2,4-Difluorobenzaldehyde supplier

Name
2,4-Difluorobenzaldehyde
EINECS 216-287-2
CAS No. 1550-35-2
Article Data28
CAS DataBase
Density 1.297 g/cm³
Solubility
Melting Point 2-3 °C(lit.)
Formula C₇H₄F₂O
Boiling Point 168.572 °C at 760 mmHg
Molecular Weight 142.105
Flash Point 64.276 °C
Transport Information UN 1989 3/PG 3
Appearance Colorless to slightly yellow liquid
Safety 26-36-37/39-16
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 4-Fluoro-2-fluorobenzaldehyde;
PSA 17.07000
LogP 1.77730

Synthetic route

: 56456-47-4
2,4-difluorobenzyl alcohol

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper diacetate In water; acetonitrile at 20℃; for 6h; Green chemistry;	89%
With nitric acid; ytterbium(III) triflate In 1,2-dichloro-ethane for 2h; Oxidation; Heating;	80%

: 201230-82-2
carbon monoxide

: 2265-93-2
2,4-difluoro-1-iodobenzene

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
With rhodium(III) chloride trihydrate; hydrogen; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 90℃; under 7500.75 Torr; for 12h; Autoclave;	76%

: 348-57-2
2,4-difluorobromobenzene

: 109-94-4
formic acid ethyl ester

A: 1550-35-2
2,4-difluorobenzaldehyde

B: 182192-99-0
bis-(2,4-difluorophenyl)methanol

Conditions

Conditions	Yield
With n-butyllithium In diethyl ether; hexane 1.) -78 deg C, 30 min, 2.) -78 to 20 deg C, overnight;	A 12.8% B 74%

...Expand

: 874-42-0
2,4-dichlorobenzaldeyhde

A: 1550-35-2
2,4-difluorobenzaldehyde

B: 84194-36-5
2-chloro-4-fluorobenzaldehyde

C: 61072-56-8
4-chloro-2-fluorobenzaldehyde

Conditions

Conditions	Yield
With potassium fluoride In sulfolane at 220℃; for 12h; Product distribution; also with other 1) molar ratios, 2) solvents, 3) temperatures, 4) times;	A 66% B 7% C 5%
With potassium fluoride In sulfolane at 220℃; for 12h;	A 66% B 7% C 5%
With potassium fluoride In sulfolane at 220℃; for 12h; Yield given. Title compound not separated from byproducts;	A 13% B n/a C n/a

...Expand

: 622372-75-2
1-(azidomethyl)-2,4-difluorobenzene

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
With sodium dithionite; spermwhale myoglobin (H64V,V68A) In methanol; aq. phosphate buffer at 20℃; for 24h; pH=7; Catalytic behavior;	60%
With sodium dithionite In methanol; aq. phosphate buffer at 20℃; for 24h; pH=7; Catalytic behavior; Enzymatic reaction;

: 874-42-0
2,4-dichlorobenzaldeyhde

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
With potassium fluoride; 18-crown-6 ether; tetraphenylphosphonium bromide at 230℃; for 7h;	49%

: 127598-80-5
N-(2,4-difluorobenzyl) N-(2-cyanoethyl)-4-methylaniline

A: 1550-35-2
2,4-difluorobenzaldehyde

B: 118072-35-8
3-(2-Dimethylaminomethyl-4-methyl-phenylamino)-propionitrile

C: 127598-87-2
N-(2-cyanoethyl) N-(2,4-difluorobenzyl)-2-amino-5-methylbenzaldehyde

Conditions

Conditions	Yield
With water; trichlorophosphate In N,N-dimethyl-formamide Vilsmeier reaction;	A 30% B 39% C 42.5%
With trichlorophosphate In N,N-dimethyl-formamide Vilsmeier reaction;	A 30% B 39% C 42.5%

...Expand

: 4885-02-3
Dichloromethyl methyl ether

: 372-18-9
1,3-Difluorobenzene

A: 696589-33-0
bis(2,4-difluorophenyl)chloromethane

B: 1550-35-2
2,4-difluorobenzaldehyde

C: tris(2,4-difluorophenyl)methane

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane	A n/a B 33% C n/a

...Expand

: 452-76-6
2,4-difluorotoluene

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
With sodium molybdate; dihydrogen peroxide; sodium bromide In acetic acid at 105℃; for 0.111111h; Temperature;	31.1%
With chlorine anschliessenden Erwaermen mit H2SO4;
With bromine anschliessenden Erwaermen mit H2SO4;

N-<2,4-difluoro-benzyl>-hexamethylenetetraminium chloride: N-<2,4-difluoro-benzyl>-hexamethylenetetraminium chloride

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
With acetic acid

: 127598-60-1
N-(2,4-difluorobenzylidene)-4-methylaniline

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 91 percent / sodium borohydride / Heating 2: 46 percent / CuCl 3: 30 percent / POCl3 / dimethylformamide / Vilsmeier reaction View Scheme

: 127598-67-8
N-(2,4-difluorobenzyl)-4-methylaniline

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 46 percent / CuCl 2: 30 percent / POCl3 / dimethylformamide / Vilsmeier reaction View Scheme

: 348-57-2
2,4-difluorobromobenzene

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
With n-butyllithium; ammonium chloride In N-methyl-acetamide; diethyl ether; hexane; water

: 64-18-6
formic acid

: 372-18-9
1,3-Difluorobenzene

: 1550-35-2
2,4-difluorobenzaldehyde

Conditions

Conditions	Yield
Stage #1: 1,3-Difluorobenzene With potassium tert-butylate In tetrahydrofuran; chloroform at 30 - 40℃; for 2.5h; Stage #2: formic acid at 65℃; for 3h; Reagent/catalyst; Solvent; Temperature;

: 1550-35-2
2,4-difluorobenzaldehyde

: 829-20-9
2',4'-dimethoxyacetophenone

: RL390

Conditions

Conditions	Yield
With sodium hydroxide In methanol Ambient temperature;	100%
With sodium hydroxide In methanol at 28℃; Claisen Schmidt condensation;	75.3%

: 107-10-8
propylamine

: 1550-35-2
2,4-difluorobenzaldehyde

: 1191057-85-8
(E)-N-(2,4-difluorobenzylidene)propan-1-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane; water at 24.84℃; for 4h;	100%

: 1550-35-2
2,4-difluorobenzaldehyde

: 619-45-4
4-methoxycarbonyl aniline

: 1391608-80-2
4-{[1-(2,4-difluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h;	100%
With toluene-4-sulfonic acid In toluene for 12h; Reflux;	100%

: 1550-35-2
2,4-difluorobenzaldehyde

: 762-04-9
phosphonic acid diethyl ester

: 1386395-18-1
diethyl [(2,4-difluorophenyl)(hydroxy)methyl]phosphonate

Conditions

Conditions	Yield
With triethylamine at 0 - 20℃;	100%

: 1550-35-2
2,4-difluorobenzaldehyde

: 56456-47-4
2,4-difluorobenzyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere;	100%
Stage #1: 2,4-difluorobenzaldehyde With C36H44F4N2Ni2P2; diphenylsilane In tetrahydrofuran at 45℃; for 3h; Schlenk technique; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; methanol at 60℃; for 24h; Schlenk technique; Inert atmosphere;	92%
With methanol; sodium tetrahydroborate at 0℃; for 1h;	88%

: 109-80-8
1.3-propanedithiol

: 1550-35-2
2,4-difluorobenzaldehyde

: 2-(2,4-difluorophenyl)-1,3-dithiane

Conditions

Conditions	Yield
With Lewis acid	100%
With boron trifluoride diethyl etherate In dichloromethane at 0 - 25℃;	78%

: 1550-35-2
2,4-difluorobenzaldehyde

: [(2,4-difluorophenyl)methylidene]hydrazine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 20℃; for 1h; Inert atmosphere;	100%
With hydrazine hydrate In ethanol at 20℃; Inert atmosphere;

: 1016234-89-1
2-amino-4-bromo-5-fluorophenol

: 1550-35-2
2,4-difluorobenzaldehyde

: 1016234-91-5
4-bromo-2-[[(2,4-difluorophenyl)methylene]amino]-5-fluorophenol

Conditions

Conditions	Yield
Stage #1: 2-amino-4-bromo-5-fluorophenol; 2,4-difluorobenzaldehyde With toluene-4-sulfonic acid In toluene for 0.5h; Heating / reflux; Stage #2: With triethylamine In toluene at 20℃;	99%
toluene-4-sulfonic acid In toluene for 0.5h; Heating / reflux; Dean-Stark apparatus;	99%

: 1550-35-2
2,4-difluorobenzaldehyde

: 24045-02-1
(benzothiazole-2-sulfonyl)-acetic acid ethyl ester

: ethyl 5-(2,4-difluoro-phenyl)-2H-[1,2,3]triazole-4-carboxylate

Conditions

Conditions	Yield
With sodium azide; ammonium acetate In methanol; water at 30℃; for 4h;	99%

: 5927-18-4
trimethyl phosphonoacetate

: 1550-35-2
2,4-difluorobenzaldehyde

: 186758-21-4
methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate

Conditions

Conditions	Yield
Stage #1: trimethyl phosphonoacetate With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,4-difluorobenzaldehyde In tetrahydrofuran at 20℃; for 3.16667h;	99%
Stage #1: trimethyl phosphonoacetate With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,4-difluorobenzaldehyde In tetrahydrofuran at 20℃; for 3.16667h;	99%
With potassium tert-butylate In tetrahydrofuran at 20℃; for 5.5h;	86%

: 83-72-7
2-Hydroxy-1,4-naphthoquinone

: 1550-35-2
2,4-difluorobenzaldehyde

: C27H12F2O5

Conditions

Conditions	Yield
With silica-supported tungstic acid In neat (no solvent) at 60℃; for 0.0833333h; Sonication; Green chemistry;	99%

: 1550-35-2
2,4-difluorobenzaldehyde

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 2-((2,4-difluorobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
With C34H28N6Zn In neat (no solvent) at 20℃; for 2h; Glovebox; Schlenk technique;	99%

: 6272-26-0
6-hydroxybenzofuran-3-one

: 1550-35-2
2,4-difluorobenzaldehyde

: 1613190-04-7
(Z)-2-(2,4-difluorobenzylidene)-6-hydroxybenzofuran-3(2H)-one

Conditions

Conditions	Yield
With potassium hydroxide In water at 20℃; for 4h;	98%

: 83-72-7
2-Hydroxy-1,4-naphthoquinone

: 1550-35-2
2,4-difluorobenzaldehyde

: 504-02-9
1,3-cylohexanedione

: C23H14F2O4

Conditions

Conditions	Yield
With silica-supported tungstic acid In neat (no solvent) at 60℃; for 0.0666667h; Sonication; Green chemistry;	98%

...Expand

: 1550-35-2
2,4-difluorobenzaldehyde

: 7400-27-3
tertbutylhydrazine hydrochloride

: (E)-1-(tert-butyl)-2-(2,4-difluorobenzylidene)hydrazine

Conditions

Conditions	Yield
Stage #1: tertbutylhydrazine hydrochloride With sodium hydroxide In ethanol; water at 0℃; for 0.25h; Stage #2: 2,4-difluorobenzaldehyde With acetic acid In ethanol; water at 0 - 20℃; for 24h; diastereoselective reaction;	98%

: 1550-35-2
2,4-difluorobenzaldehyde

: 2,4-difluoro-5-nitrobenzaldehyde

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate at 0 - 20℃; for 0.166667h;	97.5%
With sulfuric acid; potassium nitrate at 20℃; for 3h;	95%

: 1550-35-2
2,4-difluorobenzaldehyde

: 62-53-3
aniline

: 80617-34-1
N-<(2,4-difluorophenyl)methylene>benzamine

Conditions

Conditions	Yield
In toluene for 2h; Heating;	97%

: 177755-45-2
2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile

: 1550-35-2
2,4-difluorobenzaldehyde

: 94010-80-7
2,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile

Conditions

Conditions	Yield
	97%

: 1550-35-2
2,4-difluorobenzaldehyde

: 40594-29-4, 51523-79-6
(2,4-difluorophenyl)hydrazinium chloride

: C13H8F4N2

Conditions

Conditions	Yield
In ethanol at 80℃; for 1h;	97%

: 1550-35-2
2,4-difluorobenzaldehyde

: (2,5-difluorophenyl)hydrazine hydrochloride

: C13H8F4N2

Conditions

Conditions	Yield
In ethanol for 3.25h; Heating;	96%

: 853735-41-8
4'-N-(N'-p-methoxyphenylurenyl)acetophenone

: 1550-35-2
2,4-difluorobenzaldehyde

: 1-{4-[(E)-3-(2,4-Difluoro-phenyl)-acryloyl]-phenyl}-3-(4-methoxy-phenyl)-urea

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃; Claisen-Schmidt condensation;	95%

: 1550-35-2
2,4-difluorobenzaldehyde

: 101095-67-4
4'-N-(N'-p-chlorophenylurenyl)acetophenone

: 1-(4-Chloro-phenyl)-3-{4-[(E)-3-(2,4-difluoro-phenyl)-acryloyl]-phenyl}-urea

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃; Claisen-Schmidt condensation;	95%

: 771-99-3
4-phenylpiperidine

: 1550-35-2
2,4-difluorobenzaldehyde

: 1194654-72-2
2-(4-phenylpiperidin-1-yl)-4-fluorobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 20h;	95%

: 769-92-6
4-tert-Butylaniline

: 1550-35-2
2,4-difluorobenzaldehyde

: 24850-33-7
allyltributylstanane

: 1281881-46-6
4-tert-butylphenyl[1-(2, 4-difluorophenyl)but-3-enyl]amine

Conditions

Conditions	Yield
With trifluoroacetic acid In acetonitrile at 25℃; for 0.75h; Inert atmosphere;	95%

...Expand

: 1550-35-2
2,4-difluorobenzaldehyde

: 1424351-63-2
1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone

: 1424351-66-5
(E)-3-(2,4-difluorophenyl)-1-(2-hydroxy-4,6-dimethoxy-3-(1-methyl-1H-pyrazol-5-yl)phenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 24h; Claisen-Schmidt Condensation;	95%
Stage #1: 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]ethanone With sodium hydroxide In ethanol; water for 0.0833333h; Claisen-Schmidt Condensation; Stage #2: 2,4-difluorobenzaldehyde In ethanol; water at 20℃; for 24h; Claisen-Schmidt Condensation;

: 7169-37-1
7-methoxy-3-benzofuranone

: 1550-35-2
2,4-difluorobenzaldehyde

: 1613190-01-4
(Z)-2-(2,4-difluorobenzylidene)-7-methoxybenzofuran-3(2H)-one

Conditions

Conditions	Yield
With aluminum oxide In methanol for 48h; Reflux; Inert atmosphere;	95%

: 606-23-5
1H-indene-1,3(2H)-dione

: 269726-49-0
2-amino-1-tert-butyl-4-cyanopyrrole

: 1550-35-2
2,4-difluorobenzaldehyde

: 1-tert-butyl-4-(2,4-difluorophenyl)-5-oxo-1,5-dihydroindeno[1,2-b]pyrrolo[3,2-e]pyridine-3-carbonitrile

Conditions

Conditions	Yield
With indium(III) chloride In ethanol for 2.5h; Reflux;	95%

...Expand

: 110-00-9
furan

: 1550-35-2
2,4-difluorobenzaldehyde

: exo-6-(2,4-difluorophenyl)-2,7-dioxabicyclo[3.2.0]hept-3-ene

Conditions

Conditions	Yield
at 25℃; Paterno-Buechi Cycloaddition; Irradiation; Flow reactor;	95%

: 1550-35-2
2,4-difluorobenzaldehyde

: 2924-16-5
3-fluorophenylhydrazine hydrochloride

: C13H9F3N2

Conditions

Conditions	Yield
In ethanol at 80℃; for 1h;	95%

: (3,5-difluorophenyl)hydrazine hydrochloride

: 1550-35-2
2,4-difluorobenzaldehyde

: C13H8F4N2

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	95%

2,4-Difluorobenzaldehyde Specification

The 2,4-Difluorobenzaldehyde, with the CAS registry number 1550-35-2, is also known as 4-Fluoro-2-fluorobenzaldehyde. It belongs to the product categories of Fluorin-contained benzaldehyde series; Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde; Fluorobenzene; Fluorobenzaldehyde Series; Aldehydes; C7; Carbonyl Compounds. Its EINECS number is 216-287-2. This chemical's molecular formula is C₇H₄F₂O and molecular weight is 142.10. What's more, its systematic name is 2,4-Difluorobenzaldehyde. This chemical should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides, air and alkali. It should be ensured that the workshop is well ventilated or equipped with exhaust devices. It is used as intermediates in medicine, pesticide and liquid crystal materials.

Physical properties of 2,4-Difluorobenzaldehyde are: (1)ACD/LogP: 1.198; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.20; (4)ACD/LogD (pH 7.4): 1.20; (5)ACD/BCF (pH 5.5): 4.79; (6)ACD/BCF (pH 7.4): 4.79; (7)ACD/KOC (pH 5.5): 106.82; (8)ACD/KOC (pH 7.4): 106.82; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.514; (14)Molar Refractivity: 32.993 cm³; (15)Molar Volume: 109.519 cm³; (16)Polarizability: 13.08×10^-24cm³; (17)Surface Tension: 35.1 dyne/cm; (18)Density: 1.297 g/cm³; (19)Flash Point: 64.276 °C; (20)Enthalpy of Vaporization: 40.501 kJ/mol; (21)Boiling Point: 168.572 °C at 760 mmHg; (22)Vapour Pressure: 1.6 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable, so you should keep it away from sources of ignition - No smoking. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=Cc1ccc(F)cc1F
(2)Std. InChI: InChI=1S/C7H4F2O/c8-6-2-1-5(4-10)7(9)3-6/h1-4H
(3)Std. InChIKey: WCGPCBACLBHDCI-UHFFFAOYSA-N

Product Name

2,4-Difluorobenzaldehyde

Synthetic route

2,4-Difluorobenzaldehyde Specification

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