2-Bromoaniline supplier | CasNO.615-36-1

Name
2-Bromoaniline
EINECS 210-421-3
CAS No. 615-36-1
Article Data223
CAS DataBase
Density 1.594 g/cm³
Solubility soluble in alcohol and ether, insoluble in water
Melting Point 29 °C
Formula C₆H₆BrN
Boiling Point 227 °C at 760 mmHg
Molecular Weight 172.024
Flash Point 91.1 °C
Transport Information UN 2811 6.1/PG 3
Appearance clear yellow to red-brown liquid after melting
Safety 36/37-45-61-36/37/39-26
Risk Codes 23/24/25-33-52/53-36/37/38-20/21/22
Molecular Structure
Hazard Symbols T, Xn,
Synonyms Aniline,o-bromo- (8CI);2-Amino-1-bromobenzene;2-Bromobenzenamine;2-Bromophenylamine;NSC 7086;o-Aminobromobenzene;o-Bromoaniline;
PSA 26.02000
LogP 2.61250

Synthetic route

: 577-19-5
2-nitrophenyl bromide

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With hydrogen In tetrahydrofuran; water at 120℃; under 22502.3 Torr; for 4h; Autoclave;	99%
With hydrazine In ethanol at 80℃; for 0.333333h; Catalytic behavior; chemoselective reaction;	99.6%
With hydrogen In water at 120℃; under 15001.5 Torr; for 5h; Green chemistry; chemoselective reaction;	99%

: 583-53-9
1,2-dibromobenzene

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With 2-((dicyclohexylphosphino)methyl)-1,3-bis(2,6-diisopropylphenyl)-4,5-dimethyl-1H-imidazol-3-ium iodide; ammonia; palladium diacetate; sodium t-butanolate In 1,4-dioxane at 120℃; under 7500.75 Torr; for 24h; Autoclave; Inert atmosphere;	99%
With 2-(di-tert-butylphosphino)-1-mesityl-4,5-diphenyl-1H-imidazole; ammonia; palladium diacetate; sodium t-butanolate In 1,4-dioxane at 120℃; under 7500.75 Torr; for 24h; Autoclave; Inert atmosphere;	> 99 %Chromat.

: 2593-27-3
2-bromo-N-hydroxybenzamide

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
Stage #1: o-bromo-N-hydroxybenzamide With acetic anhydride; potassium carbonate In dimethyl sulfoxide at 50℃; for 2h; Lossen Rearrangement; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 0℃;	99%
With sodium hydroxide In dimethyl sulfoxide at 80℃; for 1.5h; Lossen rearrangement;
Stage #1: o-bromo-N-hydroxybenzamide With potassium carbonate In dimethyl sulfoxide at 90℃; for 3h; Lossen Rearrangement; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 20℃; for 0.0833333h;

: 577-19-5
2-nitrophenyl bromide

A: 62-53-3
aniline

B: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With hydrazine hydrate In toluene at 20℃; for 3h; Inert atmosphere;	A n/a B 97%
With hydrogenchloride; zinc(II) chloride In benzene Ambient temperature; electrolysis; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With water; zinc at 250℃; for 0.3h; Reduction; Title compound not separated from byproducts;
With 5%-palladium/activated carbon; hydrazine hydrate In methanol at 80℃; for 0.0833333h; Overall yield = 95 %;
With hydrogen In toluene at 110℃; under 7500.75 Torr; for 0.75h; Autoclave;

: 10113-38-9
N-(2-bromophenyl)formamide

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With potassium phosphate; C29H55FeNOP2; hydrogen In tetrahydrofuran at 110℃; under 15001.5 Torr; for 3h; Catalytic behavior;	97%
With sodium hydroxide In ethanol; water at 40℃; Kinetics;

: 3302-39-4
1-azido-2-bromobenzene

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With ammonium hydroxide at 90℃; for 1.25h;	96%
With D-glucose; potassium hydroxide In water at 85℃; for 0.166667h; Green chemistry; chemoselective reaction;	85%
With tributylgermanium hydride; thiophenol In toluene for 0.5h; Heating;	5%

: 15426-16-1
bis-(2-bromo-phenyl)-diazene

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With aminomethyl polystyrene resin formic acid salt; zinc In methanol at 20℃; for 0.25h;	94%
With formic acid; zinc In methanol at 20℃; for 0.116667h;	93%
With ammonium formate; nickel In methanol at 20℃; for 0.116667h;	93%

: 15426-16-1
(E)-1,2-bis(2-bromophenyl)diazene

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With nickel; hydrazinium monoformate In methanol for 0.116667h; Heating;	93%

: 62-53-3
aniline

A: 106-40-1
4-bromo-aniline

B: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With dihydrogen peroxide; potassium bromide In water; acetonitrile	A 87% B 12%
With pyridinium hydrobromide perbromide In tetrahydrofuran for 0.25h; Product distribution; other aromatic amines;	A 84% B n/a
With N-Bromosuccinimide; silver hexafluoroantimonate; 1-methylthiotriptycene In 1,2-dichloro-ethane at 20℃; for 1h; Inert atmosphere; Schlenk technique; Overall yield = 95 percentSpectr.;	A 76% B n/a

: 244205-40-1
(2-bromophenyl)boronic acid

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide; air In methanol at 20℃; for 16h;	87%
With copper(I) oxide; ammonium hydroxide; oxygen; sodium hydroxide In water at 25℃; for 15h;	78%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h;	70%

: 132431-13-1
N-(2-bromophenyl)-O-benzyl carbamate

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; ethanethiol for 36h; Ambient temperature;	85%

: C86H71BrN2O5Si4W

A: 874-90-8
4-methoxybenzonitrile

B: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With water Inert atmosphere;	A 51% B 73%

: 614-76-6
N-acetyl-2-bromoaniline

A: 69083-47-2
2-bromo-N-ethylbenzeneamine

B: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); formic acid; bis(trifluoromethanesulfonyl)amide; triethylamine; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In dibutyl ether at 130℃; for 24h;	A n/a B 73%

: 1164112-16-6
2-(2-bromophenyl)-1,3,2-dioxaborolane

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide; air In methanol at 20℃; for 15h;	71%

: 583-55-1
1-Bromo-2-iodobenzene

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With copper(l) iodide; tetra(n-butyl)ammonium hydroxide; ammonia In water at 45℃; for 48h; Inert atmosphere; Sealed tube; chemoselective reaction;	71%
Stage #1: 1-Bromo-2-iodobenzene With TurboGrignard In tetrahydrofuran at -45℃; for 2h; Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; toluene at -45℃; for 2h; Inert atmosphere;	29%

: 2039-88-5
2-bromostyrene

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With methanesulfonic acid; trimethylsilylazide In tetrachloromethane at 80℃; for 4h;	70%

: 62-53-3
aniline

A: 591-19-5
3-bromoaniline

B: 106-40-1
4-bromo-aniline

C: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With bromine; hydrogen fluoride; antomony(V) at -40℃; for 0.25h;	A 29% B 62% C 3%
With bromine; hydrogen fluoride; antomony(V) at -40℃; for 0.25h; Mechanism; Product distribution; dependence of product distribution on ammount of catalyst;

...Expand

: 6674-22-2
1,8-diazabicyclo[5.4.0]undec-7-ene

: 25216-70-0
2-bromophenyl carbamic acid methyl ester

air: air

A: 615-36-1
2-bromoaniline

B: bicarbonate salt of 1,8-diazabicyclo[5.4.0]undec-7-ene

Conditions

Conditions	Yield
In 1,4-dioxane; water at 80℃; under 760.051 Torr; for 2h;	A 61% B 53%

...Expand

: 613-29-6
N-Dibutylaniline

A: 3-(N,N-dibutylaminophenyl)-acrolein

B: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
	A 60% B n/a

: 915920-68-2
2-(2-bromophenoxy)propanamide

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 140℃; for 4h; Green chemistry;	60%

: 64-17-5
ethanol

: 577-19-5
2-nitrophenyl bromide

A: 90944-48-2
2-bromo-N,N-diethylaniline

B: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With Au NCs/TiO2 for 4h; Kinetics; Reagent/catalyst; Inert atmosphere; UV-irradiation;	A 24.2% B 52.8%

...Expand

: 62-53-3
aniline

: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With dihydrogen peroxide; copper diacetate; potassium bromide In water at 20℃; for 2h; Concentration; Reagent/catalyst;	50%
With D-glucose; Escherichia coli flavin reductase; Bacillus megaterium glucose dehydrogenase; Lechevalieria aerocolonigenes tryptophan-7-halogenase; flavin adenine dinucleotide; NADH In aq. phosphate buffer; isopropyl alcohol pH=7.4; Enzymatic reaction;
With hydrogen bromide; dimethyl sulfoxide In water; ethyl acetate at 60℃; for 12h;
With N-Bromosuccinimide In dichloromethane

: 82127-40-0
E-Ethyl ester of 4-methyl-4,5-epoxy-2-pentenoic acid

: 104669-28-5
(2-Bromo-phenyl)-[1-phenyl-meth-(E)-ylidene]-amine

A: ethyl-(3Z)-2-[[(2-bromophenyl)amino](phenyl)methyl]-4-methyl-5-oxopent-3-enoate

B: ethyl-(3E)-2-[[(2-bromophenyl)amino](phenyl)methyl]-4-methyl-5-oxopent-3-enoate

C: 100-52-7
benzaldehyde

D: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
scandium tris(trifluoromethanesulfonate) In tetrahydrofuran at 0℃; Title compound not separated from byproducts;	A n/a B 48% C n/a D n/a

...Expand

: 108-86-1
bromobenzene

A: 106-40-1
4-bromo-aniline

B: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With O-(4-nitrobenzoyl)hydroxylammonium trifluoromethanesulfonate; iron(II) bromide; silver(I) triflimide In 2,2,2-trifluoroethanol; water at 30℃; for 2h;	A 40.2% B 26.8%

: 6165-68-0
thiophene boronic acid

: 3302-39-4
1-azido-2-bromobenzene

A: 545442-25-9
2-(2-azidephenyl)thiophene

B: 62532-99-4
2-(thiophen-2-yl)aniline

C: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane at 100℃; for 6h; Suzuki-Miyaura cross-coupling reaction;	A 40% B 3% C 2%

...Expand

: 108-86-1
bromobenzene

A: 591-19-5
3-bromoaniline

B: 106-40-1
4-bromo-aniline

C: 615-36-1
2-bromoaniline

Conditions

Conditions	Yield
With tris-(2-chloro-ethyl)-amine; trifluorormethanesulfonic acid; trifluoroacetic acid In chloroform at 60℃; for 3h;	A 10% B 25% C 30%
With hydroxylamine-O-sulfonic acid; iron(II) sulfate In water; acetic acid at 40℃; for 2h; Yield given. Yields of byproduct given;
With hydroxylamine-O-sulfonic acid; iron(II) sulfate In water; acetic acid at 40℃; for 2h; Product distribution; Mechanism; k(C6H5Br)/k(C6H6);

...Expand

: 98-88-4
benzoyl chloride

: 615-36-1
2-bromoaniline

: 70787-27-8
N-(2-bromophenyl)benzamide

Conditions

Conditions	Yield
With 1,10-Phenanthroline In acetonitrile at 90℃; for 1h; Temperature; Inert atmosphere; Sealed tube;	100%
In tetrahydrofuran at 20℃; for 24h;	99%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	99%

: 103-72-0
phenyl isothiocyanate

: 615-36-1
2-bromoaniline

: 25688-29-3
1-(2-bromophenyl)-3-phenylthiourea

Conditions

Conditions	Yield
In ethanol at 20℃; for 2h;	100%
In N,N-dimethyl-formamide Heating;	99%
With C64H52CaN6 In neat (no solvent) at 60℃; for 12h; Schlenk technique; Glovebox; Inert atmosphere;	85%

: 615-36-1
2-bromoaniline

: 1548-13-6
p-trifluoromethyl-phenylisocyanate

: 23742-77-0
1-(2-bromophenyl)-3-(4-(trifluoromethyl)phenyl)urea

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h; Inert atmosphere;	100%
In acetonitrile

: 3282-30-2
pivaloyl chloride

: 615-36-1
2-bromoaniline

: 65854-92-4
N-(2-bromophenyl)-2,2-dimethylpropanamide

Conditions

Conditions	Yield
In ethyl acetate at 85℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 16h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;	98%

: 100-39-0
benzyl bromide

: 615-36-1
2-bromoaniline

: 71687-81-5
N-benzyl-2-bromoaniline

Conditions

Conditions	Yield
Stage #1: 2-bromoaniline With n-butyllithium In tetrahydrofuran; hexane at -40℃; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; hexane at -60 - 20℃; Inert atmosphere;	100%
Stage #1: 2-bromoaniline With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: benzyl bromide In tetrahydrofuran; hexane at -78 - 20℃; Further stages.;	95%
Stage #1: 2-bromoaniline With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; Schlenk technique; Stage #2: benzyl bromide In tetrahydrofuran; hexane at 20℃; for 10h; Inert atmosphere; Schlenk technique;	90%

: 108-24-7
acetic anhydride

: 615-36-1
2-bromoaniline

: 614-76-6
N-acetyl-2-bromoaniline

Conditions

Conditions	Yield
for 0.5h; Heating;	100%
at 70℃; for 20h;	100%
With dmap In chloroform for 0.5h; Reflux;	100%

: 108-31-6
maleic anhydride

: 615-36-1
2-bromoaniline

: (Z)-3-(2-Bromo-phenylcarbamoyl)-acrylic acid

Conditions

Conditions	Yield
In diethyl ether Ring cleavage; Substitution;	100%
In diethyl ether at 20℃;

: 7677-24-9
trimethylsilyl cyanide

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 615-36-1
2-bromoaniline

: 240486-10-6
ethyl 4-(2-bromophenylamino)-4-cyano-1-piperidinecarboxylate

Conditions

Conditions	Yield
Stage #1: trimethylsilyl cyanide; N-ethoxycarbonyl-4-piperidone; 2-bromoaniline With acetic acid for 40h; Stage #2: With ammonia In water	100%
In acetic acid at 20℃; for 112h; Condensation; modified Strecker reaction;	94%

...Expand

: 40400-15-5
2-(2-iodophenyl)acetonitrile

: 615-36-1
2-bromoaniline

: 325141-76-2
2-{2'-amino-[1,1'-biphenyl]-2-yl}acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-bromoaniline With Pinacolborane; triethylamine; CyJohnPhos; palladium diacetate In 1,4-dioxane at 80℃; Stage #2: 2-(2-iodophenyl)acetonitrile With barium dihydroxide In 1,4-dioxane at 100℃; Suzuki-Miyaura coupling; Further stages.;	100%
Stage #1: 2-bromoaniline With palladium diacetate; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; CyJohnPhos In 1,4-dioxane at 25 - 80℃; Inert atmosphere; Stage #2: 2-(2-iodophenyl)acetonitrile With barium hydroxide octahydrate In 1,4-dioxane; water at 100℃; for 1h; Inert atmosphere;	99%
Stage #1: 2-bromoaniline With palladium diacetate; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; CyJohnPhos In 1,4-dioxane at 25 - 80℃; for 1h; Inert atmosphere; Stage #2: 2-(2-iodophenyl)acetonitrile With barium hydroxide octahydrate In 1,4-dioxane at 100℃; for 1h;	99%
Stage #1: 2-bromoaniline With palladium diacetate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; CyJohnPhos In 1,4-dioxane at 80℃; for 1h; Stage #2: 2-(2-iodophenyl)acetonitrile With barium dihydroxide In 1,4-dioxane; water at 100℃; for 1h; Suzuki coupling; Further stages.;	79%
Stage #1: 2-bromoaniline With palladium diacetate; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; CyJohnPhos In 1,4-dioxane at 80℃; Stage #2: 2-(2-iodophenyl)acetonitrile With barium hydroxide octahydrate In 1,4-dioxane; water at 100℃; Suzuki Coupling;	77%

: 615-36-1
2-bromoaniline

: 13831-31-7
Acetoxyacetyl chloride

: 901335-15-7
acetic acid (2-bromo-phenylcarbamoyl)-methyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane for 2h;	100%
With pyridine In dichloromethane at 20℃; for 2h;

: 591-50-4
iodobenzene

: 615-36-1
2-bromoaniline

: 61613-22-7
2-bromodiphenylamine

Conditions

Conditions	Yield
With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium diacetate In 1,4-dioxane at 110℃; for 16h;	100%
With potassium hydroxide In neat (no solvent) at 90℃; for 7.5h;	60%
With tris(dibenzylideneacetone)dipalladium (0); sodium t-butanolate In 1,4-dioxane at 45℃;

: 32161-06-1
1-acetyl-4-piperidinone

: 615-36-1
2-bromoaniline

: 919118-89-1
1-(4-(2-bromophenylamino)piperidin-1-yl)ethanone

Conditions

Conditions	Yield
Stage #1: 1-acetyl-4-piperidinone; 2-bromoaniline With sodium tris(acetoxy)borohydride; acetic acid In toluene at 120℃; for 0.25h; Microwave irradiation; Stage #2: With water; sodium hydrogencarbonate In toluene	100%

: 1765-93-1
4-fluoroboronic acid

: 615-36-1
2-bromoaniline

: 321-63-1
4'-fluoro-biphenyl-2-ylamine

Conditions

Conditions	Yield
Stage #1: 4-fluoroboronic acid; 2-bromoaniline With potassium carbonate In 1,4-dioxane; water for 0.333333h; Inert atmosphere; Stage #2: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 100℃;	100%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane at 100℃; for 3h; Suzuki Coupling;	94%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane at 100℃; for 3h;	94%

: 615-36-1
2-bromoaniline

: 19519-75-6
1-bromo-2-nitrosobenzene

Conditions

Conditions	Yield
With potassium peroxomonosulphate In dichloromethane; water at 20℃; Inert atmosphere;	100%
With Oxone In dichloromethane; water at 20℃; Inert atmosphere;	99%
With Oxone In dichloromethane; water at 20℃; for 20h; Inert atmosphere;	98%

: 102-92-1
cinnamoyl chloride

: 615-36-1
2-bromoaniline

: 71910-51-5
N-(2-bromophenyl)-3-phenylacrylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Inert atmosphere;	100%
With pyridine In dichloromethane at 0 - 20℃;	98%
With pyridine In dichloromethane at 0 - 20℃;	98%

: 14900-39-1
phenylvinylboronic acid

: 615-36-1
2-bromoaniline

: 64097-92-3
2-(1-phenylvinyl)aniline

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene for 24h; Reflux;	100%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 100℃; for 24h; Suzuki Coupling; Inert atmosphere;	85%

: 6165-68-0
thiophene boronic acid

: 615-36-1
2-bromoaniline

: 62532-99-4
2-(thiophen-2-yl)aniline

Conditions

Conditions	Yield
With C11H8Cl4N2O3Pd; tetrabutylammomium bromide; potassium carbonate In methanol; water; N,N-dimethyl-formamide at 100℃; for 0.166667h; Suzuki Coupling;	100%
With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate In chloroform; water at 80 - 100℃; for 0.166667h; Suzuki Coupling;	99%
With 2-[5-(4-methylphenyl)isoxazol-3-yl]-5-(5-phenylisoxazol-3-yl)-1,3,4-oxadiazole·2PdCl2; tetrabutylammomium bromide; potassium carbonate In water; N,N-dimethyl-formamide at 100℃; for 0.0166667h; Suzuki Coupling;	98%

: 100-39-0
benzyl bromide

: 615-36-1
2-bromoaniline

: 1075193-04-2
N,N-dibenzyl-2-bromoaniline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 48h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 48h; Inert atmosphere;	100%
Stage #1: 2-bromoaniline With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 0.25h; Stage #2: benzyl bromide In tetrahydrofuran for 0.25h; Further stages;	83%
With N-ethyl-N,N-diisopropylamine In toluene for 24h; Reflux;
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 120℃; for 24h;	82 %Spectr.

: 32315-10-9
bis(trichloromethyl) carbonate

: 615-36-1
2-bromoaniline

: 1592-00-3
2-bromophenyl isocyanate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
Stage #1: bis(trichloromethyl) carbonate; 2-bromoaniline In dichloromethane at 20℃; for 0.5h; Stage #2: With triethylamine In dichloromethane at -35 - 20℃; for 2h;	81%
With triethylamine In toluene for 7h; Reflux; Cooling with ice;	65.6%

: 1711-09-7
3-bromobenzoyl chloride

: 615-36-1
2-bromoaniline

: 99586-31-9
2‐(3‐bromophenyl)benzo[d]oxazole

Conditions

Conditions	Yield
With caesium carbonate; copper(l) iodide; 1,10-Phenanthroline In 1,4-dioxane at 120℃; for 24h; Product distribution / selectivity; Inert atmosphere;	100%
With caesium carbonate; copper(l) iodide; 1,10-Phenanthroline In 1,4-dioxane at 120℃; for 8h;	76%

: 150-19-6
O-methylresorcine

: 615-36-1
2-bromoaniline

: C21H20N3O2Pol

Conditions

Conditions	Yield
With pyridine; copper(I) bromide dimethylsulfide complex; sodium carbonate In acetonitrile at 75℃; for 48h; Inert atmosphere; solid phase reaction;	100%

: 1192-58-1
N-methylpyrrole aldehyde

: 615-36-1
2-bromoaniline

: 2-bromo-N-[(1-methyl-1H-pyrrol-2-yl)methylene]aniline

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 36h; Dean-Stark; Reflux; Inert atmosphere;	100%

: 104-49-4
1,4-diisocyanatobenzene

: 615-36-1
2-bromoaniline

: C20H16Br2N4O2

Conditions

Conditions	Yield
With triethylamine In toluene at 20℃; for 19h;	100%

: 292638-84-7
styrene

: 615-36-1
2-bromoaniline

: 27652-35-3
(E)-2-styrylaniline

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine at 125℃;	99%
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine at 125℃;	88%
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine at 125℃;	88%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 615-36-1
2-bromoaniline

: 136340-96-0
thiophene-2-carboxylic acid (2-bromophenyl)amide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 24h;	99%
In tetrahydrofuran at 20℃; for 24h;	96%
With triethylamine In dichloromethane at 0 - 20℃;	84%
In toluene
With triethylamine In dichloromethane at 20℃; for 3h;

: 102-92-1
Cinnamoyl chloride

: 615-36-1
2-bromoaniline

: 71910-51-5
E-N-(2-bromophenyl)-3-phenylpropenamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 24h;	99%
With potassium carbonate In water; acetone at 0℃; for 2h;	97%
With potassium carbonate In water; acetone at 0℃; for 2h;	92%

: 615-36-1
2-bromoaniline

: 407-25-0
trifluoroacetic anhydride

: 2727-71-1
N-(2-bromophenyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With sodium carbonate In diethyl ether for 24h; Ambient temperature;	99%
With triethylamine In dichloromethane at 0 - 20℃;	89%
With triethylamine In dichloromethane at 0 - 20℃;	89%

: 10400-19-8
3-pyridinecarbonyl chloride

: 615-36-1
2-bromoaniline

: 75075-29-5
N-(2-bromophenyl)-3-pyridinecarboxamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 24h;	99%
With pyridine at 0 - 20℃; Acylation;
With N,N-diethyl-N-isopropylamine In acetonitrile at 60℃; for 24h; Inert atmosphere; Schlenk technique;

: 3859-41-4
1,3-cyclopentadione

: 615-36-1
2-bromoaniline

: 3-[(2-bromophenyl)amino]cyclopent-2-en-1-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	99%
at 120℃;	70%

2-Bromoaniline Specification

The IUPAC name of this chemical is 2-bromoaniline. With the CAS registry number 615-36-1, it is also named as Benzenamine, 2-bromo-. The product's categories are Amines; Blocks; Bromides; Anilines, Aromatic Amines and Nitro Compounds; Miscellaneous; Anilines, Amides & Amines; Bromine Compounds; C2 to C6; Nitrogen Compounds. It is clear yellow to red-brown liquid after melting which is soluble in alcohol and ether, insoluble in water. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.19; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.19; (4)ACD/LogD (pH 7.4): 2.19; (5)#H bond acceptors: 1; (6)#H bond donors: 2; (7)#Freely Rotating Bonds: 1; (8)Index of Refraction: 1.625; (9)Molar Refractivity: 38.17 cm³; (10)Molar Volume: 107.8 cm³; (11)Polarizability: 15.13×10^-24 cm³; (12)Surface Tension: 47.7 dyne/cm; (13)Enthalpy of Vaporization: 46.35 kJ/mol; (14)Vapour Pressure: 0.0795 mmHg at 25°C; (15)Exact Mass: 170.968362; (16)MonoIsotopic Mass: 170.968362; (17)Topological Polar Surface Area: 26; (18)Heavy Atom Count: 8; (19)Complexity: 74.9.

Preparation of 2-Bromoaniline: It can be obtained by nitrophenylamine with diazotization, bromination and deoxidation.

Uses of 2-Bromoaniline: It is used as intermediate in organic synthesis. For example: it can react with benzoyl chloride to get benzoic acid-(2-bromo-anilide). This reaction needs reagent N,N-Dimethylaniline at temperature of 100 °C. The reaction time is 45 min. The yield is 95%.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. And it is also harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) Avoid release to the environment. Refer to special instructions / safety data sheets.

People can use the following data to convert to the molecule structure.
1. SMILES:Nc1ccccc1Br
2. InChI:InChI=1/C6H6BrN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
3. InChIKey:AOPBDRUWRLBSDB-UHFFFAOYAG

Product Name

2-Bromoaniline

Synthetic route

2-Bromoaniline Specification

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