2-Mercaptopropionic acid supplier

Name
2-Mercaptopropionic acid
EINECS 201-206-5
CAS No. 79-42-5
Article Data55
CAS DataBase
Density 1.218 g/cm³
Solubility miscible with water
Melting Point 10-14 °C(lit.)
Formula C₃H₆O₂S
Boiling Point 205.3 °C at 760 mmHg
Molecular Weight 106.145
Flash Point 87 °C
Transport Information UN 2936 6.1/PG 2
Appearance Clear colorless to slightly yellow liquid
Safety 26-36/37/39-45-25
Risk Codes 34-22
Molecular Structure
Hazard Symbols C
Synonyms Propionicacid, 2-mercapto- (8CI);Propionic acid, a-mercapto- (3CI);2-Thiolactic acid;Thiolacticacid;a-Mercaptopropanoic acid;a-Mercaptopropionic acid;Thiolactic acid;
PSA 76.10000
LogP 0.38930

Synthetic route

: 19788-49-9
Ethyl 2-mercaptopropionate

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In phosphate buffer for 2h;	99%

: 129975-20-8
Ethyl (R,S)-2-(Acetylthio)propionate

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 805179-10-6
2,2'-trisulfanediyl-di-propionic acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; zinc
With sodium amalgam
With sulfuric acid durch Elektrolytische Reduktion an Blei-Kathode;

: 598-78-7
(R,S)-2-chloropropionic acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With sodium hydrogensulfide; hydrogen sulfide; water und Erhitzen des Reaktionsgemisches mit wss.Salzsaeure;

: 598-72-1
2-Bromopropionic acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With alkali disulfide Reduktion der entstehenden Thiodilactylsaeure mit granuliertem Zink und Schwefelsaeure;

: 535-13-7
2-chloro-propanoic acid, ethyl ester

: 922-52-1, 4775-93-3, 20664-26-0, 20664-27-1, 21793-77-1
(S)-2-((S)-1-Carboxy-ethyldisulfanyl)-propionic acid

B: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With potassium hydrosulfide

: 51440-83-6
2-(ethoxycarbonothioyl)sulfanyl propanoic acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With ammonium hydroxide; ethanol ueber mehrere Stufen;

: 51440-83-6
2-(ethoxycarbonothioyl)sulfanyl propanoic acid

A: 625-57-0
O-ethyl thiocarbamate

B: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With ammonia

: 4775-93-3
2,2'-dithiobispropanoic acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; zinc
With sodium amalgam

: 21793-77-1
(+)-2,2'-dithiobispropionic acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
at 25℃; Redoxgleichgewicht (polarimetrische Bestimmung);

: (+/-)-2.2'-thionyl-dipropionic acid

A: 127-17-3
2-oxo-propionic acid

B: 79-42-5
2-mercaptopropanoic acid

: 924-57-2, 924-58-3, 998-87-8, 20664-32-8, 6332-91-8
2,2'-(thiocarbonylbis(sulfanediyl))-dipropanoic acid

A: 1986-44-3
5-methyl-2-thioxo-thiazolidin-4-one

B: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With ammonia

: 56554-80-4, 123540-84-1
1-chloro-heptadec-8-ene

: 2,6-dimethyl-3,5-dithia-4-tellura-heptanedioic acid ; compound with thiolactic acid

A: 25417-80-5
bis(1-carboxyethanethio)tellurium(II)

B: 79-42-5
2-mercaptopropanoic acid

...Expand

: 3805-14-9
2-amino-5-methylthiazolin-4-one

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide
With barium dihydroxide

: 127-17-3
2-oxo-propionic acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With ammonium hydrosulphide
With ammonium hydrosulphide at 110℃;
With hydrogenchloride; hydrogen sulfide; water at 60 - 70℃; man reduziert die sich ausscheidende Trithiodilactylsaeure in mit verd.Schwefelsaeure schwach sauer gehaltener Loesung mit Natriumamalgam; der angesaeuerten Loesung wird Thiomilchsaeure mit Aether entzogen;
With hydrogenchloride; hydrogen sulfide; water; zinc

: 4695-28-7
3,5-dimethylthiazolidine-2,4-dione

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 25℃; Rate constant; Mechanism; different pH's;

: 18792-26-2
5-methyl-2-o-toluidino-thiazol-4-one

diluted alkalies: diluted alkalies

: 79-42-5
2-mercaptopropanoic acid

: 5-methyl-2-(N-methyl-anilino)-thiazol-4-one

diluted alkaline solution: diluted alkaline solution

: 79-42-5
2-mercaptopropanoic acid

: 3805-14-9
2-amino-5-methylthiazolin-4-one

aq. barium hydroxide solution: aq. barium hydroxide solution

A: 7664-41-7
ammonia

B: 79-42-5
2-mercaptopropanoic acid

C: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

...Expand

acidic l-dithiodilactylacidic l-phenethylamine: acidic l-dithiodilactylacidic l-phenethylamine

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With sodium amalgam; water levorotatory α-mercapto-propionic acid;

: 127-17-3
2-oxo-propionic acid

ammonium hydrosulfide: ammonium hydrosulfide

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
at 110℃;

cysteine-hydrochloride: cysteine-hydrochloride

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
at 140 - 145℃;

sodium-<2-bromo propionate>: sodium-<2-bromo propionate>

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With sodium polysulfide; water und Behandeln des Reaktionsprodukts mit wss.Schwefelsaeure und Zink;

sodium-<2-chloro propionate>: sodium-<2-chloro propionate>

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
With water; potassium hydrosulfide und Erhitzen des vom Loesungsmittel befreiten Reaktionsgemisches auf 110grad;

α-chloro-propionic acid: α-chloro-propionic acid

A: 79-42-5
2-mercaptopropanoic acid

B thiodilactylic acid: thiodilactylic acid

Conditions

Conditions	Yield
With water; potassium hydrosulfide

: 805179-10-6
2,2'-trisulfanediyl-di-propionic acid

: 7664-93-9
sulfuric acid

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
bei der elektrolytischen Reduktion an Blei-Kathode;

: 51440-83-6
(R)-2-ethoxythiocarbonylmercapto-propionic acid

: 7664-41-7
ammonia

: 79-42-5
2-mercaptopropanoic acid

: 100704-24-3
2-carbamoylsulfanyl-propionic acid

alkali: alkali

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
Hydrolysis;

: 922-52-1, 4775-93-3, 20664-26-0, 20664-27-1, 21793-77-1
(S)-2-((S)-1-Carboxy-ethyldisulfanyl)-propionic acid

alkali: alkali

: 79-42-5
2-mercaptopropanoic acid

Conditions

Conditions	Yield
Spaltung;

: 26555-40-8
Methoxycarbonylsulfenyl chloride

: 79-42-5
2-mercaptopropanoic acid

: methoxycarbonylsulfenylthiolactic acid

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; Inert atmosphere;	100%

: C15H20N2O2

: 79-42-5
2-mercaptopropanoic acid

: N‐(2,8‐dimethyl‐3‐oxo‐1‐thia‐4‐azaspiro[4.5]dec‐4‐yl)‐2‐phenoxyacetamide

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	100%

: C18H26N2O2

: 79-42-5
2-mercaptopropanoic acid

: C21H30N2O3S

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	100%

: N'-[4-(trifluoromethyl)cyclohexylidene]-2-phenoxyacetohydrazide

: 79-42-5
2-mercaptopropanoic acid

: N‐[2‐methyl‐3‐oxo‐8‐(trifluoromethyl)‐1‐thia‐4‐azaspiro[4.5]dec‐4‐yl]‐2‐phenoxyacetamide

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	100%

: C20H22N2O2

: 79-42-5
2-mercaptopropanoic acid

: N‐(2‐methyl‐8‐phenyl‐3‐oxo‐1‐thia‐4‐azaspiro[4.5]dec‐4‐yl)‐2‐phenoxyacetamide

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	100%

: C15H20N2O

: 79-42-5
2-mercaptopropanoic acid

: N‐(2‐methyl‐3‐oxo‐1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)‐3‐phenylpropanamide

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	100%

: C16H22N2O

: 79-42-5
2-mercaptopropanoic acid

: N‐(2,8‐dimethyl‐3‐oxo‐1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)‐3‐phenylpropanamide

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	100%

: C19H28N2O

: 79-42-5
2-mercaptopropanoic acid

: N‐(2‐methyl‐8‐tert‐butyl‐3‐oxo‐1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)‐3‐phenylpropanamide

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	100%

: 79-42-5
2-mercaptopropanoic acid

: 139744-05-1
methyl 2-bromo-3-(3,4-methylenedioxyphenyl)propionate

: 139767-08-1
methyl 2-(1-carboxyethylthio)-3-(3,4-methylenedioxyphenyl)propionate

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 0℃; for 1h;	99%

: 13577-19-0
8-iodo-1-naphthoic acid

: 79-42-5
2-mercaptopropanoic acid

: 20760-29-6
2H-naphtho<1,8-b,c>thiophene-2-one

Conditions

Conditions	Yield
Stage #1: 8-iodo-1-naphthoic acid; 2-mercaptopropanoic acid With potassium hydroxide; copper In water for 7h; Heating / reflux; Stage #2: With hydrogenchloride; water pH=1;	99%

: 64-17-5
ethanol

: 79-42-5
2-mercaptopropanoic acid

: 19788-49-9
Ethyl 2-mercaptopropionate

Conditions

Conditions	Yield
toluene-4-sulfonic acid for 16h; Heating;	98%
With toluene-4-sulfonic acid In chloroform esterified azeotropically;	63%
With sulfuric acid
With toluene-4-sulfonic acid

: 79-42-5
2-mercaptopropanoic acid

: 25417-80-5
bis(1-carboxyethanethio)tellurium(II)

Conditions

Conditions	Yield
With tellurium oxide; sodium hydroxide	98%
With sodium tellurite; water

: 3847-58-3
2,4-difluoro-3-chloro-nitrobenzene

: 79-42-5
2-mercaptopropanoic acid

: 116176-49-9
S-(2-chloro-3-fluoro-6-nitrophenyl)thiolactic acid

Conditions

Conditions	Yield
With sodium hydroxide In water; dimethyl sulfoxide at 80℃; for 2h;	98%

: 118-29-6
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

: 79-42-5
2-mercaptopropanoic acid

: 2-(phthalimidomethylsulfanyl)propionic acid

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride In trifluoroacetic acid	98%

: 79-42-5
2-mercaptopropanoic acid

: 474460-01-0
(6-phenyl-imidazo[2,1-b]thiazol-3-yl)-acetic acid (4-ethyl-cyclohexylidene)-hydrazide

: N-(8-ethyl-2-methyl-3-oxo-1-thia-4-aza-spiro[4.5]dec-4-yl)-2-(6-phenyl-imidazo[2,1-b]thiazol-3-yl)-acetamide

Conditions

Conditions	Yield
97 In benzene for 48h; Heating;	98%

: 79-42-5
2-mercaptopropanoic acid

: 474460-04-3
[6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-3-yl]-acetic acid (3-methyl-cyclohexylidene)-hydrazide

: 2-[6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-3-yl]-N-(2,7-dimethyl-3-oxo-1-thia-4-aza-spiro[4.5]dec-4-yl)-acetamide

Conditions

Conditions	Yield
97 In benzene for 48h; Heating;	98%

: 79-42-5
2-mercaptopropanoic acid

: 474460-06-5
[6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-3-yl]-acetic acid (4-methyl-cyclohexylidene)-hydrazide

: 2-[6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-3-yl]-N-(2,8-dimethyl-3-oxo-1-thia-4-aza-spiro[4.5]dec-4-yl)-acetamide

Conditions

Conditions	Yield
97 In benzene for 48h; Heating;	98%

: 79-42-5
2-mercaptopropanoic acid

: 474460-07-6
[6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-3-yl]-acetic acid (4-ethyl-cyclohexylidene)-hydrazide

: 2-[6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-3-yl]-N-(8-ethyl-2-methyl-3-oxo-1-thia-4-aza-spiro[4.5]dec-4-yl)-acetamide

Conditions

Conditions	Yield
97 In benzene for 48h; Heating;	98%

: 608-05-9
5-methyl-indole-2,3-dione

: 83-07-8
4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

: 79-42-5
2-mercaptopropanoic acid

: 3'-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-5,5'-dimethyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide In water Sonication; Combinatorial reaction / High throughput screening (HTS);	98%

...Expand

: 83-07-8
4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

: 17630-76-1
5-chloroindole 2,3-dione

: 79-42-5
2-mercaptopropanoic acid

: 5-chloro-3'-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-5'-methyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide In water Sonication; Combinatorial reaction / High throughput screening (HTS);	98%

...Expand

: 936-02-7
2-Hydroxybenzoylhydrazine

: 79-42-5
2-mercaptopropanoic acid

: 589-92-4
1-methylcyclohexan-4-one

: 2-hydroxy-N-(2,8-dimethyl-3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)benzamide

Conditions

Conditions	Yield
In benzene for 6h; Reflux; Dean-Stark;	98%

...Expand

: 19847-12-2
2-pyrazine carbonitrile

: 79-42-5
2-mercaptopropanoic acid

: 338409-28-2
5-methyl-2-(pyrazin-2-yl)thiazol-4-ol

Conditions

Conditions	Yield
With pyridine at 100℃; for 2h;	97.1%
With pyridine at 100℃; for 2h;	97.1%
With pyridine at 100℃; for 2h;	97.1%

: 79-42-5
2-mercaptopropanoic acid

: 474460-00-9
(6-phenyl-imidazo[2,1-b]thiazol-3-yl)-acetic acid (4-methyl-cyclohexylidene)-hydrazide

: N-(2,8-dimethyl-3-oxo-1-thia-4-aza-spiro[4.5]dec-4-yl)-2-(6-phenyl-imidazo[2,1-b]thiazol-3-yl)-acetamide

Conditions

Conditions	Yield
97 In benzene for 48h; Heating;	97%

: 79-42-5
2-mercaptopropanoic acid

: 474459-99-9
(6-phenyl-imidazo[2,1-b]thiazol-3-yl)-acetic acid (3-methyl-cyclohexylidene)-hydrazide

: N-(2,7-dimethyl-3-oxo-1-thia-4-aza-spiro[4.5]dec-4-yl)-2-(6-phenyl-imidazo[2,1-b]thiazol-3-yl)-acetamide

Conditions

Conditions	Yield
In benzene for 48h; Heating;	97%

: 91-56-5
indole-2,3-dione

: 79-42-5
2-mercaptopropanoic acid

: 62-53-3
aniline

: 91870-65-4
5'-methyl-3'-phenylspiro<3H-indole-3,2'-thiazolidine>-2,4'(1H)-dione

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide In water Sonication; Combinatorial reaction / High throughput screening (HTS);	97%
In toluene for 16h; Reflux;	60%

...Expand

: 10381-82-5
8-bromocaffeine

: 79-42-5
2-mercaptopropanoic acid

: 2-((1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)thio)propanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 1.5h; Reflux;	97%

: 81912-98-3
5-Chloro-3-[(Z)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylimino]-1,3-dihydro-indol-2-one

: 79-42-5
2-mercaptopropanoic acid

: 5-chloro-3'-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-5'-methyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione

Conditions

Conditions	Yield
With Montmorillonite KSF for 0.0833333h; microwave irradiation;	96%

: 617-94-7
1-methyl-1-phenylethyl alcohol

: 79-42-5
2-mercaptopropanoic acid

: 40201-77-2
2-[(2-phenylpropan-2-yl)thio]propanoic acid

Conditions

Conditions	Yield
With indium(III) triflate In nitromethane at 20℃; for 0.5h; Sealed tube; chemoselective reaction;	96%

: C21H24N2O

: 79-42-5
2-mercaptopropanoic acid

: N‐(2‐methyl‐8‐phenyl‐3‐oxo‐1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)‐3‐phenylpropanamide

Conditions

Conditions	Yield
In toluene Reflux; Dean-Stark;	96%

2-Mercaptopropionic acid Chemical Properties

Molecular Structure of 2-Thiolactic acid (CAS NO.79-42-5):

IUPAC Name: 2-Sulfanylpropanoic acid
Molecular Formula: C₃H₆O₂S
Molecular Weight: 106.14
XLogP3-AA: 0.5
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 201-206-5
Index of Refraction: 1.494
Molar Refractivity: 25.36 cm³
Molar Volume: 87.1 cm³
Surface Tension: 42.6 dyne/cm
Density: 1.218 g/cm³
Flash Point: 87 °C
Enthalpy of Vaporization: 48.66 kJ/mol
Boiling Point: 205.3 °C at 760 mmHg
Vapour Pressure: 0.103 mmHg at 25 °C
Melting Point: 10-14 °C(lit.)
Water Solubility: MISCIBLE
Product Categories: acid Flavor
Appearance: Clear colorless to slightly yellow liquid
Canonical SMILES: CC(C(=O)O)S
InChI: InChI=1S/C3H6O2S/c1-2(6)3(4)5/h2,6H,1H3,(H,4,5)
InChIKey: PMNLUUOXGOOLSP-UHFFFAOYSA-N
Air & Water Reactions: Soluble in water and denser than water

2-Mercaptopropionic acid Uses

2-Thiolactic acid (CAS NO.79-42-5) is used as temporarily allow the use of food spices. It is also used as a depilatory and in hair waving preparations.

2-Mercaptopropionic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LCLo	inhalation	700ppm (700ppm)		Kodak Company Reports. Vol. 21MAY1971,

2-Mercaptopropionic acid Consensus Reports

Reported in EPA TSCA Inventory.

2-Mercaptopropionic acid Safety Profile

Safety Information of 2-Thiolactic acid (CAS NO.79-42-5):
Hazard Codes: Corrosive C
Risk Statements: 34-22
R22:Harmful if swallowed.
R34:Causes burns.
Safety Statements: 26-36/37/39-45-25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S25:Avoid contact with eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2936 6.1/PG 2
WGK Germany: 1
RTECS: UF5250000
HazardClass: 6.1
PackingGroup: II
Poison by ingestion. Moderately toxic by inhalation. When heated to decomposition it emits toxic fumes of SO_x.

2-Mercaptopropionic acid Standards and Recommendations

DOT Classification: 6.1; Label: Poison

2-Mercaptopropionic acid Specification

2-Thiolactic acid (CAS NO.79-42-5), its Synonyms are 2-Mercaptopropanoic acid ; 2-Mercaptopropionic acid ; Propanoic acid, 2-mercapto- ; Propionic acid, 2-mercapto- ; Thiolactic acid ; alpha-Mercaptopropanoic acid ; alpha-Mercaptopropionic acid ; 2-Thiolpropionic acid .

Product Name

2-Mercaptopropionic acid

Synthetic route

2-Mercaptopropionic acid Chemical Properties

2-Mercaptopropionic acid Uses

2-Mercaptopropionic acid Toxicity Data With Reference

2-Mercaptopropionic acid Consensus Reports

2-Mercaptopropionic acid Safety Profile

2-Mercaptopropionic acid Standards and Recommendations

2-Mercaptopropionic acid Specification

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