2-Amino-2-methyl-1-propanol supplier

Name
2-Amino-2-methyl-1-propanol
EINECS 204-709-8
CAS No. 124-68-5
Article Data44
CAS DataBase
Density 0.93 g/cm³
Solubility water: 0.1 M at 20 °C, clear, colorless
Melting Point 24-28 °C(lit.)
Formula C₄H₁₁NO
Boiling Point 167.2 °C at 760 mmHg
Molecular Weight 89.1374
Flash Point 67.2 °C
Transport Information 2735
Appearance white crystals or viscous liquid
Safety 61
Risk Codes 36/38-52/53
Molecular Structure
Hazard Symbols Xi,F
Synonyms AMP 75;AMP 90(amine);AMP Regular;Corrguard 75;Hydroxy-tert-butylamine;Isobutanol-2-amine;KV 5088;NSC 441;Pamabron;b-Aminoisobutanol;1,1-Dimethyl-2-hydroxyethylamine;2,2-Dimethylethanolamine;2-Amino-1-hydroxy-2-methylpropane;2-Amino-2,2-dimethylethanol;2-Aminoisobutanol;2-Hydroxy-1,1-dimethylethylamine;2-Hydroxymethyl-2-propylamine;2-Methyl-2-aminopropanol;AMP 100;2-Amino-2-methyl-1-propanol;
PSA 46.25000
LogP 0.41630

Synthetic route

: C13H17NO3

A: 90-02-8
salicylaldehyde

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With hydrogenchloride In water at 80℃; for 4h;	A 96% B 80%

: 201230-82-2
carbon monoxide

: 75-31-0
isopropylamine

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With tricresyl phosphate; hydrogen; palladium diacetate In diphenylether at 140℃; under 22502.3 - 60006 Torr; Autoclave;	93%

: 2658-24-4
2,2-dimethylaziridine

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With sulfuric acid In water at 40 - 50℃; for 1h; pH=3 - 5.4;	91%

: 82922-13-2
2-(ethylamino)-2-methylpropanol hydrochloride

A: 50-00-0
formaldehyd

B: 75-04-7
ethylamine

C: 124-68-5
2-Amino-2-methyl-1-propanol

D: 75-07-0
acetaldehyde

E: 67-64-1
acetone

Conditions

Conditions	Yield
With water at 25℃; Product distribution; Mechanism; anodic oxidation, carbonate buffer, pH 10; effect of substituents investigated with different types of β-alkanolamines;	A 50% B 44% C 14% D 26% E 66%

...Expand

: 82922-13-2
2-(ethylamino)-2-methylpropanol hydrochloride

A: 50-00-0
formaldehyd

B: 75-04-7
ethylamine

C: 124-68-5
2-Amino-2-methyl-1-propanol

D: 67-64-1
acetone

Conditions

Conditions	Yield
With water at 25℃; anodic oxidation, pH 10, carbonate buffer; Further byproducts given;	A 50% B 44% C 14% D 66%

...Expand

: 76-39-1
2-nitro-2-methylpropanol

A: 4706-13-2
N-(1-hydroxy-2-methylprop-2-yl)-hydroxylamine

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With citrate buffer; potassium chloride In ethanol at 30℃; cotrolled potential electrolysis, cathod: Hg, vs. S.C.E.;	A 64% B 25%

: 86241-96-5
2-methyl-3-(vinyloxy)propan-2-amine

A: N-ethylidene-2-methyl-1-vinyloxypropan-2-amine

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With mercury(II) diacetate In benzene Heating;	A 3% B n/a

: 76-39-1
2-nitro-2-methylpropanol

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With methanol; carbon dioxide; nickel at 70℃; under 25742.8 Torr; Hydrogenation;
With methanol; nickel at 30℃; under 25742.8 Torr; Hydrogenation;
With nickel Hydrogenation;

: 1113-49-1
2-methylalanine ethyl ester

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With ethanol; nickel at 100℃; under 257428 Torr; Hydrogenation;

: 62-57-7
2-Aminoisobutyric acid

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With tetrahydrofuran; lithium aluminium tetrahydride
With lithium aluminium tetrahydride In tetrahydrofuran
With sodium tetrahydroborate; iodine In tetrahydrofuran for 20h; Heating;
With sodium tetrahydroborate; iodine In tetrahydrofuran Reflux;
With lithium aluminium tetrahydride In tetrahydrofuran

: 115-11-7
isobutene

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
(i) MeCN, Cl2, (ii) H2O; Multistep reaction;

: 22451-34-9
2-ammonio-2-methyl-1-propanol cation

: 114444-46-1
C14H13NO

A: 124225-44-1
1-methyl-4-(phenylacetyl)pyridinium cation

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant; Rate constant;

...Expand

: 116221-74-0
N-chloro-2-amino-2-methylpropan-1-ol

A: 124-68-5
2-Amino-2-methyl-1-propanol

B: N,N-dichloro-2-amino-2-methyl-1-propanol

Conditions

Conditions	Yield
In water at 25℃; Rate constant; Thermodynamic data; E(a);

: 3-Amino-1-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-5-methyl-hexan-2-ol

A: 49642-07-1
statine

B: 124-68-5
2-Amino-2-methyl-1-propanol

C: (3S,4R)-4-amino-3-hydroxy-6-methylheptanoic acid

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 87730-42-5
3-(N-succinimido)-2-propanol

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With hydrogenchloride; sodium tetrahydroborate In isopropyl alcohol

: 64-17-5
ethanol

: 1113-49-1
2-methylalanine ethyl ester

Raney nickel: Raney nickel

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
at 100℃; under 250073 Torr; Hydrogenation;

...Expand

: 13257-67-5
2-amino-2-methylpropionic acid methyl ester

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With hydrogen; Nishimura catalyst <(45.9% Rh/19.9% Pt) oxide> In methanol at 25℃; under 75007.5 Torr;

: 15028-41-8
methyl 2-aminoisobutyrate hydrochloride

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With sodium tetrahydroborate; sodium hydrogencarbonate

: 102520-97-8
2-((tert-butyloxycarbonyl)amino)-2-methylpropan-1-ol

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane

: trans-N-{4-[5-(2-Hydroxy-1,1-dimethyl-ethylamino)-pentyl]-cyclohexyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide

A: trans-N-[4-(5-Bromo-pentyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide

B: 124-68-5
2-Amino-2-methyl-1-propanol

: 497258-63-6
(+)-pinanediol (1R)-1-acetylamino-1-[3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)phenyl]methylboronate

A: 124-68-5
2-Amino-2-methyl-1-propanol

B: (1R)-1-acetylamino-1-(3-carboxyphenyl)methylboronic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 120℃; for 1h;

: (2-hydroxy-1,1-dimethyl-ethyl)-carbamic acid

A: 124-38-9
carbon dioxide

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
at 125℃; Inert atmosphere; Schlenk technique;

: 117052-89-8
N-(1-hydroxy-2-methylpropan-2-yl)-1-naphthamide

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 135℃; for 0.166667h; Microwave irradiation;

: 32831-43-9
2-(hydroxymethyl)-2-methylpropylamine

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With sodium hypochlorite; sodium hydroxide In water at 0 - 70℃; for 0.333333h; Temperature; Hofmann Rearrangement;	103 g

: 2-((E)-(1-hydroxy-2-methylpropan-2-ylimino)methyl)-6-methoxyphenol

A: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With cerium(III) nitrate hexahydrate In methanol

: 58004-55-0
N-(1-cyano-1-methyl-ethyl)formamide

A: 682-85-9
N-(1-hydroxy-2-methylpropan-2-yl)formamide

B: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); hydrogen In 1,4-dioxane; water at 140℃; under 33753.4 Torr; for 18h; Reagent/catalyst; Pressure; Autoclave;	A n/a B 24 %Spectr.
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); hydrogen In 1,4-dioxane; water at 20 - 150℃; under 41254.1 - 101260 Torr; for 48h; Autoclave;	A n/a B 73 %Chromat.
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); water; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In 1,4-dioxane at 150℃; under 41254.1 - 101260 Torr; for 48h; Catalytic behavior; Pressure; Reagent/catalyst; Temperature; Autoclave;	A 22 %Chromat. B 58.3 %Chromat.

: C13H17NO3

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With hydrogenchloride In water at 80℃;

: 58004-55-0
N-(1-cyano-1-methyl-ethyl)formamide

: 124-68-5
2-Amino-2-methyl-1-propanol

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; water; hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 140℃; under 41254.1 Torr; for 18h; Catalytic behavior; Reagent/catalyst; Pressure; Autoclave;	24 %Spectr.

: 124-68-5
2-Amino-2-methyl-1-propanol

: 927-82-2
2-amino-2-methylpropyl hydrogensulfate

Conditions

Conditions	Yield
With sulfuric acid In water at 50 - 120℃; for 3h; Product distribution / selectivity;	100%
With chlorosulfonic acid In diethyl ether at 0℃;	96%
With sulfuric acid In water at 150 - 170℃; for 4h;	94%

: 1121-60-4
pyridine-2-carbaldehyde

: 124-68-5
2-Amino-2-methyl-1-propanol

: 134777-99-4
4,4-dimethyl-2-pyridin-2-yl-1,3-oxazolidine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%
In ethanol at 20℃; for 3h;	94%

: 872-85-5
pyridine-4-carbaldehyde

: 124-68-5
2-Amino-2-methyl-1-propanol

: 134778-11-3
4-(4,4-Dimethyl-oxazolidin-2-yl)-pyridine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 124-68-5
2-Amino-2-methyl-1-propanol

: 134778-05-5
3-(4,4-Dimethyl-oxazolidin-2-yl)-pyridine

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	100%

: 93-89-0
benzoic acid ethyl ester

: 124-68-5
2-Amino-2-methyl-1-propanol

: 19312-05-1
N-(2-hydroxyl-1,1-dimethylethyl) benzamide

Conditions

Conditions	Yield
Stage #1: 2-Amino-2-methyl-1-propanol With n-butyllithium; lanthanum(III) chloride In 1,2-dichloro-ethane at 0℃; Metallation; after the reagent addition stirring for 15 min at this temperature under nitrogen, than warming to reflux; Stage #2: benzoic acid ethyl ester for 1h; Amidation; reflux;	100%
With sodium hydride 1.) toluene, RT, 1 h, 2.) toluene, 30 min; Yield given. Multistep reaction;
With n-butyllithium; lanthanum(lll) triflate 1) toluene, 0 deg C, 15 min then 0 to 100 deg C, 2) toluene, reflux, 12 h; Yield given. Multistep reaction;

: 24424-99-5
di-tert-butyl dicarbonate

: 124-68-5
2-Amino-2-methyl-1-propanol

: 102520-97-8
2-((tert-butyloxycarbonyl)amino)-2-methylpropan-1-ol

Conditions

Conditions	Yield
In acetonitrile at 20℃; Condensation;	100%
With triethylamine In dichloromethane at 20℃; for 2.83333h;	100%
Stage #1: di-tert-butyl dicarbonate With molybdenium(VI) dioxodichloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2-Amino-2-methyl-1-propanol In dichloromethane at 20℃; for 10h;	99%

: 96227-40-6
5-methoxy-3-methylbenzoic acid chloride

: 124-68-5
2-Amino-2-methyl-1-propanol

: N-(2-Hydroxy-1,1-dimethyl-ethyl)-3-methoxy-5-methyl-benzamide

Conditions

Conditions	Yield
In dichloromethane at 25℃; for 24h;	100%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 933-88-0
ortho-toluoyl chloride

: 95217-40-6
N-(1-hydroxy-2-methylpropan-2-yl)-2-methylbenzamide

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 0.5h;	100%
With triethylamine In dichloromethane at 0℃;
With triethylamine In dichloromethane at 0℃; for 3h; Inert atmosphere;

: 123-19-3
4-heptanone

: 124-68-5
2-Amino-2-methyl-1-propanol

: 4,4-dimethyl-2,2-dipropyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 110-43-0
n-pentyl methyl ketone

: 124-68-5
2-Amino-2-methyl-1-propanol

: 51805-99-3
2,4,4-trimethyl-2-pentyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 502-56-7
5-Nonanone

: 124-68-5
2-Amino-2-methyl-1-propanol

: 174153-08-3
2,2-dibutyl-4,4-dimethyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 821-55-6
2-Nonanone

: 124-68-5
2-Amino-2-methyl-1-propanol

: 2-heptyl-2,4,4-trimethyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 693-54-9
Decan-2-one

: 124-68-5
2-Amino-2-methyl-1-propanol

: 2,4,4-trimethyl-2-octyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 927-49-1
dipentyl ketone

: 124-68-5
2-Amino-2-methyl-1-propanol

: 174153-09-4
4,4-dimethyl-2,2-dipentyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 112-12-9
methyl nonyl ketone

: 124-68-5
2-Amino-2-methyl-1-propanol

: 69184-35-6
2,4,4-trimethyl-2-nonyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 504-57-4
10-Nonadecanon

: 124-68-5
2-Amino-2-methyl-1-propanol

: 174153-10-7
4,4-dimethyl-2,2-dinonyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 111-13-7
hexyl-methyl-ketone

: 2-hexyl-2,4,4-trimethyloxazolidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 7169-12-2
2,3-dimethoxyterephthalic acid chloride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 179693-92-6
N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2,3-dimethoxyterephthalamide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 2h;	100%
In dichloromethane; water	6.27 g (100%)

: 69146-58-3
2,3-bis(benzyloxy)benzoyl chloride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 437613-96-2
2,3-dibenzyloxy-N-(2-hydroxy-1,1-dimethylethyl)benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 6.5h;	100%

: 14562-10-8
2-hydroxy-3-phenylbenzaldehyde

: 124-68-5
2-Amino-2-methyl-1-propanol

: 3-[(2-hydroxy-1,1-dimethylethylimino)methyl]biphenyl-2-ol

Conditions

Conditions	Yield
for 1h; Heating;	100%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 156660-22-9
2,2'-dihydroxybiphenyl-3-carboxaldehyde

: 3-[(2-hydroxy-1,1-dimethylethylimino)methyl]biphenyl-2,2'-diol

Conditions

Conditions	Yield
for 1h; Heating;	100%

: 108-24-7
acetic anhydride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 1569-96-6
N-(1-hydroxy-2-methylpropan-2-yl)acetamide

Conditions

Conditions	Yield
Stage #1: acetic anhydride With molybdenium(VI) dioxodichloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2-Amino-2-methyl-1-propanol In dichloromethane at 20℃; for 0.5h;	100%
Stage #1: acetic anhydride; 2-Amino-2-methyl-1-propanol In ethyl acetate at 20℃; for 18h; Inert atmosphere; Stage #2: With potassium carbonate In ethyl acetate at 20℃; Inert atmosphere; chemoselective reaction;	98%
With Methylenediphosphonic acid at 20℃; for 1h; neat (no solvent); chemoselective reaction;	95%
With sodium hydrogencarbonate In water at 20℃; for 16h;
With triethylamine In chloroform at 20℃; for 24h; Temperature; chemoselective reaction;	99 %Spectr.

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 848598-54-9
N-(2-hydroxy-1,1-dimethylethyl)-2,2-dimethylpropionamide

Conditions

Conditions	Yield
Stage #1: 2,2-dimethylpropanoic anhydride With molybdenium(VI) dioxodichloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2-Amino-2-methyl-1-propanol In dichloromethane at 20℃; for 1h;	100%

: 98-88-4
benzoyl chloride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 19312-06-2
4,5-dihydro-4,4-dimethyl-2-phenoxazole

Conditions

Conditions	Yield
Stage #1: benzoyl chloride; 2-Amino-2-methyl-1-propanol In dichloromethane at 20℃; for 18h; Stage #2: With thionyl chloride In dichloromethane Further stages.;	100%
Stage #1: benzoyl chloride; 2-Amino-2-methyl-1-propanol With triethylamine In dichloromethane at 0 - 20℃; for 10h; Stage #2: With thionyl chloride In chloroform at 0 - 20℃; for 24h; Stage #3: With sodium hydroxide In methanol at 0 - 20℃; for 12h;	92%

: 864296-43-5
3-methyl-4-isocyanato-benzoic acid methyl ester

: 124-68-5
2-Amino-2-methyl-1-propanol

: 864296-97-9
4-(3-[1,1-dimethyl-2-hydroxy-ethyl]-ureido)-3-methyl-benzoic acid methyl ester

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;	100%
In tetrahydrofuran at 20℃; for 2h;

: 860035-10-5
1-[[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]oxy]ethyl 2-methylpropanoate

: 124-68-5
2-Amino-2-methyl-1-propanol

: 1131570-15-4
[N-(2-hydroxy-tert-butyl)carbamoyloxy]ethyl 2-methylpropanoate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetonitrile at 20℃; for 12h;	100%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 609-08-5
Diethyl methylmalonate

: N,N'-bis(1-hydroxy-2-methylpropan-2-yl)-2-methylmalonamide

Conditions

Conditions	Yield
With sodium hydride In mineral oil at 160℃; Inert atmosphere;	100%
With sodium hydride at 140℃; for 4h; Inert atmosphere;	95%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 83-13-6
diethyl 2-phenylmalonate

: N,N'-bis(1-hydroxy-2-methylpropan-2-yl)-2-phenylmalonamide

Conditions

Conditions	Yield
With sodium hydride In mineral oil at 160℃; Inert atmosphere;	100%

: 78775-72-1
2-tert-butylmalonyl dichloride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 2-tert-butyl-N,N'-bis(1-hydroxy-2-methylpropan-2-yl)malonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	100%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 105-53-3
diethyl malonate

: N,N'-bis(1-hydroxy-2-methylpropan-2-yl)malonamide

Conditions

Conditions	Yield
With sodium hydride In mineral oil at 160℃; Inert atmosphere;	100%

2-Amino-2-methyl-1-propanol History

2-AMINO-2-METHYL-1-PROPANOL(AMP) was collected on the same media used in OSHA Method 60, for diethylene triamine, so those extraction and analytical parameters were used as a starting point for AMP. The AMP was found to readily derivatize with the NITC to form a stable derivative. The samples were extracted with N,N-dimethylformamide (DMF), with a desorption efficiency mean of 100% for the concentration range of 224 to 11.2 μg/tube. The storage study showed no loss for samples stored for up to 14 days under both refrigerated and ambient conditions.

2-Amino-2-methyl-1-propanol Analytical Methods

Partially evaluated method. This method has been subjected to established evaluation procedures of the Solvents Branch and is presented for information and trial use.

2-Amino-2-methyl-1-propanol Specification

The CAS register number of 2-Amino-2-methyl-1-propanol is 124-68-5. It also can be called as 1-Propanol, 2-amino-2-methyl- and the IUPAC name about this chemical is 2-amino-2-methylpropan-1-ol. The molecular formula about this chemical is C₄H₁₁NO and the molecular weight is 89.14. It belongs to the following product categories, such as Industrial/Fine Chemicals; Chemical Amines; Aliphatics; Amines and so on. This chemical is stable and combustible. It incompatibles with strong oxidizing agents and it may present an explosion hazard if heated. This chemical can be used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase.

Physical properties about 2-Amino-2-methyl-1-propanol are:
(1)ACD/LogD (pH 5.5): -3.7; (2)ACD/LogD (pH 7.4): -3.1; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 2; (8)#H bond donors: 3; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 46.25Å²; (11)Index of Refraction: 1.447; (12)Molar Refractivity: 25.61 cm³; (13)Molar Volume: 95.7 cm³; (14)Polarizability: 10.15x10^-24cm³; (15)Surface Tension: 34.4 dyne/cm; (16)Enthalpy of Vaporization: 47.01 kJ/mol; (17)Boiling Point: 167.2 °C at 760 mmHg; (18)Vapour Pressure: 0.566 mmHg at 25°C.

Preparation of 2-Amino-2-methyl-1-propanol:
2-Amino-2-methyl-1-propanol can be prepared by 2-methyl-2-nitro-propan-1-ol, this reaction can also produce b-hydroxyamino-isobutyl alcohol. This reaction will need reagent citrate buffer (pH 4.2), KCl and solvent ethanol. The reaction temperature of 30 ℃. The yield is about 25%. This reaction also need cotrolled potential electrolysis, cathod: Hg, vs. S.C.E.

Uses of 2-Amino-2-methyl-1-propanol:
it can be used to produce 2-(2-hydroxy-ethylamino)-2-methyl-propan-1-o. This reaction will need reagent water.

Safety information of 2-Amino-2-methyl-1-propanol:
When you are using this chemical, please be cautious about it as the following:This chemical is irritating to eyes and skin and it is harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. When you are using it, you need avoid release to the environment. Refer to special instructions / safety data sheets.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(CO)N
(2)InChI: InChI=1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3
(3)InChIKey: CBTVGIZVANVGBH-UHFFFAOYSA-N

The toxicity data of 2-Amino-2-methyl-1-propanol is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	2150mg/kg (2150mg/kg)		Journal of the American College of Toxicology. Vol. 9(2), Pg. 203, 1990.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rat	LD50	oral	2900mg/kg (2900mg/kg)		Journal of the American College of Toxicology. Vol. 9(2), Pg. 203, 1990.

Product Name

2-Amino-2-methyl-1-propanol

Synthetic route

2-Amino-2-methyl-1-propanol History

2-Amino-2-methyl-1-propanol Analytical Methods

2-Amino-2-methyl-1-propanol Specification

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