2-Aminoterephthalic acid supplier

Name
2-Aminoterephthalic acid
EINECS
CAS No. 10312-55-7
Article Data34
CAS DataBase
Density 1.551 g/cm³
Solubility Slightly soluble in water.
Melting Point 324 °C (dec.)(lit.)
Formula C₈H₇NO₄
Boiling Point 450.7 °C at 760 mmHg
Molecular Weight 181.148
Flash Point 226.4 °C
Transport Information
Appearance slight yellow crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Aminoterephthalic acid;
PSA 100.62000
LogP 1.24640

Synthetic route

: 610-29-7
2-nitroterephthalic acid

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With potassium hydroxide; hydrogen; palladium on activated charcoal In water under 2585.7 Torr; for 12h;	100%
With palladium 10% on activated carbon; ammonium formate; silica gel In methanol for 1.5h; Milling;	99%
With hydrogen In ethanol at 20℃; under 760.051 Torr; for 4h;	92%

: 5372-81-6
dimethyl aminoterephthalate

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol at 60℃; for 3h;	94%
With sodium hydroxide for 2h; Heating;
With potassium hydroxide In tetrahydrofuran; water at 20℃;

: 89-78-1
menthol

: 610-29-7
2-nitroterephthalic acid

: 10312-55-7
3-aminoterephthalic acid

: 860754-74-1
monoamide of trimellitic acid

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With potassium hydroxide; bromine

: 99185-32-7
2-acetamidoterephthalic acid

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With ethanol; sulfuric acid

: 7647-01-0
hydrogenchloride

: 610-29-7
2-nitroterephthalic acid

tin: tin

: 10312-55-7
3-aminoterephthalic acid

...Expand

: 64-17-5
ethanol

: 7664-93-9
sulfuric acid

: 99185-32-7
2-acetamidoterephthalic acid

: 10312-55-7
3-aminoterephthalic acid

...Expand

: 860754-74-1
monoamide of trimellitic acid

: 7726-95-6
bromine

KOH-solution: KOH-solution

: 10312-55-7
3-aminoterephthalic acid

...Expand

: 7647-01-0
hydrogenchloride

: 2,2′,5,5′-azobenzenetetracarboxylic acid

tin: tin

: 10312-55-7
3-aminoterephthalic acid

...Expand

: 95-63-6
1,2,4-Trimethylbenzene

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 2: sulfuric acid 3: aqueous-methanolic KOH-solution 5: 100 °C / im Rohr 6: bromine; KOH-solution View Scheme

: 100-21-0
terephthalic acid

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HNO3+H2SO4 2: tin; hydrochloric acid View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / 10 h / 60 - 80 °C 2: tin(II) chloride dihdyrate; hydrogenchloride / water / 3 h / 80 °C View Scheme
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 1 h / 5 - 60 °C 2: tin(ll) chloride; hydrogenchloride / water / 3 h / 70 °C View Scheme

: 54699-35-3
1,2-dimethyl 1,2,4-benzenetricarboxylate

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: 100 °C / im Rohr 3: bromine; KOH-solution View Scheme

: 528-44-9
1,2,4-benzene tricarboxylic acid

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: sulfuric acid 2: aqueous-methanolic KOH-solution 4: 100 °C / im Rohr 5: bromine; KOH-solution View Scheme

: 2459-10-1
benzene-1,2,4-tricarboxylic acid trimethyl ester

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: aqueous-methanolic KOH-solution 3: 100 °C / im Rohr 4: bromine; KOH-solution View Scheme

: 13940-95-9
benzene-1,2,4-tricarboxylic acid-2-methyl ester

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 °C / im Rohr 2: bromine; KOH-solution View Scheme

: 2050-44-4
N-(2,5-dimethylphenyl)acetamide

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium permanganate; magnesium sulfate 2: sulfuric acid; aqueous alcohol View Scheme

: 52-90-4
L-Cysteine

: 1391926-97-8
1-phenyl 2-nitrosoterephthalate

A: 31499-93-1
6-carboxylic benzo[c]isoxazol-3(1H)-one

B: C14H11NO5

C: 1391926-99-0
C22H14N2O9

D: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Inert atmosphere; aq. phosphate buffer;

...Expand

: 4Zn(2+)*3C10H7NO5(2-)*O(2-)

A: 10312-55-7
3-aminoterephthalic acid

B: 99185-32-7
2-acetamidoterephthalic acid

Conditions

Conditions	Yield
With hydrogen chloride In dimethylsulfoxide-d6; water-d2 Sonication;

: IRMOF-3-AM4

A: 1050145-59-9
C13H15NO5

B: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With hydrogen chloride In dimethylsulfoxide-d6; water-d2 Sonication;

: 4Zn(2+)*3C15H17NO5(2-)*O(2-)

A: C15H19NO5

B: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With hydrogen chloride In dimethylsulfoxide-d6; water-d2 Sonication;

: 4Zn(2+)*3C22H31NO5(2-)*O(2-)

A: C22H33NO5

B: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With hydrogen chloride In dimethylsulfoxide-d6; water-d2 Sonication;

: 4Zn(2+)*3C15H9NO5(2-)*O(2-)

A: 156042-89-6
2-(benzoylamide)terephthalic acid

B: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With hydrogen chloride In dimethylsulfoxide-d6; water-d2 Sonication;

: 959-26-2
Bis(2-Hydroxyethyl)terephthalat

: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide; water / 0.67 h / 80 °C 2: sulfuric acid; nitric acid / 10 h / 60 - 80 °C 3: tin(II) chloride dihdyrate; hydrogenchloride / water / 3 h / 80 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide; water / 0.67 h / 70 °C 2: nitric acid; sulfuric acid / 1 h / 5 - 60 °C 3: tin(ll) chloride; hydrogenchloride / water / 3 h / 70 °C View Scheme

: [(chromium(III))3(μ3-O)(OH)(H2O)2((2-aminoterephthalic acid)0.35(2-(trimethylacetamide)terephthalic acid)0.65)3]*nH2O

A: 2-(trimethylacetamide)terephthalic acid

B: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With sodium hydroxide In water-d2

: [(chromium(III))3(μ3-O)(OH)(H2O)2((2-aminoterephthalic acid)0.37(2-(benzoylamide)terephthalic acid)0.63)3]*nH2O

A: 156042-89-6
2-(benzoylamide)terephthalic acid

B: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With sodium hydroxide In water-d2

: [(chromium(III))3(μ3-O)(OH)(H2O)2((2-aminoterephthalic acid)0.46(2-(oxalic acid monoamide)terephthalic acid)0.54)3]*nH2O

A: 243989-64-2
2-(oxalic acid monoamide)terephthalic acid

B: 10312-55-7
3-aminoterephthalic acid

Conditions

Conditions	Yield
With sodium hydroxide In water-d2

: 10312-55-7
3-aminoterephthalic acid

: 1829-22-7
2-iodo-1,4-benzenedicarboxylic acid

Conditions

Conditions	Yield
Stage #1: 3-aminoterephthalic acid With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: With potassium iodide In water at 20℃; for 19h;	100%
Stage #1: 3-aminoterephthalic acid With sodium nitrite In hydrogenchloride at 0 - 5℃; for 1.25h; Stage #2: With potassium iodide In water at 20℃; for 18h; Further stages.;	86%
Stage #1: 3-aminoterephthalic acid With hydrogenchloride; sodium nitrite In water at 0℃; for 1.25h; Stage #2: With potassium iodide In water at 20℃; for 18h;	83%
With hydrogenchloride; potassium iodide; sodium nitrite In water at 20℃; Sandmeyer Reaction;	74%
Stage #1: 3-aminoterephthalic acid With hydrogenchloride; sodium nitrite In water Stage #2: With potassium iodide

: 67-56-1
methanol

: 10312-55-7
3-aminoterephthalic acid

: 5372-81-6
dimethyl aminoterephthalate

Conditions

Conditions	Yield
With sulfuric acid for 18h; Reflux;	99%
With hydrogenchloride In water Reflux;	87%
With sulfuric acid at 70℃; for 18h; High pressure; Sealed tube;	69%

: lutetium(III) nitrate hexahydrate

: 10312-55-7
3-aminoterephthalic acid

: {Lu2(H2O)4(2-aminoterephthalic acid)3·4H2O}n

Conditions

Conditions	Yield
With lithium hydroxide In water at 20℃; for 1h;	99%

: 10312-55-7
3-aminoterephthalic acid

: 108-94-1
cyclohexanone

: 1314749-35-3
9-oxo-5,6,7,8,9,10-hexahydro-acridine-3-carboxylic acid

Conditions

Conditions	Yield
In diphenylether at 250℃;	98%
In diphenylether at 250℃;

: 32315-10-9
bis(trichloromethyl) carbonate

: 10312-55-7
3-aminoterephthalic acid

: 77423-14-4
2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-7-carboxylic acid

Conditions

Conditions	Yield
In tetrahydrofuran at 40 - 50℃; for 3h;	97%
In 1,4-dioxane at 20℃; for 6h;	96.2%
In tetrahydrofuran at 45 - 50℃; for 3h; Inert atmosphere;	81%

: 10312-55-7
3-aminoterephthalic acid

: 5970-45-6
zinc(II) acetate dihydrate

: C8H5NO4(2-)*Zn(2+)*1.5H2O

Conditions

Conditions	Yield
In methanol for 0.25h;	97%

: aluminium(III) chloride hexahydrate

: 10312-55-7
3-aminoterephthalic acid

: Al3O(OH)(6+)*3C8H5NO4(2-)*xH2O

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃;	96%

: 10312-55-7
3-aminoterephthalic acid

: 2052-49-5
tetra(n-butyl)ammonium hydroxide

: C8H5NO4(2-)*2C16H36N(1+)

Conditions

Conditions	Yield
In methanol; ethanol	95%

: 79791-29-0
2-(3-(2,5-dimethylphenoxy)propyl)-2-methylpropionyl chloride

: 10312-55-7
3-aminoterephthalic acid

: 2-(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamido)terephthalic acid

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 0℃; for 10.5h;	94.4%

: lutetium(III) nitrate hexahydrate

: 10312-55-7
3-aminoterephthalic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: {Lu2(H2O)2(dimethylformamide)2(2-aminoterephthalic acid)3}n

Conditions

Conditions	Yield
With lithium hydroxide In water at 100℃; for 5h; Autoclave;	93%

...Expand

: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

: 10312-55-7
3-aminoterephthalic acid

: 6046-93-1
copper(II) acetate monohydrate

: 2Cu(2+)*2C6H3NH2(COO)2(2-)*N(CH2CH2)3N=(Cu2(C6H3NH2(COO)2)2(N(CH2CH2)3N))

Conditions

Conditions	Yield
Stage #1: 1,4-diaza-bicyclo[2.2.2]octane; 3-aminoterephthalic acid; copper(II) acetate monohydrate In neat (no solvent) at 20℃; for 2h; Milling; Stage #2: at 120℃; for 12h;	93%

...Expand

: 10312-55-7
3-aminoterephthalic acid

: 10026-11-6
zirconium(IV) chloride

: [ZrO(2-amino-1,4-benzendicarboxylate)]

Conditions

Conditions	Yield
In acetic acid; N,N-dimethyl-formamide at 220℃; for 0.0166667h; Microwave irradiation;	92.5%

: 10312-55-7
3-aminoterephthalic acid

: 57-13-6
urea

: quinazoline-2,4(1H,3H)-dione-7-carboxylic acid

Conditions

Conditions	Yield
at 160℃;	92%

: 872-85-5
pyridine-4-carbaldehyde

: 10312-55-7
3-aminoterephthalic acid

: 2-((pyridin-4-ylmethylene)amino)terephthalic acid

Conditions

Conditions	Yield
In ethanol at 130℃; for 0.0833333h;	92%

: lead(II) nitrate

: 552843-44-4
2-(2-carboxylphenyl)-imidazo[4,5-f ]-1,10-phenanthroline

: 10312-55-7
3-aminoterephthalic acid

: 7732-18-5
water

: [Pb2(2-(2-carboxyphenyl)imidazo(4,5-f )-(1,10)phenanthroline)2(2-amino-1,4-benzenedicarboxylic acid)]n·2nH2O

Conditions

Conditions	Yield
With sodium hydroxide at 174.84℃; for 72h; pH=7; Autoclave;	92%

...Expand

: 37148-47-3
1-(4-amino-3,5-dichlorophenyl)-2-bromoethan-1-one

: 10312-55-7
3-aminoterephthalic acid

: 2-aminoterephthalic acid bis-[2-(4-amino-3,5-dichlorophenyl)-2-oxo-ethyl] ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 1h;	90%

: 10312-55-7
3-aminoterephthalic acid

: 70-11-1
α-bromoacetophenone

: 2-aminoterephthalic acid bis-[2-phenyl-2-oxo-ethyl] ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 1h;	90%

: 10312-55-7
3-aminoterephthalic acid

: 108-24-7
acetic anhydride

: 99-61-6
3-nitro-benzaldehyde

: C17H12N2O7

Conditions

Conditions	Yield
Stage #1: 3-aminoterephthalic acid; 3-nitro-benzaldehyde In methanol at 20℃; for 1h; Stage #2: acetic anhydride for 1h; Heating; Further stages.;	90%

...Expand

: zinc(II) nitrate hexahydrate

: 10312-55-7
3-aminoterephthalic acid

: [Zn4O(2-aminoterephthalate)3]

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide Zn(NO3)2*6H2O (15 mmol) and 2-aminoterephthalic acid (5 mmol) dissolved in DMF (490 ml) + H2O (10 ml); heated (373 K, 24 h); cooled to room temp.; transfered in N2 box; solvent decanted; solid washed with anhyd. DMF by soaking (8 h); washed with anhyd. CH2Cl2 by soaking (8 h); dried (vac., 12 h); XRD;	90%
In further solvent(s) Zn(NO3)2*6H2O (61 mmol) and 2-aminoterephthalic acid (20 mmol) dissolvedin diethylformamide; heated (363 K, 24 h); cooled to room temp.; transfered in N2 box; solvent decanted; solid washed with anhyd. DMF by soaking (8 h); washed with anhyd. CH2Cl2 by soaking (8 h); dried (vac., 12 h); XRD;	70%
With triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;
With N,N-dimethyl-formamide at 105℃; for 18h;

: 10312-55-7
3-aminoterephthalic acid

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 1428976-98-0
2-(4-(мethoxycarbonyl)benzamido)terephthalic acid

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl acetamide at 20℃; for 1.5h; Cooling with ice;	90%

: 10312-55-7
3-aminoterephthalic acid

: 7732-18-5
water

: 10026-11-6
zirconium(IV) chloride

: UiO-66-NH2

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In N,N-dimethyl-formamide at 120℃; for 24h; Autoclave;	90%

...Expand

: lutetium(III) nitrate hexahydrate

: 10312-55-7
3-aminoterephthalic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: {Lu2(dimethylformamide)(2-aminoterephthalic acid)3}n

Conditions

Conditions	Yield
With lithium hydroxide In water at 150℃; for 5h; Autoclave;	90%

...Expand

: 1,4-bis(4-pyridylethenyl)benzene

: zinc(II) nitrate hexahydrate

: 10312-55-7
3-aminoterephthalic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: [Zn(COO)(1,4-bis[2-(pyridin-4-yl)ethenyl]benzene)0.5(2-aminoterephthalate)0.5]

Conditions

Conditions	Yield
In water at 115℃; for 72h; High pressure; Autoclave;	90%

...Expand

: 82-34-8
1-nitroanthraquinone

: 10312-55-7
3-aminoterephthalic acid

: C22H13NO6

Conditions

Conditions	Yield
With sodium acetate In nitrobenzene at 150℃; for 48h;	90%

: 10312-55-7
3-aminoterephthalic acid

: 90-60-8
3,5-dichlorosalicyclaldehyde

: C15H9Cl2NO5

Conditions

Conditions	Yield
Stage #1: 3-aminoterephthalic acid With sodium hydroxide In methanol for 0.166667h; Sonication; Stage #2: 3,5-dichlorosalicyclaldehyde In methanol at 20℃; for 2h;	90%

7-carboxyisatoic anhydride: 7-carboxyisatoic anhydride

: 32315-10-9
bis(trichloromethyl) carbonate

: 10312-55-7
3-aminoterephthalic acid

: 542-53-0
N-ethyl glycine hydrochloride

: 195985-12-7
8-[2,3,4,5-Tetrahydro-1H-1,4-benzodiazepin-2,5-dionyl]-carboxylic acid

Conditions

Conditions	Yield
In pyridine; ethyl acetate	88%

...Expand

: 33948-36-6
2-iodocyclohex-2-en-1-one

: 10312-55-7
3-aminoterephthalic acid

: 566155-74-6
5-phenylamino-terephthalic acid dimethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol at 75℃; for 3h; Inert atmosphere;	88%

: terbium(III) oxide

: 10312-55-7
3-aminoterephthalic acid

: 7732-18-5
water

: [Tb2(2-aminoterephthalic acid(-2H))3(H2O)5]n ·2nH2O

Conditions

Conditions	Yield
In neat (no solvent) at 170℃; for 72h; Autoclave;	88%

...Expand

2-Aminoterephthalic acid Specification

The 2-Aminoterephthalic acid, with the CAS registry number of 10312-55-7, is also known as Aminoterephthalicacid. It belongs to the product categories of Phthalic Acids, Esters and Derivatives; Derivatives of phthalic acid; Aromatic Amino Acids; Peptide Synthesis; Unnatural Amino Acid Derivatives. This chemical's molecular formula is C₈H₇NO₄ and molecular weight is 181.15. What's more, its IUPAC name is 2-Aminoterephthalic acid. In addition, it must be stored in airtight containers and placed in a dry, cool place.

Physical properties about the 2-Aminoterephthalic acid are: (1)ACD/LogP: 1.49; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.01; (4)ACD/LogD (pH 7.4): -2.65; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 5; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 55.84 Å²; (13)Index of Refraction: 1.684; (14)Molar Refractivity: 44.34 cm³; (15)Molar Volume: 116.7 cm³; (16)Surface Tension: 87.7 dyne/cm; (17)Density: 1.551 g/cm³; (18)Flash Point: 226.4 °C; (19)Enthalpy of Vaporization: 74.78 kJ/mol; (20)Boiling Point: 450.7 °C at 760 mmHg; (21)Vapour Pressure: 6.54E-09 mmHg at 25 °C.

Preparation: this chemical is prepared by Nitro-terephthalic acid. The reaction needs reagents 37 % HCl, Hydrogen and solvents Tetrahydrofuran, Ethanol. It also needs catalyst Pd/C. The reaction time is 4 hours. The yield is about 73 %.

Uses: it is used to produce other chemicals. For example, it is used to produce Amino-terephthalic acid-4-methyl ester. This reaction needs reagent 98 % H₂SO₄. Other condition of this reaction is reaction time of 8 minutes at 60 °C. The yield is about 57 %.

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is irritating to eyes, respiratory system and skin. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice. Besides, during using it, wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1) SMILES:O=C(O)c1ccc(cc1N)C(=O)O
(2) InChI:InChI=1/C8H7NO4/c9-6-3-4(7(10)11)1-2-5(6)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)
(3) InChIKey:GPNNOCMCNFXRAO-UHFFFAOYAI

Product Name

2-Aminoterephthalic acid

Synthetic route

2-Aminoterephthalic acid Specification

Related Products

Hot Products