2,4,5-Trimethylaniline supplier

Name
2,4,5-TRIMETHYLANILINE
EINECS 205-282-0
CAS No. 137-17-7
Article Data17
CAS DataBase
Density 0.78
Solubility AUTOIGNITION
Melting Point 62 - 65 C
Formula C9H13 N
Boiling Point 234 - 235 C
Molecular Weight 135.209
Flash Point -5 ºC
Transport Information UN 1648
Appearance Colorless to reddish yellow liquid
Safety 2352436
Risk Codes R11;R20/21/22;R36
Molecular Structure
Hazard Symbols
Synonyms Aniline,2,4,5-trimethyl- (6CI,7CI,8CI); 2,4,5-Trimethylaniline;2,4,5-Trimethylbenzenamine; 2,4,5-Trimethylphenylamine; NSC 37004; NSC 5297;Pseudocumidine; y-Cumidine
PSA 26.02000
LogP 2.77520

Synthetic route

: 610-91-3
5-nitropseudocumene

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal under 22800 Torr; Ambient temperature;	97%
With sodium dithionite
With iron
palladium In methanol
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 35℃; for 2h;

: 67-56-1
methanol

: 638-03-9
m-toluidine hydrochloride

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
at 235℃;

: 67-56-1
methanol

: 638-03-9
m-toluidine hydrochloride

A: 488-71-1
2,3,4,6-tetramethylaniline

B: 3238-38-8
isodurenol

C: 137-17-7
2,4,5-trimethylaniline

D: 95-64-7
4-amino-o-xylene

Conditions

Conditions	Yield
je nach Mengenverhaeltnis und Temperatur; Produkt 5:Pentamethylphenol;

...Expand

: 67-56-1
methanol

: 7356-54-9
3,4-dimethylaniline hydrochloride

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
at 300 - 320℃;

: 121-72-2
N,N-dimethyl-m-toluidine

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
at 300℃;

: 121-72-2
N,N-dimethyl-m-toluidine

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
With zinc(II) chloride at 300℃;

: 64-17-5
ethanol

: 108-24-7
acetic anhydride

: 64-19-7
acetic acid

: 94378-05-9
1-(2,4,5-Trimethyl-phenylazo)-[2]naphthol

zinc: zinc

A: 137-17-7
2,4,5-trimethylaniline

B: 88166-77-2
2,4,5-trimethylacetanilide

C: 117-93-1
1-acetylamino-naphthalen-2-ol

D: 2834-92-6
1-amino-2-naphthol

...Expand

: 7647-01-0
hydrogenchloride

: 67-56-1
methanol

: 95-78-3
2,5-Dimethylaniline

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
at 300 - 320℃;

...Expand

: 7647-01-0
hydrogenchloride

: 50-00-0
formaldehyd

: 95-78-3
2,5-Dimethylaniline

A: 137-17-7
2,4,5-trimethylaniline

B: 5339-30-0
bis-(4-amino-2,5-dimethyl-phenyl)-methane

Conditions

Conditions	Yield
Erhitzen des Reaktionsprodukts mit Calciumhydroxid;
Erhitzen des Reaktionsprodukts mit Natriumcarbonat;

...Expand

5-nitro-pseudocumene: 5-nitro-pseudocumene

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
With hydrogenchloride; tin

: 67-56-1
methanol

hydrochloride of asymm.o-xylidine: hydrochloride of asymm.o-xylidine

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
at 300 - 320℃;

: 67-56-1
methanol

hydrochloride of p-xylidine: hydrochloride of p-xylidine

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
at 300 - 320℃;

xylidine: xylidine

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
Darstellung;

: 7647-01-0
hydrogenchloride

: 1,3-bis-(2,4,5-trimethyl-phenyl)-triazene

A: 496-78-6
2,4,5-trimethylphenol

B: 137-17-7
2,4,5-trimethylaniline

...Expand

: 3,4,6-trimethyl-2-(2,4,5-trimethyl-phenylazo)-aniline

: hydrogen trichloro-stannate(II)

A: 137-17-7
2,4,5-trimethylaniline

B: 4846-22-4
3,4,6-trimethyl-o-phenylenediamine

...Expand

: 1-(2,4,5-trimethyl-phenylazo)-[2]naphthylamine

copper: copper

A: 137-17-7
2,4,5-trimethylaniline

B: 938-25-0
1,2-diaminonaphthalene

C 2-<2.4.5-trimethyl-phenyl>-: 2-<2.4.5-trimethyl-phenyl>-

Conditions

Conditions	Yield
in verschiedenen Loesungsmitteln;

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

: 137-17-7
2,4,5-trimethylaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 38 percent / HNO3 (d= 1,40), H2SO4 (d = 1,83) 2: 97 percent / H2, aq. HCl / 10percent Pd/C / 22800 Torr / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid 2: Na2S2O4 View Scheme

: 137-17-7
2,4,5-trimethylaniline

: 123-54-6
acetylacetone

: 50519-33-0
2,4,5,6,8-pentamethyl-quinoline

Conditions

Conditions	Yield
	90%
With sulfuric acid

: 2033-24-1
cycl-isopropylidene malonate

: 137-17-7
2,4,5-trimethylaniline

: 149-73-5
trimethyl orthoformate

: 1129400-01-6
2,2-dimethyl-5-{[(2,4,5-trimethylphenyl)amino]methylene}-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
Stage #1: cycl-isopropylidene malonate; trimethyl orthoformate for 2h; Inert atmosphere; Reflux; Stage #2: 2,4,5-trimethylaniline for 2h; Inert atmosphere; Reflux;	82%

...Expand

: 137-17-7
2,4,5-trimethylaniline

: 586-96-9
Nitrosobenzene

: 1-phenyl-2-(2,4,5-trimethylphenyl)diazene

Conditions

Conditions	Yield
With acetic acid at 20℃; Cooling;	79%

: 50-00-0
formaldehyd

: 137-17-7
2,4,5-trimethylaniline

: 111437-12-8
1,2,4,7,8,10-hexamethyl-6H,12H-5,11-methanodibenzo<1,5>diazocine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 24h; Ambient temperature;	78%

: 475158-80-6
(R)-3,5-dichloro-1-(1-cyclopropylpropyl)pyrazin-2(1H)-one

: 137-17-7
2,4,5-trimethylaniline

: 1173523-71-1
(R)-5-chloro-1-(1-cyclopropylpropyl)-3-(2,4,5-trimethylphenylamino)pyrazin-2(1H)-one

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 5h; Inert atmosphere; Reflux;	71%

: 137-17-7
2,4,5-trimethylaniline

: 532-55-8
Benzoyl isothiocyanate

: 117174-81-9
1-Benzoyl-3-(2,4,5-trimethyl-phenyl)-thiourea

Conditions

Conditions	Yield
In acetone for 0.5h; Heating;	70%

: 93-60-7
methyl 3-pyridinecarboxylate

: 137-17-7
2,4,5-trimethylaniline

: N-mesitylnicotinamide

Conditions

Conditions	Yield
With C18H15IMnN3O3; sodium t-butanolate In toluene at 120℃; for 18h; Inert atmosphere; Schlenk technique;	56%

: 1173435-13-6
(R)-3,5-dichloro-1-(1-cyclopropylethyl)pyrazin-2(1H)-one

: 137-17-7
2,4,5-trimethylaniline

: 1173435-75-0
(R)-5-chloro-1-(1-cyclopropylethyl)-3-(2,4,5-trimethylphenylamino)pyrazin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: (R)-3,5-dichloro-1-(1-cyclopropylethyl)pyrazin-2(1H)-one; 2,4,5-trimethylaniline With sodium hexamethyldisilazane In tetrahydrofuran at 0 - 10℃; Inert atmosphere; Stage #2: With water; sodium hydrogencarbonate In tetrahydrofuran	41%

: 204394-69-4
4-chloro-2-(3-pyridyl)-6-(trifluoromethyl)pyrimidine

: 137-17-7
2,4,5-trimethylaniline

: 438249-55-9
4-(2,4,5-Trimethylanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine

Conditions

Conditions	Yield
	30%

: 137-17-7
2,4,5-trimethylaniline

: 4891-38-7
phenylpropynoic acid methyl ester

A: 1041644-10-3
(E)-methyl 3-(2-amino-3,5,6-trimethylphenyl)-3-phenylpropenoate

B: 1041644-09-0
(E)-methyl 3-(3-amino-2,5,6-trimethylphenyl)-3-phenylpropenoate

Conditions

Conditions	Yield
With fluorosulphonic acid at -30℃; for 1h;	A 18% B 30%
With fluorosulphonic acid at -30℃;	A 18% B 30%

...Expand

: 137-17-7
2,4,5-trimethylaniline

: 30824-26-1
N,N-bis(2-Chloroethyl)-3-methoxypropylamine Hydrochloride

: 76088-51-2
1-(3-Methoxypropyl)-4-(2,4,5-trimethylphenyl)piperazine

Conditions

Conditions	Yield
With sodium hydroxide; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride 1) ethanol, reflux, 5.5 h; 2) tetrahydrofurane, reflux, 15 min;;	28%

: 137-17-7
2,4,5-trimethylaniline

: 7515-16-4
methyl 3-(4-methylphenyl)prop-2-ynoate

A: 1139721-55-3
(E)-methyl 3-(2-amino-3,5,6-trimethylphenyl)-3-(4-methylphenyl)acrylate

B: 1139719-59-7
(E)-methyl 3-(3-amino-2,5,6-trimethylphenyl)-3-(4-methylphenyl)acrylate

Conditions

Conditions	Yield
With fluorosulphonic acid at -75℃;	A 19% B 11%

...Expand

: 7515-17-5
methyl 3-(4-methoxyphenyl)propynoate

: 137-17-7
2,4,5-trimethylaniline

A: (Z)-methyl 3-(3-amino-2,5,6-trimethylphenyl)-3-(4-methoxyphenyl)acrylate

B: 1139719-60-0
(E)-methyl 3-(3-amino-2,5,6-trimethylphenyl)-3-(4-methoxyphenyl)acrylate

Conditions

Conditions	Yield
With fluorosulphonic acid at -75℃;	A 9% B 17%

...Expand

: 137-17-7
2,4,5-trimethylaniline

: 80221-02-9
4-(p-tolyl)but-3-yn-2-one

: 1139719-64-4
(Z)-4-(3-amino-2,5,6-trimethylphenyl)-4-(4-methylphenyl)but-3-en-2-one

Conditions

Conditions	Yield
With fluorosulphonic acid at -30℃;	16%

: 553-90-2
Dimethyl oxalate

: 137-17-7
2,4,5-trimethylaniline

A: (2,4,5-trimethyl-phenyl)-oxalamic acid methyl ester

B: 778595-30-5
N,N'-bis-(2,4,5-trimethyl-phenyl)-oxalamide

...Expand

: 67-56-1
methanol

: 137-17-7
2,4,5-trimethylaniline

: 40505-10-0
1,2,4,5,7,8-hexamethyl-acridine

Conditions

Conditions	Yield
With hydrogenchloride at 252℃;

: 67-56-1
methanol

: 137-17-7
2,4,5-trimethylaniline

A: 488-71-1
2,3,4,6-tetramethylaniline

B: 40505-10-0
1,2,4,5,7,8-hexamethyl-acridine

Conditions

Conditions	Yield
at 252℃; im Autoklaven;

...Expand

: 109-65-9
1-bromo-butane

: 137-17-7
2,4,5-trimethylaniline

: N,N-dibutyl-2,4,5-trimethyl-aniline

: 75-15-0
carbon disulfide

: 137-17-7
2,4,5-trimethylaniline

: 5-(4-methoxy-benzylidene)-2-thioxo-3-(2,4,5-trimethyl-phenyl)-thiazolidin-4-one

Conditions

Conditions	Yield
With ammonium hydroxide Behandeln des Reaktionsprodukts mit Chloressigester in Alkohol und Kochen mit Anisaldehyd in Eisessig;

: 75-44-5
phosgene

: 137-17-7
2,4,5-trimethylaniline

: 85324-94-3
2,4,5-trimethylphenyl isocyanate

: 85-44-9
phthalic anhydride

: 137-17-7
2,4,5-trimethylaniline

: 40101-46-0
N-(2,4,5-trimethyl-phenyl)-phthalimide

: 85-44-9
phthalic anhydride

: 137-17-7
2,4,5-trimethylaniline

: N-(2,4,5-trimethyl-phenyl)-phthalamic acid

Conditions

Conditions	Yield
man spaltet das hierbei entstandene N-<2.4.5-Trimethyl-phenyl>-phthalimid durch 1/2-stdg. Kochen mit alkoh. Kali;

: 50-00-0
formaldehyd

: 90-15-3
α-naphthol

: 137-17-7
2,4,5-trimethylaniline

: 8,9,11-trimethyl-benz[c]acridine

Conditions

Conditions	Yield
und Eingiessen der Fluessigkeit in Kalilauge;

...Expand

: 50-00-0
formaldehyd

: 17579-79-2
2-methyl-6-hydroxynaphthalene

: 137-17-7
2,4,5-trimethylaniline

: 111584-57-7
3,8,10,11-tetramethyl-benz[a]acridine

...Expand

: 111-24-0
1,5-dibromo-pentane

: 137-17-7
2,4,5-trimethylaniline

: N,N'-bis-(2,4,5-trimethyl-phenyl)-pentanediyldiamine

: 64-18-6
formic acid

: 137-17-7
2,4,5-trimethylaniline

: 858244-30-1
N-(2,4,5-trimethylphenyl)formamide

2,4,5-Trimethylaniline Chemical Properties

Molecular Structure of 2,4,5-Trimethylaniline (CAS NO.137-17-7):

EINECS: 205-282-0
IUPAC Name: 2,4,5-Trimethylaniline
Molecular Formula: C₉H₁₃N
Molecular Weight: 135.206220 g/mol
XLogP3-AA: 2.3
H-Bond Donor: 1
H-Bond Acceptor: 1
Canonical SMILES: CC1=CC(=C(C=C1C)N)C
InChI: InChI=1S/C9H13N/c1-6-4-8(3)9(10)5-7(6)2/h4-5H,10H2,1-3H3
InChIKey: BMIPMKQAAJKBKP-UHFFFAOYSA-N
Index of Refraction: 1.552
Molar Refractivity: 44.96 cm³
Molar Volume: 140.5 cm³
Surface Tension: 36.7 dyne/cm
Density: 0.962 g/cm³
Flash Point: 102.9 °C
Enthalpy of Vaporization: 47.12 kJ/mol
Boiling Point: 234.5 °C at 760 mmHg
Vapour Pressure: 0.0527 mmHg at 25 °C
Melting Point: 62 °C
Water Solubility: 1009 mg/L at 25 °C
Storage Temp.: 2-8 °C

2,4,5-Trimethylaniline Toxicity Data With Reference

1.	mma-sat 10 µg/plate	ENMUDM Environmental Mutagenesis. 8 (Suppl 7)(1986),1.
2.	dnd-ham:lng 10 mmol/L	MUREAV Mutation Research. 77 (1980),317.
3.	orl-rat LD50:1250 mg/kg	MarJV# Personal Communication from Josef V. Marhold, VUOS, 539-18, Pardubice, Czechoslovakia, to the Editor of RTECS, Cincinnati, OH, March 29, 1977 29MAR77 .

2,4,5-Trimethylaniline Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 27 ,1982,p. 177.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); Clear Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-160 ,1979. .

2,4,5-Trimethylaniline Safety Profile

Safety Information of 2,4,5-Trimethylaniline (CAS NO.137-17-7):
Hazard Codes: F ,Xn Harmful ,N Dangerous ,T Toxic
Hazard Note: Harmful
Risk Statements: 11-20/21/22-36-51/53-23/24/25-45
R11:Highly flammable
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36:Irritating to eyes
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed
R45:May cause cancer
Safety Statements: 16-36/37-61-45-53
S16:Keep away from sources of ignition
S36/37:Wear suitable protective clothing and gloves
S61:Avoid release to the environment. Refer to special instructions / safety data sheets
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use
RIDADR: UN1648 3/PG 2
RTECS: BZ0520000
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Used as a dye, pigment, and printing ink. See also ANILINE DYES.

2,4,5-Trimethylaniline Standards and Recommendations

DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

2,4,5-Trimethylaniline Specification

2,4,5-Trimethylaniline with CAS Registry Number of 137-17-7 is white crystals or beige powder. It is also called for 1,2,4-Trimethyl-5-aminobenzene ; 1-Amino-2,4,5-trimethylbenzene ; 2,4,5-Trimethylanilin ; 2,4,5-Trimethylanilin [Czech] ; 2,4,5-Trimethylbenzenamine ; Benzenamine, 2,4,5-trimethyl- ; CCRIS 608 ; HSDB 2908 ; NCI-C02299 ; NSC 37004 ; Pseudocumidine ; Pseudokumidin ; Pseudokumidin [Czech] ; Psi-cumidine ; psi-Cumidine ; Aniline, 2,4,5-trimethyl- ; Benzenamine, 2,4,5-trimethyl- (9CI) . 2,4,5-Trimethylaniline may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.

Product Name

2,4,5-TRIMETHYLANILINE

Synthetic route

2,4,5-Trimethylaniline Chemical Properties

2,4,5-Trimethylaniline Toxicity Data With Reference

2,4,5-Trimethylaniline Consensus Reports

2,4,5-Trimethylaniline Safety Profile

2,4,5-Trimethylaniline Standards and Recommendations

2,4,5-Trimethylaniline Specification

Related Products

Hot Products