Product Name

  • Name

    2-DIMETHYLAMINO-2-METHYL-1-PROPANOL

  • EINECS
  • CAS No. 7005-47-2
  • Article Data11
  • CAS DataBase
  • Density 0.95g/mLat 20°C(lit.)
  • Solubility 1000g/L at 20℃
  • Melting Point 19°C
  • Formula C6H15 N O
  • Boiling Point 61°C20mm Hg
  • Molecular Weight 117.191
  • Flash Point 145°F
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes 34-35
  • Molecular Structure Molecular Structure of 7005-47-2 (2-DIMETHYLAMINO-2-METHYL-1-PROPANOL)
  • Hazard Symbols C
  • Synonyms 2-(Dimethylamino)-2-methyl-1-propanol;2-(Dimethylamino)-2-methylpropyl alcohol;2-(N,N-Dimethylamino)-2-methyl-1-propanol; DMAMP; DMAMP 80;N,N-Dimethyl-2-amino-2-methylpropan-1-ol; NSC 17706; T-Amine WR 500
  • PSA 23.47000
  • LogP 0.31890

Synthetic route

formaldehyd
50-00-0

formaldehyd

2-Amino-2-methyl-1-propanol
124-68-5

2-Amino-2-methyl-1-propanol

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

Conditions
ConditionsYield
With formic acid at 80℃; for 24h;46%
With formic acid; water
With titanium(IV) isopropylate; sodium tetrahydroborate 1.) diglyme, 60 deg C, 30 min then r.t., 30 min; 2.) diglyme, r.t., 3 h then 60 deg C, 3 h; Yield given. Multistep reaction;
With sodium tetrahydroborate; zinc(II) chloride 1.) CH2Cl2, RT, 1 h, 2.) CH2Cl2, 11 h; Yield given. Multistep reaction;
Stage #1: formaldehyd; 2-Amino-2-methyl-1-propanol With formic acid In water at 0 - 90℃; for 5h;
Stage #2: With sodium hydroxide; water pH=14;
2-Amino-2-methyl-1-propanol
124-68-5

2-Amino-2-methyl-1-propanol

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

Conditions
ConditionsYield
(methylation);
formaldehyd
50-00-0

formaldehyd

2-nitro-2-methylpropanol
76-39-1

2-nitro-2-methylpropanol

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

Conditions
ConditionsYield
Stage #1: 2-nitro-2-methylpropanol With hydrogen
Stage #2: formaldehyd
With hydrogen In methanol at 100℃; Autoclave;
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

N,N-dimethylphosphoramidic difluoride
354-43-8

N,N-dimethylphosphoramidic difluoride

2,N1,N1,N2,N2-Pentamethyl-propane-1,2-diamine; compound with GENERIC INORGANIC NEUTRAL COMPONENT

2,N1,N1,N2,N2-Pentamethyl-propane-1,2-diamine; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Conditions
ConditionsYield
In benzene at 60℃;100%
In benzene at 60℃;28.3 g
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

methyl iodide
74-88-4

methyl iodide

2-(1-hydroxy-2-methyl)propyltrimethylammonium iodide
17199-19-8

2-(1-hydroxy-2-methyl)propyltrimethylammonium iodide

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 45℃; for 4h; Inert atmosphere;94%
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

sodium thiocyanide
540-72-7

sodium thiocyanide

copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

[Cu((CH3)4NCCH2O)(NCS)]2
500128-69-8

[Cu((CH3)4NCCH2O)(NCS)]2

Conditions
ConditionsYield
In methanol MeOH soln. of NaNCS was added to MeOH soln. of Cu(OAc)2*H2O and ligand, allowed to stand at 25°C for several ds; filtered, dried in vacuo; elem. anal.;90%
...Expand
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

copper dichloride

copper dichloride

[Cu((CH3)4NCCH2O)Cl]2
500128-70-1

[Cu((CH3)4NCCH2O)Cl]2

Conditions
ConditionsYield
In methanol MeOH soln. of CuCl2 was added to MeOH soln. of ligand, allowed to stand at 25°C for several ds; filtered, dried in vacuo; elem. anal.;90%
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

benzo[b]thiophene-3-carbonyl azide
78676-35-4

benzo[b]thiophene-3-carbonyl azide

Benzo[b]thiophen-3-yl-carbamic acid 2-dimethylamino-2-methyl-propyl ester; hydrochloride

Benzo[b]thiophen-3-yl-carbamic acid 2-dimethylamino-2-methyl-propyl ester; hydrochloride

Conditions
ConditionsYield
In benzene Heating;80%
N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-fluoro-6-nitroquinazolin-4-amine
897441-42-8

N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-fluoro-6-nitroquinazolin-4-amine

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-(2-(dimethylamino)-2-methylpropoxy)-6-nitroquinazolin-4-amine

N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-(2-(dimethylamino)-2-methylpropoxy)-6-nitroquinazolin-4-amine

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 25℃; for 2h;77%
benzothiophene-3-carbonyl chloride
39827-12-8

benzothiophene-3-carbonyl chloride

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

Benzo[b]thiophene-3-carboxylic acid 2-dimethylamino-2-methyl-propyl ester; hydrochloride

Benzo[b]thiophene-3-carboxylic acid 2-dimethylamino-2-methyl-propyl ester; hydrochloride

Conditions
ConditionsYield
In benzene Heating;70%
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

1,1'-oxybis(N,N,2-trimethylpropane-2-amine)
1232367-14-4

1,1'-oxybis(N,N,2-trimethylpropane-2-amine)

Conditions
ConditionsYield
Stage #1: 2-dimethylamino-2-methylpropan-1-ol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 3h; Reflux;
Stage #2: With p-toluenesulfonyl chloride; potassium iodide In tetrahydrofuran; toluene; mineral oil Reflux;		43%
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

dimethyl sulfate
77-78-1

dimethyl sulfate

N,N-dimethyl-2(1-methoxy-2-methyl)propylamine

N,N-dimethyl-2(1-methoxy-2-methyl)propylamine

Conditions
ConditionsYield
Stage #1: 2-dimethylamino-2-methylpropan-1-ol With sodium hydride In tetrahydrofuran at 20℃; for 4h;
Stage #2: dimethyl sulfate In tetrahydrofuran at 24℃;		35%
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

(2-chloroethyl)dimethylamine hydrochloride
4584-46-7

(2-chloroethyl)dimethylamine hydrochloride

1-(2-(dimethylamino)ethoxy)-N,N,2-trimethylpropane-2-amine
1232367-13-3

1-(2-(dimethylamino)ethoxy)-N,N,2-trimethylpropane-2-amine

Conditions
ConditionsYield
With sodium hydroxide In toluene at 70℃; for 5.5h; Reflux;27%
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

(chloro-tert-butyl)-dimethyl-amine
51660-31-2

(chloro-tert-butyl)-dimethyl-amine

Conditions
ConditionsYield
With thionyl chloride; benzene
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

N,N-diethylthiocarbamoyl chloride
88-11-9

N,N-diethylthiocarbamoyl chloride

diethyl-thiocarbamic acid O-(β-dimethylamino-isobutyl ester)

diethyl-thiocarbamic acid O-(β-dimethylamino-isobutyl ester)

Conditions
ConditionsYield
With pyridine
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

succinoyl dichloride
543-20-4

succinoyl dichloride

succinic acid bis-(β-dimethylamino-isobutyl ester)

succinic acid bis-(β-dimethylamino-isobutyl ester)

Conditions
ConditionsYield
With hydrogenchloride; chloroform
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

acryloyl chloride
814-68-6

acryloyl chloride

acrylic acid-(β-dimethylamino-isobutyl ester)
73029-81-9

acrylic acid-(β-dimethylamino-isobutyl ester)

Conditions
ConditionsYield
With benzene
phosgene
75-44-5

phosgene

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

3,4,4-trimethyloxazolidin-2-one
15833-17-7

3,4,4-trimethyloxazolidin-2-one

Conditions
ConditionsYield
With pyridine In dichloromethane for 5h;
phosgene
75-44-5

phosgene

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

3,3,4,4-tetramethyl-2-oxo-oxazolidinium; chloride
15833-13-3

3,3,4,4-tetramethyl-2-oxo-oxazolidinium; chloride

Conditions
ConditionsYield
With triethylamine In dichloromethane; toluene
With pyridine In dichloromethane
1-Adamantyl bromide
768-90-1

1-Adamantyl bromide

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

(2-Dimethylamino-2,2-dimethyl-ethyl)-adamantyl-(1)-ether
21623-94-9

(2-Dimethylamino-2,2-dimethyl-ethyl)-adamantyl-(1)-ether

Conditions
ConditionsYield
With triethylamine
4-Chlorophenoxyacetic acid
122-88-3

4-Chlorophenoxyacetic acid

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

4-Chlorphenoxyessigsaeure-<2-dimethylaminoisobutylester>
15485-43-5

4-Chlorphenoxyessigsaeure-<2-dimethylaminoisobutylester>

Conditions
ConditionsYield
(i) SOCl2, (ii) /BRN= 1732837/; Multistep reaction;
3-methyl-1-benzofuran-2-carbonyl chloride
2256-86-2

3-methyl-1-benzofuran-2-carbonyl chloride

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

3-Methyl-benzofuran-2-carboxylic acid 2-dimethylamino-2-methyl-propyl ester

3-Methyl-benzofuran-2-carboxylic acid 2-dimethylamino-2-methyl-propyl ester

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

1-bromo dodecane
112-29-8

1-bromo dodecane

Decyl-(2-hydroxy-1,1-dimethyl-ethyl)-dimethyl-ammonium; bromide

Decyl-(2-hydroxy-1,1-dimethyl-ethyl)-dimethyl-ammonium; bromide

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

methyl benzilate
76-89-1

methyl benzilate

Benzilsaeure-<2-dimethylamino-2-methyl-propylester>
3477-97-2

Benzilsaeure-<2-dimethylamino-2-methyl-propylester>

Conditions
ConditionsYield
With sodium In benzene
3-methylbenzofuran-2-carbonyl azide
66041-95-0

3-methylbenzofuran-2-carbonyl azide

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

(3-Methyl-benzofuran-2-yl)-carbamic acid 2-dimethylamino-2-methyl-propyl ester
66041-89-2

(3-Methyl-benzofuran-2-yl)-carbamic acid 2-dimethylamino-2-methyl-propyl ester

2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

Dimethyl-(2-hydroxy-1,1-methyl-ethyl)-aminoxid

Dimethyl-(2-hydroxy-1,1-methyl-ethyl)-aminoxid

Conditions
ConditionsYield
With dihydrogen peroxide In isopropyl alcohol
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

acetic anhydride
108-24-7

acetic anhydride

methyl iodide
74-88-4

methyl iodide

(acetoxy-tert-butyl)-trimethyl-ammonium; iodide

(acetoxy-tert-butyl)-trimethyl-ammonium; iodide

Conditions
ConditionsYield
(i) iPrOH, (ii) /BRN= 969135/; Multistep reaction;
...Expand
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

diethyl phosphorochloridothioate
2524-04-1

diethyl phosphorochloridothioate

O-<2-(N,N-Dimethylamino)-2-methyl-propyl>-O',O''-diethyl-thionphosphat
103502-59-6

O-<2-(N,N-Dimethylamino)-2-methyl-propyl>-O',O''-diethyl-thionphosphat

Conditions
ConditionsYield
(i) Na, benzene, (ii) /BRN= 471434/; Multistep reaction;
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

2-(dimethylamino)-2-methylpropanal
16042-92-5

2-(dimethylamino)-2-methylpropanal

Conditions
ConditionsYield
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane
Stage #1: 2-dimethylamino-2-methylpropan-1-ol With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -78℃; for 0.833333h;
Stage #2: With triethylamine In dichloromethane at -78℃; for 0.666667h;
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -78 - 20℃; for 1.66667h;1 g
2-dimethylamino-2-methylpropan-1-ol
7005-47-2

2-dimethylamino-2-methylpropan-1-ol

aniline
62-53-3

aniline

2-methyl-2-(N-phenylamino)-3-(N,N-dimethylamino)propane
139528-49-7

2-methyl-2-(N-phenylamino)-3-(N,N-dimethylamino)propane

Conditions
ConditionsYield
With methanesulfonyl chloride; triethylamine 1) THF, 2) benzene, reflux; Yield given. Multistep reaction;

2-Dimethylamino-2-Methyl-1-Propanol Chemical Properties

Chemistry informtion about 2-Dimethylamino-2-Methyl-1-Propanol (CAS NO.7005-47-2) is:
IUPAC Name: 2-(Dimethylamino)-2-Methylpropan-1-Ol
Synonyms: Dmamp-80(Tm) ; 2-(N,N-Dimethylamino)Isobutanol ; 2-Dimethylaminoisobutanol ; 2-Dimethylamino-2-Methyl-1-Propanol ; 2-(Dimethylamino)-2-Methyl-1-Propano ; 2-(Dimethylamino)-2-Methylpropanol ; 2-(N,N-Dimethylamino)-2-Methyl-1-Propanol ; 2-Dimethylamino-2-Methyl-1-Propano 
MF: C6H15NO
MW: 117.19
EINECS: 230-279-6 
Density: 0.885 g/cm3
Flash Point: 39.9 °C
Boiling Point: 151 °C at 760 mmHg
Vapour Pressure: 1.41 mmHg at 25°C 
Enthalpy of Vaporization: 45.18 kJ/mol
Refractive Index: n20/D 1.447
Following is the molecular structure of 2-Dimethylamino-2-Methyl-1-Propanol (CAS NO.7005-47-2) is:

2-Dimethylamino-2-Methyl-1-Propanol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 25mg/kg (25mg/kg)   National Technical Information Service. Vol. AD277-689,

2-Dimethylamino-2-Methyl-1-Propanol Consensus Reports

Reported in EPA TSCA Inventory.

2-Dimethylamino-2-Methyl-1-Propanol Safety Profile

Safty information about 2-Dimethylamino-2-Methyl-1-Propanol (CAS NO.7005-47-2) is:
Poison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. 
Hazard Codes:
CorrosiveC
Risk Statements:
R34:Causes burns. 
Safety Statements:
S23:Do not breathe vapour. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2735 8/PG 3
RTECS: UB3325000
F:
F 10: Keep under argon.
F 34: Sensitive to CO2.
HazardClass: 3.2
PackingGroup: III

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