2-Fluoro-5-nitrobenzaldehyde supplier

Name
2-Fluoro-5-nitrobenzaldehyde
EINECS -0
CAS No. 27996-87-8
Article Data12
CAS DataBase
Density 1.443 g/cm³
Solubility It is insoluble in water.
Melting Point 57-60 °C(lit.)
Formula C₇H₄FNO₃
Boiling Point 269.7 °C at 760 mmHg
Molecular Weight 169.112
Flash Point 116.9 °C
Transport Information
Appearance Beige to light brown crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 5-NITRO-2-FLUOROBENZALDEHYDE;2-FLUORO-5-NITROBENZALDEHYDE;FLUORO NITROBENZALDEHYDE;2-Fluoro-5-Nitrobenzaldehyde 5-Nitro-2-Fluorobenzaldehyde;2-Fluoro-5-nitrobenzaldehyde,97%;4-Fluoro-3-formylnitrobenzene;Benzaldehyde,2-fluoro-5-nitro-
PSA 62.89000
LogP 2.06960

Synthetic route

: 374538-01-9
(4-fluoro-3-formylphenyl)boronic acid

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 20℃; for 16h; regioselective reaction;	100%

: 446-52-6
2-Fluorobenzaldehyde

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride; ethylammonium nitrate at 0 - 30℃; for 4h; Inert atmosphere; regioselective reaction;	97%

: C12H11BFNO5

A: 27996-87-8
2-fluoro-5-nitrobenzaldehye

B: C12H10BFN2O7

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 20℃; for 16h; regioselective reaction;	A 65% B 32%

: 455-88-9
5-nitro-2-fluorotoluene

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

Conditions

Conditions	Yield
(i) CrO3, H2SO4, Ac2O, AcOH, (ii) aq. H2SO4, EtOH; Multistep reaction;

: 6361-21-3
2-chloro-5-nitrobenzaldehyde

A 2-Fluoro-5-notrobenzaldehyde: 2-Fluoro-5-notrobenzaldehyde

B: 27996-87-8
2-fluoro-5-nitrobenzaldehye

Conditions

Conditions	Yield
With potassium fluoride In N-methyl-acetamide; water

: 6361-21-3
2-chloro-5-nitrobenzaldehyde

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

Conditions

Conditions	Yield
With potassium fluoride In N-methyl-acetamide; water
With potassium fluoride In N,N-dimethyl-formamide at 20 - 160℃;
With potassium fluoride In N,N-dimethyl-formamide at 20 - 160℃; for 1.5h;
With potassium fluoride In N,N-dimethyl-formamide

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 63878-73-9
(2-fluoro-5-nitrophenyl)methanol

Conditions

Conditions	Yield
	100%
With methanol; sodium tetrahydroborate at 0℃; for 3h;	99%
With methanol; sodium tetrahydroborate at 0 - 20℃; for 1h;	99.8%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 15231-41-1
tert-butyl 3-aminopropanoate

: 147290-94-6
tert-butyl N-<(2-fluoro-5-nitrophenyl)methyl>-3-aminopropionate

Conditions

Conditions	Yield
With sodium acetate; sodium cyanoborohydride In methanol for 2h; Ambient temperature;	99%

: 72745-66-5
3-methyl-4-benzyl-2-isoxazolin-5-one

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 2-(4-benzyl-3-methyl-5-oxo-5H-isoxazol-2-yl)-5-nitro-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 3-methyl-4-benzyl-2-isoxazolin-5-one With sodium In methanol Stage #2: 2-fluoro-5-nitrobenzaldehye In N,N-dimethyl-formamide at 45 - 50℃; for 0.5h;	99%

: 29879-44-5
4,5,6,7-tetrahydrobenzo[c]isoxazol-3(3aH)-one

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 5-nitro-2-(3-oxo-4,5,6,7-tetrahydro-3H-benzo[c]isoxazol-1-yl)-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 4,5,6,7-tetrahydrobenzo[c]isoxazol-3(3aH)-one With sodium In methanol Stage #2: 2-fluoro-5-nitrobenzaldehye In N,N-dimethyl-formamide at 45 - 50℃; for 5h;	99%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 108-95-2
phenol

: 99847-09-3
5-nitro-2-(phenoxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 70℃;	99%
With potassium carbonate In 1,4-dioxane at 70℃;	99%
With potassium carbonate In N,N-dimethyl acetamide at 170℃; for 2h;

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 74-89-5
methylamine

: 50609-41-1
2-methylamino-5-nitro-benzaldehyde

Conditions

Conditions	Yield
In ethanol; dimethyl sulfoxide at 20℃; for 12h; Inert atmosphere;	99%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1017782-93-2
4-(2-formyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; Inert atmosphere;	99%
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	94.8%
With potassium carbonate In dimethyl sulfoxide at 95℃; for 96h; Sealed vessel;	80%
With potassium carbonate In dimethyl sulfoxide at 95℃; for 32h;	78.9%
With potassium carbonate In N,N-dimethyl-formamide for 12h;	55%

: 123-75-1
pyrrolidine

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 30742-59-7
5-nitro-2-(1-pyrrolidinyl)-benzaldehyde

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	99%
With potassium carbonate In dimethyl sulfoxide at 60℃; for 3h;	85%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; Inert atmosphere;
In water at 25℃; for 0.5h; Sealed tube; Green chemistry;

: 371-41-5
4-Fluorophenol

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 57388-43-9
2-(4-fluorophenoxy)-5-nitrobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 3h; Inert atmosphere;	99%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 63878-71-7
2‐(difluoromethyl)‐1‐fluoro‐4‐nitrobenzene

Conditions

Conditions	Yield
With diethylamino-sulfur trifluoride In dichloromethane at 20℃; Cooling with ice;	98%
With diethylamino-sulfur trifluoride In dichloromethane at 20℃; for 16h; Inert atmosphere;	82%
With diethylamino-sulfur trifluoride In dichloromethane at 20℃; for 16h; Inert atmosphere;	82%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 1-(4-fluorophenyl)-2-(imidazolidin-2-yl)ethanone

: 4-(4-chlorobenzoyl)-7-nitro-1,2-dihydro-imidazo[1,2-a]quinoline

Conditions

Conditions	Yield
With piperidine In ethanol at 40℃; for 12h;	98%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 24589-77-3, 52455-33-1
4-hydrazinobenzoic acid hydrochloride

: C14H10FN3O4

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 2h; Inert atmosphere;	98%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 292638-85-8
acrylic acid methyl ester

: methyl 6-nitro-2H-thiochromene-3-carboxylate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; carbon disulfide In acetonitrile at 20℃; for 20h; Inert atmosphere;	97%

: 109-96-6
3-Pyrroline

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 2-(2,5-dihydro-1H-pyrrol-1-yl)-5-nitrobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide Reflux;	97%
With potassium carbonate In N,N-dimethyl-formamide at 20 - 90℃; for 7h;

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 1-(4-fluorophenyl)-2-(imidazolidin-2-yl)ethanone

: 4-(4-bromobenzoyl)-7-nitro-1,2-dihydro-imidazo[1,2-a]quinoline

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 65℃; for 2h;	97%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 64944-80-5
2-benzoylmethyleneimidazolidine

: 4-benzoyl-7-nitro-1,2-dihydro-imidazo[1,2-a]quinoline

Conditions

Conditions	Yield
With piperidine; calcium chloride In 1,4-dioxane at 65℃; for 0.5h;	97%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 104-86-9
4-chlorobenzylamine

: (4-chloro-benzyl)-(2-fluoro-5-nitro-benzyl)-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid; trimethyl orthoformate In toluene at 20℃; for 6h; Reductive amination;	96%

: 110-89-4
piperidine

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 1530-45-6
(carbethoxymethyl)triphenylphosphonium bromide

: ethyl (E)-3-(5-nitro-2-(piperidin-1-yl)phenyl)acrylate

Conditions

Conditions	Yield
With sodium hydroxide In water for 5h; Solvent; Inert atmosphere; Reflux; Green chemistry; stereoselective reaction;	96%

...Expand

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 100-46-9
benzylamine

: C36H35FN4O6

Conditions

Conditions	Yield
In methanol; dichloromethane at 20℃; for 72h; Ugi Condensation;	96%

...Expand

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 623-51-8
ethyl 2-sulfanylacetate

: 25785-09-5
ethyl 5-nitro-2-benzo[b]thiophenecarboxylate

Conditions

Conditions	Yield
With hydrogenchloride; potassium carbonate In methanol; N,N-dimethyl-formamide	95.1%

: 23244-37-3
4-methyl-3-phenylisoxazole-5(4H)-one

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 2-(4-methyl-5-oxo-3-phenyl-5H-isoxazol-2-yl)-5-nitro-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 4-methyl-3-phenylisoxazole-5(4H)-one With sodium In methanol Stage #2: 2-fluoro-5-nitrobenzaldehye In N,N-dimethyl-formamide at 45 - 50℃; for 2h;	95%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 122-51-0
orthoformic acid triethyl ester

: 773850-31-0
2-fluoro-5-nitrobenzaldehyde diethylacetal

Conditions

Conditions	Yield
With sulfuric acid In ethanol for 3h;	95%

: 120-72-9
indole

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 3-((2-fluoro-5-nitrophenyl)(1H-indol-3-yl)methyl)-1H-indole

Conditions

Conditions	Yield
With boric acid In water at 20℃; for 0.416667h; Green chemistry;	95%

: 603-76-9
1-methylindole

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 3-((2-fluoro-5-nitrophenyl)(1-methyl-1H-indol-3-yl)methyl)-1-methyl-1H-indole

Conditions

Conditions	Yield
With boric acid In water at 20℃; for 0.333333h; Green chemistry;	95%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 17422-32-1
5-chloro-1H-indole

: 5-chloro-3-((5-chloro-1H-indol-3-yl)(2-fluoro-5-nitrophenyl)methyl)-1H-indole

Conditions

Conditions	Yield
With boric acid In water at 20℃; for 0.416667h; Green chemistry;	95%

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 4,4-difluoropiperidine hydrochloride

: 2-(4,4-difluoropiperidin-1-yl)-5-nitrobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; Inert atmosphere;	95%

: 75-15-0
carbon disulfide

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 100-63-0
phenylhydrazine

: 1-[(2-fluoro-5-nitrophenyl)methylidene]-2-phenylhydrazine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 0 - 20℃; for 15h;	95%

...Expand

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 82100-23-0
2-(imidazolidin-2-ylidene)-1-(p-tolyl)ethanone

: 4-p-toluyl-7-nitro-1,2-dihydro-imidazo[1,2-a]quinoline

Conditions

Conditions	Yield
With piperidine; calcium oxide In 1,4-dioxane at 65℃; for 2h;	95%

2-Fluoro-5-nitrobenzaldehyde Chemical Properties

Product Name: Benzaldehyde,2-fluoro-5-nitro- (CAS NO.27996-87-8)

Molecular Formula: C₇H₄FNO₃
Molecular Weight: 169.11g/mol
Mol File: 27996-87-8.mol
Appearance: Beige to light brown crystalline powder
Melting Point: 57-60 °C(lit.)
Sensitive: Air Sensitive
Index of Refraction: 1.59
Molar Refractivity: 39.54 cm³
Molar Volume: 117.1 cm³
Surface Tension: 52.2 dyne/cm
Density: 1.443 g/cm³
Flash Point: 116.9 °C
Enthalpy of Vaporization: 50.79 kJ/mol
Boiling Point: 269.7 °C at 760 mmHg
Vapour Pressure: 0.00713 mmHg at 25°C
XLogP3-AA: 1.3
H-Bond Donor: 0
H-Bond Acceptor: 4
Structure Descriptors of Benzaldehyde,2-fluoro-5-nitro- (CAS NO.27996-87-8):
IUPAC Name: 2-fluoro-5-nitrobenzaldehyde
Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])C=O)F
InChI: InChI=1S/C7H4FNO3/c8-7-2-1-6(9(11)12)3-5(7)4-10/h1-4H
InChIKey: VVXFDFQEIRGULC-UHFFFAOYSA-N
Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde; Miscellaneous; Aldehydes; C7; Carbonyl Compounds

2-Fluoro-5-nitrobenzaldehyde Safety Profile

Safety Information of Benzaldehyde,2-fluoro-5-nitro- (CAS NO.27996-87-8):
Hazard Codes: Xi Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: PG3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT

2-Fluoro-5-nitrobenzaldehyde Specification

Benzaldehyde,2-fluoro-5-nitro- , its CAS NO. is 27996-87-8, the synonyms are Fluoro Nitrobenzaldehyde ; 2-Fluoro-5-nitrobenzaldehyde .

Product Name

2-Fluoro-5-nitrobenzaldehyde

Synthetic route

2-Fluoro-5-nitrobenzaldehyde Chemical Properties

2-Fluoro-5-nitrobenzaldehyde Safety Profile

2-Fluoro-5-nitrobenzaldehyde Specification

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