2-Chloroethylamine hydrochloride supplier

Name
2-Chloroethylamine hydrochloride
EINECS 212-793-2
CAS No. 870-24-6
Article Data24
CAS DataBase
Density 1.038 g/cm3
Solubility Soluble in water
Melting Point 140-150 °C(lit.)
Formula C₂H₇Cl₂N
Boiling Point 108.9 °C at 760 mmHg
Molecular Weight 115.99
Flash Point 19.7 °C
Transport Information UN 3261
Appearance white to light beige crystalline powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Ethanamine,2-chloro-, hydrochloride (9CI);Ethylamine, 2-chloro-, hydrochloride(6CI,7CI,8CI);1-Amino-2-chloroethane hydrochloride;2-Aminoethyl chloridehydrochloride;2-Chloroethylamine monohydrochloride;b-Chloroethylaminehydrochloride;2-Chloroethylamino Hydrochloride;
PSA 26.02000
LogP 1.68620

Synthetic route

: 2002-24-6
2-amino-ethanol hydrochloride

: 870-24-6
2-chloroethanamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform for 5h; Heating;	100%
With thionyl chloride In N-methyl-acetamide; water; benzene	98%
With thionyl chloride In toluene at 75℃; for 3h; Temperature; Concentration;	95%

: 7719-09-7
thionyl chloride

: 2002-24-6
2-amino-ethanol hydrochloride

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 870-24-6
2-chloroethanamine hydrochloride

Conditions

Conditions	Yield
In benzene	97%

...Expand

: 141-43-5
ethanolamine

: 870-24-6
2-chloroethanamine hydrochloride

Conditions

Conditions	Yield
Stage #1: ethanolamine With hydrogenchloride; sodium hydroxide In water at 20℃; for 0.75h; Stage #2: With hydrogenchloride; Adipic acid In water at 120℃; for 4h; Temperature; Reagent/catalyst;	92.2%
With hydrogenchloride; thionyl chloride 1) 0 deg C then toluene, azeotropic dist., 2) 85 deg C, 1 h; Yield given. Multistep reaction;
With thionyl chloride In chloroform for 0.5h; Reflux;
With thionyl chloride In chloroform Reflux; Cooling with ice;

: 151-56-4
ethyleneimine

: 870-24-6
2-chloroethanamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 3891-07-4
N-(2-Hydroxyethyl)phthalimide

: 870-24-6
2-chloroethanamine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 180 - 200℃;

: 870-24-6
2-chloroethanamine hydrochloride

: 689-98-5
chloroethylamine

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 5℃; for 1.5h; Inert atmosphere;	100%
With triethylamine In acetonitrile at 5℃; for 1h; Inert atmosphere;	100%
With sodium hydroxide In chloroform at 0℃;

: 24424-99-5
di-tert-butyl dicarbonate

: 870-24-6
2-chloroethanamine hydrochloride

: 71999-74-1
tert-butyl N-(2-chloroethyl)carbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at -10 - 25℃; for 24.5h; Inert atmosphere;	100%
With triethylamine In dichloromethane for 72h;	99%
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;	99%

: 2552-45-6
methyl 4-chloro-3,5-dinitrobenzoate

: 870-24-6
2-chloroethanamine hydrochloride

: 110991-77-0
methyl 4-((2-chloroethyl)amino)-3,5-dinitrobenzoate

Conditions

Conditions	Yield
With triethylamine In methanol for 0.0833333h; Heating / reflux;	100%
With triethylamine In ethanol Reflux;	86%
With triethylamine In methanol at 80℃; for 1h;

: 870-24-6
2-chloroethanamine hydrochloride

: 24801-88-5
3-(triethoxypropyl) isocyanate

: 10387-40-3
potassium thioacetate

: C14H30N2O5SSi

Conditions

Conditions	Yield
Stage #1: 2-chloroethanamine hydrochloride; 3-(triethoxypropyl) isocyanate With sodium ethanolate In ethanol at -78 - -65℃; for 3h; Stage #2: potassium thioacetate In ethanol at 50℃; for 4h; Reflux;	100%

...Expand

: 870-24-6
2-chloroethanamine hydrochloride

: 60-34-4
methylhydrazine

: 14478-62-7
2-(1-methylhydrazinyl)ethan-1-amine

Conditions

Conditions	Yield
In neat liquid at 20℃; for 18h; Inert atmosphere;	100%

: 870-24-6
2-chloroethanamine hydrochloride

: 96-53-7
2-mercaptothiazoline

: 2-(2-aminoethylthio)-thiazoline dihydrochloride powder

Conditions

Conditions	Yield
In benzene	99.7%

: 870-24-6
2-chloroethanamine hydrochloride

: 2351-37-3
4,4'-biphenyldicarboxylic acid dichloride

: 1404167-15-2
N,N'-bis(2-chloroethyl)biphenyl-4,4'-dicarboxamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water	99.5%

: 870-24-6
2-chloroethanamine hydrochloride

: 60-24-2
2-hydroxyethanethiol

: 24304-84-5
2-[(2-aminoethyl)thio]ethanol

Conditions

Conditions	Yield
With sodium hydroxide In water at 50℃; for 1.5h; Reagent/catalyst; Solvent;	99.5%
at 55℃; for 4h; pH=4.8;
at 55℃; for 4h; pH=4.8; pH-value;

: 32315-10-9
bis(trichloromethyl) carbonate

: N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-2-fluorobenzyl)aniline

: 870-24-6
2-chloroethanamine hydrochloride

: 3-(2-chloroethyl)-1-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-2-fluorobenzyl)-1-phenylurea

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; N-(4-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-2-fluorobenzyl)aniline With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h; Stage #2: 2-chloroethanamine hydrochloride In dichloromethane at 20℃; for 18h;	99.1%

...Expand

: 178822-03-2
C17H19N6(1+)

: 870-24-6
2-chloroethanamine hydrochloride

: 1174012-59-9
C19H20ClN6O(1+)

Conditions

Conditions	Yield
In acetonitrile at 20℃;	99%

: 1185019-02-6
C14H15ClFNO3

: 870-24-6
2-chloroethanamine hydrochloride

: 1258458-27-3
ethyl 3-[(2-chloroethyl)amino]-2-(2-chloro-4-fluorobenzoyl)prop-2-enoate

Conditions

Conditions	Yield
In diethyl ether; ethanol at 20℃; for 12h;	99%

: 870-24-6
2-chloroethanamine hydrochloride

: 18171-19-2
3-chloropropylmethyldimethoxysilane

: C8H20ClNO2Si

Conditions

Conditions	Yield
Stage #1: 2-chloroethanamine hydrochloride With ammonium hydroxide for 2.5h; Cooling with ice; Stage #2: 3-chloropropylmethyldimethoxysilane In dimethyl sulfoxide at 120℃; for 12h; Inert atmosphere;	99%

: 18171-14-7
γ-chloropropyldimethylmethoxysilane

: 870-24-6
2-chloroethanamine hydrochloride

: C8H20ClNOSi

Conditions

Conditions	Yield
Stage #1: 2-chloroethanamine hydrochloride With potassium carbonate for 2h; Cooling with ice; Stage #2: γ-chloropropylmethoxydimethylsilane In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	99%

: 5089-70-3
(3-chloropropyl)triethoxysilane

: 870-24-6
2-chloroethanamine hydrochloride

: C11H26ClNO3Si

Conditions

Conditions	Yield
Stage #1: 2-chloroethanamine hydrochloride With potassium hydroxide for 1h; Cooling with ice; Stage #2: (3-chloropropyl)triethoxysilane In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	99%

: 870-24-6
2-chloroethanamine hydrochloride

: 98-86-2
acetophenone

: 40371-21-9
N-(2-Chloraethyl)-N-(2-hydroxy-2-phenylaethyl)-amin

Conditions

Conditions	Yield
Stage #1: acetophenone With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 1h; Stage #2: 2-chloroethanamine hydrochloride In N,N-dimethyl-formamide at 100℃; for 6h; Reagent/catalyst; Temperature; Solvent;	99%

: 33512-03-7
3-(4-chlorophenyl)oxirane-2,2-dicarbonitrile

: 870-24-6
2-chloroethanamine hydrochloride

: 103807-61-0
2-Chloro-N-(2-chloro-ethyl)-2-(4-chloro-phenyl)-acetamide

Conditions

Conditions	Yield
In acetonitrile for 1h; Heating;	98%

: 870-24-6
2-chloroethanamine hydrochloride

: 100-52-7
benzaldehyde

: 1026774-15-1
(E)-N-(phenylmethylidene)-2-chloroethylamine

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In dichloromethane for 0.5h; Heating;	98%
With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 1h;	90%

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 870-24-6
2-chloroethanamine hydrochloride

: 59320-29-5
4-(2-chloroethylamino)-3-nitro-benzoic acid methyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 15h;	98%

: 696-63-9
4-Methoxybenzenethiol

: 870-24-6
2-chloroethanamine hydrochloride

: 36155-36-9
2-<(4-methoxyphenyl)thio>-1-aminoethane

Conditions

Conditions	Yield
With potassium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran Reflux;	97%
With potassium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran Inert atmosphere;	97%
With potassium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran Inert atmosphere; Reflux;	97%
With potassium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 16h; Inert atmosphere; Reflux;	95%
With potassium carbonate In chloroform at 50℃; Sealed vial;	89%

: 870-24-6
2-chloroethanamine hydrochloride

: 24801-88-5
3-(triethoxypropyl) isocyanate

: (EtO)3Si-CH2CH2CH2-NH-CO-NH-CH2CH2-Cl

Conditions

Conditions	Yield
With sodium ethoxide In ethanol at -78 - 50℃; for 3h;	96.9%
With sodium ethanolate In ethanol

: 4530-20-5
BOC-glycine

: 870-24-6
2-chloroethanamine hydrochloride

: 116394-15-1
N-tert-butyloxycarbonyl-glycine-2'-chloroethylamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine 1.) 0 deg C, 2 h, 2.) r. t., 20 h; other 1-amino-2-halogenoethane;	96%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane 1.) 0 deg C, 2 h, 2.) r. t., 20 h;	96%
Stage #1: BOC-glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0℃; for 0.333333h; Stage #2: 2-chloroethanamine hydrochloride In dichloromethane at 0 - 20℃; for 6h;	70%

: 33512-02-6
3-phenyl-2,2-oxiranedicarbonitrile

: 870-24-6
2-chloroethanamine hydrochloride

: 103807-63-2
2-Chloro-N-(2-chloro-ethyl)-2-phenyl-acetamide

Conditions

Conditions	Yield
In acetonitrile for 1h; Heating;	96%

: 870-24-6
2-chloroethanamine hydrochloride

: 2524-64-3
chlorophosphoric acid diphenyl ester

: (2-Chloro-ethyl)-phosphoramidic acid diphenyl ester

Conditions

Conditions	Yield
In diethyl ether for 5h; Heating;	96%

: 870-24-6
2-chloroethanamine hydrochloride

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 910317-13-4
(E)-2-chloro-N-(((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)methylidene)ethylamine

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 1h;	96%

: 870-24-6
2-chloroethanamine hydrochloride

: 100-53-8
phenylmethanethiol

: 1007-54-1
2-benzylsulfanyl-ethylamine

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 4h; Reflux; Inert atmosphere;	96%
With sodium In ethanol for 24h; Friedel-Crafts Alkylation; Reflux;	85%

2-Chloroethylamine hydrochloride Chemical Properties

Molecular Structure of 2-chloroethanamine hydrochloride (CAS NO.870-24-6):

IUPAC Name: 2-chloroethanamine hydrochloride
Empirical Formula: C₂H₆ClN
Molecular Weight: 79.5287
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 3.24 Å²
Index of Refraction: 1.427
Molar Refractivity: 19.69 cm³
Molar Volume: 76.6 cm³
Surface Tension: 29.9 dyne/cm
Density: 1.038 g/cm³
Flash Point: 19.7 °C
Enthalpy of Vaporization: 34.77 kJ/mol
Boiling Point: 108.9 °C at 760 mmHg
Vapour Pressure: 25.3 mmHg at 25°C
CAS Registry Number: 870-24-6
EINECS: 212-793-2
Melting point: 140-150 ^oC
Water solubility: Soluble
Sensitive: Hygroscopic
InChI
InChI=1/C2H6ClN.ClH/c3-1-2-4;/h1-2,4H2;1H
Smiles
C(C[NH3+])Cl.[ClH-]
Product Categories: omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; omega-Haloalkylamines

2-Chloroethylamine hydrochloride Toxicity Data With Reference

1.	mmo-sat 8600 µmol/L	ENMUDM Environmental Mutagenesis. 3 (1981),11.
2.	mmo-esc 8600 µmol/L	ENMUDM Environmental Mutagenesis. 3 (1981),11.
3.	dns-rat:lvr 100 µmol/L	ENMUDM Environmental Mutagenesis. 3 (1981),11.
4.	ipr-mus LD50:2204 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 94 (1948),249.

2-Chloroethylamine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

2-Chloroethylamine hydrochloride Safety Profile

Moderately toxic by intraperitoneal route. Mutation data reported. Explosive reaction with concentrated alkali above 50°C. When heated to decomposition it emits toxic fumes of Cl⁻, NH₃, and NO_x.
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN3261
WGK Germany: 3
RTECS: KR1800000
F: 3-10-34
HazardClass: 8
PackingGroup: III
HS Code: 29211980

2-Chloroethylamine hydrochloride Specification

2-Chloroethylamine hydrochloride , with CAS number of 870-24-6, can be called Ethanamine,2-chloro-, hydrochloride (9CI) ; 1-Amino-2-chloroethane hydrochloride ; 2-Aminoethyl chloridehydrochloride ; 2-Chloroethylamine hydrochloride ; 2-Chloroethylamine monohydrochloride . It is a white to light beige crystalline powder.

Product Name

2-Chloroethylamine hydrochloride

Synthetic route

2-Chloroethylamine hydrochloride Chemical Properties

2-Chloroethylamine hydrochloride Toxicity Data With Reference

2-Chloroethylamine hydrochloride Consensus Reports

2-Chloroethylamine hydrochloride Safety Profile

2-Chloroethylamine hydrochloride Specification

Related Products

Hot Products