2-Amino-5-Methoxybenzoic Acid supplier

Name
2-Amino-5-methoxybenzoic acid
EINECS
CAS No. 6705-03-9
Article Data47
CAS DataBase
Density 1.303 g/cm³
Solubility
Melting Point 148-152 °C
Formula C₈H₉NO₃
Boiling Point 349.9 °C at 760 mmHg
Molecular Weight 167.164
Flash Point 165.4 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-36/37/39-36
Risk Codes 22-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Anthranilicacid, 5-methoxy- (4CI);m-Anisic acid, 6-amino- (6CI,7CI,8CI);5-Methoxy-2-aminobenzoic acid;5-Methoxyanthranilic acid;6-Amino-m-anisic acid;NSC 126996;
PSA 72.55000
LogP 1.55680

Synthetic route

: 1882-69-5
5-methoxy-2-nitro-benzoic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h;	100%
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h;	100%
With 5%-palladium/activated carbon; hydrogen In methanol under 775.743 Torr; for 15h; Inert atmosphere;	100%

: 2475-80-1
methyl 2-amino-5-methoxybenzoate

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran; methanol; water at 20℃;	99%

: 1006-94-6
5-methoxylindole

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Stage #1: 5-methoxylindole With bromamine B; sodium hydroxide; palladium dichloride In water; acetonitrile at 60℃; for 3.33333h; pH=12; Stage #2: In water Acidic conditions;	96%
With ruthenium trichloride; osmium(VIII) oxide; bromamine B; sodium hydroxide In water; acetonitrile at 39.84℃; for 4.5h;	96%

: 100174-55-8
5,5′-dimethoxyindigo

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Stage #1: 5,5′-dimethoxyindigo With bromamine B; sodium hydroxide; palladium dichloride In water; acetonitrile at 60℃; for 2.16667h; pH=12; Stage #2: In water Acidic conditions;	96%

: 180690-91-9
2-(3,3-Dimethyl-ureido)-5-methoxy-benzoic acid methyl ester

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride at 100℃; for 24h;	89%

: 6335-41-7
2-hydroxyimino-N-(4-methoxyphenyl)acetamide

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With sulfuric acid Behandeln des erhaltenen 5-Methoxy-isatins mit wss. Natronlauge und wss. Wasserstoffperoxid;

: 101351-28-4
6-methoxy-3-(4-methoxy-phenyl)-1H-quinazoline-2,4-dione

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 1882-71-9
2-amino-5-methoxybenzamide

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With potassium hydroxide Hydrolysis;

: 38985-80-7
2-(acetylamino)-5-methoxybenzoic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride
With sodium hydroxide

: 201230-82-2
carbon monoxide

: 79069-37-7
1-(acetamino)-2-bromo-4-methoxybenzene

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; tributyl-amine; water; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride 1) 110-125 deg C, 2-3 atm, 7 h, 2) H2O, EtOH, 95 deg C, 18 h; Yield given. Multistep reaction;

: 7160-02-3
N-(4-methoxyphenyl)-N',N'-dimethylurea

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) tert-butyllithium, N,N,N',N'-tetramethylethylenediamine / 1.) diethyl ether, -50 deg C, 2 h, 2.) diethyl ether 2: diethyl ether 3: 89 percent / hydrochloric acid / 24 h / 100 °C View Scheme

: 104-94-9
4-methoxy-aniline

isosuccinic acid ester: isosuccinic acid ester

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / pyridine / CH2Cl2 / 20 h / Heating 2: 1.) tert-butyllithium, N,N,N',N'-tetramethylethylenediamine / 1.) diethyl ether, -50 deg C, 2 h, 2.) diethyl ether 3: diethyl ether 4: 89 percent / hydrochloric acid / 24 h / 100 °C View Scheme

: 2-(3,3-Dimethyl-ureido)-5-methoxy-benzoic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether 2: 89 percent / hydrochloric acid / 24 h / 100 °C View Scheme

: 2581-34-2
3-methyl-4-nitrophenol

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 58.6 percent / aq. NaOH 2: 34 percent / KMnO4, pyridine / H2O / 6 h / Heating 3: 97.5 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr / Ambient temperature View Scheme

: 5367-32-8
5-methoxy-2-nitrotoluene

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 34 percent / KMnO4, pyridine / H2O / 6 h / Heating 2: 97.5 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr / Ambient temperature View Scheme

: 20265-97-8
p-anisidine hydrochloride

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium sulfate; water; hydroxylamine hydrochloride 2: sulfuric acid / Behandeln des erhaltenen 5-Methoxy-isatins mit wss. Natronlauge und wss. Wasserstoffperoxid View Scheme

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: diluted alkaline solution / 60 °C 2: permanganate 3: tin (II)-chloride; concentrated hydrochloric acid View Scheme

: 20357-24-8
5-methoxy-2-nitro-benzaldehyde

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: permanganate 2: tin (II)-chloride; concentrated hydrochloric acid View Scheme
Multi-step reaction with 2 steps 2: ferrosulfate; ammonia View Scheme

: 100-83-4
meta-hydroxybenzaldehyde

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: bei der Nitrierung 2: diluted alkaline solution / 60 °C 3: permanganate 4: tin (II)-chloride; concentrated hydrochloric acid View Scheme

: 501-58-6, 21650-55-5, 82570-64-7
(E)-1,2-bis(4-methoxyphenyl)diazene

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2; benzene / 220 - 230 °C / 110326 Torr 2: aqueous NaOH View Scheme

: 39495-15-3
4-acetamido-3-methylphenol

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: alkali 2: permanganate; magnesium sulfate 3: concentrated hydrochloric acid View Scheme

: 31601-41-9
N-(4-methoxy-2-methylphenyl)acetamide

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: permanganate; magnesium sulfate 2: concentrated hydrochloric acid View Scheme

: 394-31-0
2-amino-5-hydroxybenzoic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: alkali 3: concentrated hydrochloric acid View Scheme

: 1882-76-4
2-acetylamino-5-hydroxy-benzoic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: alkali 2: concentrated hydrochloric acid View Scheme

: 5-methoxy-2-nitro-benzoic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In ethanol at 20℃; under 759.826 Torr; for 8h;

: 108-24-7
acetic anhydride

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 38527-50-3
2-methyl-6-(methoxy)-3,1-benzoxazin-4-one

Conditions

Conditions	Yield
In neat (no solvent) at 130℃; for 6h; Sealed tube; Inert atmosphere;	100%
for 5h; Reflux;	100%
for 4h; Reflux;	99%

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 55414-72-7
(2-amino-5-methoxyphenyl)methanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h;	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃;	90%

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 37795-77-0
6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate In tetrahydrofuran at 20℃;	100%
With bis(trichloromethyl) carbonate In tetrahydrofuran at 0 - 20℃;	91%
With hydrogenchloride; bis(trichloromethyl) carbonate In water at 20℃; for 4h;	89%
With bis(trichloromethyl) carbonate In tetrahydrofuran at 60℃; for 10h;

: 1204-28-0
trimellitic anhydride acid chloride

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 2-(1,3-dioxo-1,3-dihydroisobenzofuran-5-carboxamido)-5-methoxybenzoic acid

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: 446-11-7
4-fluoro-3-nitrotoluene

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: C15H14N2O5

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 120℃;	100%

: 32315-10-9
bis(trichloromethyl) carbonate

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 37795-77-0
6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 18h;	98%
In tetrahydrofuran at 20℃; for 18h;	97%
With triethylamine In tetrahydrofuran at 0 - 20℃;	96%

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 2-azido-5-methoxybenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-Amino-5-methoxybenzoic acid With hydrogenchloride In water at -5℃; Stage #2: With sodium nitrite In water at -5 - 0℃; for 0.583333h; Stage #3: With sodium azide In water at -5 - 20℃;	95%

: 4-(methylsulfanyl)-1-phenyl-5H-pyrrolo[2,1-d][1,2,5]triazepine

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 9-methoxy-14-phenylpyrrolo[2',1':4,5][1,2,5]triazepino[7,1-b]quinazolin-11(5H)-one

Conditions

Conditions	Yield
In acetic acid for 8h; Niementowski Quinazolone Synthesis; Reflux;	95%

: 75-44-5
phosgene

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 37795-77-0
6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

Conditions

Conditions	Yield
With hydrogenchloride at 25℃;	94%
In 1,4-dioxane at 60℃; for 3h;	89%
In 1,4-dioxane; benzene Ambient temperature;	88%

: 6068-72-0
4-cyanobenzoyl chlorIde

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 2-(4-cyanobenzamido)-5-methoxybenzoic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at -5 - 20℃; for 1.33333h;	94%

: 103-72-0
phenyl isothiocyanate

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1402932-21-1
6-methoxy-3-phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

Conditions

Conditions	Yield
With triethylamine In ethanol for 3h; Reflux;	92%
In ethanol for 5h; Reflux;

: 590-28-3
potassium cyanate

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 32618-84-1
6-Methoxyquinazolin-2,4-dione

Conditions

Conditions	Yield
With acetic acid In water at 35℃; for 1h;	91%
With acetic acid In water at 35℃; for 4h;	65%
With acetic acid In water at 35℃; for 4h;	65%
Stage #1: potassium cyanate; 2-Amino-5-methoxybenzoic acid With acetic acid In water at 35℃; Stage #2: With sodium hydroxide In water at 40℃; Heating; Stage #3: With hydrogenchloride In water pH=5;	50%
With acetic acid for 2h;

: 64-17-5
ethanol

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 64018-98-0
2-amino-5-methoxybenzoic acid ethyl ester

Conditions

Conditions	Yield
With hydrogenchloride for 24h; Heating;	91%
With thionyl chloride for 18h; Reflux; Inert atmosphere; Cooling with ice;
With sulfuric acid at 80℃;

: 201230-82-2
carbon monoxide

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 37795-77-0
6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

Conditions

Conditions	Yield
With oxygen; copper diacetate; palladium diacetate; potassium iodide In acetonitrile at 60℃; under 760.051 Torr; for 4h;	91%

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 19181-64-7
6-Methoxyquinazolin-4-one

Conditions

Conditions	Yield
at 140 - 145℃; for 4h;	90%
at 145 - 165℃;	75%

: 65178-90-7
2-[4-(4-chlorobenzoyl)-phenoxy]-2-methylpropionyl chloride

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: C25H22ClNO6

Conditions

Conditions	Yield
Stage #1: 2-Amino-5-methoxybenzoic acid With sodium hydroxide In 1,4-dioxane; water at 0℃; for 0.5h; Stage #2: 2-[4-(4-chlorobenzoyl)-phenoxy]-2-methylpropionyl chloride In 1,4-dioxane; water at 0℃; for 10h;	89.7%

: 1-(4-methoxyphenyl)-4-(methylsulfanyl)-5H-pyrrolo[2,1-d][1,2,5]triazepine

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 9-methoxy-14-(4-methoxyphenyl)pyrrolo[2',1':4,5][1,2,5]triazepino[7,1-b]quinazolin-11(5H)-one

Conditions

Conditions	Yield
In acetic acid Niementowski Quinazolone Synthesis; Reflux;	89%

: 122-51-0
orthoformic acid triethyl ester

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 6-methoxy-4H-benzo[d][1,3]oxazin-4-one

Conditions

Conditions	Yield
Reflux;	89%
With toluene-4-sulfonic acid for 4h; Reflux;

: 6068-72-0
4-cyanobenzoyl chlorIde

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 2-(4-cyanophenyl)-6-methoxybenzo[d]-1,3-oxazin-4-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane; toluene at 0 - 30℃; for 8h; Concentration; Reagent/catalyst; Temperature;	88.6%

: 610-97-9
o-iodo-methyl-benzoic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 112239-05-1
5-Methoxy-2-(2-methoxycarbonyl-phenylamino)-benzoic acid

Conditions

Conditions	Yield
With N-ethylmorpholine;; copper In various solvent(s) at 120℃; for 2h;	88%

: 57-13-6
urea

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 32618-84-1
6-Methoxyquinazolin-2,4-dione

Conditions

Conditions	Yield
at 200℃; for 1h;	88%
at 150℃; for 5h;	70%
In phenol at 150℃; for 10h;	41%

: 124-63-0
methanesulfonyl chloride

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1353628-12-2
C9H11NO5S

Conditions

Conditions	Yield
With sodium carbonate In water at 20℃; for 24h;	88%

: 3473-63-0
formamidine acetic acid

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 19181-64-7
6-Methoxyquinazolin-4-one

Conditions

Conditions	Yield
In 2-methoxy-ethanol at 125℃; for 18h;	87%
In 2-methoxy-ethanol at 20 - 140℃; for 0.17h;

: 83476-93-1
2-(4-methylpent-3-en-1-yl)benzaldehyde

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 9-methoxy-7,7-dimethyl-5,6,6a,7,12,12a-hexahydrobenzo[c]acridine-11-carboxylic acid

Conditions

Conditions	Yield
With bismuth(III) chloride In acetonitrile for 1h; Diels-Alder Cycloaddition; Inert atmosphere; diastereoselective reaction;	87%

: 622-78-6
Benzyl isothiocyanate

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 3-benzyl-2,3-dihydro-6-methoxy-2-thioxoquinazolin-4(1H)-one

Conditions

Conditions	Yield
With triethylamine In ethanol for 1h; Reflux;	86%

2-Amino-5-Methoxybenzoic Acid Chemical Properties

IUPAC Name: 2-Amino-5-methoxybenzoic acid
Molecular Formula: C₈H₉NO₃
Molecular Weight: 167.162g/mol
Density: 1.303 g/cm³
Melting Point: 150-152°C
Boiling Point: 349.9 °C at 760 mmHg
Flash Point: 165.4 °C
Freely Rotating Bonds: 3
Polar Surface Area: 38.77Å²
Index of Refraction: 1.603
Molar Refractivity: 44.09 cm³
Molar Volume: 128.2 cm³
Polarizability: 17.48 ×10^-24cm³
Surface Tension: 56.6 dyne/cm
Enthalpy of Vaporization: 62.73 kJ/mol
Vapour Pressure: 1.71E-05 mmHg at 25°C
2-Amino-5-methoxybenzoic acid ,its Cas Register Number is 6705-03-9.The chemical synonyms of 2-Amino-5-methoxybenzoic acid (CAS No.6705-03-9) are 2-Amino-5-methoxybenzoic acid ; 5-Methoxyanthranilic acid ; 5-Methoxyanththranillic acid ; 2-Amino-5-methoxylbenzoic acid ; 2-Amino-5-MethoxybenzoicAcid98% ; 2-Amino-5-Methoxybenzoic .Product categories of 2-Amino-5-methoxybenzoic acid (CAS No.6705-03-9) are Aromatic Carboxylic acids, amides, anilides,anhydrides & salts ; Carboxylic acids ; Phenyls & phenyl-het ; Organic acids ; Carboxylic acids ; Phenyls & phenyl-het ; Aromatic amino acids ; Peptide synthesis ; Unnatural amino acid derivatives .The molecular structure of 2-Amino-5-methoxybenzoic acid (CAS No.6705-03-9) is .

2-Amino-5-Methoxybenzoic Acid Uses

It is used in organic synthesis.

2-Amino-5-Methoxybenzoic Acid Safety Profile

Hazard Codes: Harmful Xn,Xi
Xn: Harmful
Xi: Irritant
Risk Statements: 22-36/37/38-20/21/22
22: Harmful if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
Safety Statements: 26-36/37/39-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
36/37/39: Wear suitable protective clothing, gloves and eye/face protection

Product Name

2-Amino-5-methoxybenzoic acid

Synthetic route

2-Amino-5-Methoxybenzoic Acid Chemical Properties

2-Amino-5-Methoxybenzoic Acid Uses

2-Amino-5-Methoxybenzoic Acid Safety Profile

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