2,4,6-Trimethybromombenzene supplier

Name
2,4,6-Trimethybromombenzene
EINECS 209-405-9
CAS No. 576-83-0
Article Data89
CAS DataBase
Density 1.289 g/cm³
Solubility Insoluble in water(20°C) .
Melting Point 2 °C(lit.)
Formula C₉H₁₁Br
Boiling Point 224.999 °C at 760 mmHg
Molecular Weight 199.09
Flash Point 96.111 °C
Transport Information
Appearance Colorless liquid
Safety 26-36-36/37/39-23
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Mesitylene,2-bromo- (6CI,7CI,8CI);1-Bromo-2,4,6-trimethylbenzene;1-Bromomesitylene;2,4,6-Trimethyl-1-bromobenzene;2,4,6-Trimethylphenyl bromide;2-Bromo-1,3,5-trimethylbenzene;2-Bromomesitylene;Mesityl bromide;NSC 8064;
PSA 0.00000
LogP 3.37430

Synthetic route

: 108-67-8
1,3,5-trimethyl-benzene

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With N-Bromosuccinimide; perchloric acid In tetrachloromethane for 22h; Ambient temperature;	99%
With hydrogen bromide; dihydrogen peroxide In water at 20℃; for 24h; Darkness;	98%
With gold(III) chloride; N-Bromosuccinimide In dichloromethane at 20℃; for 12h; Inert atmosphere;	98%

: 480-63-7
mesitylenecarboxylic acid

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With potassium phosphate; tetrabuthylammonium tribromide In acetonitrile at 100℃; for 16h;	94%

: 88-05-1
2,4,6-trimethylaniline

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With N-Bromosuccinimide; sodium nitrite In N,N-dimethyl-formamide at 20℃; for 6h;	88%
With tert.-butylnitrite; copper(ll) bromide In acetonitrile

: triethyl(mesityl)germane

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 4h;	80%

: 108-67-8
1,3,5-trimethyl-benzene

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 6942-99-0
2,4-dibromomesitylene

Conditions

Conditions	Yield
With bromine In tetrachloromethane Product distribution / selectivity;	A 73% B n/a
With bromine; silica gel In tetrachloromethane at 20℃;	A 13% B 70 % Chromat.
With N-Bromosuccinimide; toluene-4-sulfonic acid In dichloromethane Product distribution; Ambient temperature; var. catalyst, var solvent, var. aromatic;

: 108-67-8
1,3,5-trimethyl-benzene

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 1667-04-5
2-bromomesitylene

Conditions

Conditions	Yield
With chloroamine-T; iron(II) bromide In dichloromethane for 189.6h; Ambient temperature;	A 51% B 0.3%
With bromine at 100℃; for 4h; Reflux; Ionic liquid;

: 108-67-8
1,3,5-trimethyl-benzene

A: 27129-86-8
1-bromomethyl-3,5-dimethylbenzene

B: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With sodium bromate; sodium hydrogensulfite In cyclohexane; water at 50℃; for 4h; Bromination;	A 50% B 11%
With bromine at 120℃; for 6h; UV-irradiation; Title compound not separated from byproducts;
With N-Bromosuccinimide at 150℃; under 2625.26 Torr; for 0.0666667h; microwave irradiation;	A 42 % Chromat. B 6 % Chromat.

: 22739-91-9
isopropyl mesityl sulfone

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 60057-49-0
2,4,6-trimethylbenzenesulfonyl bromide

C: α-bromoisopropyl mesityl sulfone

D: 2,3-dimethyl-3-mesitylenesulfonyl-2-butanol

Conditions

Conditions	Yield
Stage #1: isopropyl mesityl sulfone With n-butyllithium In tetrahydrofuran; hexane at -63℃; for 1h; Stage #2: With bromine In tetrahydrofuran; hexane at -55℃; for 1.5h; Further stages.;	A 6% B 5% C 48% D 37%

...Expand

: (2,4,6-trimethylphenyl)diazonium tetrafluoronorate

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 1667-04-5
2-bromomesitylene

Conditions

Conditions	Yield
With sodium bromide; sodium chloride In water; glycerol at 21 - 23.5℃; Product distribution; Kinetics; investigations of thermal dediazoniation in various solvents as a function of viscosity; the reaction are diffusion controlled;	A 14.5% B 6%

: 3453-83-6
mesitylene sulfonic acid

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With copper(ll) bromide

: 1483-92-7
bis(2,4,6-trimethylphenyl)disulfide

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With bromine In dichloromethane at -30℃; for 0.166667h;

: 7726-95-6
bromine

: 7697-37-2
nitric acid

: 108-67-8
1,3,5-trimethyl-benzene

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
je nach dem Mengenverhaeltnis der Verbindungen;

...Expand

: 7727-15-3
aluminium bromide

: 108-67-8
1,3,5-trimethyl-benzene

diselenium dibromide: diselenium dibromide

carbon disulfide solution: carbon disulfide solution

A: 576-83-0
2,4,6-trimethylphenyl bromide

B dimesityl: dimesityl

...Expand

Ni(mes)(Ph)(PMe2Ph)2: Ni(mes)(Ph)(PMe2Ph)2

A: 108-86-1
bromobenzene

B: 3976-35-0
1-phenyl-2,4,6-trimethylbenzene

C: 576-83-0
2,4,6-trimethylphenyl bromide

D: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With bromine In diethyl ether for 0.5h; Ambient temperature; Yield given;

...Expand

Ni(mes)(o-tol)(PEt3)2: Ni(mes)(o-tol)(PEt3)2

A: 95-46-5
2-methylphenyl bromide

B: 576-83-0
2,4,6-trimethylphenyl bromide

C: 89970-02-5
2,2',4,6-tetramethylbiphenyl

D: 3-bromo-2,2',4,6-tetramethyl-1,1'-biphenyl

Conditions

Conditions	Yield
With bromine In diethyl ether for 0.5h; Ambient temperature; Yield given;

...Expand

Ni(mes)(o-tol)(PMe2Ph)2: Ni(mes)(o-tol)(PMe2Ph)2

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 31543-75-6
2,4-dibromotoluene

C: 89970-02-5
2,2',4,6-tetramethylbiphenyl

D: 3-bromo-2,2',4,6-tetramethyl-1,1'-biphenyl

Conditions

Conditions	Yield
With bromine In diethyl ether for 0.5h; Ambient temperature; Yield given. Further byproducts given;

...Expand

Ni(o-ClPh)(mes)(PMe2Ph)2: Ni(o-ClPh)(mes)(PMe2Ph)2

A: 694-80-4
2-bromo-1-chlorobenzene

B: 576-83-0
2,4,6-trimethylphenyl bromide

C: 108-90-7
chlorobenzene

D: 3-Bromo-2'-chloro-2,4,6-trimethyl-biphenyl

Conditions

Conditions	Yield
With bromine In diethyl ether for 0.5h; Ambient temperature; Yield given;

...Expand

: Di-tert-butylmesitylsilan

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 59409-85-7
Di-tert-butyl-bromsilan

Conditions

Conditions	Yield
With bromine In pentane at -5 - 20℃; Title compound not separated from byproducts;

: (2,4,6-trimethylphenyl)diazonium tetrafluoronorate

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 392-69-8
1-fluoro-2,4,6-trimethylbenzene

Conditions

Conditions	Yield
With trimethylsilyl bromide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 55℃; for 2h;	A 87 % Chromat. B 13 % Chromat.
With trimethylsilyl bromide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; copper(I) bromide at 70℃; Schiemann reaction;	A 4 % Chromat. B 96 % Chromat.

: 37055-29-1
2,4,6-trimethyl 1-deuterio benzene

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 1332484-20-4
C9H10(2)HBr

Conditions

Conditions	Yield
With gold(III) chloride; N-Bromosuccinimide In 1,2-dichloro-ethane at 20℃; for 6h; Kinetics;

: 108-67-8
1,3,5-trimethyl-benzene

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 608-72-0
2,4,6-tribromomesitylene

C: 6942-99-0
2,4-dibromomesitylene

Conditions

Conditions	Yield
With Oxone; quartz; sodium bromide In n-heptane for 0.333333h; Milling;

...Expand

: 2633-66-1
2-mesitylmagnesium bromide

A: 576-83-0
2,4,6-trimethylphenyl bromide

B: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With C44H45Br3N4Ni In benzene-d6 Inert atmosphere;	A 50 %Spectr. B 33 %Spectr.

: mesityldiazonium tetrakis(pentafluorophenyl)borate

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 16 h / 30 °C / Sealed tube 2: sodium bromide / [(2)H6]acetone; water / 0.17 h / 20 °C View Scheme

: (2,4,6-trimethylphenyl)diazonium tetrafluoronorate

: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dichloromethane; toluene / 1 h / 0 °C 2: 16 h / 30 °C / Sealed tube 3: sodium bromide / [(2)H6]acetone; water / 0.17 h / 20 °C View Scheme

: (E)-(2-chlorovinyl)(mesityl)[tetrakis(pentafluorophenyl)borato]-λ3-chlorane

A: 72256-09-8
Z-1-bromo-2-chloroethylene

B: 576-83-0
2,4,6-trimethylphenyl bromide

Conditions

Conditions	Yield
With sodium bromide In [(2)H6]acetone; water at 20℃; for 0.166667h; stereoselective reaction;	A n/a B n/a

: 576-83-0
2,4,6-trimethylphenyl bromide

: 111-40-0
1,5-diamino-3-azapentane

: 236111-35-6
(2,4,6-Me3C6H2NHCH2CH2)2NH

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene Heating;	100%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 5713-61-1
thiophen-2-yl magnesium bromide

: 920449-57-6
2-(2,4,6-trimethylphenyl)thiophene

Conditions

Conditions	Yield
Stage #1: thiophen-2-yl magnesium bromide With dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); zinc(II) chloride In tetrahydrofuran at 23℃; for 0.333333h; Inert atmosphere; Stage #2: 2,4,6-trimethylphenyl bromide In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 23℃; for 24h; Negishi coupling; Inert atmosphere;	100%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 66818-61-9
2′,4′,6′-trimethylbiphenyl-4-amine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane for 17h; Suzuki-Miyaura Coupling; Inert atmosphere; Reflux;	100%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 2,2'-(5,10-dimesitylindeno[2,1-a]indene-2,7-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

: 2,5,7,10-tetramesitylindeno[2,1-a]indene

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In water; toluene at 95℃; for 20h; Suzuki-Miyaura Coupling; Inert atmosphere;	100%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 88-05-1
2,4,6-trimethylaniline

Conditions

Conditions	Yield
With 2-((dicyclohexylphosphino)methyl)-1,3-bis(2,6-diisopropylphenyl)-4,5-dimethyl-1H-imidazol-3-ium iodide; ammonia; palladium diacetate; sodium t-butanolate In 1,4-dioxane at 120℃; under 7500.75 Torr; for 24h; Autoclave; Inert atmosphere;	99%
With copper(l) iodide; sodium azide; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 100℃; for 10h; Inert atmosphere;	72%
Stage #1: 2,4,6-trimethylphenyl bromide With magnesium In tetrahydrofuran Inert atmosphere; Stage #2: With 3-tert-butyl-3-phenyloxaziridine In tetrahydrofuran; toluene at -45℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Reagent/catalyst; Inert atmosphere;	31%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 98-80-6
phenylboronic acid

: 3976-35-0
1-phenyl-2,4,6-trimethylbenzene

Conditions

Conditions	Yield
With caesium carbonate; palladium diacetate; P(i-BuNCH2CH2)3N In toluene at 80℃; Suzuki cross-coupling reaction;	99%
With [(trineopentylphosphine)PdCl2]2; sodium carbonate In water; toluene at 23℃; for 17h; Catalytic behavior; Temperature; Reagent/catalyst; Solvent; Suzuki-Miyaura Coupling; Sealed tube; Inert atmosphere;	99%
With palladium diacetate; N,N'-dicyclohexylethylenediimine; caesium carbonate In 1,4-dioxane at 80℃; for 4h; Suzuki-Miyaura cross-coupling reaction;	97%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 90-04-0
2-methoxy-phenylamine

: 39267-49-7
N-(2-methoxyphenyl)-N-(2,4,6-trimethylphenyl)amine

Conditions

Conditions	Yield
With palladium diacetate; P(i-BuNCH2CH2)3N; sodium t-butanolate In toluene at 80℃;	99%
With palladium diacetate; 9,9-dimethyl-4,6-bis(diphenylphosphino)xanthene; sodium t-butanolate In toluene at 80℃; for 68h;	97%
With palladium diacetate; sodium t-butanolate; tri tert-butylphosphoniumtetrafluoroborate In toluene at 120℃; for 24h; Glovebox; Inert atmosphere;	79%
With 5,5-dimethyl-1,9-(PPh2)2-xanthene; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 100℃;

: 576-83-0
2,4,6-trimethylphenyl bromide

: 16419-60-6
2-Methylphenylboronic acid

: 89970-02-5
2,2',4,6-tetramethylbiphenyl

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) In tetrahydrofuran; toluene at 60℃; for 16h; Inert atmosphere;	99%
With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine In tetrahydrofuran at 20℃; for 18h; Reagent/catalyst; Concentration; Temperature; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox;	98%
With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; potassium carbonate In water at 20℃; for 22h; Suzuki-Miyaura coupling;	94%

: 1013-88-3
Benzophenone imine

: 576-83-0
2,4,6-trimethylphenyl bromide

: 67565-93-9
N-(diphenyl methylene)-2,4,6-trimethylaniline

Conditions

Conditions	Yield
With potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0); 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In 1,4-dioxane at 80℃; for 10h;	99%

: 110-91-8
morpholine

: 576-83-0
2,4,6-trimethylphenyl bromide

: N-(2,4,6-trimethylphenyl)morpholine

Conditions

Conditions	Yield
With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate In neat (no solvent) at 110℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere; Green chemistry;	99%
With [Pd(N,N'-bis(2,6-bis(di-p-tolylmethyl)-4-methylphenyl)-imidazol-2-ylidene)(acetylacetonate)Cl]; lithium hexamethyldisilazane In 1,4-dioxane at 110℃; for 3h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube;	95%
With (SIPr)Pd(cinnanmyl)Cl; potassium tert-butylate In 1,2-dimethoxyethane at 20℃; for 0.5h; Buchwald-Hartwig reaction;	94%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 62-53-3
aniline

: 23592-67-8
N-mesitylaniline

Conditions

Conditions	Yield
With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate In neat (no solvent) at 110℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere; Green chemistry;	99%
With (2-mesityl-1H-inden-3-yl)dicyclohexyl phosphine; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In 1,2-dimethoxyethane at 120℃; for 24h; Buchwald-Hartwig amination; Inert atmosphere;	98%
With air; potassium 2-methylbutan-2-olate; [(1,3-(2,6-iPr2C6H3)2-1,3-dihydroimidazol-2-ylidene)PdCl2]2 In 1,2-dimethoxyethane for 4h; Heating;	92%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 108-67-8
1,3,5-trimethyl-benzene

Conditions

Conditions	Yield
With potassium fluoride In tetrahydrofuran; water at 80℃; for 8h; Time; Schlenk technique; Sealed tube; Inert atmosphere;	99%
With [2-(di-tert-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine]ruthenium(II) chlorocarbonyl hydride; isopropyl alcohol; sodium t-butanolate at 100℃; for 48h; Inert atmosphere; Sealed tube; Green chemistry;	89%
With isopropyl alcohol at 20℃; for 24h; UV-irradiation; chemoselective reaction;	88%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 87-62-7
2,6-dimethylaniline

: 68014-58-4
N-(2,4,6-trimethylphenyl)-N-(2,6-dimethylphenyl)amine

Conditions

Conditions	Yield
With palladium diacetate; P(i-BuNCH2CH2)3N; sodium t-butanolate In toluene at 80℃;	99%
With sodium t-butanolate; palladium diacetate In toluene at 80℃; for 4h; Buchwald-Hartwig amination;	98%
With tris-(dibenzylideneacetone)dipalladium(0); rac-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; sodium t-butanolate In toluene at 110℃; for 20h; Inert atmosphere;	98%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 13922-41-3
1-Naphthylboronic acid

: 22187-05-9
1-(2,4,6-trimethylphenyl)naphthalene

Conditions

Conditions	Yield
With potassium phosphate; C29H37O2P; palladium diacetate In toluene at 110℃; for 3h; Reagent/catalyst; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;	99%
With C36H43Br2ClN2Pd; potassium tert-butylate In isopropyl alcohol at 20℃; for 2h; Reagent/catalyst; Suzuki Coupling; Inert atmosphere; Schlenk technique; Glovebox;	97%
With (IPr)Pd(cinnanmyl)Cl; potassium tert-butylate In isopropyl alcohol at 20℃; for 3.5h; Suzuki-Miyaura coupling;	89%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 536-74-3
phenylacetylene

: 29778-31-2
1-(phenylethynyl)-2,4,6-trimethylbenzene

Conditions

Conditions	Yield
With pyrrolidine; triphenylphosphine; 1-butyl-3-methylimidazolium Tetrafluoroborate; bis(η3-allyl-μ-chloropalladium(II)) at 130℃; for 48h; Heck alkynylation;	99%
With caesium carbonate; Pd[1,3,5,7-Me4-2,4,8-trioxa-6-Ph-6-phosphaadamantane]2*dba In acetonitrile at 60℃; for 12h; Sonogashira reaction;	93%
With dichloro[1-(3,5-dimethylbenzyl)-3-(4-adamantylbenzyl)-5,6-dimethylbenzimidazole-2-ylidene]triphenylphosphine palladium(II); potassium tert-butylate In N,N-dimethyl-formamide at 100℃; for 3h; Reagent/catalyst; Sonogashira Cross-Coupling; Schlenk technique;	90%

: 611-94-9
4-Methoxybenzophenone

: 576-83-0
2,4,6-trimethylphenyl bromide

: (4-methoxyphenyl)phenyl(2,4,6-trimethylphenyl)methanol

Conditions

Conditions	Yield
Stage #1: 2,4,6-trimethylphenyl bromide With magnesium In tetrahydrofuran Stage #2: 4-Methoxybenzophenone In tetrahydrofuran for 18h; Heating;	99%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 6783-05-7
trans-2-phenylvinylboronic acid

: 17024-58-7
(E)-2,4,6-trimethylstilbene

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In tetrahydrofuran at 40℃; for 24h; Suzuki-Miyaura coupling;	99%
With potassium tert-butylate; ClPd[N,N(2,6-iPr2C6H3)2-imidazol-2-yl]cinnamyl In isopropyl alcohol at 20℃; for 1.5h; Suzuki-Miyaura cross-coupling reaction;	92%

: 2627-95-4
tetramethyldivinyldisiloxane

: 576-83-0
2,4,6-trimethylphenyl bromide

: 769-25-5
2,4,6-trimethylstyrene

Conditions

Conditions	Yield
With johnphos; bis(η3-allyl-μ-chloropalladium(II)) In N,N-dimethyl-formamide at 40℃; for 24h;	99%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 2401-24-3
2-chloro-5-methoxyaniline

: 1188930-01-9
2-chloro-5-methoxy-N-(2,4,6-trimethylphenyl)aniline

Conditions

Conditions	Yield
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene for 18h; Inert atmosphere; Reflux;	99%

: 462-94-2
1,5-diaminopentane

: 576-83-0
2,4,6-trimethylphenyl bromide

: 1226754-96-6
N1,N5-dimesitylpentane-1,5-diamine

Conditions

Conditions	Yield
With sodium t-butanolate; (R)-(-)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate In 1,2-dimethoxyethane at 100℃; for 6h;	99%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 2571-52-0
cyanomesitylene

Conditions

Conditions	Yield
Stage #1: 2,4,6-trimethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -70 - 0℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at 0℃; for 1h; Stage #3: With ammonia; iodine In tetrahydrofuran; hexane; water at 0 - 20℃;	99%
Stage #1: 2,4,6-trimethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -70 - 0℃; for 0.583333h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at 0℃; for 1h; Stage #3: With ammonia; iodine In tetrahydrofuran; hexane; water at 0 - 20℃; for 2h;	99%
Stage #1: 2,4,6-trimethylphenyl bromide; N,N-dimethyl-formamide With magnesium In tetrahydrofuran at 20℃; Stage #2: With ammonia; iodine In tetrahydrofuran; water at 20℃;	79%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 847818-55-7
(1-methyl-1H-pyrazol-4-yl)boronic acid

: 1246888-97-0
4-mesityl-1-methyl-1H-pyrazole

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); rac-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole In water; butan-1-ol at 100℃; for 24h; Suzuki coupling; Inert atmosphere;	99%

: 576-83-0
2,4,6-trimethylphenyl bromide

: C14H20BO3(1-)*K(1+)

: 4482-03-5
bimesityl

Conditions

Conditions	Yield
With palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl; copper(l) chloride In N,N-dimethyl-formamide at 80℃; for 14h; Inert atmosphere;	99%

: lithium trimethoxy(1,2,2-trifluorovinyl)borate

: 576-83-0
2,4,6-trimethylphenyl bromide

: 2972-89-6
1,3,5-trimethyl-2-(1,2,2-trifluorovinyl)benzene

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); XPhos In tetrahydrofuran at 20 - 80℃; for 15.25h; Suzuki coupling; Inert atmosphere;	99%

: 629-05-0
n-octyne

: 576-83-0
2,4,6-trimethylphenyl bromide

: 1421336-58-4
(E)-1,3,5-trimethyl-3-(oct-1-en-1-yl)benzene

Conditions

Conditions	Yield
Stage #1: n-octyne With bis(pentamethylcyclopentadienyl)zirconium(IV) dichloride; dichloroalane bis(tetrahydrofuran) solvate In tetrahydrofuran Reflux; Inert atmosphere; Stage #2: 2,4,6-trimethylphenyl bromide With 1,4-diaza-bicyclo[2.2.2]octane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; XPhos In tetrahydrofuran for 2h; Reflux; Inert atmosphere;	99%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 154549-38-9
2,4,6-triisopropylphenylboronic acid

: 2,4,6-triisopropyl-2',4',6'-trimethylbiphenyl

Conditions

Conditions	Yield
With BI-DIME; palladium diacetate; sodium t-butanolate In toluene at 110℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere;	99%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 195062-57-8
p-tolylboronic pinacol ester

: 3976-37-2
2,4,4',6-tetramethyl-1,1'-biphenyl

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide In neat (no solvent) at 110℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere;	99%

: 110-00-9
furan

: indium(III) chloride

: 576-83-0
2,4,6-trimethylphenyl bromide

: 81698-99-9
1,3,5-trimethyl 2-(α-furyl)benzene

Conditions

Conditions	Yield
Stage #1: furan With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.5h; Inert atmosphere; Stage #2: indium(III) chloride In tetrahydrofuran at -78 - 25℃; for 0.5h; Stage #3: 2,4,6-trimethylphenyl bromide With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; dicylclohexylphosphino(2',4',6'-triisopropyl)biphenyl In tetrahydrofuran; methanol for 15h; Reflux;	99%

...Expand

: 576-83-0
2,4,6-trimethylphenyl bromide

: 23112-96-1
(2,6-dimethoxyphenyl)boronic acid

: 2′,6′-dimethoxy-2,4,6-trimethyl-1,1′-biphenyl

Conditions

Conditions	Yield
With [Pd(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(cinnamyl)Cl]; potassium 2-methylbutan-2-olate In 1,4-dioxane at 110℃; for 12h; Suzuki-Miyaura Coupling; Inert atmosphere; Sealed tube;	99%
With potassium phosphate; C29H37O2P; palladium diacetate In toluene at 110℃; for 3h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;	81%

2,4,6-Trimethybromombenzene Specification

The Benzene,2-bromo-1,3,5-trimethyl-, with the CAS registry number 576-83-0, is also known as 2,4,6-Trimethybromombenzene. It belongs to the product category of Aromatic Hydrocarbons (substituted) & Derivatives. Its EINECS number is 209-405-9. This chemical's molecular formula is C₉H₁₁Br and formula weight is 199.09. What's more, its IUPAC name is 2-bromo-1,3,5-trimethylbenzene.

Physical properties of Benzene,2-bromo-1,3,5-trimethyl- are: (1)ACD/LogP: 4.37; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4.37; (4)Index of Refraction: 1.539; (5)Molar Refractivity: 48.41 cm³; (6)Molar Volume: 154.4 cm³; (7)Surface Tension: 33.1 dyne/cm; (8)Density: 1.289 g/cm³; (9)Flash Point: 96.1 °C; (10)Enthalpy of Vaporization: 44.27 kJ/mol; (11)Boiling Point: 225 °C at 760 mmHg; (12)Vapour Pressure: 0.132 mmHg at 25°C.

Preparation: this chemical can be prepared by 1,3,5-trimethyl-benzene at the temperature of 20°C. This reaction will need reagent PyHBrCl₂ and solvent aq. methanol with the reaction time of 5 min. The yield is about 96%.

Uses of Benzene,2-bromo-1,3,5-trimethyl-: it can be used to produce 1-bromo-3,5-bis-chloromethyl-2,4,6-trimethyl-benzene at the temperature of 20°C. It will need reagent SnCl₄ and solvent CH₂Cl₂. The yield is about 84%.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you need rinse immediately with plenty of water and seek medical advice. When using it, you should wear suitable protective clothing, gloves and eye/face protection.You should not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC1=CC(=C(C(=C1)C)Br)C
(2)InChI: InChI=1S/C9H11Br/c1-6-4-7(2)9(10)8(3)5-6/h4-5H,1-3H3
(3)InChIKey: RRTLQRYOJOSPEA-UHFFFAOYSA-N

Product Name

2,4,6-Trimethybromombenzene

Synthetic route

2,4,6-Trimethybromombenzene Specification

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