Product Name

  • Name

    2-Chlorophenylacetic acid

  • EINECS 219-482-0
  • CAS No. 2444-36-2
  • Article Data47
  • CAS DataBase
  • Density 1.324 g/cm3
  • Solubility
  • Melting Point 92-95 °C(lit.)
  • Formula C8H7ClO2
  • Boiling Point 294.1 °C at 760 mmHg
  • Molecular Weight 170.595
  • Flash Point 131.7 °C
  • Transport Information
  • Appearance White to light yellow powder
  • Safety 26-36/37-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 2444-36-2 (2-Chlorophenylacetic acid)
  • Hazard Symbols IrritantXi
  • Synonyms Aceticacid, (o-chlorophenyl)- (7CI,8CI);(2-Chlorophenyl)acetic acid;(o-Chlorophenyl)acetic acid;2-(o-Chlorophenyl)ethanoic acid;NSC 4613;O-chlorophenylacetic acid;
  • PSA 37.30000
  • LogP 1.96710

Synthetic route

2-(2-chloro-phenyl)-1-pyrrolidin-1-yl-ethanone
512787-31-4

2-(2-chloro-phenyl)-1-pyrrolidin-1-yl-ethanone

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 38h; Heating;98%
2-chlorophenylacetic acid ethyl ester
40061-54-9

2-chlorophenylacetic acid ethyl ester

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14;94%
1-chloro-2-(chloromethyl)benzene
611-19-8

1-chloro-2-(chloromethyl)benzene

butan-1-ol
71-36-3

butan-1-ol

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
Stage #1: butan-1-ol With cobalt(II) acetate; cobalt(II) nitrate at 40℃; under 3750.38 Torr; for 2h; Autoclave;
Stage #2: 1-chloro-2-(chloromethyl)benzene With sodium hydroxide In water at 40℃; under 2250.23 Torr; for 12h; Concentration; Pressure; Temperature; Autoclave;
93.7%
carbon dioxide
124-38-9

carbon dioxide

1-chloro-2-(chloromethyl)benzene
611-19-8

1-chloro-2-(chloromethyl)benzene

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; manganese; palladium diacetate; magnesium chloride In N,N-dimethyl-formamide under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;92%
With (1,2-dimethoxyethane)dichloronickel(II); C15H27P*(x)BF4*H(1+); magnesium chloride; zinc In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; Schlenk technique;62%
With samarium; chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; under 760.051 Torr; for 2h; Electrochemical reaction; Cooling with ice;42%
Stage #1: 1-chloro-2-(chloromethyl)benzene With magnesium; lithium chloride; zinc(II) chloride In tetrahydrofuran at 25℃; for 1h;
Stage #2: carbon dioxide In tetrahydrofuran at 50℃; for 12h;
272 mg
C15H14ClNO4S

C15H14ClNO4S

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With sodium tetrahydroborate; trifluoroacetic acid In dichloromethane at 15 - 25℃;92%
carbon monoxide
201230-82-2

carbon monoxide

1-bromomethyl-2-chlorobenzene
611-17-6

1-bromomethyl-2-chlorobenzene

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Autoclave;92%
With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave;70%
carbon monoxide
201230-82-2

carbon monoxide

1-chloro-2-(chloromethyl)benzene
611-19-8

1-chloro-2-(chloromethyl)benzene

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry;
Stage #2: 1-chloro-2-(chloromethyl)benzene With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;
88%
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Reagent/catalyst; Autoclave;88%
With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; under 11251.1 Torr; for 20h; Autoclave; regioselective reaction;85%
With sodium hydroxide; cerium(III) chloride; cetyltrimethylammonim bromide; nickel cyanide In toluene at 85 - 95℃; under 1 Torr; for 6.5h;76%
With water; palladium diacetate at 110℃; under 37503.8 Torr; for 4h; Ionic liquid;96 %Chromat.
carbon dioxide
124-38-9

carbon dioxide

2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1365565-86-1

2-(2-chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With potassium ethoxide In 1,4-dioxane at 100℃; for 24h;57%
formic acid
64-18-6

formic acid

1-chloro-2-(chloromethyl)benzene
611-19-8

1-chloro-2-(chloromethyl)benzene

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium diacetate In N,N-dimethyl-formamide at 115℃; for 24h; Inert atmosphere;50%
1-Phenylethanol
98-85-1, 13323-81-4

1-Phenylethanol

2-(2-chlorophenyl)acetyl chloride
51512-09-5

2-(2-chlorophenyl)acetyl chloride

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
In diethyl ether47%
carbon monoxide
201230-82-2

carbon monoxide

2-chlorobenzal bromide
67013-54-1

2-chlorobenzal bromide

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With potassium hydroxide; dicobalt octacarbonyl; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 12h; Ambient temperature;34%
1-methyl-4-nitrosobenzene
623-11-0

1-methyl-4-nitrosobenzene

2-(2-chloro-phenyl)-3-hydroxy-3-propyl-hexanoic acid

2-(2-chloro-phenyl)-3-hydroxy-3-propyl-hexanoic acid

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-(2-chlorophenyl)acetamide
10268-06-1

2-(2-chlorophenyl)acetamide

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With cis-nitrous acid
(saponification);
2-Chlorophenylacetonitrile
2856-63-5

2-Chlorophenylacetonitrile

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With sulfuric acid
With potassium hydroxide
With potassium hydroxide In ethanol for 24h; Heating;
4-(2-chlorobenzylidene)-2-phenyl-5-oxazolone
52900-69-3, 77435-90-6, 82301-55-1

4-(2-chlorobenzylidene)-2-phenyl-5-oxazolone

furan-2,3,5(4H)-trione pyridine (1:1)

furan-2,3,5(4H)-trione pyridine (1:1)

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
nachfolgend Oxydation mit Wasserstoffperoxyd;
2-acetoxy-2-(2-chlorophenyl)acetic acid
178437-75-7

2-acetoxy-2-(2-chlorophenyl)acetic acid

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With Pd-BaSO4; tetralin
carbon dioxide
124-38-9

carbon dioxide

(2-chloro-benzyl)-dimethyl-silane
51801-46-8

(2-chloro-benzyl)-dimethyl-silane

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
(i) Mg, (ii) /BRN= 1900390/; Multistep reaction;
2-(2-chlorophenyl)malonic acid
144616-14-8

2-(2-chlorophenyl)malonic acid

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With AMDase; buffer solution at 15 - 35℃; Kinetics; ΔS(excit.), ΔH(excit.), ΔG(excit.);
With AMDase; buffer solution at 15℃; Rate constant;
With AMDase; buffer solution at 25℃; Rate constant;
With AMDase; buffer solution at 35℃; Rate constant;
[(E)-2-(2-Chloro-phenyl)-1-piperidin-1-yl-vinyl]-phosphonic acid diethyl ester

[(E)-2-(2-Chloro-phenyl)-1-piperidin-1-yl-vinyl]-phosphonic acid diethyl ester

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With hydrogenchloride for 0.5h; Heating; Yield given;
2-phenyl-4-<2-chloro-benzyliden>-oxazolone-(5)

2-phenyl-4-<2-chloro-benzyliden>-oxazolone-(5)

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With sodium hydroxide Behandlung mit Wasserstoffperoxyd;
<2-chloro-phenyl>-thioacetic acid morpholide

<2-chloro-phenyl>-thioacetic acid morpholide

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With sulfuric acid
etheric 2-chloro-benzyl magnesium chloride-solution

etheric 2-chloro-benzyl magnesium chloride-solution

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
at 0℃; Einleiten von Kohlendioxid;
tetralin
119-64-2

tetralin

2-acetoxy-2-(2-chlorophenyl)acetic acid
178437-75-7

2-acetoxy-2-(2-chlorophenyl)acetic acid

palladium

palladium

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
Hydrogenation;
2-(2-chloro-phenyl)-3-hydroxy-butyric acid

2-(2-chloro-phenyl)-3-hydroxy-butyric acid

aqueous KOH-solution

aqueous KOH-solution

A

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

B

acetaldehyde
75-07-0

acetaldehyde

1-(2-chlorophenyl)-2-diazoethan-1-one
50878-84-7

1-(2-chlorophenyl)-2-diazoethan-1-one

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
With silver(l) oxide In 1,4-dioxane Rearrangement;
2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

(+-)-piperoin

(+-)-piperoin

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / PPh3 / CH2Cl2 / 0.5 h / 0 °C
2: 96 percent / H2O / ethyl acetate / 8 h / 20 °C
3: 98 percent / aq. HCl / dioxane / 38 h / Heating
View Scheme
1-chloro-2-(2,2-dibromovinyl)benzene
401514-40-7

1-chloro-2-(2,2-dibromovinyl)benzene

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96 percent / H2O / ethyl acetate / 8 h / 20 °C
2: 98 percent / aq. HCl / dioxane / 38 h / Heating
View Scheme
o-chlorobenzoyl chloride
609-65-4

o-chlorobenzoyl chloride

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethyl ether / 0 °C
2: aq. Ag2O / dioxane
View Scheme
methanol
67-56-1

methanol

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

methyl (2-chlorophenyl)acetate
57486-68-7

methyl (2-chlorophenyl)acetate

Conditions
ConditionsYield
With hydrogenchloride for 1h; Heating;100%
With ammonium cerium(IV) nitrate at 20℃; for 12h;99%
sulfuric acid for 16h; Heating / reflux;97.5%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-(2-chlorophenyl)acetyl chloride
51512-09-5

2-(2-chlorophenyl)acetyl chloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide In toluene100%
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane at 0 - 25℃; for 1h;99%
With phosphorus pentachloride
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

4-bromo-2-(2-(dimethylamino)ethoxy)aniline
1072906-05-8

4-bromo-2-(2-(dimethylamino)ethoxy)aniline

N-(4-bromo-2-(2-(dimethylamino)ethoxy)phenyl)-2-(2-chlorophenyl)acetamide
1610875-39-2

N-(4-bromo-2-(2-(dimethylamino)ethoxy)phenyl)-2-(2-chlorophenyl)acetamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;100%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

4-bromo-2-(2-methoxyethoxy)aniline
1219730-72-9

4-bromo-2-(2-methoxyethoxy)aniline

N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide
1610875-66-5

N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;100%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

C8H7ClO2*C12H23N

C8H7ClO2*C12H23N

Conditions
ConditionsYield
In methanol at 20℃;100%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

ethyl-3-benzylamino propionate
23583-21-3

ethyl-3-benzylamino propionate

3-{N-benzyl-N-[2-(2-chlorophenyl)acetyl]amino}propionic acid ethyl ester

3-{N-benzyl-N-[2-(2-chlorophenyl)acetyl]amino}propionic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 2'-chloro-benzeneacetic acid; ethyl-3-benzylamino propionate With dmap In dichloromethane at 0℃; for 1h; Inert atmosphere;
Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane
99%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

3-Formylchromone
17422-74-1

3-Formylchromone

(E)-2'-chloro-3-styrylchromone

(E)-2'-chloro-3-styrylchromone

Conditions
ConditionsYield
With pyridine; potassium tert-butylate for 12h; Heating;98.4%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-Chloro-5-nitrophenylacetic acid monohydrate

2-Chloro-5-nitrophenylacetic acid monohydrate

Conditions
ConditionsYield
With nitric acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid98%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

ethanol
64-17-5

ethanol

2-chlorophenylacetic acid ethyl ester
40061-54-9

2-chlorophenylacetic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid Reflux;97%
With toluene-4-sulfonic acid for 2h; Reflux;94%
With hydrogenchloride Heating;90%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

trimethyl orthoformate
149-73-5

trimethyl orthoformate

methyl (2-chlorophenyl)acetate
57486-68-7

methyl (2-chlorophenyl)acetate

Conditions
ConditionsYield
With sulfuric acid In methanol; water at 20℃; for 4h;97%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

Cyclohexanethiol
1569-69-3

Cyclohexanethiol

C14H17ClOS
1384863-33-5

C14H17ClOS

Conditions
ConditionsYield
With trifluoroacetic acid In acetonitrile at 60℃; for 5h;96%
methanol
67-56-1

methanol

2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

methyl (2-hydroxyphenyl)acetate
22446-37-3

methyl (2-hydroxyphenyl)acetate

Conditions
ConditionsYield
Stage #1: 2'-chloro-benzeneacetic acid With copper(l) chloride; sodium hydroxide In water at 250℃; for 8h; Autoclave;
Stage #2: methanol With sulfuric acid In dichloromethane Temperature; Reflux;
95%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

Conditions
ConditionsYield
With dihydrogen peroxide In water; acetonitrile at 25℃; for 10h; UV-irradiation;94%
With potassium 12-tungstocobaltate(III) In water; acetonitrile for 0.25h; Microwave irradiation;92%
With 1H-imidazole; sodium periodate; {Mn(III)[5,10,15,20-tetrakis(4-H2N-Ph)porphyrin]}polystyrene In acetonitrile at 20℃; for 4h;90%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

5-(2,3-dihydro-1H-indol-5-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride

5-(2,3-dihydro-1H-indol-5-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride

5-{1-[(2-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
1337531-39-1

5-{1-[(2-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;94%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

3-methoxy-4-(4-methyloxazol-5-yl)aniline
1239719-44-8

3-methoxy-4-(4-methyloxazol-5-yl)aniline

2-(2-chlorophenyl)-N-(3-methoxy4-(4-methyloxazol-5-yl)phenyl)acetamide
1610874-83-3

2-(2-chlorophenyl)-N-(3-methoxy4-(4-methyloxazol-5-yl)phenyl)acetamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 3.5h;94%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

4-bromo-2-[2-(morpholin-4-yl)ethoxy]aniline
1219728-38-7

4-bromo-2-[2-(morpholin-4-yl)ethoxy]aniline

N-(4-bromo-2-(2-morpholinoethoxy)phenyl)-2-(2-chlorophenyl)acetamide
1610875-56-3

N-(4-bromo-2-(2-morpholinoethoxy)phenyl)-2-(2-chlorophenyl)acetamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;94%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-Chlorobenzyl alcohol
17849-38-6

2-Chlorobenzyl alcohol

Conditions
ConditionsYield
With sodium tetrahydroborate; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; oxygen; caesium carbonate In dichloromethane at 40℃; for 40h; Irradiation;94%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

copper(II) sulfate heptahydrate

copper(II) sulfate heptahydrate

2-Hydroxyphenylacetic acid
614-75-5

2-Hydroxyphenylacetic acid

Conditions
ConditionsYield
With hydrogenchloride In water93%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

N,0-dimethylhydroxylamine
1117-97-1

N,0-dimethylhydroxylamine

2-(2-chlorophenyl)-N-methoxy-N-methylacetamide
946402-82-0

2-(2-chlorophenyl)-N-methoxy-N-methylacetamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;93%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; Inert atmosphere;
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-Chlorobenzonitrile
873-32-5

2-Chlorobenzonitrile

Conditions
ConditionsYield
With oxygen; copper(II) trifluoroacetate; urea In dimethyl sulfoxide at 110℃; for 26h; Green chemistry;93%
With iron(III) trifluoromethanesulfonate; sodium nitrite In dimethyl sulfoxide at 50℃; for 10h; Inert atmosphere; Sealed tube;46%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

(2-aminophenyl)(phenyl)methanone
2835-77-0

(2-aminophenyl)(phenyl)methanone

2-(2-chlorophenyl)-4-phenylquinazoline
1283751-33-6

2-(2-chlorophenyl)-4-phenylquinazoline

Conditions
ConditionsYield
With ammonium acetate; oxygen; copper diacetate In 1-methyl-pyrrolidin-2-one at 120℃; under 760.051 Torr; for 20h;93%
With ammonium acetate; oxygen; copper diacetate In 1-methyl-pyrrolidin-2-one at 120℃; under 760.051 Torr; for 20h;93%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl 2-(2-chlorophenyl)-2-diazoacetate

isopropyl 2-(2-chlorophenyl)-2-diazoacetate

Conditions
ConditionsYield
Stage #1: 2'-chloro-benzeneacetic acid; isopropyl alcohol With sulfuric acid at 90℃; for 12h;
Stage #2: With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 12h;
92%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

di-tert-butyl-diazodicarboxylate
870-50-8

di-tert-butyl-diazodicarboxylate

di-tert-butyl 1-(2-chlorobenzyl)hydrazine-1,2-dicarboxylate

di-tert-butyl 1-(2-chlorobenzyl)hydrazine-1,2-dicarboxylate

Conditions
ConditionsYield
With iron(III) sulfate; bis[(2-pyridyl)methyl]amine In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere; Sealed tube; Irradiation;92%
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-Hydroxyphenylacetic acid
614-75-5

2-Hydroxyphenylacetic acid

Conditions
ConditionsYield
With copper(II) oxide; sodium hydroxide In water at 200℃; under 750.075 Torr; for 12h; Autoclave;91.2%

2-Chlorophenylacetic acid Chemical Properties

Molecular Structure of 2-Chlorophenylacetic acid (CAS NO.2444-36-2):

IUPAC Name: 2-(2-Chlorophenyl)acetic acid 
Molecular Formula: C8H7ClO2
Molecular Weight: 170.59 g/mol
Density: 1.324 g/cm3 
Melting Point: 92-95 °C(lit.)
Boiling Point: 294.1 °C at 760 mmHg 
Flash Point: 131.7 °C
Index of Refraction: 1.569
Molar Refractivity: 42.26 cm3
Molar Volume: 128.8 cm3 
Surface Tension: 49.3 dyne/cm 
Enthalpy of Vaporization: 56.37 kJ/mol
Vapour Pressure: 0.000751 mmHg at 25 °C
XLogP3: 2
H-Bond Donor: 1
H-Bond Acceptor: 2
Index of Refraction: 1.569
Molar Refractivity: 42.26 cm3
Molar Volume: 128.8 cm3
Surface Tension: 49.3 dyne/cm
Canonical SMILES: C1=CC=C(C(=C1)CC(=O)O)Cl
InChI: InChI=1S/C8H7ClO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)
InChIKey: IUJAAIZKRJJZGQ-UHFFFAOYSA-N
EINECS: 219-482-0 
Product Categories: Phenylacetic acid series; Acids and Derivatives; Aromatic Phenylacetic Acids and Derivatives; Organic acids; C8; Carbonyl Compounds; Carboxylic Acids

2-Chlorophenylacetic acid Uses

 2-Chlorophenylacetic acid (CAS NO.2444-36-2) is used as intermediate of diclofenac. It is also used in the synthesis of high efficient anti-inflammatory drugs. 2-Chlorophenylacetic acid can be used as pharmaceutical intermediates.

2-Chlorophenylacetic acid Production

 2-Chlorophenylacetic acid (CAS NO.2444-36-2) is obtained from o-chlorotoluene , o-chlorobenzyl chloride , and o-chlorophenyl acetonitrile .

2-Chlorophenylacetic acid Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves. 
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 13
Hazard Note: Irritant

2-Chlorophenylacetic acid Specification

 2-Chlorophenylacetic acid (CAS NO.2444-36-2) is also named as (2-Chlorophenyl)acetic acid ; (o-Chlorophenyl)acetic acid ; Acetic acid, (o-chlorophenyl)- (8CI) ; Benzeneacetic acid, 2-chloro- (9CI) . It is white to light yellow powder.

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View