRRSZ-UHFFFAOYSA-N
EINECS: 201-677-7
Product Categories: Aromatic Aldehydes & Derivatives (substituted); BenzaldehydeDerivative; Benzaldehyde; Aldehydes; C9; Carbonyl Compounds

2,3-Dimethoxybenzaldehyde Uses

2,3-Dimethoxybenzaldehyde (CAS NO.86-51-1) can be used as the materials for the organic synthesis intermediates. It also can be used in pharmaceutical industry for the synthesis of berberine and others.

2,3-Dimethoxybenzaldehyde Production

2,3-Dimethoxybenzaldehyde has been derived from the reaction 2- methoxy-3-hydroxybenzaldehyde (o-vanillin) with dimethyl sulfate .

2,3-Dimethoxybenzaldehyde Toxicity Data With Reference

orl-rat TDLo:7.3 mg/kg

BIPBU* Biological & pharmaceutical bulletin. 24 (2001),1277.

2,3-Dimethoxybenzaldehyde Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: CU5732000
Hazard Note: Irritant
HS Code: 29124900
A poison by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.

2,3-Dimethoxybenzaldehyde Specification

2,3-Dimethoxybenzaldehyde (CAS NO.86-51-1) is also named as AI3-00141 ; NSC 403661 ; Benzaldehyde, 2,3-dimethoxy- (9CI) ; o-Veratraldehyde (8CI) . 2,3-Dimethoxybenzaldehyde (CAS NO.86-51-1) is white to brown crystalline powder.

Product Name

2,3-Dimethoxybenzaldehyde

Synthetic route

2,3-Dimethoxybenzaldehyde Chemical Properties

2,3-Dimethoxybenzaldehyde Uses

2,3-Dimethoxybenzaldehyde Production

2,3-Dimethoxybenzaldehyde Toxicity Data With Reference

2,3-Dimethoxybenzaldehyde Safety Profile

2,3-Dimethoxybenzaldehyde Specification

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