Product Name

  • Name

    2-Furoyl chloride

  • EINECS 208-422-9
  • CAS No. 527-69-5
  • Article Data19
  • CAS DataBase
  • Density 1.323 g/cm3
  • Solubility Soluble in ether and chloroform, decomposed in water and ethanol
  • Melting Point -2 °C
  • Formula C5H3ClO2
  • Boiling Point 170.9 at 760 mmHg
  • Molecular Weight 130.531
  • Flash Point 57.1 °C
  • Transport Information UN 3265 8/PG 2
  • Appearance colorless or light yellow liquid
  • Safety 26-36/37/39-45
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 527-69-5 (2-Furoyl chloride)
  • Hazard Symbols CorrosiveC
  • Synonyms 2-Furoylchloride (6CI,7CI,8CI);2-(Chlorocarbonyl)furan;2-(Chloroformyl)furan;2-Furancarboxylic acid chloride;2-Furanoic acid chloride;Furan-2-carboxylic chloride;Pyromucyl chloride;a-Furoic chloride;
  • PSA 30.21000
  • LogP 1.65860

Synthetic route

2-furanoic acid
88-14-2

2-furanoic acid

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

Conditions
ConditionsYield
With thionyl chloride for 3h; Heating;95%
With thionyl chloride In benzene for 18h; Heating;86%
With thionyl chloride for 0.5h; Heating;82%
2-amino-4,6-difluoro-benzothiazole
119256-40-5

2-amino-4,6-difluoro-benzothiazole

A

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

B

furan-2-carboxylic acid (4,6-difluoro-benzothiazol-2-yl)-amide

furan-2-carboxylic acid (4,6-difluoro-benzothiazol-2-yl)-amide

Conditions
ConditionsYield
A n/a
B 81%
1-(2-furyl)-1-ethanone
1192-62-7

1-(2-furyl)-1-ethanone

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

Conditions
ConditionsYield
Stage #1: 1-(2-furyl)-1-ethanone With pyridine; disulfur dichloride In chlorobenzene at 20℃; for 2h;
Stage #2: With sulfuryl dichloride In chlorobenzene at 20 - 132℃; for 15.5h;		65%
Stage #1: 1-(2-furyl)-1-ethanone With pyridine; sulfur monochloride In chlorobenzene at 75℃; for 2.5h;
Stage #2: In chlorobenzene at 137℃; for 19h;
With pyridine; disulfur dichloride at 70 - 138℃; for 21.5h;44 %Spectr.
pyromucate ethylamine

pyromucate ethylamine

A

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

B

N,N'-diethyl-furan-2-carboxamidine

N,N'-diethyl-furan-2-carboxamidine

Conditions
ConditionsYield
With phosphorus pentachloride anschliessend Destillieren;
pyromucate ethylamine

pyromucate ethylamine

A

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

B

N.N'-diethyl-furfurenylamidine

N.N'-diethyl-furfurenylamidine

Conditions
ConditionsYield
With phosphorus pentachloride Destillieren des Reaktionsprodukts;
2-furanoic acid
88-14-2

2-furanoic acid

thionyl chloride

thionyl chloride

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

Conditions
ConditionsYield
In dichloromethane for 12h; Heating;
2-furanoic acid
88-14-2

2-furanoic acid

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

Conditions
ConditionsYield
With thionyl chloride In dichloromethane
potassium furan-2-carboxylate
20842-02-8

potassium furan-2-carboxylate

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane for 3.5h; Cooling with ice; Reflux;
2-furanoic acid
88-14-2

2-furanoic acid

2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline
3416-93-1

2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

N-<2-(3,4-dimethoxyphenyl)ethyl>furan-2-carboxamide

N-<2-(3,4-dimethoxyphenyl)ethyl>furan-2-carboxamide

Conditions
ConditionsYield
With pyridine In acetonitrile at 20℃; for 3h;100%
With triethylamine In chloroform for 2h; Ambient temperature;73%
neat (no solvent);
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

3-methyl-piperazine-1-carboxylic acid tert-butyl ester
120737-59-9

3-methyl-piperazine-1-carboxylic acid tert-butyl ester

4-(furan-2-ylcarbonyl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester
146951-98-6

4-(furan-2-ylcarbonyl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In chloroform for 48h; Ambient temperature;100%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methoxy-N-methyl-2-furancarboxamide
95091-92-2

N-methoxy-N-methyl-2-furancarboxamide

Conditions
ConditionsYield
With pyridine; sodium carbonate In tetrahydrofuran at 20℃; Inert atmosphere;100%
With triethylamine In dichloromethane Ambient temperature;92%
With potassium carbonate In 2-methyltetrahydrofuran; water at 0 - 20℃;92%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

phenethylamine
64-04-0

phenethylamine

N-phenethylfuran-2-carboxamide
153579-79-4

N-phenethylfuran-2-carboxamide

Conditions
ConditionsYield
With pyridine In acetonitrile at 20℃; for 3h;100%
In dichloromethane at 20 - 70℃; for 5h; Alkaline conditions;44%
tetrahydrofuran
109-99-9

tetrahydrofuran

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

furan-2-carboxylic acid 4-iodo-butyl ester

furan-2-carboxylic acid 4-iodo-butyl ester

Conditions
ConditionsYield
With bis(iodozinc)methane at 25℃; Substitution;100%
(4aR,5R,6R,7R)-1-Benzyl-6-hydroxy-7-methoxy-3,4a,5-trimethyl-1,4,4a,5,6,7-hexahydro-benzo[f]indol-2-one
209332-44-5

(4aR,5R,6R,7R)-1-Benzyl-6-hydroxy-7-methoxy-3,4a,5-trimethyl-1,4,4a,5,6,7-hexahydro-benzo[f]indol-2-one

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

(4AR,5R,6R,7R)-1-Benzyl-6-(2-furancarbonyloxy)-7-methoxy-4a,5,6,7-tetrahydro-3,4a,5-trimethylbenz[f]indol-2(4H)-one

(4AR,5R,6R,7R)-1-Benzyl-6-(2-furancarbonyloxy)-7-methoxy-4a,5,6,7-tetrahydro-3,4a,5-trimethylbenz[f]indol-2(4H)-one

Conditions
ConditionsYield
With pyridine at 20℃;100%
7-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-3,4a,5-trimethyl-4a,5,6,7-tetrahydro-4H-naphtho[2,3-b]furan-2-one
194789-88-3

7-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-3,4a,5-trimethyl-4a,5,6,7-tetrahydro-4H-naphtho[2,3-b]furan-2-one

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

Furan-2-carboxylic acid (4aR,5R,6R,7S)-7-(tert-butyl-dimethyl-silanyloxy)-3,4a,5-trimethyl-2-oxo-2,4,4a,5,6,7-hexahydro-naphtho[2,3-b]furan-6-yl ester
902462-74-2

Furan-2-carboxylic acid (4aR,5R,6R,7S)-7-(tert-butyl-dimethyl-silanyloxy)-3,4a,5-trimethyl-2-oxo-2,4,4a,5,6,7-hexahydro-naphtho[2,3-b]furan-6-yl ester

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 3h;100%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile
925923-78-0

2-amino-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridine-3-carbonitrile

N-{3-cyano-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridin-2-yl}furan-2-carboxamide
925923-79-1

N-{3-cyano-6-[2-(methoxymethoxy)phenyl]-5-methyl-4-(3-nitrophenyl)pyridin-2-yl}furan-2-carboxamide

Conditions
ConditionsYield
With pyridine at 20℃; for 20h;100%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

(3S,5S)-3-Hydroxy-7-oxa-8-cholesten-6-one
1262676-25-4

(3S,5S)-3-Hydroxy-7-oxa-8-cholesten-6-one

(3S,5S)-7-Oxa-8-cholesten-6-on-3-ol furan-2-carboxylate
1262677-21-3

(3S,5S)-7-Oxa-8-cholesten-6-on-3-ol furan-2-carboxylate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0℃; for 3h;100%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

3-methyl-3,4-dihydro-2(1H)-quinazolinone
24365-65-9

3-methyl-3,4-dihydro-2(1H)-quinazolinone

6-(furan-2-carbonyl)-3-methyl-3,4-dihydroquinazolin-2(1H)-one

6-(furan-2-carbonyl)-3-methyl-3,4-dihydroquinazolin-2(1H)-one

Conditions
ConditionsYield
With aluminum (III) chloride In carbon disulfide at 50℃; for 24h; Friedel-Crafts Acylation; Reflux;100%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

2-(4-isopropyl-5-methylhex-3-en-1-yl)-2-(pent-4-yn-1-yl)propane-1,3-diol
930116-67-9

2-(4-isopropyl-5-methylhex-3-en-1-yl)-2-(pent-4-yn-1-yl)propane-1,3-diol

2-(4-isopropyl-5-methylhex-3-en-1-yl)-2-(pent-4-yn-1-yl)propane-1,3-diyl bis(furan-2-carboxylate)

2-(4-isopropyl-5-methylhex-3-en-1-yl)-2-(pent-4-yn-1-yl)propane-1,3-diyl bis(furan-2-carboxylate)

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃; for 22h; Schlenk technique; Inert atmosphere;100%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

C21H26F2O5

C21H26F2O5

C26H28F2O7

C26H28F2O7

Conditions
ConditionsYield
With diethylamine In butanone at 20 - 30℃; Reagent/catalyst; Solvent;100%
thiophene
188290-36-0

thiophene

2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

(furan-2-yl)(thiophen-2-yl)methanone
20409-51-2

(furan-2-yl)(thiophen-2-yl)methanone

Conditions
ConditionsYield
With ethylaluminum dichloride In dichloromethane at 0℃; for 2h; Inert atmosphere;99%
With tin(IV) chloride; benzene Behandeln des Reaktionsgemisches mit Wasser;
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

phenol
108-95-2

phenol

furan-2-carboxylic acid phenyl ester
2948-14-3

furan-2-carboxylic acid phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.5h; Reflux;99%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; Schlenk technique; Inert atmosphere;85%
With triethylamine In dichloromethane at 20℃; for 0.5h;77%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

2-furoic anhydride
615-08-7

2-furoic anhydride

Conditions
ConditionsYield
With water; triethylamine In acetone at 20℃; for 0.5h;99%
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at -10℃; for 3h;60%
With zinc In N,N-dimethyl-formamide; pentane at 20℃; for 20h; Inert atmosphere; Schlenk technique;36%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

2-furoyl-1H-1,2,3-benzotriazole
144223-33-6

2-furoyl-1H-1,2,3-benzotriazole

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.5h; Ambient temperature;99%
With triethylamine In dichloromethane for 4h; Heating;87%
With triethylamine In dichloromethane at 0 - 20℃;
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

(2S,5S)-2,5-bis(methoxymethyl)pyrrolidine
90290-05-4, 93621-94-4, 105016-60-2, 144993-81-7

(2S,5S)-2,5-bis(methoxymethyl)pyrrolidine

(2'S,5'S)-[2',5'-Bis(methoxymethyl)-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl](2-furyl)methanone
328575-55-9

(2'S,5'S)-[2',5'-Bis(methoxymethyl)-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl](2-furyl)methanone

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane99%
With sodium hydroxide In dichloromethane at 20℃; for 24h;99%
With sodium hydroxide In dichloromethane at 20℃;99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

phenylboronic acid
98-80-6

phenylboronic acid

(furan-2-yl)(phenyl)methanone
2689-59-0

(furan-2-yl)(phenyl)methanone

Conditions
ConditionsYield
With PEG200; sodium carbonate; palladium diacetate at 60℃; for 1h; Suzuki reaction;99%
With sodium dodecyl-sulfate; potassium carbonate; palladium dichloride In water at 60℃; for 6h;88%
With potassium carbonate In water; acetone at 50℃; for 0.17h; Catalytic behavior; Suzuki-Miyaura Coupling;87%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

beta-methyl aspartate hydrochloride

beta-methyl aspartate hydrochloride

dichloromethane
75-09-2

dichloromethane

methyl 3-Carboxy-3-(2-furoylamino)propionate

methyl 3-Carboxy-3-(2-furoylamino)propionate

Conditions
ConditionsYield
With triethylamine99%
...Expand
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid

9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid

9,11-epoxy-17α-[(2-furanylcarbonyl)oxy]-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

9,11-epoxy-17α-[(2-furanylcarbonyl)oxy]-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-furancarbonyl chloride; 9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid With triethylamine In acetone at 25 - 30℃; for 4h;
Stage #2: With diethylamine In acetone at 10 - 20℃; for 1h;		99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

7-amino-2-trifluoromethylbenzimidazole dihydrochloride

7-amino-2-trifluoromethylbenzimidazole dihydrochloride

C13H8F3N3O2
727663-80-1

C13H8F3N3O2

Conditions
ConditionsYield
Stage #1: 2-furancarbonyl chloride; 7-amino-2-trifluoromethylbenzimidazole dihydrochloride With pyridine In benzene at 20℃;
Stage #2: With methanol; triethylamine for 1h; Heating; Further stages.;		99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid
159264-49-0

9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid

diethylamine
109-89-7

diethylamine

9,11-epoxy-17α-[(2-furanylcarbonyl)oxy]16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
948565-89-7

9,11-epoxy-17α-[(2-furanylcarbonyl)oxy]16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-furancarbonyl chloride; 9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid With triethylamine In acetone at 10 - 30℃; for 4h;
Stage #2: diethylamine In acetone at 10 - 20℃; for 1h;		99%
...Expand
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

(S)-α,α-diphenyl-2-pyrrolidine-2-methanol

(S)-α,α-diphenyl-2-pyrrolidine-2-methanol

furan-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone
1152061-10-3

furan-2-yl-[(S)-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl]-methanone

Conditions
ConditionsYield
Stage #1: (S)-α,α-diphenyl-2-pyrrolidine-2-methanol With caesium carbonate In acetonitrile at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2-furancarbonyl chloride In acetonitrile for 4h; Inert atmosphere;		99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

3-amino-N-<(benzyloxy)carbonyl>-D-alanine methyl ester hydrochloride

3-amino-N-<(benzyloxy)carbonyl>-D-alanine methyl ester hydrochloride

(R)-2-benzyloxycarbonylamino-3-[(furan-2-carbonyl)amino]propionic acid methyl ester
1182348-97-5

(R)-2-benzyloxycarbonylamino-3-[(furan-2-carbonyl)amino]propionic acid methyl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at -10℃; for 6h;99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

2-amino-5-iodo-benzamide
32658-67-6

2-amino-5-iodo-benzamide

N-(2-carbamoyl-4-iodophenyl)furan-2-carboxamide
1158963-83-7

N-(2-carbamoyl-4-iodophenyl)furan-2-carboxamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 2h;99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

C20H31N3O2

C20H31N3O2

C25H33N3O4

C25H33N3O4

Conditions
ConditionsYield
With triethylamine In dichloromethane99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

6,6,6-Trifluoro-1-phenyl-4-hexyn-3-ol
94792-93-5

6,6,6-Trifluoro-1-phenyl-4-hexyn-3-ol

6,6,6-trifluoro-1-phenylhex-4-yn-3-yl 2-furoate
1388859-81-1

6,6,6-trifluoro-1-phenylhex-4-yn-3-yl 2-furoate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one
16619-68-4

1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one

2-(3-phenylprop-2-ynoyl)phenyl furan-2-carboxylate
1415385-02-2

2-(3-phenylprop-2-ynoyl)phenyl furan-2-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
28416-82-2

6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid

GW694301X

GW694301X

Conditions
ConditionsYield
Stage #1: 2-furancarbonyl chloride; 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid With triethylamine In acetone at 0 - 5℃; for 3h;
Stage #2: With diethylamine In acetone at 40 - 45℃; for 2.5h;		99%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

1α,2α,8β,9α,15-pentacetoxy-4β,6β-dihydroxy-3β,13-[4′-(3-carboxybutyl)]nicotinic acid-dicarbolactone-β-dihydroagarofuran

1α,2α,8β,9α,15-pentacetoxy-4β,6β-dihydroxy-3β,13-[4′-(3-carboxybutyl)]nicotinic acid-dicarbolactone-β-dihydroagarofuran

1α,2α,8β,9α,15-pentacetoxy-6β-(2-furoyloxy)-4β-hydroxy-3β,13-[4′-(3-carboxybutyl)]nicotinic acid-dicarbolactone-β-dihydroagarofuran

1α,2α,8β,9α,15-pentacetoxy-6β-(2-furoyloxy)-4β-hydroxy-3β,13-[4′-(3-carboxybutyl)]nicotinic acid-dicarbolactone-β-dihydroagarofuran

Conditions
ConditionsYield
With dmap; triethylamine In toluene for 24h; Reflux;99%

2-Furoyl chloride Specification

The 2-Furoyl chloride with CAS registry number of 527-69-5 is also known as 2-Furancarbonyl chloride. The IUPAC name is Furan-2-carbonyl chloride. It belongs to product categories of Pharmaceutical Intermediates. Its EINECS registry number is 208-422-9. In addition, the formula is C5H3ClO2 and the molecular weight is 130.53. This chemical is a colorless or light yellow liquid and should be stored in cool, ventilated, dry place away from oxidizing agents.

Physical properties about 2-Furoyl chloride are: (1)ACD/LogP: 1.37; (2)ACD/LogD (pH 5.5): 1.37; (3)ACD/LogD (pH 7.4): 1.37; (4)ACD/BCF (pH 5.5): 6.48; (5)ACD/BCF (pH 7.4): 6.48; (6)ACD/KOC (pH 5.5): 132.63; (7)ACD/KOC (pH 7.4): 132.63; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 1; (10)Polar Surface Area: 30.21Å2; (11)Index of Refraction: 1.495; (12)Molar Refractivity: 28.79 cm3; (13)Molar Volume: 98.6 cm3; (14)Surface Tension: 38.1 dyne/cm; (15)Density: 1.323 g/cm3; (16)Flash Point: 57.1 °C; (17)Enthalpy of Vaporization: 40.73 kJ/mol; (18)Boiling Point: 170.9 °C at 760 mmHg; (19)Vapour Pressure: 1.44 mmHg at 25 °C.

Preparation of 2-Furoyl chloride: it is prepared by reaction of 2-furancarboxylato with thionyl chloride. Firstly, the reaction mixture is refluxed at 100 °C for 1 hour. Then, mixture is distillated to steam excess thionyl chloride. At last, product is obtained by collecting fraction at 173-174 °C. The yield is about 79%.

Uses of 2-Furoyl chloride: it is used for organic synthesis. It is used to produce 2-diazo-1-furan-2-yl-ethanone by reaction with diazomethane. The reaction occurs with solvent diethyl ether at 20 °C. The yield is about 90%.

2-Furoyl chloride is used to produce 2-diazo-1-furan-2-yl-ethanone by reaction with diazomethane.

When you are using this chemical, please be cautious about it. As a chemical, it may cause burns. During using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If accident happens or you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=COC(=C1)C(=O)Cl
2. InChI: InChI=1S/C5H3ClO2/c6-5(7)4-2-1-3-8-4/h1-3H
3. InChIKey: OFTKFKYVSBNYEC-UHFFFAOYSA-N

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