2-Bromo-2'-hydroxyacetophenone supplier

Name
2-BROMO-2'-HYDROXYACETOPHENONE
EINECS
CAS No. 2491-36-3
Article Data53
CAS DataBase
Density 1.622 g/cm³
Solubility
Melting Point 44-48 °C(lit.)
Formula C₈H₇BrO₂
Boiling Point 272.1 °C at 760 mmHg
Molecular Weight 215.046
Flash Point 118.347 °C
Transport Information UN 3263 8
Appearance off-white powder
Safety 26-36/37/39-45
Risk Codes 22-34
Molecular Structure
Hazard Symbols C
Synonyms Acetophenone,2-bromo-2'-hydroxy- (6CI,7CI,8CI);2-Hydroxyphenacyl bromide;2'-Hydroxy-2-bromoacetophenone;a-Bromo-2-hydroxyacetophenone;w-Bromo-o-hydroxyacetophenone;
PSA 37.30000
LogP 1.96980

Synthetic route

: 118-93-4
o-hydroxyacetophenone

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

Conditions

Conditions	Yield
With copper(ll) bromide In chloroform Reflux;	100%
With copper(ll) bromide In chloroform; ethyl acetate Heating;	96%
With copper(ll) bromide In chloroform; ethyl acetate for 5h; Reflux;	94%

: 40231-08-1
o-(Bromoacetyl)phenyl acetate

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

Conditions

Conditions	Yield
With hydrogenchloride In water for 4h; Reflux;	70%

: 582-24-1
1-phenyl-2-hydroxyethanone

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

Conditions

Conditions	Yield
With bromine; acetic acid for 2h; Reflux;	60%

: 118-93-4
o-hydroxyacetophenone

A: 67029-74-7
2-bromo-1-(5-bromo-2-hydroxyphenyl)ethan-1-one

B: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

Conditions

Conditions	Yield
With bromine; acetic acid

: 100-66-3
methoxybenzene

: 598-21-0
2-Bromoacetyl bromide

A: 2491-38-5
2-bromo-1-(4'-hydroxyphenyl)-1-ethanone

B: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

Conditions

Conditions	Yield
With aluminium trichloride; 1,2-Dichloropropane
With aluminium trichloride; 1,2-Dichloropropane

...Expand

: 118-93-4
o-hydroxyacetophenone

A: 1450-75-5
5-Bromo-2-hydroxyacetophenone

B: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

Conditions

Conditions	Yield
With bromine; acetic acid

: 620-72-4
phenyl 2-bromoacetate

A: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

B 2-bromo-1-<4-hydroxy-phenyl>-ethanone-(1): 2-bromo-1-<4-hydroxy-phenyl>-ethanone-(1)

Conditions

Conditions	Yield
With aluminium trichloride at 140℃;

: 108-95-2
phenol

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 150 - 155 °C 2: AlCl3 / 140 °C View Scheme

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 5188-07-8
sodium thiomethoxide

: 56986-82-4
α,α-dibromo-o-hydroxyacetophenone

Conditions

Conditions	Yield
In methanol for 0.5h; Ambient temperature;	98%

: 603-35-0
triphenylphosphine

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: [2-(2-Hydroxy-phenyl)-2-oxo-ethyl]-triphenyl-phosphonium; bromide

Conditions

Conditions	Yield
In benzene	96%

: 79-19-6
thiosemicarbazide

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 36640-52-5
1-phenyl-3-(p-tolyl)-1H-pyrazole-4-carbaldehyde

: (E)-2-(2-(2-((1-phenyl-3-p-tolyl-1H-pyrazol-4-yl)methylene)hydrazinyl)thiazol-4-yl)phenol

Conditions

Conditions	Yield
With 3,3'-(pentane-1,5-diyl)bis(1,2-dimethyl-1H-imidazol-3-ium) bromide In neat (no solvent) at 20℃; for 1h; Green chemistry;	96%

...Expand

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 67139-49-5
1-(2-hydroxyphenyl)-2-azidoethanone

Conditions

Conditions	Yield
With sodium azide In glycerol at 25℃; for 3h;	95%
With sodium azide In water; acetone for 0.5h;	90%
With sodium azide
With sodium azide In N,N-dimethyl-formamide at 0℃; for 2h;

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 103-85-5
monophenylthiourea

: 310430-56-9
2-(2-(phenylamino)thiazol-4-yl)phenol

Conditions

Conditions	Yield
In ethanol at 71℃; for 0.0125h; Microwave irradiation;	95%

: 119-65-3
isoquinoline

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 1616300-34-5
C25H23NO6

Conditions

Conditions	Yield
Stage #1: isoquinoline; 2-(2-bromoacetyl)hydroxybenzene With cetyltrimethylammonim bromide In water at 20℃; for 0.5h; Micellar solution; Green chemistry; Stage #2: acetylenedicarboxylic acid diethyl ester With 1,8-diazabicyclo[5.4.0]undec-7-ene In water at 20℃; for 0.583333h; Micellar solution; Green chemistry;	94%

...Expand

: 74227-66-0
1-indanone thiosemicarbazone

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: N-indan-1-ylidene-N'-[4-(2-hydroxy-phenyl)-thiazol-2-yl]-hydrazine

Conditions

Conditions	Yield
With triethylamine In ethanol at 80℃;	94%

: 637-89-8
4-sulfanylphenol

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 333957-79-2
2'-hydroxy-2-(4-hydroxyphenylthio)acetophenone

Conditions

Conditions	Yield
With potassium hydroxide In methanol	93%

: 119-65-3
isoquinoline

: 762-42-5
dimethyl acetylenedicarboxylate

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 1616300-29-8
C23H19NO6

Conditions

Conditions	Yield
Stage #1: isoquinoline; 2-(2-bromoacetyl)hydroxybenzene With cetyltrimethylammonim bromide In water at 20℃; for 0.5h; Micellar solution; Green chemistry; Stage #2: dimethyl acetylenedicarboxylate With 1,8-diazabicyclo[5.4.0]undec-7-ene In water at 20℃; for 0.583333h; Micellar solution; Green chemistry;	92%

...Expand

: 95-54-5
1,2-diamino-benzene

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 17392-20-0
2-(2-hydroxyphenyl)quinoxaline

Conditions

Conditions	Yield
With β‐cyclodextrin In methanol; water at 70℃; for 2h;	90%
With polymeric resin-bound hexafluorophosphate ion In methanol; water at 20℃; for 7h;	83%
With γ-maghemite-silica nanocomposite In neat (no solvent) for 6h; Green chemistry;	78%
With β‐cyclodextrin In methanol; water	58%

: 824-80-6
sodium 4-fluorobenzenesulfinate

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 2-(4-fluorobenzenesulfonyl)-1-(2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
In 1,4-dioxane; water at 25℃; for 3h; Reflux; Inert atmosphere;	90%
In 1,4-dioxane; water for 3h; Reflux;
In 1,4-dioxane; water for 3h; Reflux;

: (E)-2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carbothioamide

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: (E)-3-(2-(4-(2-hydroxyphenyl)thiazol-2-yl)hydrazono)-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
In ethanol for 4h; Hantzsch Thiazole Synthesis; Reflux;	89.5%

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 118-93-4
o-hydroxyacetophenone

Conditions

Conditions	Yield
With water; zinc In acetonitrile at 80℃; for 6h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;	89%

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 1-(2-hydroxyphenyl)ethan-1-one-2-d

Conditions

Conditions	Yield
With water-d2; zinc In acetonitrile at 80℃; for 6h; Time; Inert atmosphere; Sealed tube;	89%

: (E)-2-((E)-4-(5-ethoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)but-3-en-2-ylidene)hydrazine-1-carbothioamide

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 2-(2-(2-((2E,3E)-4-(5-ethoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)but-3-en-2-ylidene)hydrazinyl)thiazol-4-yl)phenol

Conditions

Conditions	Yield
In methanol for 5h; Reflux;	89%

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 7169-34-8
3-oxo-2,3-dihydrobenzo[b]furan

Conditions

Conditions	Yield
With sodium acetate In N,N-dimethyl-formamide for 1h; Heating;	88%
With sodium acetate In ethanol
With potassium fluoride In N,N-dimethyl-formamide at 20℃;

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 10272-07-8
3,5-Dimethoxyaniline

: 342808-82-6
2-hydroxy-(3,5-dimethoxyanilino)-acetophenone

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol for 2.5h; Heating;	88%

: 102423-75-6
2,6-diamino-4-(4-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 3-(4-chloro-phenyl)-2-[4-(2-hydroxy-phenyl)-thiazol-2-yl]-acrylonitrile

Conditions

Conditions	Yield
In ethanol for 8h; Heating;	88%

: 6462-50-6
sodium 4-methoxybenzenesulfinate

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 1-(2-hydroxyphenyl)-2-(4-methoxybenzenesulfonyl)ethanone

Conditions

Conditions	Yield
In 1,4-dioxane; water at 25℃; for 3h; Reflux; Inert atmosphere;	88%
In 1,4-dioxane; water for 3h; Reflux;
In 1,4-dioxane; water for 3h; Reflux;

: 79-19-6
thiosemicarbazide

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 36663-00-0
1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde

: (E)-2-(2-(2-((3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)thiazol-4-yl)phenol

Conditions

Conditions	Yield
With 3,3'-(pentane-1,5-diyl)bis(1,2-dimethyl-1H-imidazol-3-ium) bromide In neat (no solvent) at 20℃; for 1.5h; Green chemistry;	87%

...Expand

: 824-79-3
sodium 4-methylbenzenesulfinate

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 1-(2-hydroxyphenyl)-2-(toluene-4-sulfonyl)ethanone

Conditions

Conditions	Yield
In 1,4-dioxane; water at 25℃; for 3h; Reflux; Inert atmosphere;	86%
In 1,4-dioxane; water for 3h; Reflux;
In 1,4-dioxane; water for 3h; Reflux;

: 106-95-6
allyl bromide

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 1450629-56-7
2-(1-bromo-2-hydroxypent-4-en-2-yl)phenol

Conditions

Conditions	Yield
With indium In tetrahydrofuran; water at 20℃;	85%

: 1639-09-4
heptanethiol

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 2-(heptylthio)-1-(2-hydroxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 0 - 20℃; for 3h; Inert atmosphere;	85%

: 62-55-5
thioacetamide

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 2-(2-methylthiazol-4-yl)phenol

Conditions

Conditions	Yield
In ethanol for 4h; Reflux;	85%

: 18803-44-6
sodium p-chlorothiophenolate

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 113272-14-3
2-(4-chlorophenylthio)-2'-hydroxyacetophenone

Conditions

Conditions	Yield
In 1,4-dioxane; ethanol for 1h; Ambient temperature;	84%

: 1122-58-3
dmap

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 1-[2-(2-hydroxyphenyl)-2-oxoethyl]-4-(dimethylamino)pyridinium bromide

Conditions

Conditions	Yield
In acetone for 0.5h; Heating;	84%

: 10486-08-5
sodium p-thiocresolate

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 108378-94-5
1-(2-Hydroxyphenyl)-2-<(4-methylphenyl)thio>ethanone

Conditions

Conditions	Yield
In 1,4-dioxane; ethanol for 1h; Ambient temperature;	83%
In 1,4-dioxane; ethanol for 1h; Ambient temperature;	83%

: 841-77-0
diphenylmethylpiperazine

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 2-(4-Benzhydryl-piperazin-1-yl)-1-(2-hydroxy-phenyl)-ethanone

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol for 3h; Ambient temperature;	83%

: 38425-47-7
3-phenyl-2-cyclobuten-1-one

: 2491-36-3
2-(2-bromoacetyl)hydroxybenzene

: 4-(bromomethyl)-4-hydroxy-3-(1-phenylvinyl)chroman-2-one

Conditions

Conditions	Yield
With (1R,1'R,2S,2'S)-1,1'-(propane-1,3-diyl)bis(2-((2,6-diisopropylphenyl)carbamoyl)pyrrolidine-1-oxide); scandium tris(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 60℃; for 72h; Molecular sieve; Inert atmosphere; enantioselective reaction;	83%

2-Bromo-2'-hydroxyacetophenone Specification

The Ethanone,2-bromo-1-(2-hydroxyphenyl)-, with the CAS registry number 2491-36-3, is also known as 2-Hydroxyphenacyl bromide. It belongs to the product categories of API intermediates; Aromatics; C7 to C8; Carbonyl Compounds; Ketones. This chemical's molecular formula is C₈H₇BrO₂ and molecular weight is 215.04398. Its IUPAC name is called 2-bromo-1-(2-hydroxyphenyl)ethanone. This chemical's classification code is Skin / Eye Irritant. It is off-white powder.

Physical properties of Ethanone,2-bromo-1-(2-hydroxyphenyl)-: (1)ACD/LogP: 2.49; (2)#H bond acceptors: 2; (3)#H bond donors: 1; (4)#Freely Rotating Bonds: 3; (5)Index of Refraction: 1.608; (6)Molar Refractivity: 45.89 cm³; (7)Molar Volume: 132.5 cm³; (8)Surface Tension: 54.1 dyne/cm; (9)Density: 1.622 g/cm³; (10)Flash Point: 118.3 °C; (11)Enthalpy of Vaporization: 53.09 kJ/mol; (12)Boiling Point: 272.1 °C at 760 mmHg; (13)Vapour Pressure: 0.00373 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may destroy living tissue on contact. It is harmful if swallowed. This chemical can cause burns. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC=C(C(=C1)C(=O)CBr)O
(2)InChI: InChI=1S/C8H7BrO2/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4,10H,5H2
(3)InChIKey: SGPKEYSZPHMVNI-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	821mg/kg (821mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 183, 1992.

Product Name

2-BROMO-2'-HYDROXYACETOPHENONE

Synthetic route

2-Bromo-2'-hydroxyacetophenone Specification

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