2,4-Dimethylpyrrole supplier

Name
2,4-Dimethylpyrrole
EINECS 210-912-2
CAS No. 625-82-1
Article Data69
CAS DataBase
Density 0.924 g/cm³
Solubility
Melting Point 6.5°C (estimate)
Formula C₆H₉N
Boiling Point 171 °C at 760 mmHg
Molecular Weight 95.1442
Flash Point 56.6 °C
Transport Information
Appearance clear light yellow to light yellow-orange liquid
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Pyrrole,2,4-dimethyl- (6CI,7CI,8CI);2,4-Dimethyl-1-pyrrole;2,4-Dimethyl-1H-pyrrole;NSC 81347;
PSA 15.79000
LogP 1.63150

Synthetic route

: 2436-79-5
diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With potassium hydroxide In ethylene glycol at 160℃; for 4h; Schlenk technique; Inert atmosphere;	92%
With potassium hydroxide In ethylene glycol at 160℃; for 4h; Inert atmosphere; Schlenk technique;	92%
With potassium hydroxide In ethylene glycol at 160℃;	92%

: 2199-44-2
3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With ethylene glycol; potassium hydroxide; hydrazinium sulfate for 1h; Reflux; without air access;	75%
With phosphoric acid
With ethylene glycol; potassium hydroxide

: 90433-85-5
1-(1,2,5-trimethyl-1H-pyrrol-3-yl)-ethanone

A: 625-82-1
2,4-dimethyl-1H-pyrrole

B: 930-87-0
1,2,5-trimethyl-1H-pyrrole

Conditions

Conditions	Yield
With ethylene glycol; toluene-4-sulfonic acid In benzene for 0.25h; Heating;	A 68% B 68%

: 1,1,1,3,3,3-Hexamethyl-2-(2-methyl-4-trimethylsilanyloxy-penta-2,3-dienyl)-disilazane

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With hydrogenchloride In tetrachloromethane for 0.166667h;	65%

: 2199-44-2
3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole

: 540-88-5
acetic acid tert-butyl ester

A: 625-82-1
2,4-dimethyl-1H-pyrrole

B: 28991-95-9
ethyl 4-tert-butyl-3,5-dimethyl-1H-pyrrole-2-carboxylate

Conditions

Conditions	Yield
With sulfuric acid In nitromethane at 75℃; for 4h;	A n/a B 49%

...Expand

: 2386-25-6
2,4-dimethyl-3-acetylpyrrole

A: 625-82-1
2,4-dimethyl-1H-pyrrole

B: 628-35-3
ethylene glycol monoformate

Conditions

Conditions	Yield
With ethylene glycol; toluene-4-sulfonic acid In benzene for 0.25h; Heating;	A 40% B n/a

: (2,4-Dimethyl-pyrrol-1-yl)-dimethyl-amine

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With ammonia; sodium In tetrahydrofuran under 6000.5 - 7500.6 Torr; for 3h; Ambient temperature;	32%

: 3710-43-8
2,4-dimethylfuran

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With ammonia Gegenwart von aktiviertem Aluminiumoxid;

: 2806-54-4
epoxy-1,2 methyl-2 pentyne-3

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With ethanol; ammonia

: 2386-25-6
2,4-dimethyl-3-acetylpyrrole

: 124-41-4
sodium methylate

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
at 200℃;

: 2386-25-6
2,4-dimethyl-3-acetylpyrrole

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With sodium methylate at 200℃; im Rohr;

: 5434-29-7
NSC 15758

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With glycerol
In water at 160℃; for 8h;	29 g

: 5434-29-7
NSC 15758

A: 625-82-1
2,4-dimethyl-1H-pyrrole

B: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

Conditions

Conditions	Yield
at 260℃;

: 3,5-bis-carboxymethyl-pyrrole-2,4-dicarboxylic acid

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
at 220℃;

: 5431-96-9
<3,3',5,5'-tetrakis(ethoxycarbonyl)-4,4'-dimethyl-2,2'-dipyrryl>methane

A: 616-43-3
3-methylpyrrole

B: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With sodium hydroxide Erhitzen der eingeengten Reaktionsloesung mit 50%ig. wss. Kalilauge in einem Kupfer-Gefaess;

: 298-08-8
glycine methyl ketone

: furan-2,3,5(4H)-trione pyridine (1:1)

: 67-64-1
acetone

: 625-82-1
2,4-dimethyl-1H-pyrrole

...Expand

: 7737-17-9
1-aminopropan-2-one hydrochloride

: 67-64-1
acetone

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With sodium hydroxide

: 17975-59-6
4-isopropylidene-3-methylisoxazol-5(4H)-one

A: 625-82-1
2,4-dimethyl-1H-pyrrole

B: 625-84-3
2,5-Dimethylpyrrole

Conditions

Conditions	Yield
at 550 - 700℃; under 0.0005 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 111077-83-9
1-tert-butyl-3,5-dimethyl-2-oxo-2-phenyl-1,2-dihydro-1,2-azaphosphinine

A: 625-82-1
2,4-dimethyl-1H-pyrrole

B: 507-20-0
tertiary butyl chloride

C: 3-chloro-4,6-dipropylpyridine

Conditions

Conditions	Yield
at 600℃; under 0.02 Torr;

...Expand

: 2644-60-2
γ-phylloporphyrin-XV

A: 600-28-2
2,3-dimethyl-1H-pyrrole

B: 625-82-1
2,4-dimethyl-1H-pyrrole

C: 517-22-6
2,4-dimethyl-3-ethyl-pyrrole

D: 491-18-9
4-ethyl-2,3-dimethyl-1H-pyrrole

E: 53365-83-6
3-(4,5-dimethyl-pyrrol-3-yl)-propionic acid methyl ester

F: 54474-51-0
methyl 2,4-dimethyl-3-pyrrolepropionate

Conditions

Conditions	Yield
With hydrogen iodide Product distribution; structural analysis by degradative techniques;

...Expand

: 2,4-dimethylpyrrole-1-d

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With n-butanethiol In tetrachloromethane at 25℃; Rate constant;

α.α-bis-<2.4-dimethyl-5-acetyl-pyrryl-(3)>-ethane: α.α-bis-<2.4-dimethyl-5-acetyl-pyrryl-(3)>-ethane

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid

α.α-bis-<3.5-dimethyl-4-acetyl-pyrryl-(2)>-ethane: α.α-bis-<3.5-dimethyl-4-acetyl-pyrryl-(2)>-ethane

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid

α.α-bis-<3.5-dimethyl-4-ethoxycarbonyl-pyrryl-(2)>-ethane: α.α-bis-<3.5-dimethyl-4-ethoxycarbonyl-pyrryl-(2)>-ethane

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid

β-<3.5-dimethyl-pyrryl-(2)>-propionic acid: β-<3.5-dimethyl-pyrryl-(2)>-propionic acid

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
bei der Destillation;

11.11-bis-<3.5-dimethyl-4-ethoxycarbonyl-pyrryl-(2)>-toluene: 11.11-bis-<3.5-dimethyl-4-ethoxycarbonyl-pyrryl-(2)>-toluene

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid

: 7647-01-0
hydrogenchloride

: 1500-93-2
1-(3,5-dimethyl-1H-pyrrol-2-yl)ethan-1-one

: 625-82-1
2,4-dimethyl-1H-pyrrole

2.4-dimethyl-pyrrole-carboxylic acid-(3): 2.4-dimethyl-pyrrole-carboxylic acid-(3)

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
bei der Destillation;
With sulfuric acid

2.4-dimethyl-pyrrole-dicarboxylic acid-(3.5): 2.4-dimethyl-pyrrole-dicarboxylic acid-(3.5)

: 625-82-1
2,4-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
bei der Destillation;
With sulfuric acid

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 70547-87-4
2,6-dimethyl-4-hydroxybenzaldehyde

: C21H24N2O

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole; 2,6-dimethyl-4-hydroxybenzaldehyde With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere; Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃;	100%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 1003-29-8
2-pyrrole aldehyde

: 109-63-7
boron trifluoride diethyl etherate

: 154793-49-4
5,5-difluoro-1,3-dimethyl-5H-4λ4,5λ,4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole; 2-pyrrole aldehyde With trichlorophosphate In dichloromethane at -5 - 20℃; for 6h; Inert atmosphere; Stage #2: boron trifluoride diethyl etherate With N-ethyl-N,N-diisopropylamine In dichloromethane Inert atmosphere;	99%
Stage #1: 2,4-dimethyl-1H-pyrrole; 2-pyrrole aldehyde With trichlorophosphate In dichloromethane at 0 - 20℃; for 2h; Stage #2: boron trifluoride diethyl etherate With triethylamine In dichloromethane at 20℃; for 1h;	36.1%
With N-ethyl-N,N-diisopropylamine; trichlorophosphate In dichloromethane (N2) to soln. pyrrole 2-carboxyaldehyde in CH2Cl2 at -5°C, 2,4-dimethylpyrrole was added, stirred for 3 min, POCl3 was dropwise added, stirred at -5°C for 3 h and at room temp. 3 h, i-Pr2NEt and BF3*Et2O were added, stirred for 3 h; react. mixt. was washed with H2O, dried over Na2SO4, evapd., residue waschromd. on silica (hexane/EtOAc, 5:1);	32.8%

...Expand

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 122-51-0
orthoformic acid triethyl ester

: 117864-49-0
tris[3,5-dimethylpyrrol-2-yl]methane

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In neat liquid at 20℃; for 1h; Friedel-Crafts Alkylation;	99%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 22065-57-2
ethyl 2-phenyldiazoacetate

: C16H19NO2

Conditions

Conditions	Yield
With hydrotris(3,4,5-tribromo)pyrazolylborate Cu(NCMe) In 1,2-dichloro-ethane at 60℃; for 4h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Schlenk technique;	99%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 653-37-2
perfluorobenzaldehyde

: 5-pentafluorophenyl-1,3,7,9-tetramethyldipyrromethane

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole; perfluorobenzaldehyde With trifluoroacetic acid In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane for 0.0833333h; Inert atmosphere;	98%
With trifluoroacetic acid In dichloromethane Inert atmosphere;
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 48h; Inert atmosphere;
With trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 1001162-89-5
1-(N-methoxycarbonyl)indole-2-boronic acid

: 2-(5-((3,5-dimethyl-2H-pyrrol-2-ylidene)methyl)-4-methoxy-1H-pyrrol-2-yl)-1H-indole

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole; 1-(N-methoxycarbonyl)indole-2-boronic acid With hydrogenchloride In methanol at 16 - 20℃; Stage #2: In N,N-dimethyl-formamide for 0.333333h;	98%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 956410-70-1
O,O-diethyl α-iminotrifluoroethylphosphonate

: 1599437-84-9
diethyl 1-amino-1-(3,5-dimethylpyrrol-2-yl)-2,2,2-trifluoroethylphosphonate

Conditions

Conditions	Yield
at 20℃; regioselective reaction;	98%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 1374781-78-8
C18H16N2O2

: C24H23N3O

Conditions

Conditions	Yield
Stage #1: C18H16N2O2 With C80H49NO6P2; hydroxypropyl-β-cyclodextrin In tetrahydrofuran at 55℃; for 0.166667h; Friedel-Crafts Alkylation; Stage #2: 2,4-dimethyl-1H-pyrrole In tetrahydrofuran at 55℃; for 12h; Friedel-Crafts Alkylation; enantioselective reaction;	98%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: (R)-2-(prop-1-en-2-yl)-1-tosylaziridine

: C18H24N2O2S

Conditions

Conditions	Yield
With bis(norbornadiene)rhodium(l)tetrafluoroborate In 1,2-dichloro-ethane at 25℃; for 0.25h; enantioselective reaction;	98%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 5-(4-fluoro-3-nitrophenyl)-1,3,7,9-tetramethyldipyrromethane

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole; 4-fluoro-3-nitrobenzaldehyde With trifluoroacetic acid In dichloromethane at 20℃; for 2.5h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane for 0.0833333h; Inert atmosphere;	98%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 87751-69-7
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene

: (E)-3,5-dimethyl-2-(1,3-diphenyl-2-propenyl)pyrrole

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); C34H23P; potassium carbonate In toluene; acetonitrile at -20℃; for 38h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	97%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: mesityl(2-(pentafluoro-λ6-sulfaneyl)pyridyl)-6-iodonium trifluoromethanesulfonate

: 2-(3,5-dimethyl-1H-pyrrol-2-yl)-6-(pentafluoro-λ6-sulfaneyl)pyridine

Conditions

Conditions	Yield
With sodium hydroxide at 80℃; for 10h; Inert atmosphere;	97%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 588-73-8
(Z)-β-bromostyrene

: 2,4-dimethyl-1-[(Z)-2-phenylethenyl]-1H-pyrrole

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole In 1,2-dimethoxyethane; toluene at 20℃; for 0.5h; Stage #2: (Z)-β-bromostyrene With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) In 1,2-dimethoxyethane; toluene at 100℃; for 10h; Further stages.;	96%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: methyl 3,3,3-trifluoro-2-iminopropanoate

: 1599437-85-0
C10H13F3N2O2

Conditions

Conditions	Yield
at 20℃; regioselective reaction;	96%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 1350764-68-9
C15H5BBr6F2N2

: C27H21BBr4F2N4

Conditions

Conditions	Yield
In toluene at 20℃; for 0.5h; Inert atmosphere;	96%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 2199-58-8
3,5-dimethylpyrrole-2-carbaldehyde

: 109-63-7
boron trifluoride diethyl etherate

: 21658-70-8
4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole; 3,5-dimethylpyrrole-2-carbaldehyde With trichlorophosphate In dichloromethane Stage #2: With N-ethyl-N,N-diisopropylamine In toluene Stage #3: boron trifluoride diethyl etherate	96%

...Expand

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 2-hydroxy-2-(3,5-dimethylpyrrol-2-yl)-3,3,3-trifluoropropionic acid ethyl ester

Conditions

Conditions	Yield
With K-10 montmorillonite In toluene at 60℃; for 0.0833333h; Friedel-Crafts hydroxyalkylation;	95%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 2199-58-8
3,5-dimethylpyrrole-2-carbaldehyde

Conditions

Conditions	Yield
With trichlorophosphate In dichloromethane for 2h; Reflux;	95%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0 - 20℃; Inert atmosphere; Stage #2: 2,4-dimethyl-1H-pyrrole In 1,2-dichloro-ethane at 0℃; for 0.833333h; Reflux; Stage #3: With water; sodium acetate In 1,2-dichloro-ethane for 0.5h; Reflux;	89%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0 - 20℃; Inert atmosphere; Stage #2: 2,4-dimethyl-1H-pyrrole at 0 - 40℃; Inert atmosphere;	82%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 60434-13-1
5-chloro-1-methylindoline-2, 3-dione

: 1338697-43-0
5-chloro-1-methyl-3,3-di-(3,5-dimethyl-1H-pyrrol-2-yl)-indolin-2-one

Conditions

Conditions	Yield
With C28H19F9InN3O11S3 In acetonitrile at -22 - 20℃; Molecular sieve; Inert atmosphere;	95%
With zinc trifluoromethanesulfonate In acetonitrile at 20℃; for 0.0833333h;	91%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 881397-68-8
rac-(E)-1,3-bis(4-methylphenyl)-2-propen-1-yl acetate

: (E)-3,5-dimethyl-2-(1,3-di-4-tolyl-2-propenyl)pyrrole

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); C34H23P; potassium carbonate In toluene; acetonitrile at -20℃; for 38h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	95%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 27226-50-2
3,4,5-trimethyl-1H-pyrrole-2-carbaldehyde

: 1,2,3,7,9-pentamethyldipyrrin hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide In methanol; water at 20℃; for 0.5h;	95%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 2-((difluoromethyl)thio)-3,5-dimethyl-1H-pyrrole

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole With water; iodine; thiourea; potassium iodide In 1,4-dioxane at 20℃; Stage #2: With sodium hydroxide In 1,4-dioxane at 50℃; for 1h; Stage #3: diethyl (bromodifluoromethyl)phosphonate In 1,4-dioxane at 20℃; for 4h;	94%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 487-68-3
mesytaldehyde

: 109-63-7
trifluoroborane diethyl ether

: 1308671-66-0
5,5-difluoro-10-mesityl-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine

Conditions

Conditions	Yield
With N(CH2CH3)3; 2,3-dichloro-5,6-dicyanobenzoquinone; CF3COOH In dichloromethane addn. of CF3COOH to pyrrole deriv. and benzaldehyde deriv. in CH2Cl2 at room temp., stirring for 1 h, addn. of quinone deriv. at 0°C, stirring for 10 min and for 1 h at room temp., addn. of amine deriv. and then of boron compd., stirring for 2 h; washing with aq. satd. soln. of Na2CO3, drying over Na2SO4, evapn., chromy. (silica, n-pentane/CH2Cl2 (5:1), then n-pentane/CH2Cl2 (2:1), then CH2Cl2), evapn., NMR and MS;	93%

Yield

With N(CH2CH3)3; 2,3-dichloro-5,6-dicyanobenzoquinone; CF3COOH In dichloromethane addn. of CF3COOH to pyrrole deriv. and benzaldehyde deriv. in CH2Cl2 at room temp., stirring for 1 h, addn. of quinone deriv. at 0°C, stirring for 10 min and for 1 h at room temp., addn. of amine deriv. and then of boron compd., stirring for 2 h; washing with aq. satd. soln. of Na2CO3, drying over Na2SO4, evapn., chromy. (silica, n-pentane/CH2Cl2 (5:1), then n-pentane/CH2Cl2 (2:1), then CH2Cl2), evapn., NMR and MS;

93%

...Expand

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 803712-70-1
tert-butyl 2-(5-formyl-4-methoxy-1H-pyrrol-2-yl)-1H-indole-1-carboxylate

: C20H19N3O*ClH

Conditions

Conditions	Yield
With hydrogenchloride In methanol Inert atmosphere;	93%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 24424-99-5
di-tert-butyl dicarbonate

: 484698-44-4
tert-butyl 2,4-dimethyl-1H-pyrrole-1-carboxylate

Conditions

Conditions	Yield
With dmap In acetonitrile at 25℃; for 16h;	92%
With dmap In acetonitrile at 20℃; for 1h;	92%
With dmap In acetonitrile at 25℃; for 24h;	55%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 677-25-8
ethylenesulfonyl fluoride

: 2-(3,5-dimethyl-1H-pyrrol-2-yl)ethane-1-sulfonyl fluoride

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.333333h;	92%

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 109-63-7
boron trifluoride diethyl etherate

: hexyl 4-formylbenzoate

: C26H31BF2N2O2

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole; hexyl 4-formylbenzoate With trifluoroacetic acid In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Darkness; Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane for 0.25h; Inert atmosphere; Stage #3: boron trifluoride diethyl etherate Further stages;	92%

...Expand

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 2199-58-8
3,5-dimethylpyrrole-2-carbaldehyde

: 2534-93-2
3,5,3',5'-tetramethyl-1H,2'H-2,2'-methanylylidene-bis-pyrrole

Conditions

Conditions	Yield
With trichlorophosphate In hexane; dichloromethane at 0℃; for 0.25h; Schlenk technique; Inert atmosphere;	91%
With ethanol; hydrogen bromide

: 625-82-1
2,4-dimethyl-1H-pyrrole

: 588-72-7
[(E)-2-bromoethenyl]benzene

: 2,4-dimethyl-1-[(E)-2-phenylethenyl]-1H-pyrrole

Conditions

Conditions	Yield
Stage #1: 2,4-dimethyl-1H-pyrrole With n-butyllithium In 1,2-dimethoxyethane; toluene at 20℃; for 0.5h; Stage #2: [(E)-2-bromoethenyl]benzene With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) In 1,2-dimethoxyethane; toluene at 70℃; for 9h; Further stages.;	91%

2,4-Dimethylpyrrole Specification

The 1H-Pyrrole,2,4-dimethyl-, with the CAS registry number 625-82-1, is also known as 2,4-Dimethylpyrrole. It belongs to the product categories of Pharmaceutial Intermediates; Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines; Building Blocks; Heterocyclic Building Blocks; Pyrroles. Its EINECS registry number is 210-912-2. This chemical's molecular formula is C₆H₉N and molecular weight is 95.14236. Its IUPAC name is called 2,4-dimethyl-1H-pyrrole. The product should be sealed and stored in cool and dry place. What's more, it should be protected from strong oxides.

Physical properties of 1H-Pyrrole,2,4-dimethyl-: (1)ACD/LogP: 1.67; (2)ACD/LogD (pH 5.5): 1.67; (3)ACD/LogD (pH 7.4): 1.67; (4)ACD/BCF (pH 5.5): 10.95; (5)ACD/BCF (pH 7.4): 10.95; (6)ACD/KOC (pH 5.5): 192.97; (7)ACD/KOC (pH 7.4): 193; (8)#H bond acceptors: 1; (9)#H bond donors: 1; (10)Index of Refraction: 1.516; (11)Molar Refractivity: 30.33 cm³; (12)Molar Volume: 100.3 cm³; (13)Surface Tension: 33.9 dyne/cm; (14)Density: 0.948 g/cm³; (15)Flash Point: 56.6 °C; (16)Enthalpy of Vaporization: 39.07 kJ/mol; (17)Boiling Point: 171 °C at 760 mmHg; (18)Vapour Pressure: 1.9 mmHg at 25°C.

Uses of 1H-Pyrrole,2,4-dimethyl-: it can be used to produce 1-(diethoxyphosphino)-2,4-dimethylpyrrole at temperature of -10 °C. This reaction will need reagent (C₂H₅)₃N and solvent diethyl ether with reaction time of 1 hour. The yield is about 45%.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC1=CC(=CN1)C
(2)InChI: InChI=1S/C6H9N/c1-5-3-6(2)7-4-5/h3-4,7H,1-2H3
(3)InChIKey: MFFMQGGZCLEMCI-UHFFFAOYSA-N

Product Name

2,4-Dimethylpyrrole

Synthetic route

2,4-Dimethylpyrrole Specification

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