2-Amino-4,6-dichlorophenol supplier

Name
2-AMINO-4,6-DICHLOROPHENOL
EINECS 208-421-3
CAS No. 527-62-8
Article Data23
CAS DataBase
Density 1.56 g/cm³
Solubility
Melting Point 97 ºC
Formula C6H5 Cl2 N O
Boiling Point 286.5 °C at 760 mmHg
Molecular Weight 178.018
Flash Point 127.1 °C
Transport Information
Appearance light yellow or white solid
Safety Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2,4-Dichloro-6-aminophenol;2-Amino-4,6-dichlorophenol; 4,6-Dichloro-2-aminophenol;4,6-Dichloro-o-aminophenol; 6-Amino-2,4-dichlorophenol; NSC 658464
PSA 46.25000
LogP 2.86240

Synthetic route

: 609-89-2
2,4-dichloro-6-nitrophenol

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In ethanol at 20℃; under 750.06 Torr; for 96h;	99%
With tin(ll) chloride In ethanol	97%
With sodium dithionite In ethanol; water at 65℃; for 4h;	60%

: 609-89-2
2,4-dichloro-6-nitrophenol

: 7772-99-8
stannous chloride

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
In ethanol	80%
In ethanol	80%
In ethanol	80%

: 139137-46-5
trans-2,4-dichloro-6-phenylazo-phenol

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
With sodium dithionite

: 7647-01-0
hydrogenchloride

: 858013-68-0
4,6,4',6'-tetrachloro-2,2'-azo-di-phenol

tin (II)-chloride: tin (II)-chloride

: 527-62-8
2,4-dichloro-6-aminophenol

...Expand

: 2,4-dichloro-6-isopropylideneamino-phenol

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
With hydrogenchloride In benzene

: propan-2-one O-(2,4-dichloro-phenyl)-oxime

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ZrCl4 / benzene / 0.2 h / reflux 2: 10 percent HCl / benzene View Scheme

: 120-83-2
2,4-dichlorophenol

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: fuming nitric acid 2: tin; hydrochloric acid View Scheme

: 108-95-2
phenol

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: chlorine 2: fuming nitric acid 3: tin; hydrochloric acid View Scheme

: sodium dithionate

: 609-89-2
2,4-dichloro-6-nitrophenol

: 527-62-8
2,4-dichloro-6-aminophenol

Conditions

Conditions	Yield
In water; sodium hydrogencarbonate

: 527-62-8
2,4-dichloro-6-aminophenol

: 219963-60-7
4-methoxy-3-(4-(2,2,2-trichloro-acetyl)piperazin-1-yl)benzene-1-sulfonylchloride

: 1331830-34-2
N-(3,5-dichloro-2-hydroxyphenyl)-4-methoxy-3-[4-(2,2,2-trichloroethanoyl)-piperazin-1-yl]-benzenesulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	96%

: 75-15-0
carbon disulfide

: 527-62-8
2,4-dichloro-6-aminophenol

: 98279-11-9
5,7-dichloro-2-mercaptobenzoxazole

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 20℃; for 6h; Reflux;	95%
Stage #1: carbon disulfide; 2,4-dichloro-6-aminophenol With potassium hydroxide In methanol for 8h; Cooling with ice; Reflux; Stage #2: With acetic acid In methanol pH=6; Cooling with ice;	84.25%
With potassium hydroxide In ethanol for 8h; Heating;
With potassium hydroxide In ethanol Heating;

: 527-62-8
2,4-dichloro-6-aminophenol

: 108-24-7
acetic anhydride

: 55202-45-4
2-acetamido-4,6-dichlorophenol

Conditions

Conditions	Yield
for 0.25h; Ambient temperature;	92%

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 527-62-8
2,4-dichloro-6-aminophenol

: 73397-13-4
6,8,10-trichloro-5H-benzophenoxazin-5-one

Conditions

Conditions	Yield
With potassium acetate In ethanol at 90 - 100℃; for 20h;	87%

: 527-62-8
2,4-dichloro-6-aminophenol

: 506-68-3
bromocyane

: 98555-67-0
5,7-dichloro-benzoxazol-2-ylamine

Conditions

Conditions	Yield
In ethanol at 60℃; for 12h;	86%

: 527-62-8
2,4-dichloro-6-aminophenol

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 1427468-73-2
N-(tert-butyl)-5,7-dichlorobenzo[d]oxazol-2-amine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 50℃; for 8h;	85%

: 527-62-8
2,4-dichloro-6-aminophenol

: 1395499-28-1
2-(2'-anthraquinonylamino-3'-hydroxy)-4-anilino-6-chloro-s-triazine

: 1395499-23-6
C29H18Cl2N6O4

Conditions

Conditions	Yield
In nitrobenzene at 60 - 65℃; for 5h;	83%

: 527-62-8
2,4-dichloro-6-aminophenol

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: C17H20Cl2N2O3

Conditions

Conditions	Yield
With zinc dibromide In toluene Heating;	83%

: 527-62-8
2,4-dichloro-6-aminophenol

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: C16H20Cl2N2O4

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane	82%

: 527-62-8
2,4-dichloro-6-aminophenol

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 1427468-91-4
N-(tert-butyl)-2-(tert-butylimino)-6,8-dichloro-2H-benzo[b][1,4]oxazin-3-amine

Conditions

Conditions	Yield
With palladium dichloride In 1,4-dioxane at 50℃; for 4h;	82%

: 527-62-8
2,4-dichloro-6-aminophenol

: 63969-35-7
2,4-dichloro-6-diazocyclohexa-2,4-dien-1-one

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-6-aminophenol With hydrogenchloride In ethanol; water at 0℃; for 0.166667h; Inert atmosphere; Schlenk technique; Stage #2: With sodium nitrite In ethanol; water at 0℃; for 2.16667h; Inert atmosphere; Schlenk technique;	81%
Stage #1: 2,4-dichloro-6-aminophenol With hydrogenchloride In ethanol Stage #2: With 1-nitro-3-methylbutane In methanol	80%
Stage #1: 2,4-dichloro-6-aminophenol With hydrogenchloride In ethanol; water at 0℃; for 0.166667h; Stage #2: With sodium nitrite In ethanol; water at 0℃; for 2.16667h; Stage #3: With potassium carbonate In dichloromethane; water Cooling with ice;

: 527-62-8
2,4-dichloro-6-aminophenol

: C19H20O5

: tert-butyl 2-(benzyloxy)-4-(3,5-dichloro-2-hydroxybenzoyl)benzoate

Conditions

Conditions	Yield
With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 16h;	81%

: 527-62-8
2,4-dichloro-6-aminophenol

: (1R,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hexane-2-yl-4-formyl-2-hydroxybenzoate

: (1R,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hexane-2-yl 4-((3,5-dichloro-2-hydroxyanilino)methyl)-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In 1,2-dichloro-ethane for 1h; Reflux;	80%

: 527-62-8
2,4-dichloro-6-aminophenol

: 1060757-29-0
5-(4-trifluoromethylphenyl)-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxylic acid

: 5-(4-trifluoromethylphenyl)-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxylic acid (3,5-dichloro-2-hydroxyphenyl)amide

Conditions

Conditions	Yield
Stage #1: 5-(4-trifluoromethylphenyl)-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.25h; Inert atmosphere; Cooling with ice; Stage #2: 2,4-dichloro-6-aminophenol With 2,4,6-trimethyl-pyridine In dichloromethane at 20℃; for 12h; Inert atmosphere;	79%

: 527-62-8
2,4-dichloro-6-aminophenol

: 5600-21-5
2-amino-6-methyl-4-chloropyrimidine

: 2-((2-amino-6-methylpyrimidin-4-yl)amino)-4,6-dichlorophenol

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 140℃; for 1.5h; Microwave irradiation; Sealed tube;	71%

: 500-22-1
3-pyridinecarboxaldehyde

: 527-62-8
2,4-dichloro-6-aminophenol

: 2,4-dichloro-6-(pyridine-3-methylamino)phenol

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In 1,2-dichloro-ethane at 50℃; for 8h;	68%

: 527-62-8
2,4-dichloro-6-aminophenol

: 50-00-0
formaldehyd

: 1022250-47-0
2-dimethylamino-4,6-dichlorophenol

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-6-aminophenol; formaldehyd With sodium cyanoborohydride; acetic acid In water; acetonitrile at 0℃; for 2h; Stage #2: With sodium hydrogencarbonate In water; acetonitrile	64%
With sodium cyanoborohydride; acetic acid In water; acetonitrile at 20℃; for 12h; Cooling with ice;	55.16%

: 527-62-8
2,4-dichloro-6-aminophenol

: 4-hydroxyquinazolin-7-benzaldehyde

: 4-hydroxy-7-(((3,5-dichloro-2-hydroxyphenyl)amino)methyl)quinazoline

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-6-aminophenol; 4-hydroxyquinazolin-7-benzaldehyde With titanium(IV) isopropylate In 1,2-dichloro-ethane for 5h; Reflux; Stage #2: With sodium cyanoborohydride In 1,2-dichloro-ethane Reflux;	63%

: 527-62-8
2,4-dichloro-6-aminophenol

: 1514-82-5
2-bromo-3,3,3-trifluoropropene

: 5,7-dichloro-2-(2,2,2-trifluoroethyl)benzoxazole

Conditions

Conditions	Yield
With sulfur; 2,2'-azobis-(2,4-dimethylvaleronitrile); sodium hydrogencarbonate; bis(pinacol)diborane In N,N-dimethyl-formamide at 100℃; for 15h; Reagent/catalyst; Solvent; Inert atmosphere;	62%

: 527-62-8
2,4-dichloro-6-aminophenol

: 308846-06-2
5-(bromomethyl)pyridine-2-carbonitrile

: 5-((2-amino-4,6-dichlorophenyl)methyl)-2-cyanopyridine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; potassium iodide In acetonitrile for 2h;	60%

: 527-62-8
2,4-dichloro-6-aminophenol

: 109-97-7
pyrrole

: 121789-62-6
2-(3,5-Dichlor-2-hydroxyphenyl)-1H-pyrrol

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-6-aminophenol With tert.-butylnitrite In dimethyl sulfoxide at 20℃; for 0.5h; Inert atmosphere; Stage #2: pyrrole With chlorpromazine hydrochloride In dimethyl sulfoxide at 0℃; Inert atmosphere;	55%

: 527-62-8
2,4-dichloro-6-aminophenol

: N-(2-formylquinolin-8-yl)-4-(trifluoromethyl)benzenesulfonamide

: N-(2-(((3,5-dichloro-2-hydroxyphenyl)amino)methyl)quinolin-8-yl)-4-(trifluoromethyl)benzenesulfonamide

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 18h;	55%
With sodium tris(acetoxy)borohydride In ethanol; 1,2-dichloro-ethane at 20℃; for 18h;	38%

: 527-62-8
2,4-dichloro-6-aminophenol

: 131747-68-7
2-cyanopyridine-5-carboxyaldehyde

: 5-((3,5-dichloro-2-hydroxyphenyl)amino)methyl-2-cyanopyridine

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid In methanol at 60℃;	53%

: 527-62-8
2,4-dichloro-6-aminophenol

: 1895-39-2
sodium chlorodifluoroacetate

: 5,7-dichloro-3-(difluoromethyl)benzo[d]oxazole-2(3H)-thione

Conditions

Conditions	Yield
With sulfur; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium t-butanolate In N,N-dimethyl-formamide at 70℃; for 3h; Molecular sieve; Inert atmosphere;	52%
With sulfur; sodium t-butanolate In N,N-dimethyl-formamide at 70℃; for 3h; Molecular sieve;	52%

: 527-62-8
2,4-dichloro-6-aminophenol

: 5,7-dichloro-2-(2,2,2-trifluoroethyl)benzoxazole

Conditions

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile); sodium hydrogencarbonate; sulfur; bis(pinacol)diborane In N,N-dimethyl-formamide at 100℃; for 15h; Inert atmosphere;	52%

: 527-62-8
2,4-dichloro-6-aminophenol

: (1R,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]hexane-2-yl-4-formyl-2-hydroxybenzoate

: (1R,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]hexane-2-yl 4-((3,5-dichloro-2-hydroxyaniline)methyl)-2-hydroxybenzoic acid

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In 1,2-dichloro-ethane for 1h; Reflux;	50%

: 527-62-8
2,4-dichloro-6-aminophenol

: Acetylsalicylic acid chloride

: 50-78-2
aspirin

: 81665-46-5
salicylic acid-(3,5-dichloro-2-hydroxy-anilide)

Conditions

Conditions	Yield
With sodium hydroxide; thionyl chloride In N,N-dimethyl-aniline; acetone	49%

...Expand

: 527-62-8
2,4-dichloro-6-aminophenol

: 28621-54-7
N,N-diethyl-N'-chlorosulfonyl chloroformamidine

: 1155876-12-2
7,9-dichloro-4-(diethylamino)-2,2-dioxo-2λ6-5H-[1,2,3,5]benzoxathiadiazepine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In various solvent(s) at 20℃;	48%

2-Amino-4,6-dichlorophenol Chemical Properties

Empirical Formula: C₆H₅Cl₂NO
Molecular Weight: 178.016
EINECS: 208-421-3
Index of Refraction: 1.661 Molar
Density: 1.56 g/cm³
Flash Point: 127.1 °C
Enthalpy of Vaporization: 54.67 kJ/mol
Boiling Point: 286.5 °C at 760 mmHg
Vapour Pressure: 0.00153 mmHg at 25 °C
Melting point: 97 °C
Appearance: Long needles
Product categories of 2-Amino-4,6-dichlorophenol (CAS.527-62-8): Aromatic Phenols
Structure of 2-Amino-4,6-dichlorophenol (CAS.527-62-8):

2-Amino-4,6-dichlorophenol Toxicity Data With Reference

1.		mnt-ham-lng 200 mg/L		MUREAV Mutation Research. 368 (1996),149.
2.		sce-ham-lng 100 mg/L		MUREAV Mutation Research. 368 (1996),149.

2-Amino-4,6-dichlorophenol Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.

Hazard Note: Irritant

2-Amino-4,6-dichlorophenol Specification

2-Amino-4,6-dichlorophenol (CAS.527-62-8) also can be called 2,4-Dichloro-6-aminophenol and; Phenol, 2-amino-4,6-dichloro- . It is probably combustible, and may react with strong oxidizers and mineral acids or bases .

Product Name

2-AMINO-4,6-DICHLOROPHENOL

Synthetic route

2-Amino-4,6-dichlorophenol Chemical Properties

2-Amino-4,6-dichlorophenol Toxicity Data With Reference

2-Amino-4,6-dichlorophenol Safety Profile

2-Amino-4,6-dichlorophenol Specification

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