2-Methoxy-1-propanol supplier

Name
(2S)-2-Methoxy-1-propanol
EINECS 216-455-5
CAS No. 1589-47-5
Article Data84
CAS DataBase
Density 0.912 g/cm³
Solubility
Melting Point -84.2°C (estimate)
Formula C4H10 O2
Boiling Point 130 °C at 760 mmHg
Molecular Weight 90.1222
Flash Point 41.9 °C
Transport Information UN 1993
Appearance
Safety Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Risk Codes 61-10-37/38-41 2
Molecular Structure
Hazard Symbols A reproductive hazard.
Synonyms 2-Methoxy-1-hydroxypropane;2-Methoxy-1-propanol; 2-Methoxypropanol
PSA 29.46000
LogP 0.01360

Synthetic route

: 67-56-1
methanol

: 75-56-9, 16033-71-9
methyloxirane

: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With C2H3N4(1-)0.5C8H4O4(2-)Zn(2+) for 6h; Heating;	95.4%

: 67-56-1
methanol

: 75-56-9, 16033-71-9
methyloxirane

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With MCM-41-encapsulated cetyltrimethylammonium hydroxide at 110℃; for 3h; regioselective reaction;	A 92% B n/a
With boron trifluoride diethyl etherate	A 36% B 39%
at 200℃;

...Expand

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 1589-47-5
2-methoxypropanol

D: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With dihydrogen peroxide; titanium-silicate In methanol at 40℃;	A n/a B n/a C n/a D 92%
With dihydrogen peroxide; titanium-silicate In methanol at 40℃;	A n/a B n/a C n/a D 78%
With dihydrogen peroxide; titanium-silicate In water at 30 - 80℃; under 18751.9 Torr; pH=4.5;	A n/a B n/a C n/a D 61%

...Expand

: 67-56-1
methanol

: 15448-47-2
(R)-propylene oxide

A: 4984-22-9
(R)-1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With sodium hydroxide for 5h; Reflux;	A 79% B n/a

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 108-32-7
1,2-propylene cyclic carbonate

B: 57-55-6
propylene glycol

C: 107-98-2
1-methoxy-2-propanol

D: 1589-47-5
2-methoxypropanol

E: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With 6,7,9,10,12,13,20,21-octahydrodibenzo[b,h][1,4,7,10,13,16]hexaoxacyclooctadecine; potassium chloride at 130℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Autoclave; High pressure;	A 69.2% B 12.5% C n/a D n/a E 13.2%
With 6,7,9,10,12,13,20,21-octahydrodibenzo[b,h][1,4,7,10,13,16]hexaoxacyclooctadecine; potassium bromide at 130℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Autoclave; High pressure;	A 62.9% B 14.4% C n/a D n/a E 12.5%
With potassium bromide at 130℃; under 15001.5 Torr; for 8h; Autoclave; High pressure;	A 44.1% B 6.7% C n/a D n/a E 5.8%

...Expand

: 67-56-1
methanol

: 75-56-9, 16033-71-9
methyloxirane

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

C: 127-00-4
1-Chloro-2-propanol

Conditions

Conditions	Yield
With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H2O)0.5(MeOH)0.5 at 25℃;	A 56% B 40% C 4%
With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H2O)0.5(MeOH)0.5 at 60℃;	A 49% B 47% C 4%

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 108-32-7
1,2-propylene cyclic carbonate

B: 107-98-2
1-methoxy-2-propanol

C: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With lithium iodide at 130℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Autoclave; High pressure;	A 54.8% B n/a C n/a
With potassium carbonate at 100℃; for 6h; Supercritical conditions; Green chemistry;	A 35.6% B n/a C n/a

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 108-32-7
1,2-propylene cyclic carbonate

B: 57-55-6
propylene glycol

C: 107-98-2
1-methoxy-2-propanol

D: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With lithium bromide at 130℃; under 15001.5 Torr; for 8h; Autoclave; High pressure;	A 52.4% B 5.7% C n/a D n/a

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 57-55-6
propylene glycol

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With H(+)-zeolite-X In benzene at 25℃; for 0.5h; Product distribution; further alcohols, thiols, aminoalcohols; further catalyst;	A 51% B 33%
With H(+)-zeolite-X In benzene at 25℃; for 0.5h;	A 51 % Chromat. B 33 % Chromat.
With sulfuric acid In benzene at 25℃; for 0.5h;	A 37 % Chromat. B 38 % Chromat.

...Expand

: 534-15-6
1,1-dimethoxyethane

A: 6142-38-7
2-methoxypropanal

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With carbon monoxide; hydrogen; cobalt at 200℃; under 661957 Torr;

: phosphoric acid mono-(2-methoxy-propyl ester)

: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
in saurer wss. Loesung.Hydrolysis;

: 4324-39-4
ethyl 2-methoxypropanoate

: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With copper chromite at 250℃; under 294203 Torr; Hydrogenation;
With lithium aluminium tetrahydride
With diisobutylaluminium hydride

: 17639-76-8
methyl 2-methoxypropionate

: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride
Stage #1: methyl 2-methoxypropionate With lithium aluminium tetrahydride In diethyl ether at 20℃; Cooling with ice bath; Stage #2: With ammonia; water In diethyl ether Cooling with ice bath;

: 1072-47-5
4-methyl-1,3-dioxolane

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; boron trichloride 1.) CH2Cl2, 10 min, 2.) Et2O, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

: 107-18-6
allyl alcohol

: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate; mercury(II) nitrate 1) water, THF, 4h; 2) ca. 0.5 h; Multistep reaction;

: phosphoric acid mono-(2-methoxy-propyl ester)

: 7732-18-5
water

lanthanum (III)-hydroxide: lanthanum (III)-hydroxide

: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
pH 8.5.Hydrolysis;

...Expand

: 534-15-6
1,1-dimethoxyethane

carbon monoxide: carbon monoxide

A: 6142-38-7
2-methoxypropanal

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With hydrogen; cobalt at 200℃; under 661957 Torr;

...Expand

: 23465-33-0
1-bromo-2-methoxypropane

: 7732-18-5
water

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
at 100℃;

...Expand

Reaxys ID: 11354065: Reaxys ID: 11354065

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
Purification / work up; Industry scale;

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 74-98-6
propane

D: 1589-47-5
2-methoxypropanol

E: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With dihydrogen peroxide; titanium silicate In methanol at 59℃; under 18751.9 Torr; Product distribution / selectivity;

...Expand

: 67-56-1
methanol

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 74-98-6
propane

D: 1589-47-5
2-methoxypropanol

E: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With ammonia; dihydrogen peroxide; titanium-silicate catalyst In water at 41 - 59℃; under 18751.9 Torr; pH=4.5; Product distribution / selectivity; Continuously procces;
With water; hydrogen; oxygen; Pd-Bi/TiO2; tegafur at 60℃; under 16274.9 Torr; for 18h; pH=6; Product distribution / selectivity; aqueous ammonium phosphate buffer;
With water; hydrogen; oxygen; Pd-Au/TiO2; tegafur at 60℃; under 16274.9 Torr; for 18h; pH=6; Product distribution / selectivity; aqueous ammonium phosphate buffer;
With water; hydrogen; oxygen; Pd-Bi-Au/TiO2; tegafur at 60℃; under 16274.9 Torr; for 18h; pH=6; Product distribution / selectivity; aqueous ammonium phosphate buffer;
With ammonium acetate; hydrogen; oxygen at 60℃; under 56255.6 Torr; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; Supercritical conditions;	A n/a B n/a C n/a D n/a E 11.8 %Chromat.

...Expand

: 7440-32-6
titanium

: 187737-37-7
propene

: 98-85-1, 13323-81-4
1-Phenylethanol

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With dihydrogen peroxide In methanol

...Expand

: 67-56-1
methanol

: 187737-37-7
propene

A: 3,6-dioxa-2,4-dimethyl-1-heptanol

B: 57-55-6
propylene glycol

C: 108-61-2
2,2'-oxydipropanol

D: 107-98-2
1-methoxy-2-propanol

E: 74-98-6
propane

F: 1589-47-5
2-methoxypropanol

G: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With hydrogen; oxygen; Pd/TS-1 In water at 60℃; under 16274.9 Torr; pH=6; Product distribution / selectivity; ammonium phosphate buffer;

...Expand

: 7778-85-0
1,2-dimethoxypropane

A: 74-87-3
methylene chloride

B: 26198-63-0, 78-87-5
1,2-Dichloropropane

C: 107-98-2
1-methoxy-2-propanol

D: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
Stage #1: 1,2-dimethoxypropane With dichloromethane; tungsten(VI) chloride In Chloroform-D at 100℃; for 3h; Stage #2: With water In Chloroform-D at -20℃;

...Expand

: 75-56-9, 16033-71-9
methyloxirane

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With 0.5% Pt/Al2O3; dihydrogen peroxide at 59.84℃; under 3750.38 Torr; for 2h; Inert atmosphere; Autoclave;

...Expand

: 187737-37-7
propene

: 75-56-9, 16033-71-9
methyloxirane

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 74-98-6
propane

D: 1589-47-5
2-methoxypropanol

E: 67-63-0
isopropyl alcohol

F: 79-10-7
acrylic acid

G: 107-02-8
acrolein

Conditions

Conditions	Yield
With dihydrogen peroxide In methanol at 60℃; under 60006 Torr; for 5h; Autoclave;

...Expand

: 67-56-1
methanol

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With water; dihydrogen peroxide at 40℃; under 18751.9 Torr; Kinetics; Mechanism; Activation energy; Temperature; Pressure; Concentration; Inert atmosphere; chemoselective reaction;

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With polyethylene glycol (MW=4000) at 130℃; under 15001.5 Torr; for 8h; Autoclave; High pressure; Overall yield = 50.9 %;
With 6,7,9,10,12,13,20,21-octahydrodibenzo[b,h][1,4,7,10,13,16]hexaoxacyclooctadecine at 130℃; under 15001.5 Torr; for 8h; Autoclave; High pressure; Overall yield = 50.9 %;

...Expand

: 67-56-1
methanol

: 187737-37-7
propene

A: 107-98-2
1-methoxy-2-propanol

B: 74-98-6
propane

C: 1589-47-5
2-methoxypropanol

D: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With ammonium acetate; hydrogen; oxygen at 60℃; under 56255.6 Torr; for 7h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; Supercritical conditions;	A n/a B n/a C n/a D 17.6 %Chromat.

...Expand

: 1589-47-5
2-methoxypropanol

: 124-63-0
methanesulfonyl chloride

: C5H12O4S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	100%

: 1589-47-5
2-methoxypropanol

: 2927-83-5
2,3,3,3-tetrafluoro-2-(trifluoromethoxy)propionic acid fluoride

: heptafluoro-2-methoxypropionic acid 2-methoxypropyl ester

Conditions

Conditions	Yield
With titanium(IV) tetraethanolate In diethylene glycol dimethyl ether at -5 - 80℃; under 11251.1 Torr; for 8h; Temperature; Reagent/catalyst; Pressure; Solvent; Autoclave;	95%

: 4-[4-(2-chloro-4-bromophenoxy)phenoxy]2-pentenoic acid

: 1589-47-5
2-methoxypropanol

: 72325-98-5
2-Methoxypropyl 4-[4-(4-bromo-2-chlorophenoxy)phenoxy](2)-pentenoate

Conditions

Conditions	Yield
With thionyl chloride	91.3%

: 1589-47-5
2-methoxypropanol

: 98-59-9
p-toluenesulfonyl chloride

: 99861-96-8
racemic 2-methoxypropyl 4-methylbenzenesulphonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; Cooling with ice;	91%
With 2,6-dimethylpyridine In dichloromethane at 20℃; for 72h;	56%
In pyridine at 0 - 20℃; for 19h;
With pyridine at 20℃; for 5h; Cooling with ice bath;

: 75-21-8
oxirane

: 1589-47-5
2-methoxypropanol

: 113138-37-7
3-methyl-2,5-dioxaheptan-7-ol

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate	57%

: 1589-47-5
2-methoxypropanol

: methyl 2-(((methylsulfonyl)oxy)methyl)quinoline-6-carboxylate

: methyl 2-(isobutoxymethyl)quinoline-6-carboxylate

Conditions

Conditions	Yield
at 80℃; for 48h;	42%

: 1589-47-5
2-methoxypropanol

: 175013-46-4
(2R,3R,3aS)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}3-hydroxy-2,3,3a,9a-tetrahydro-6H-furo[2’,3’:4,5]oxazole[3,2a]-pyrimidin-6-one

A: 1244970-40-8
C29H38N2O7Si

B: 1244970-41-9
C29H38N2O7Si

Conditions

Conditions	Yield
Stage #1: 2-methoxypropanol With trimethylaluminum In n-heptane at 115℃; for 1h; Inert atmosphere; Stage #2: (2R,3R,3aS)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}3-hydroxy-2,3,3a,9a-tetrahydro-6H-furo[2’,3’:4,5]oxazole[3,2a]-pyrimidin-6-one In n-heptane at 150℃; for 72h; Inert atmosphere;	A 28% B 19%

...Expand

: 2523-94-6
methyl phosphorodichloridothionate

: 1589-47-5
2-methoxypropanol

: 28248-11-5
thiophosphorochloridic acid O-(2-methoxy-propyl) ester O'-methyl ester

: 1498-64-2
O-ethyl dichlorothiophosphate

: 1589-47-5
2-methoxypropanol

: 28248-14-8
thiophosphorochloridic acid O-ethyl ester O'-(2-methoxy-propyl) ester

: 1589-47-5
2-methoxypropanol

: 4-[4-(2-chloro-4-bromophenoxy)phenoxy](2)-pentenoic acid

: 72325-98-5
2-Methoxypropyl 4-[4-(4-bromo-2-chlorophenoxy)phenoxy](2)-pentenoate

Conditions

Conditions	Yield
(i) SOCl2, (ii) /BRN= 1731397/; Multistep reaction;

: 1589-47-5
2-methoxypropanol

: 28256-44-2
thiophosphorodichloridic acid O-(2-methoxy-propyl) ester

Conditions

Conditions	Yield
With trichlorophosphate

: 1589-47-5
2-methoxypropanol

: 148616-42-6
(-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane

: (2R,4R)-2-(2-Methoxy-propoxy)-5,5-dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-oxide

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran for 8h; Ambient temperature;

: 1589-47-5
2-methoxypropanol

: 79-22-1
methyl chloroformate

: 81112-27-8
2-methoxypropyl methyl carbonate

Conditions

Conditions	Yield
With pyridine; 1-methoxy-2-propanol

: 1589-47-5
2-methoxypropanol

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

A: ethyl (Z)-4-methoxypent-2-enoate

B: ethyl (E)-4-methoxypent-2-enoate

...Expand

: 1589-47-5
2-methoxypropanol

: 98-59-9
p-toluenesulfonyl chloride

A: 114114-86-2
toluene-4-sulfonic acid 2-methoxy-2-methylethyl ester

B: Toluene-4-sulfonic acid (R)-2-methoxy-propyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane for 16h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

2-Methoxy-1-propanol Chemical Properties

IUPAC Name: 2-Methoxypropan-1-ol
Molecular Formula: C₄H₁₀O₂
Molecular Weight: 90.14g/mol
EINECS: 216-455-5
Density: 0.912 g/cm³
Liansport Information: UN 1993
Density: 0.912 g/cm³
Boiling Point: 130 °C at 760 mmHg
Flash Point: 41.9 °C
Freely Rotating Bonds: 3
Polar Surface Area: 18.46Å²
Index of Refraction: 1.397
Molar Refractivity: 23.81 cm³
Molar Volume: 98.8 cm³
Polarizability: 9.44× 10^-24 cm³
Surface Tension: 26.9 dyne/cm
Enthalpy of Vaporization: 42.84 kJ/mol
Vapour Pressure: 4.44 mmHg at 25°C
2-Methoxy-1-propanol ,its Cas Register Number is 1589-47-5.The chemical synonyms of 2-Methoxy-1-propanol (CAS No.1589-47-5) are 2-Methoxypropanol ; 2-Methoxy-1-propanol ; 1-Propanol, 2-methoxy- ; 1-Propyleneglycol-2-methylether ; Beta-propyleneglycolmonomethylether ; 2-Methoxypropanol-1 ; 2-Methoxy-1-propano .The molecular structure of 2-Methoxy-1-propanol (CAS No.1589-47-5) is.

2-Methoxy-1-propanol Uses

2-Methoxy-1-propanol (CAS No.1589-47-5) is used in organic synthesis.

2-Methoxy-1-propanol Consensus Reports

Reported in EPA TSCA Inventory.

2-Methoxy-1-propanol Safety Profile

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes: Very T
Risk Statements: 61-10-37/38-41
R61:May cause harm to the unborn child.
R10:Flammable.
R41:Risk of serious damage to the eyes.
R37/38:Irritating to respiratory system and skin.
Safety Statements: 53-45
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
HazardClass: 3.2

2-Methoxy-1-propanol Standards and Recommendations

OSHA PEL: OSHA Analytical method #99

Product Name

(2S)-2-Methoxy-1-propanol

Synthetic route

2-Methoxy-1-propanol Chemical Properties

2-Methoxy-1-propanol Uses

2-Methoxy-1-propanol Consensus Reports

2-Methoxy-1-propanol Safety Profile

2-Methoxy-1-propanol Standards and Recommendations

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