Product Name

  • Name

    2-Ethoxybenzoic acid

  • EINECS 205-130-3
  • CAS No. 134-11-2
  • Article Data27
  • CAS DataBase
  • Density 1.166 g/cm3
  • Solubility Soluble in water.
  • Melting Point 19.3-19.5 °C(lit.)
  • Formula C9H10O3
  • Boiling Point 301.3 °C at 760 mmHg
  • Molecular Weight 166.177
  • Flash Point 117.8 °C
  • Transport Information
  • Appearance Pale yellow low melting solid
  • Safety 23-24/25
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 134-11-2 (2-Ethoxybenzoic acid)
  • Hazard Symbols IrritantXi
  • Synonyms Benzoicacid, o-ethoxy- (6CI,7CI,8CI);NSC 406710;o-Ethoxybenzoic acid;
  • PSA 46.53000
  • LogP 1.78350

Synthetic route

diethyl sulfate
64-67-5

diethyl sulfate

methyl salicylate
119-36-8

methyl salicylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: diethyl sulfate; methyl salicylate With potassium hydroxide In ethanol at 15℃; for 6h; Large scale;
Stage #2: With water; sodium hydroxide at 65℃; for 6h; Temperature; Large scale;
98.31%
(2-ethoxybenzoylamino)pyridine-1-oxide

(2-ethoxybenzoylamino)pyridine-1-oxide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 80℃; for 10h;81%
With sodium hydroxide In ethanol at 80℃; for 8h;80%
With sodium hydroxide In ethanol at 80℃; for 8h; Temperature; Schlenk technique;80%
ethyl 2-ethoxybenzoate
6290-24-0

ethyl 2-ethoxybenzoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxybenzoate With potassium tert-butylate In dimethyl sulfoxide at 70℃; for 2h;
Stage #2: With hydrogenchloride; water In dimethyl sulfoxide at 0 - 10℃;
80%
With barium dihydroxide
With water
2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With phthalic anhydride; silica gel microwave irradiation;75%
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

A

2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With potassium carbonate
7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

sodium ethanolate
141-52-6

sodium ethanolate

A

1-(4-ethoxy-2-hydroxyphenyl)ethanone
37470-42-1

1-(4-ethoxy-2-hydroxyphenyl)ethanone

B

4-ethoxy-2-hydroxybenzoic acid
10435-55-9

4-ethoxy-2-hydroxybenzoic acid

C

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

diethyl sulfate
64-67-5

diethyl sulfate

methyl salicylate
119-36-8

methyl salicylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: diethyl sulfate; methyl salicylate With potassium hydroxide In ethanol at 15℃; for 6h; Large scale;
Stage #2: With water; sodium hydroxide at 65℃; for 6h; Temperature; Large scale;
98.31%
(2-ethoxybenzoylamino)pyridine-1-oxide

(2-ethoxybenzoylamino)pyridine-1-oxide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 80℃; for 10h;81%
With sodium hydroxide In ethanol at 80℃; for 8h;80%
With sodium hydroxide In ethanol at 80℃; for 8h; Temperature; Schlenk technique;80%
ethyl 2-ethoxybenzoate
6290-24-0

ethyl 2-ethoxybenzoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxybenzoate With potassium tert-butylate In dimethyl sulfoxide at 70℃; for 2h;
Stage #2: With hydrogenchloride; water In dimethyl sulfoxide at 0 - 10℃;
80%
With barium dihydroxide
With water
2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With phthalic anhydride; silica gel microwave irradiation;75%
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

A

2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With potassium carbonate
7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

7-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

sodium ethanolate
141-52-6

sodium ethanolate

A

1-(4-ethoxy-2-hydroxyphenyl)ethanone
37470-42-1

1-(4-ethoxy-2-hydroxyphenyl)ethanone

B

4-ethoxy-2-hydroxybenzoic acid
10435-55-9

4-ethoxy-2-hydroxybenzoic acid

C

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

6-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

6-ethoxy-2-(2-ethoxy-phenyl)-chromen-4-one

sodium ethanolate
141-52-6

sodium ethanolate

A

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

B

5-ethoxy-2-hydroxybenzoic acid
14160-71-5

5-ethoxy-2-hydroxybenzoic acid

C

1-(5-ethoxy-2-hydroxyphenyl)ethanone
56414-14-3

1-(5-ethoxy-2-hydroxyphenyl)ethanone

sodium o-methoxycarbonylphenolate
7631-93-8

sodium o-methoxycarbonylphenolate

ethyl iodide
75-03-6

ethyl iodide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
at 160℃; im geschlossenen Rohr, durch Behandeln mit Barytwasser;
methyl 2-ethoxybenzoate
3686-55-3

methyl 2-ethoxybenzoate

methylamine
74-89-5

methylamine

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

diethyl sulfate
64-67-5

diethyl sulfate

salicylic acid
69-72-7

salicylic acid

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at 20℃; for 40h;
With potassium hydroxide In acetone
carbon dioxide
124-38-9

carbon dioxide

Phenetole
103-73-1

Phenetole

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
(i) nBuLi, THF, hexane, (ii) /BRN= 1900390/; Multistep reaction;
ethyl iodide
75-03-6

ethyl iodide

dipotassium salt of/the/ salicylic acid

dipotassium salt of/the/ salicylic acid

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With ethanol at 100℃; im geschlossenen Rohr; Behandeln mit Alkali;
With ethanol durch Behandeln mit Alkali;
ethyl iodide
75-03-6

ethyl iodide

potassium compound of salicylic acid ethyl ester

potassium compound of salicylic acid ethyl ester

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With ethanol at 100℃; im geschlossenen Rohr; Behandeln mit Alkali;
With ethanol durch Behandeln mit Alkali;
o-ethoxy-cis-cinnamic acid
38624-46-3

o-ethoxy-cis-cinnamic acid

KMnO4

KMnO4

alkali

alkali

A

2-ethoxylbenzaldehyde
613-69-4

2-ethoxylbenzaldehyde

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(E)-3-(2-ethoxyphenyl)prop-2-enoic acid
59923-03-4

(E)-3-(2-ethoxyphenyl)prop-2-enoic acid

potassium permanganate

potassium permanganate

alkali

alkali

A

2-ethoxylbenzaldehyde
613-69-4

2-ethoxylbenzaldehyde

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

alcoholic potash

alcoholic potash

A

2-ethoxybenzamide
938-73-8

2-ethoxybenzamide

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
im geschlossenen Rohr;
sulfuric acid
7664-93-9

sulfuric acid

2-ethoxy-N-hydroxybenzamide
50357-86-3

2-ethoxy-N-hydroxybenzamide

A

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

B

hydroxylamine
7803-49-8

hydroxylamine

salicylic acid
69-72-7

salicylic acid

o-sulfonbenzoic acid endo-anhydride

o-sulfonbenzoic acid endo-anhydride

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / acetone
2: H2O, alkali
View Scheme
methyl 2-ethoxybenzoate
3686-55-3

methyl 2-ethoxybenzoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With methanol; sodium hydroxide; water at 50℃;
With methanol; sodium hydroxide at 50℃;15.8 g
C9H10O3*C25H31N3O

C9H10O3*C25H31N3O

A

crystal violet carbinol base
467-63-0

crystal violet carbinol base

B

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
In toluene at 28℃; Kinetics;
2-benzamidopyridine 1-oxide
14178-42-8

2-benzamidopyridine 1-oxide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: silver(l) oxide; sodium acetate; cobalt(II) diacetate tetrahydrate / 12 h / 60 °C / Schlenk technique
2: sodium hydroxide / ethanol / 10 h / 80 °C
View Scheme
benzoic acid
65-85-0

benzoic acid

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2: silver(l) oxide; sodium acetate; cobalt(II) diacetate tetrahydrate / 12 h / 60 °C / Schlenk technique
3: sodium hydroxide / ethanol / 10 h / 80 °C
View Scheme
2-ethoxybenzonitrile
6609-57-0

2-ethoxybenzonitrile

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
With ethylene glycol; potassium hydroxide Heating;
salicylonitrile
611-20-1

salicylonitrile

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate
2: potassium hydroxide; ethylene glycol / Heating
View Scheme
methyl salicylate
119-36-8

methyl salicylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hydroxide / acetone / 0.5 h / 20 °C
1.2: Reflux
2.1: methanol; sodium hydroxide / 50 °C
View Scheme
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxybenzoyl chloride
42926-52-3

2-ethoxybenzoyl chloride

Conditions
ConditionsYield
With phosgene; N,N-dimethyl-formamide In acetone at 50℃;99.7%
With thionyl chloride
With phosphorus pentachloride
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxy-5-chlorosulphonyl-benzoic acid
200575-16-2

2-ethoxy-5-chlorosulphonyl-benzoic acid

Conditions
ConditionsYield
With chlorosulfonic acid; thionyl chloride at 20℃;90.6%
With chlorosulfonic acid; thionyl chloride at 0 - 25℃; for 18h;81%
With chlorosulfonic acid; thionyl chloride In water
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxybenzoic acid hydrazide
21018-13-3

2-ethoxybenzoic acid hydrazide

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere;
Stage #2: With hydrazine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.333333h; Inert atmosphere;
90%
Multi-step reaction with 2 steps
1: thionyl chloride / 0.07 h / Microwave irradiation
2: hydrazine hydrate / 0.05 h / Microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride
2: hydrazine hydrate
View Scheme
(1R)-endo-(+)-fenchol
2217-02-9

(1R)-endo-(+)-fenchol

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

C19H26O3

C19H26O3

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 5h;90%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

5-bromo-2-ethoxy-benzoic acid
60783-90-6

5-bromo-2-ethoxy-benzoic acid

Conditions
ConditionsYield
With bromine; acetic acid at 25℃;89%
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; for 48h;
With N-Bromosuccinimide In acetonitrile at 0 - 20℃; for 48h;
With bromine In acetic acid at 20℃;
C14H16F2N2O3*ClH
1574285-43-0

C14H16F2N2O3*ClH

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

N-({2-[4-(difluoromethoxy)-3-isopropoxyphenyl]oxazole-4-yl}methyl)-2-ethoxybenzamide

N-({2-[4-(difluoromethoxy)-3-isopropoxyphenyl]oxazole-4-yl}methyl)-2-ethoxybenzamide

Conditions
ConditionsYield
Stage #1: C14H16F2N2O3*ClH With triethylamine In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: 2-ethoxybenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethyl acetate at 20 - 30℃; for 1h;
88.18%
Stage #1: C14H16F2N2O3*ClH With triethylamine In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: 2-ethoxybenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethyl acetate at 20 - 30℃; for 1h;
72.6%
Stage #1: C14H16F2N2O3*ClH With sodium hydrogencarbonate In water; ethyl acetate at 50℃; for 0.166667h;
Stage #2: 2-ethoxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetone for 1h; Reflux;
18.58 g
Stage #1: C14H16F2N2O3*ClH With triethylamine In ethyl acetate at 20 - 30℃; for 1h;
Stage #2: 2-ethoxybenzoic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In ethyl acetate at 20 - 30℃; for 1h;
18.38 g
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide
247583-78-4

4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide

4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide
501120-38-3

4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid With thionyl chloride for 3h; Heating;
Stage #2: 4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide With dmap; triethylamine In benzene for 3h; Heating;
88%
4-toluenesulfonyl azide
941-55-9

4-toluenesulfonyl azide

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-ethoxy-6-[(4-methylphenyl)sulfonamido]benzoic acid

2-ethoxy-6-[(4-methylphenyl)sulfonamido]benzoic acid

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium acetate; silver(I) triflimide In 1,2-dichloro-ethane at 50℃; for 24h;88%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

triphenylbismuthane
603-33-8

triphenylbismuthane

tris-2-ethoxybenzoatobismuth

tris-2-ethoxybenzoatobismuth

Conditions
ConditionsYield
In melt byproducts: C6H6; grinding of 2.5 mmol of Ph3Bi and 7.5 mmol 2-ethoxybenzoic acid; placingin a glass vial; heating at 120°C for 3 h; addn. of a small amt. of acetone, pptn., washing, recrystn. from acetoneover 2 w; elem. anal.;87%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

diphenyl acetylene
501-65-5

diphenyl acetylene

(E)-[1-(3-ethoxyphenyl)-1,2-diphenyl]ethene

(E)-[1-(3-ethoxyphenyl)-1,2-diphenyl]ethene

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 100℃; for 24h; Inert atmosphere;87%
2-(2-amino-4-chlorophenoxy)benzeneamine

2-(2-amino-4-chlorophenoxy)benzeneamine

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2-(2-(2-ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzeneamine

2-(2-(2-ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzeneamine

Conditions
ConditionsYield
microwave irradiation;85%
4,4'-dimethoxydiphenylacetylene
2132-62-9

4,4'-dimethoxydiphenylacetylene

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(E)-[1-(3-ethoxyphenyl)-1,2-bis-(p-anisyl)]ethene

(E)-[1-(3-ethoxyphenyl)-1,2-bis-(p-anisyl)]ethene

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 100℃; for 24h; Inert atmosphere;84%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one
6458-30-6

2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one

3-(2-ethoxy-1-benzoyl)-2,2-bis(trifluoromethyl)oxazolidinone

3-(2-ethoxy-1-benzoyl)-2,2-bis(trifluoromethyl)oxazolidinone

Conditions
ConditionsYield
With thionyl chloride for 24h; Reflux; Inert atmosphere;82%
oxalyl dichloride
79-37-8

oxalyl dichloride

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

5-amino-1-propyl-1H-imidazole-4-carboxamide
61507-88-8

5-amino-1-propyl-1H-imidazole-4-carboxamide

5-(2-ethoxybenzamido)-1-n-propylimidazole-4-carboxamide
155581-73-0

5-(2-ethoxybenzamido)-1-n-propylimidazole-4-carboxamide

Conditions
ConditionsYield
In pyridine; N-methyl-acetamide; methanol; dichloromethane77%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

triphenylbismuthane
603-33-8

triphenylbismuthane

triphenylbismuth bis(2-ethoxybenozate)

triphenylbismuth bis(2-ethoxybenozate)

Conditions
ConditionsYield
With dihydrogen peroxide In diethyl ether for 0.166667h;76%
1,2-bis(4-methylphenyl)acetylene
2789-88-0

1,2-bis(4-methylphenyl)acetylene

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(E)-{1-(3-ethoxyphenyl)-1,2-bis-[p-tolyl]}ethene

(E)-{1-(3-ethoxyphenyl)-1,2-bis-[p-tolyl]}ethene

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 100℃; for 24h; Inert atmosphere;76%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

methyl iodide
74-88-4

methyl iodide

methyl 2-ethoxy-6-[(triisopropylsilyl)ethynyl]benzoate

methyl 2-ethoxy-6-[(triisopropylsilyl)ethynyl]benzoate

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid; 1-bromo-2-(triisopropylsilyl)acetylene With [Ru(O2CMes)2(p-cymene)] In 1,4-dioxane at 120℃; for 16h; Inert atmosphere; Schlenk technique;
Stage #2: methyl iodide With potassium carbonate In 1,4-dioxane; acetonitrile at 50℃; for 2h; Inert atmosphere; Schlenk technique;
76%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(Z)-methyl 2-fluoro-3-(2-ethoxyphenyl)acrylate

(Z)-methyl 2-fluoro-3-(2-ethoxyphenyl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; diastereoselective reaction;76%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

4H-carabrone
68776-20-5

4H-carabrone

carabryl 2-ethoxybenzoate

carabryl 2-ethoxybenzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h;75%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(S)-(1-(4-(aminomethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

(S)-(1-(4-(aminomethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

(S)-(1-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-4-((2-ethoxybenzylcarbamoyl)methyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

(S)-(1-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-4-((2-ethoxybenzylcarbamoyl)methyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 2-ethoxybenzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 1h;
Stage #2: (S)-(1-(4-(aminomethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazol-5-yl)ethyl)carbamic acid tert-butyl ester In tetrahydrofuran at 60℃; for 3h;
75%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

salicylic acid
69-72-7

salicylic acid

Conditions
ConditionsYield
With piperazine In N,N-dimethyl acetamide at 150℃; for 12h; Substitution;74%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one
103343-47-1

3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

2-ethoxy-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide

2-ethoxy-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;72%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

3,3'-diethoxy-1,1'-biphenyl

3,3'-diethoxy-1,1'-biphenyl

Conditions
ConditionsYield
With copper(I) oxide; dipotassium hydrogenphosphate; palladium diacetate; silver carbonate In 1,2-dimethoxyethane at 150℃; for 21h; Inert atmosphere; Sealed tube; regioselective reaction;72%
benzylacrylate
2495-35-4

benzylacrylate

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

benzyl (E)-3-(3-ethoxyphenyl)acrylate

benzyl (E)-3-(3-ethoxyphenyl)acrylate

Conditions
ConditionsYield
With [Ru(O2CMes)2(p-cymene)]; vanadia In toluene at 120℃; for 18h; Inert atmosphere;69%
2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

phenol
108-95-2

phenol

Conditions
ConditionsYield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N,N,N,-tetramethylethylenediamine; iron at 170℃; for 24h; Inert atmosphere; regioselective reaction;69%
6-ethyl-5,7-dimethyl-2,3-dihydro-1H-2,4,7a,8-tetraaza-cyclopenta[a]indene hydrochloride

6-ethyl-5,7-dimethyl-2,3-dihydro-1H-2,4,7a,8-tetraaza-cyclopenta[a]indene hydrochloride

2-ethoxybenzoic acid
134-11-2

2-ethoxybenzoic acid

(2-ethoxy-phenyl)-(6-ethyl-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]inden-2-yl)-methanone
1444115-37-0

(2-ethoxy-phenyl)-(6-ethyl-5,7-dimethyl-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]inden-2-yl)-methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 20℃; for 16h;63%

2-Ethoxybenzoic acid Specification

The 2-Ethoxybenzoic acid, with the CAS registry number 134-11-2, is also known as o-Ethoxybenzoic acid. It belongs to the product categories of Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Benzoic Acid Derivative; Organic Acids; Heterocyclic Compounds; Acids & Esters; Anisoles, Alkyloxy Compounds & Phenylacetates. Its EINECS registry number is 205-130-3. This chemical's molecular formula is C9H10O3 and molecular weight is 166.17. Its IUPAC name is called 2-ethoxybenzoic acid. What's more, this chemical can be used in organic synthesis.

Physical properties of 2-Ethoxybenzoic acid: (1)ACD/LogP: 2.03; (2)ACD/LogD (pH 5.5): 0.72; (3)ACD/LogD (pH 7.4): -0.84; (4)ACD/BCF (pH 5.5): 1.01; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 14.97; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.537; (12)Molar Refractivity: 44.49 cm3; (13)Molar Volume: 142.4 cm3; (14)Surface Tension: 43.4 dyne/cm; (15)Density: 1.166 g/cm3; (16)Flash Point: 117.8 °C; (17)Enthalpy of Vaporization: 57.17 kJ/mol; (18)Boiling Point: 301.3 °C at 760 mmHg; (19)Vapour Pressure: 0.000472 mmHg at 25°C.

Uses of 2-Ethoxybenzoic acid: it can be used to produce 2-hydroxy-benzoic acid at temperature of 150 °C. This reaction is a kind of Substitution. It will need reagent piperazine and solvent N,N-dimethyl-acetamide with reaction time of 12 hours. The yield is about 74%.

2-Ethoxybenzoic acid can be used to produce 2-hydroxy-benzoic acid

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CCOC1=CC=CC=C1C(=O)O
(2)InChI: InChI=1S/C9H10O3/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6H,2H2,1H3,(H,10,11)
(3)InChIKey: XDZMPRGFOOFSBL-UHFFFAOYSA-N

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