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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Rofecoxib Manufacturer/High quality/Best price/In stock

Cas:162011-90-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Rofecoxib

Cas:162011-90-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Rofecoxib

Cas:162011-90-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Rofecoxib 162011-90-7 GMP Manufacturer

Cas:162011-90-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Rofecoxib

Cas:162011-90-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Rofecoxib

Cas:162011-90-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Rofecoxib The alias:4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone; VIOXX CAS NO:162011-90-7 Molecular formula:C17H14O4S Molecular weight:314.3557 Product Quality 12 years of chemical raw materials Mature operation of the indus

Rofecoxib/CAS:162011-90-7/High quality

Cas:162011-90-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

Rofecoxib

Cas:162011-90-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 162011-90-7 with competitive price

Cas:162011-90-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Rofecoxib CAS162011-90-7

Cas:162011-90-7

Min.Order:1 Kilogram

FOB Price: $7.0 / 11.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Rofecoxib 162011-90-7

Cas:162011-90-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Rofecoxib CAS:162011-90-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Rofecoxib CAS:162011-90-7

Cas:162011-90-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Rofecoxib

Cas:162011-90-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Rofecoxib

Cas:162011-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Rofecoxib

Cas:162011-90-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

MK-966 Rofecoxib cas 162011-90-7

Cas:162011-90-7

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Rofecoxib

Cas:162011-90-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Rofecoxib

Cas:162011-90-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Rofecoxib

Cas:162011-90-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Rofecoxib

Cas:162011-90-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

RofecoxibAppearance:White or Almost White crystalline powder Storage:Store in refrigerator Package:according to customers' requirements Application:Steroids injection For Body building Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by se

Rofecoxib

Cas:162011-90-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Tr

Rofecoxib

Cas:162011-90-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Rofecoxib

Cas:162011-90-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Rofecoxib Basic information Product Name: Rofecoxib Synonyms: 4-[4-(MethylSLdfonyl)phenyl]-3-phenyl-2(5H)-furanone;4-[4-(Methylsulfonyl)phenyl]-3-phenyl-;Rofecoxib(Vioxx);Rofecoxib (MK0966);Rofecoxid;ROFECOXIB;MK-0966;VIOXX CAS: 162011-90-7 M

Rofecoxib 162011-90-7

Cas:162011-90-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Rofecoxib

Cas:162011-90-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Rofecoxib.99%

Cas:162011-90-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Rofecoxib

Cas:162011-90-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Rofecoxib

Cas:162011-90-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Rofecoxib

Cas:162011-90-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Rofecoxib

Cas:162011-90-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

4-(4-(methylthio)phenyl)-3-phenylfuran-2(5H)-one
162012-30-8

4-(4-(methylthio)phenyl)-3-phenylfuran-2(5H)-one

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid at 0 - 21℃; Oxidation;99%
With Oxone In water; acetone at 0 - 25℃; for 24h; Product distribution / selectivity;95%
With oxone In water; acetone at 0 - 25℃; for 24h;91%
2-(4-methanesulfonylphenyl)-2-oxoethyl 2-(diethoxyphosphoryl)-2-phenylacetate

2-(4-methanesulfonylphenyl)-2-oxoethyl 2-(diethoxyphosphoryl)-2-phenylacetate

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 2h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;95%
phenylacetic acid
103-82-2

phenylacetic acid

ethyl bromoacetate
105-36-2

ethyl bromoacetate

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water; ethyl acetate94%
2-bromo-1-(4-methanesulfonylphenyl)ethanone
50413-24-6

2-bromo-1-(4-methanesulfonylphenyl)ethanone

2-(diethoxyphosphino)-2-phenylacetic acid
38654-91-0

2-(diethoxyphosphino)-2-phenylacetic acid

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 2h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;92%
phenylacetic acid
103-82-2

phenylacetic acid

2-bromo-1-(4-methanesulfonylphenyl)ethanone
50413-24-6

2-bromo-1-(4-methanesulfonylphenyl)ethanone

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Stage #1: phenylacetic acid With sodium hydroxide In DMF (N,N-dimethyl-formamide); water at 4℃; for 1h;
Stage #2: 2-bromo-1-(4-methanesulfonylphenyl)ethanone With diisopropylamine at 45℃; for 3.5h;
78%
Stage #1: phenylacetic acid With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: 2-bromo-1-(4-methanesulfonylphenyl)ethanone In N,N-dimethyl-formamide for 1h;
Stage #3: With diisopropylamine In N,N-dimethyl-formamide at 60℃; for 4h;
76%
Stage #1: phenylacetic acid; 2-bromo-1-(4-methanesulfonylphenyl)ethanone With triethylamine In acetonitrile at 20 - 25℃; for 0.333333h;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; for 0.333333h;
58%
3-chloro-4-(4'-methylsulfonylphenyl)-5H-furan-2-one
487047-31-4

3-chloro-4-(4'-methylsulfonylphenyl)-5H-furan-2-one

phenylboronic acid
98-80-6

phenylboronic acid

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride In water; toluene for 7h; Suzuki cross-coupling; Heating;74%
With cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; N-benzyl-N,N,N-triethylammonium chloride In water; toluene for 7h; Product distribution / selectivity; Suzuki Coupling; Heating / reflux;74%
C16H11IO2

C16H11IO2

methyl p-toluene sulfonate
80-48-8

methyl p-toluene sulfonate

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin; potassium hydrogenphosphate trihydrate; tetrabutylammomium bromide In dimethyl sulfoxide at 100℃; for 10h; Inert atmosphere; Schlenk technique;59%
With 1,1'-bis-(diphenylphosphino)ferrocene; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin; potassium hydrogenphosphate trihydrate; tetrabutylammomium bromide In dimethyl sulfoxide at 100℃; for 10h; Inert atmosphere;59%
C12H10O4

C12H10O4

4-methanesulphonylphenylboronic acid
149104-88-1

4-methanesulphonylphenylboronic acid

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With palladium(0)bis(tricyclohexylphosphine) In water; toluene at 100℃; for 24h; Inert atmosphere; Glovebox;45%
4-(methylsulfonyl)benzoylmethyl phenylacetate
201737-94-2

4-(methylsulfonyl)benzoylmethyl phenylacetate

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; for 0.5h;
With diisopropylamine In DMF (N,N-dimethyl-formamide) at 45℃; for 4.25h;
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile Horner-Wadsworth-Emmons Olefination;
phenylacetic acid
103-82-2

phenylacetic acid

Fmoc-L-Val-(p-methylbenzhydrylamine resin)

Fmoc-L-Val-(p-methylbenzhydrylamine resin)

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / acetonitrile / 0.5 h / 25 °C
2: DBU / acetonitrile / 0.5 h / 0 °C
View Scheme
2-bromo-1-(4-methanesulfonylphenyl)ethanone
50413-24-6

2-bromo-1-(4-methanesulfonylphenyl)ethanone

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / acetonitrile / 0.5 h / 25 °C
2: DBU / acetonitrile / 0.5 h / 0 °C
View Scheme
(4-thiomethoxyphenyl)boronic acid
98546-51-1

(4-thiomethoxyphenyl)boronic acid

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 72 h / 20 - 25 °C
2: 85 percent / Oxone(R) / acetone; H2O / 0 - 25 °C
3: 74 percent / cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 7 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 72 h / 20 - 25 °C
2: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 20 - 25 °C
3: 91 percent / Oxone(R) / acetone; H2O / 24 h / 0 - 25 °C
View Scheme
3-bromo-4-(4'-methylthiophenyl)-5H-furan-2-one
329328-49-6

3-bromo-4-(4'-methylthiophenyl)-5H-furan-2-one

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / Heating
2: 91 percent / Oxone(R) / acetone; H2O / 24 h / 0 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: 68 percent / AsPh3; CuI / Pd2(dba)3 / 1-methyl-pyrrolidin-2-one / 63 h / 80 °C
2: 80 percent / oxone; aq. Bu4NBr / CH2Cl2 / 46.5 h / 20 °C
View Scheme
3-chloro-4-(4'-methylthiophenyl)-5H-furan-2-one
487047-30-3

3-chloro-4-(4'-methylthiophenyl)-5H-furan-2-one

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / Oxone(R) / acetone; H2O / 0 - 25 °C
2: 74 percent / cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 7 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: cesium fluoride; BnEt3NCl / PdCl2(PPh3)2 / toluene; H2O / 20 - 25 °C
2: 91 percent / Oxone(R) / acetone; H2O / 24 h / 0 - 25 °C
View Scheme
4-(Methylthio)acetophenone
1778-09-2

4-(Methylthio)acetophenone

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 100 percent / MMPP / methanol; CH2Cl2 / 3 h / 20 °C
2.1: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C
3.1: Et3N / acetonitrile / 0.33 h / 25 °C
3.2: 54 percent / DBU / acetonitrile / 0.33 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C
2.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C
2.2: 2.5 h / 25 - 58 °C
3.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C
3.2: 1 h
3.3: 4 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: tetra-N-butylammonium tribromide / methanol; dichloromethane
2: sodium hydroxide / water; dichloromethane
3: diisopropylamine / dimethyl sulfoxide
4: dihydrogen peroxide; sodium tungstate (VI) dihydrate / water; acetonitrile / 5.5 h / 65 - 70 °C
View Scheme
methyl-phenyl-thioether
100-68-5

methyl-phenyl-thioether

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 82 percent / AlCl3 / CHCl3 / 1.5 h / 5 °C
2.1: 100 percent / MMPP / methanol; CH2Cl2 / 3 h / 20 °C
3.1: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C
4.1: Et3N / acetonitrile / 0.33 h / 25 °C
4.2: 54 percent / DBU / acetonitrile / 0.33 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / chloroform / 1.5 h / -5 - 5 °C / Cooling with ice
2.1: acetic acid; dihydrogen peroxide; sulfuric acid / 2 h / 0 - 70 °C
3.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C
3.2: 2.5 h / 25 - 58 °C
4.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C
4.2: 1 h
4.3: 4 h / 60 °C
View Scheme
4-(methanesulfonyl)acetophenone
10297-73-1

4-(methanesulfonyl)acetophenone

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 86 percent / Br2; AlCl3 / CHCl3 / -5 °C
2.1: Et3N / acetonitrile / 0.33 h / 25 °C
2.2: 54 percent / DBU / acetonitrile / 0.33 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1.1: acetic acid; hydrogen bromide / 0.08 h / 20 °C
1.2: 2.5 h / 25 - 58 °C
2.1: sodium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C
2.2: 1 h
2.3: 4 h / 60 °C
View Scheme
tributylphenylstannane
960-16-7

tributylphenylstannane

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / AsPh3; CuI / Pd2(dba)3 / 1-methyl-pyrrolidin-2-one / 63 h / 80 °C
2: 80 percent / oxone; aq. Bu4NBr / CH2Cl2 / 46.5 h / 20 °C
View Scheme
3-Phenyl-2-propyn-1-ol
1504-58-1

3-Phenyl-2-propyn-1-ol

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran; cyclohexane / 19 h / 80 °C
3: 99 percent / m-CPBA / 0 - 21 °C
View Scheme
(4-methylsulfanylphenyl)magnesium chloride

(4-methylsulfanylphenyl)magnesium chloride

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran; cyclohexane / 19 h / 80 °C
3: 99 percent / m-CPBA / 0 - 21 °C
View Scheme
C16H14MgOS

C16H14MgOS

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 99 percent / m-CPBA / 0 - 21 °C
View Scheme
phenylacetic acid
103-82-2

phenylacetic acid

water
7732-18-5

water

triethylamine
121-44-8

triethylamine

2-bromo-1-(4-methanesulfonylphenyl)ethanone
50413-24-6

2-bromo-1-(4-methanesulfonylphenyl)ethanone

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile
phenylacetic acid
103-82-2

phenylacetic acid

triethylamine
121-44-8

triethylamine

2-bromo-1-(4-methanesulfonylphenyl)ethanone
50413-24-6

2-bromo-1-(4-methanesulfonylphenyl)ethanone

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In water; acetonitrile
2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone
42445-46-5

2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
2: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C
3: uranyl(VI) acetate dihydrate; oxygen / water; acetonitrile; o-xylene / 20 °C / 760.05 Torr / Schlenk technique; Irradiation
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water; dichloromethane
2: diisopropylamine / dimethyl sulfoxide
3: dihydrogen peroxide; sodium tungstate (VI) dihydrate / water; acetonitrile / 5.5 h / 65 - 70 °C
View Scheme
phenylacetic acid
103-82-2

phenylacetic acid

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
2: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C
3: uranyl(VI) acetate dihydrate; oxygen / water; acetonitrile; o-xylene / 20 °C / 760.05 Torr / Schlenk technique; Irradiation
View Scheme
2-(4-(methylthio)phenyl)-2-oxoethyl 2-phenylacetate

2-(4-(methylthio)phenyl)-2-oxoethyl 2-phenylacetate

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C
2: uranyl(VI) acetate dihydrate; oxygen / water; acetonitrile; o-xylene / 20 °C / 760.05 Torr / Schlenk technique; Irradiation
View Scheme
Multi-step reaction with 2 steps
1: diisopropylamine / dimethyl sulfoxide
2: dihydrogen peroxide; sodium tungstate (VI) dihydrate / water; acetonitrile / 5.5 h / 65 - 70 °C
View Scheme
3-phenyltetronic acid
23782-85-6

3-phenyltetronic acid

rofecoxib
162011-90-7

rofecoxib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / toluene / 17 h
2: palladium(0)bis(tricyclohexylphosphine) / toluene; water / 24 h / 100 °C / Inert atmosphere; Glovebox
View Scheme
rofecoxib
162011-90-7

rofecoxib

(3S,4R)-4-(4-Methanesulfonyl-phenyl)-3-phenyl-dihydro-furan-2-one

(3S,4R)-4-(4-Methanesulfonyl-phenyl)-3-phenyl-dihydro-furan-2-one

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol; ethyl acetate under 2585.74 Torr;100%
4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(4-(dimethylamino)benzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-89-6

(5Z)-5-(4-(dimethylamino)benzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;95%
rofecoxib
162011-90-7

rofecoxib

5-Hydroxyrofecoxib
185147-17-5

5-Hydroxyrofecoxib

Conditions
ConditionsYield
With oxygen; pyrographite In ethyl acetate92%
With hepatic enzymes; oxygen; NADPH
Multi-step reaction with 2 steps
1: NBS
2: aq. AcOH / tetrahydrofuran
View Scheme
With sodium sulfite In dimethyl sulfoxide at 60℃; for 6h; Temperature; Time;
ortho-anisaldehyde
135-02-4

ortho-anisaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(2-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-79-4

(5Z)-5-(2-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;92%
piperonal
120-57-0

piperonal

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-((benzo[d][1,3]dioxol-5-yl)methylene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-91-0

(5Z)-5-((benzo[d][1,3]dioxol-5-yl)methylene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;91%
benzaldehyde
100-52-7

benzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(benzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-77-2

(5Z)-5-(benzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;90%
3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(3-nitrobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-78-3

(5Z)-5-(3-nitrobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;90%
3,4,5-trimethoxy-benzaldehyde
86-81-7

3,4,5-trimethoxy-benzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(3,4,5-trimethoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-80-7

(5Z)-5-(3,4,5-trimethoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;90%
vanillin
121-33-5

vanillin

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-82-9

(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;90%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(4-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-92-1

(5Z)-5-(4-methoxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;90%
4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(4-cyanobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

(5Z)-5-(4-cyanobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With piperidine In methanol at 20℃; for 12h; Darkness;89%
furfural
98-01-1

furfural

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-((furan-2-yl)methylene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-81-8

(5Z)-5-((furan-2-yl)methylene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;88%
1-naphthaldehyde
66-77-3

1-naphthaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-4-(4-(methylsulfonyl)phenyl)-5-((naphthalen-1-yl)methylene)-3-phenylfuran-2(5H)-one
1448458-93-2

(5Z)-4-(4-(methylsulfonyl)phenyl)-5-((naphthalen-1-yl)methylene)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;88%
4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(4-fluorobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-84-1

(5Z)-5-(4-fluorobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;86%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(4-chlorobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-85-2

(5Z)-5-(4-chlorobenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;85%
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

rofecoxib
162011-90-7

rofecoxib

(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448458-83-0

(5Z)-5-(4-hydroxybenzylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;84%
rofecoxib
162011-90-7

rofecoxib

(E/Z)-3,7-dimethyl-2,6-octadienal
5392-40-5

(E/Z)-3,7-dimethyl-2,6-octadienal

(5Z)-5-((Z/E)-3,7-dimethylocta-2,6-dienylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
1448459-29-7

(5Z)-5-((Z/E)-3,7-dimethylocta-2,6-dienylidene)-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;80%
acetone
67-64-1

acetone

rofecoxib
162011-90-7

rofecoxib

4-(4-(methylsulfonyl)phenyl)-3-phenyl-5-(propan-2-ylidene)furan-2(5H)-one
1448458-94-3

4-(4-(methylsulfonyl)phenyl)-3-phenyl-5-(propan-2-ylidene)furan-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;70%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

rofecoxib
162011-90-7

rofecoxib

5-methoxy-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one
185147-25-5

5-methoxy-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With sodium carbonate In methanol at 65℃; stereoselective reaction;63%
rofecoxib
162011-90-7

rofecoxib

(2Z)-2-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-ene-1,4-diol
179174-76-6

(2Z)-2-[4-(methylsulfonyl)phenyl]-3-phenylbut-2-ene-1,4-diol

Conditions
ConditionsYield
With diisobutylaluminium hydride In tetrahydrofuran at 0 - 25℃;
Stage #1: rofecoxib With diisobutylaluminium hydride In dichloromethane at -78 - 20℃;
Stage #2: With sodium hydroxide; water In dichloromethane at -78 - 20℃;
With sodium hydroxide; diisobutylaluminium hydride In dichloromethane
Stage #1: rofecoxib With diisobutylaluminium hydride In dichloromethane at -78 - 20℃;
Stage #2: With sodium hydroxide In dichloromethane; water at -78 - 20℃;
rofecoxib
162011-90-7

rofecoxib

(+/-)-5-bromo-4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
691005-66-0

(+/-)-5-bromo-4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one

Conditions
ConditionsYield
With N-Bromosuccinimide
With N-Bromosuccinimide; dibenzoyl peroxide In chloroform for 24h; Heating / reflux;

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