As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:162011-90-7
Min.Order:1 Kilogram
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:162011-90-7
Min.Order:1 Gram
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Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:162011-90-7
Min.Order:1 Kilogram
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Rofecoxib The alias:4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone; VIOXX CAS NO:162011-90-7 Molecular formula:C17H14O4S Molecular weight:314.3557 Product Quality 12 years of chemical raw materials Mature operation of the indus
Cas:162011-90-7
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:162011-90-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:162011-90-7
Min.Order:1 Kilogram
FOB Price: $7.0 / 11.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:162011-90-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryRofecoxib CAS:162011-90-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:162011-90-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:162011-90-7
Min.Order:5 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:162011-90-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryRofecoxibAppearance:White or Almost White crystalline powder Storage:Store in refrigerator Package:according to customers' requirements Application:Steroids injection For Body building Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by se
Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Tr
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Rofecoxib Basic information Product Name: Rofecoxib Synonyms: 4-[4-(MethylSLdfonyl)phenyl]-3-phenyl-2(5H)-furanone;4-[4-(Methylsulfonyl)phenyl]-3-phenyl-;Rofecoxib(Vioxx);Rofecoxib (MK0966);Rofecoxid;ROFECOXIB;MK-0966;VIOXX CAS: 162011-90-7 M
Cas:162011-90-7
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle
Cas:162011-90-7
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
4-(4-(methylthio)phenyl)-3-phenylfuran-2(5H)-one
rofecoxib
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid at 0 - 21℃; Oxidation; | 99% |
With Oxone In water; acetone at 0 - 25℃; for 24h; Product distribution / selectivity; | 95% |
With oxone In water; acetone at 0 - 25℃; for 24h; | 91% |
rofecoxib
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 2h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; water; ethyl acetate | 94% |
2-bromo-1-(4-methanesulfonylphenyl)ethanone
2-(diethoxyphosphino)-2-phenylacetic acid
rofecoxib
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 2h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; | 92% |
phenylacetic acid
2-bromo-1-(4-methanesulfonylphenyl)ethanone
rofecoxib
Conditions | Yield |
---|---|
Stage #1: phenylacetic acid With sodium hydroxide In DMF (N,N-dimethyl-formamide); water at 4℃; for 1h; Stage #2: 2-bromo-1-(4-methanesulfonylphenyl)ethanone With diisopropylamine at 45℃; for 3.5h; | 78% |
Stage #1: phenylacetic acid With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 2-bromo-1-(4-methanesulfonylphenyl)ethanone In N,N-dimethyl-formamide for 1h; Stage #3: With diisopropylamine In N,N-dimethyl-formamide at 60℃; for 4h; | 76% |
Stage #1: phenylacetic acid; 2-bromo-1-(4-methanesulfonylphenyl)ethanone With triethylamine In acetonitrile at 20 - 25℃; for 0.333333h; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; for 0.333333h; | 58% |
3-chloro-4-(4'-methylsulfonylphenyl)-5H-furan-2-one
phenylboronic acid
rofecoxib
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride In water; toluene for 7h; Suzuki cross-coupling; Heating; | 74% |
With cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; N-benzyl-N,N,N-triethylammonium chloride In water; toluene for 7h; Product distribution / selectivity; Suzuki Coupling; Heating / reflux; | 74% |
Conditions | Yield |
---|---|
With 1,1'-bis-(diphenylphosphino)ferrocene; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin; potassium hydrogenphosphate trihydrate; tetrabutylammomium bromide In dimethyl sulfoxide at 100℃; for 10h; Inert atmosphere; Schlenk technique; | 59% |
With 1,1'-bis-(diphenylphosphino)ferrocene; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin; potassium hydrogenphosphate trihydrate; tetrabutylammomium bromide In dimethyl sulfoxide at 100℃; for 10h; Inert atmosphere; | 59% |
Conditions | Yield |
---|---|
With palladium(0)bis(tricyclohexylphosphine) In water; toluene at 100℃; for 24h; Inert atmosphere; Glovebox; | 45% |
4-(methylsulfonyl)benzoylmethyl phenylacetate
rofecoxib
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; for 0.5h; | |
With diisopropylamine In DMF (N,N-dimethyl-formamide) at 45℃; for 4.25h; | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile Horner-Wadsworth-Emmons Olefination; |
phenylacetic acid
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / acetonitrile / 0.5 h / 25 °C 2: DBU / acetonitrile / 0.5 h / 0 °C View Scheme |
2-bromo-1-(4-methanesulfonylphenyl)ethanone
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / acetonitrile / 0.5 h / 25 °C 2: DBU / acetonitrile / 0.5 h / 0 °C View Scheme |
(4-thiomethoxyphenyl)boronic acid
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 72 h / 20 - 25 °C 2: 85 percent / Oxone(R) / acetone; H2O / 0 - 25 °C 3: 74 percent / cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 7 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 72 h / 20 - 25 °C 2: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 20 - 25 °C 3: 91 percent / Oxone(R) / acetone; H2O / 24 h / 0 - 25 °C View Scheme |
3-bromo-4-(4'-methylthiophenyl)-5H-furan-2-one
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / Heating 2: 91 percent / Oxone(R) / acetone; H2O / 24 h / 0 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: 68 percent / AsPh3; CuI / Pd2(dba)3 / 1-methyl-pyrrolidin-2-one / 63 h / 80 °C 2: 80 percent / oxone; aq. Bu4NBr / CH2Cl2 / 46.5 h / 20 °C View Scheme |
3-chloro-4-(4'-methylthiophenyl)-5H-furan-2-one
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / Oxone(R) / acetone; H2O / 0 - 25 °C 2: 74 percent / cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 7 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 20 - 25 °C 2: 91 percent / Oxone(R) / acetone; H2O / 24 h / 0 - 25 °C View Scheme |
4-(Methylthio)acetophenone
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 100 percent / MMPP / methanol; CH2Cl2 / 3 h / 20 °C 2.1: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C 3.1: Et3N / acetonitrile / 0.33 h / 25 °C 3.2: 54 percent / DBU / acetonitrile / 0.33 h / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C 2.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C 2.2: 2.5 h / 25 - 58 °C 3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C 3.2: 1 h 3.3: 4 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetra-N-butylammonium tribromide / methanol; dichloromethane 2: sodium hydroxide / water; dichloromethane 3: diisopropylamine / dimethyl sulfoxide 4: dihydrogen peroxide; sodium tungstate (VI) dihydrate / water; acetonitrile / 5.5 h / 65 - 70 °C View Scheme |
methyl-phenyl-thioether
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 82 percent / AlCl3 / CHCl3 / 1.5 h / 5 °C 2.1: 100 percent / MMPP / methanol; CH2Cl2 / 3 h / 20 °C 3.1: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C 4.1: Et3N / acetonitrile / 0.33 h / 25 °C 4.2: 54 percent / DBU / acetonitrile / 0.33 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / chloroform / 1.5 h / -5 - 5 °C / Cooling with ice 2.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C 3.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C 3.2: 2.5 h / 25 - 58 °C 4.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C 4.2: 1 h 4.3: 4 h / 60 °C View Scheme |
4-(methanesulfonyl)acetophenone
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C 2.1: Et3N / acetonitrile / 0.33 h / 25 °C 2.2: 54 percent / DBU / acetonitrile / 0.33 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C 1.2: 2.5 h / 25 - 58 °C 2.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C 2.2: 1 h 2.3: 4 h / 60 °C View Scheme |
tributylphenylstannane
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 68 percent / AsPh3; CuI / Pd2(dba)3 / 1-methyl-pyrrolidin-2-one / 63 h / 80 °C 2: 80 percent / oxone; aq. Bu4NBr / CH2Cl2 / 46.5 h / 20 °C View Scheme |
3-Phenyl-2-propyn-1-ol
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran; cyclohexane / 19 h / 80 °C 3: 99 percent / m-CPBA / 0 - 21 °C View Scheme |
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran; cyclohexane / 19 h / 80 °C 3: 99 percent / m-CPBA / 0 - 21 °C View Scheme |
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 99 percent / m-CPBA / 0 - 21 °C View Scheme |
phenylacetic acid
water
triethylamine
2-bromo-1-(4-methanesulfonylphenyl)ethanone
rofecoxib
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile | |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile |
phenylacetic acid
triethylamine
2-bromo-1-(4-methanesulfonylphenyl)ethanone
rofecoxib
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; acetonitrile |
2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C 2: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C 3: uranyl(VI) acetate dihydrate; oxygen / water; acetonitrile; o-xylene / 20 °C / 760.05 Torr / Schlenk technique; Irradiation View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water; dichloromethane 2: diisopropylamine / dimethyl sulfoxide 3: dihydrogen peroxide; sodium tungstate (VI) dihydrate / water; acetonitrile / 5.5 h / 65 - 70 °C View Scheme |
phenylacetic acid
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C 2: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C 3: uranyl(VI) acetate dihydrate; oxygen / water; acetonitrile; o-xylene / 20 °C / 760.05 Torr / Schlenk technique; Irradiation View Scheme |
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C 2: uranyl(VI) acetate dihydrate; oxygen / water; acetonitrile; o-xylene / 20 °C / 760.05 Torr / Schlenk technique; Irradiation View Scheme | |
Multi-step reaction with 2 steps 1: diisopropylamine / dimethyl sulfoxide 2: dihydrogen peroxide; sodium tungstate (VI) dihydrate / water; acetonitrile / 5.5 h / 65 - 70 °C View Scheme |
3-phenyltetronic acid
rofecoxib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / toluene / 17 h 2: palladium(0)bis(tricyclohexylphosphine) / toluene; water / 24 h / 100 °C / Inert atmosphere; Glovebox View Scheme |
rofecoxib
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol; ethyl acetate under 2585.74 Torr; | 100% |
4-dimethylamino-benzaldehyde
rofecoxib
(5Z)-5-(4-(dimethylamino)benzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 95% |
rofecoxib
5-Hydroxyrofecoxib
Conditions | Yield |
---|---|
With oxygen; pyrographite In ethyl acetate | 92% |
With hepatic enzymes; oxygen; NADPH | |
Multi-step reaction with 2 steps 1: NBS 2: aq. AcOH / tetrahydrofuran View Scheme | |
With sodium sulfite In dimethyl sulfoxide at 60℃; for 6h; Temperature; Time; |
ortho-anisaldehyde
rofecoxib
(5Z)-5-(2-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 92% |
piperonal
rofecoxib
(5Z)-5-((benzo[d][1,3]dioxol-5-yl)methylene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 91% |
benzaldehyde
rofecoxib
(5Z)-5-(benzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 90% |
3-nitro-benzaldehyde
rofecoxib
(5Z)-5-(3-nitrobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 90% |
3,4,5-trimethoxy-benzaldehyde
rofecoxib
(5Z)-5-(3,4,5-trimethoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 90% |
vanillin
rofecoxib
(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 90% |
4-methoxy-benzaldehyde
rofecoxib
(5Z)-5-(4-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 90% |
4-cyanobenzaldehyde
rofecoxib
Conditions | Yield |
---|---|
With piperidine In methanol at 20℃; for 12h; Darkness; | 89% |
furfural
rofecoxib
(5Z)-5-((furan-2-yl)methylene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 88% |
1-naphthaldehyde
rofecoxib
(5Z)-4-(4-(methylsulfonyl)phenyl)-5-((naphthalen-1-yl)methylene)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 88% |
4-bromo-benzaldehyde
rofecoxib
(5Z)-5-(4-fluorobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 86% |
4-chlorobenzaldehyde
rofecoxib
(5Z)-5-(4-chlorobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 85% |
4-hydroxy-benzaldehyde
rofecoxib
(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 84% |
rofecoxib
(E/Z)-3,7-dimethyl-2,6-octadienal
(5Z)-5-((Z/E)-3,7-dimethylocta-2,6-dienylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 80% |
acetone
rofecoxib
4-(4-(methylsulfonyl)phenyl)-3-phenyl-5-(propan-2-ylidene)furan-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 70% |
acetic acid methyl ester
rofecoxib
5-methoxy-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With sodium carbonate In methanol at 65℃; stereoselective reaction; | 63% |
rofecoxib
(2Z)-2-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-ene-1,4-diol
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In tetrahydrofuran at 0 - 25℃; | |
Stage #1: rofecoxib With diisobutylaluminium hydride In dichloromethane at -78 - 20℃; Stage #2: With sodium hydroxide; water In dichloromethane at -78 - 20℃; | |
With sodium hydroxide; diisobutylaluminium hydride In dichloromethane | |
Stage #1: rofecoxib With diisobutylaluminium hydride In dichloromethane at -78 - 20℃; Stage #2: With sodium hydroxide In dichloromethane; water at -78 - 20℃; |
rofecoxib
(+/-)-5-bromo-4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
Conditions | Yield |
---|---|
With N-Bromosuccinimide | |
With N-Bromosuccinimide; dibenzoyl peroxide In chloroform for 24h; Heating / reflux; |
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