2-Methoxy-4-methylphenol supplier

Name
2-Methoxy-4-methylphenol
EINECS 202-252-9
CAS No. 93-51-6
Article Data183
CAS DataBase
Density 1.078 g/cm³
Solubility Slightly soluble in water.
Melting Point 5 °C(lit.)
Formula C₈H₁₀O₂
Boiling Point 220 °C at 760 mmHg
Molecular Weight 138.166
Flash Point 99.4 °C
Transport Information
Appearance Clear colorless to slightly yellow liquid
Safety 26-36-24/25
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Creosol(6CI);p-Cresol, 2-methoxy- (8CI);2-Methoxy-p-cresol;3-Methoxy-4-hydroxytoluene;4-Hydroxy-3-methoxy-1-methylbenzene;4-Hydroxy-3-methoxytoluene;4-Methyl-2-methoxyphenol;4-Methylguaiacol;Homoguaiacol;NSC 4969;p-Creosol;p-Methylguaiacol;
PSA 29.46000
LogP 1.70920

Synthetic route

: 121-33-5
vanillin

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With formic acid; palladium and silver nanoparticles over graphitic carbon nitride surface In water at 20℃; for 4h; Catalytic behavior; Reagent/catalyst; Temperature; Sealed tube; Irradiation;	100%
With hydrogen; acetic acid; palladium on activated charcoal at 55℃; for 24h;	99%
With hydrogen In water at 150℃; under 3750.38 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Time; Solvent; Autoclave;	99.8%

: 121-33-5
vanillin

A: 93-51-6
2-Methoxy-4-methylphenol

B: 498-00-0
4-hydroxymethyl-2-methoxyphenol

Conditions

Conditions	Yield
With hydrogen In water at 70℃; Catalytic behavior;	A 99.9% B n/a
With hydrogen In water at 20 - 100℃; under 3750.38 Torr; for 1h; Kinetics; Reagent/catalyst; Temperature; Pressure; Autoclave;	A 90.9% B 9.1%
With 2 wt% Pd/C; hydrogen In water at 20 - 100℃; under 3750.38 Torr; for 1h; Kinetics; Reagent/catalyst; Autoclave;	A 21.8% B 78.3%

: 6627-55-0
2-bromo-p-cresol

: 124-41-4
sodium methylate

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With Methyl formate; copper(l) chloride In methanol at 110℃; for 2h; Autoclave;	98%
In methanol at 200℃; under 120012 Torr; for 0.0333333h; Temperature; Pressure; Time; Autoclave;	13.38 g

: 498-00-0
4-hydroxymethyl-2-methoxyphenol

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
Stage #1: 4-hydroxymethyl-2-methoxyphenol With ammonium formate In ethanol; water at 22℃; for 0.166667h; Stage #2: With formic acid In ethanol; water at 22℃; for 1h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; chemoselective reaction;	95%
With lithium aluminium tetrahydride In tetrahydrofuran; chlorobenzene for 3h; Heating;	87%
With triethylsilane; palladium dichloride In ethanol at 20℃; for 0.166667h; Inert atmosphere;	96 %Chromat.

: 201359-55-9
1-(allyloxy)-2-methoxy-4-methylbenzene

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
Stage #1: 1-(allyloxy)-2-methoxy-4-methylbenzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 2h; Inert atmosphere; Stage #2: With methanol In diethyl ether; pentane at -78℃; Inert atmosphere;	88%

: 4468-59-1
4-hydroxy-3-methoxyphenylacetonitrile

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
Stage #1: 4-hydroxy-3-methoxyphenylacetonitrile With 15-crown-5; sodium In tetrahydrofuran; hexane at 0℃; for 0.333333h; Birch Reduction; Inert atmosphere; Stage #2: With water In tetrahydrofuran; hexane at 0℃; for 1h; Birch Reduction; Inert atmosphere; Stage #3: With hydrogenchloride In water pH=1; chemoselective reaction;	84%
Stage #1: 4-hydroxy-3-methoxyphenylacetonitrile With 15-crown-5; sodium In tetrahydrofuran; hexane at 0℃; for 0.333333h; Inert atmosphere; Stage #2: With water In tetrahydrofuran; hexane at 0℃; for 1h;	74%

: 100-84-5
1-methoxy-3-methyl-benzene

A: 93-51-6
2-Methoxy-4-methylphenol

B: 5307-05-1
1-hydroxy-4-methoxy-2-methylbenzene

C: 2896-67-5
2-methyl-6-methoxyphenol

Conditions

Conditions	Yield
With wild type cytochrome P450 CYP102A1 variants RLYF/A330P; oxygen; NADPH Reagent/catalyst; Enzymatic reaction;	A 11% B 80% C 7%

...Expand

: C28H44O4P2

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With chlorobis(ethylene)rhodium(I) dimer; hydrogen In 1,4-dioxane at 150℃; under 7757.43 Torr; Pressure; Reagent/catalyst;	79%

: 108439-89-0
Propionic acid 2-methoxy-4-methyl-phenyl ester

A: 93-51-6
2-Methoxy-4-methylphenol

B: 91970-98-8
hydroxy-5 methoxy-4 methyl-2 propiophenone

C: 108439-90-3
propionyloxy-5 methoxy-4 methyl-2 propiophenone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 20℃; for 8h;	A 32% B 59% C 4%
With aluminium trichloride In dichloromethane at 0℃; for 8h;	A 32% B 49% C 20%

...Expand

: 6270-23-1
2-(2-methoxy-4-methylphenoxy)acetic acid

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
Stage #1: 2-(2-methoxy-4-methylphenoxy)acetic acid With diphenyl-phosphinic acid; triethylamine In N,N-dimethyl-formamide; toluene for 3h; Curtius-rearrangement; Heating; Stage #2: With water In N,N-dimethyl-formamide; toluene Heating; Further stages.;	59%

: 121-33-5
vanillin

A: 106-44-5
p-cresol

B: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With hydrogen In water at 100℃; under 15001.5 Torr; for 3h; Autoclave;	A 6.9% B 53.7%
With isopropyl alcohol at 140℃; for 15h; Reagent/catalyst; Autoclave;

: 23990-91-2
2,4'-dimethoxy-4-methyldiphenyl ether

: 124-41-4
sodium methylate

A: 93-51-6
2-Methoxy-4-methylphenol

B: 15791-03-4
1,1,4,4-tetramethoxycyclohexa-2,5-diene

Conditions

Conditions	Yield
In methanol anodic oxidation; Pt foil anode and catode;	A n/a B 53%

...Expand

: 498-00-0
4-hydroxymethyl-2-methoxyphenol

A: 93-51-6
2-Methoxy-4-methylphenol

B: 18256-53-6
4,4’-dihydroxy-3,3’-dimethoxybibenzyl

Conditions

Conditions	Yield
With triphenylphosphine In 1,4-dioxane at 200℃; for 16h; Autoclave; Inert atmosphere;	A 33% B 53%

: 121-33-5
vanillin

A: 106-44-5
p-cresol

B: 93-51-6
2-Methoxy-4-methylphenol

C: 498-00-0
4-hydroxymethyl-2-methoxyphenol

Conditions

Conditions	Yield
With hydrogen In water at 100℃; under 15001.5 Torr; for 3h; Autoclave;	A 6.9% B 52.3% C 6.63%
With hydrogen In water at 100℃; under 15001.5 Torr; for 3h; Autoclave;	A 6.9% B 52.9% C 6.9%
With hydrogen In water at 100℃; under 15001.5 Torr; for 3h; Autoclave;	A 5.3% B 49.9% C 11.8%

...Expand

: 494-99-5
1,2-dimethoxy-4-methylbenzene

A: 1195-09-1
5-methyl-2-methoxyphenol

B: 93-51-6
2-Methoxy-4-methylphenol

C: 452-86-8
4-methyl-1,2-dihydroxybenzene

Conditions

Conditions	Yield
With orcinol; Acetobacterium dehalogenans veratrol-O-demethylase; Desulfitobacterium hafniense methyltransferase dhaf4611 In aq. buffer at 25℃; for 24h; pH=6.5; Inert atmosphere; Enzymatic reaction; regioselective reaction;	A 35% B 52% C 13%

...Expand

: 13990-86-8
3,3'-dimethoxy-5,5'-dimethyl-[1,1'-biphenyl]-2,2'-diol

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
Stage #1: 3,3'-dimethoxy-5,5'-dimethyl-[1,1'-biphenyl]-2,2'-diol With Chlorodiisopropylphosphane; sodium hydride In 1,4-dioxane at 20℃; Stage #2: With chlorobis(ethylene)rhodium(I) dimer; hydrogen In 1,4-dioxane at 150℃; under 2585.81 Torr;	50%
Multi-step reaction with 2 steps 1: triethylamine 2: hydrogen; chlorobis(ethylene)rhodium(I) dimer / 1,4-dioxane / 150 °C / 7757.43 Torr View Scheme

: 879-67-4
2-methoxy-p-tolyl acetate

A: 93-51-6
2-Methoxy-4-methylphenol

B: 6948-37-4
hydroxy-5 methoxy-4 methyl-2 acetophenone

C: 35684-86-7
acetoxy-5 methoxy-4 methyl-2 acetophenone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 0℃; for 8h;	A 32% B 45% C 15%

...Expand

: 128837-56-9
2-methoxy-4-methylphenoxybenzene

A: 93-51-6
2-Methoxy-4-methylphenol

B: 110-82-7
cyclohexane

C: 82166-21-0
methyl cyclohexane

Conditions

Conditions	Yield
With hydrogen In decalin at 200℃; under 75007.5 Torr; for 3h;	A 45% B n/a C n/a

...Expand

: allyl 2-bromo-6-methoxy-4-methylphenyl ether

A: 93-51-6
2-Methoxy-4-methylphenol

B: C11H14O2

Conditions

Conditions	Yield
Stage #1: allyl 2-bromo-6-methoxy-4-methylphenyl ether With tert.-butyl lithium In diethyl ether; pentane at -78℃; Inert atmosphere; Stage #2: With N,N,N,N,-tetramethylethylenediamine In diethyl ether; pentane at -78 - 0℃; Inert atmosphere; Stage #3: With water Inert atmosphere;	A 35% B 42%

: 13990-86-8
3,3'-dimethoxy-5,5'-dimethyl-[1,1'-biphenyl]-2,2'-diol

A: 93-51-6
2-Methoxy-4-methylphenol

B: 3598-32-1
5,5'-Dimethyl-1,1'-biphenyl-2,2',3,3'-tetrol

C: 90-05-1
2-methoxy-phenol

D: 3'-methoxy-5,5'-dimethyl-biphenyl-2,3,2'-triol

Conditions

Conditions	Yield
With sulfuric acid; water at 224.84℃; under 21752.2 Torr; for 1.5h; Inert atmosphere; Autoclave;	A 7% B 9% C 12% D 42%

...Expand

: 121-33-5
vanillin

A: 93-51-6
2-Methoxy-4-methylphenol

B: 38768-71-7
5-[(4-hydroxy-3-methoxyphenyl)methyl]-2-methoxy-4-methylphenol

Conditions

Conditions	Yield
With triethylsilane; zinc(II) iodide In 1,2-dichloro-ethane at 20℃; for 7h;	A 28% B 34%

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With Pd-BaSO4; ethyl acetate Hydrogenation;

: 6627-55-0
2-bromo-p-cresol

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With potassium hydroxide at 150 - 155℃; under 11032.6 Torr;

: 83387-13-7
5-bromo-2-methoxy-4-methylphenol

: 93-51-6
2-Methoxy-4-methylphenol

: 7452-03-1
pinoresinol

A: 93-51-6
2-Methoxy-4-methylphenol

B: 97-54-1
2-methoxy-4-propenylphenol

C: 90-05-1
2-methoxy-phenol

Conditions

Conditions	Yield
Bei der trockenen Destillation;

...Expand

: 121-33-5
vanillin

A: 93-51-6
2-Methoxy-4-methylphenol

B: 6,3'-dimethoxy-4-methyl-3,4'-methanediyl-di-phenol

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;

: 77-78-1
dimethyl sulfate

: 452-86-8
4-methyl-1,2-dihydroxybenzene

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With alkali at 50 - 60℃;

: 512-42-5
sodium methyl sulfate

: 452-86-8
4-methyl-1,2-dihydroxybenzene

A: 93-51-6
2-Methoxy-4-methylphenol

B: 494-99-5
1,2-dimethoxy-4-methylbenzene

Conditions

Conditions	Yield
With potassium hydroxide

...Expand

: 67-56-1
methanol

: 87842-95-3
2-Diazo-4-methylphenol

: 93-51-6
2-Methoxy-4-methylphenol

Conditions

Conditions	Yield
With sulfuric acid at 0℃; for 24h; Mechanism; Irradiation;	7.9 % Chromat.

: 38512-82-2
3-methoxy-4-nitrotoluene

A: 93-51-6
2-Methoxy-4-methylphenol

B: 700-38-9
2-nitro-5-methylphenol

Conditions

Conditions	Yield
With sodium hydroxide; tert-butyl alcohol In water Quantum yield; Irradiation;

: 93-51-6
2-Methoxy-4-methylphenol

: 106-95-6
allyl bromide

: 201359-55-9
1-(allyloxy)-2-methoxy-4-methylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Heating;	100%
With potassium carbonate; sodium iodide In acetone for 15h; Reflux; Inert atmosphere;	96%
With potassium carbonate In acetone for 6h; Heating;	95%

: 50-00-0
formaldehyd

: 93-51-6
2-Methoxy-4-methylphenol

: 124-40-3
dimethyl amine

: 123752-64-7
6<(dimethylamino)methyl>-2-methoxy-4-methylphenol

Conditions

Conditions	Yield
In water for 1.5h;	100%

...Expand

: 93-51-6
2-Methoxy-4-methylphenol

: C14H13IN3Pol

: C22H22N3O2Pol

Conditions

Conditions	Yield
With pyridine; copper(I) bromide dimethylsulfide complex; sodium carbonate In acetonitrile at 75℃; for 48h; Inert atmosphere; solid phase reaction;	100%

: 93-51-6
2-Methoxy-4-methylphenol

: 7329-56-8
C8H7(2)H3O2

Conditions

Conditions	Yield
With perchloric acid; d(4)-methanol at 75℃; for 96h; Inert atmosphere;	100%
With sulfuryl dichloride; water-d2 at 100℃; for 30h; Microwave irradiation; Sealed tube;	100 %Chromat.

: 93-51-6
2-Methoxy-4-methylphenol

: 452-86-8
4-methyl-1,2-dihydroxybenzene

Conditions

Conditions	Yield
With hydrogenchloride In water at 250℃; under 37503.8 Torr; for 3h; Autoclave; Inert atmosphere; Green chemistry;	99%
With aluminium(III) iodide; tetra-(n-butyl)ammonium iodide In cyclohexane for 0.7h; Heating;	98%
With aluminium(III) iodide In dimethyl sulfoxide; acetonitrile at 80℃; for 18h;	96%

: 93-51-6
2-Methoxy-4-methylphenol

: 108-24-7
acetic anhydride

: 879-67-4
2-methoxy-p-tolyl acetate

Conditions

Conditions	Yield
With zirconium(IV) chloride at 20℃; for 0.25h;	99%
With sulfuric acid
With sulfuric acid at 100℃;

: 93-51-6
2-Methoxy-4-methylphenol

: 1899-93-0
3-methylphenylsulfonyl chloride

: 2-Methoxy-4-methylphenyl 3-methylbenzenesulfonate

Conditions

Conditions	Yield
With triethylamine In hexane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran	99%

: 358-23-6
trifluoromethylsulfonic anhydride

: 93-51-6
2-Methoxy-4-methylphenol

: 138642-33-8
2-methoxy-4-methylphenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -78 - 20℃; for 14h; Inert atmosphere;	99%
Stage #1: 2-Methoxy-4-methylphenol With pyridine In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere; Schlenk technique; Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere; Schlenk technique;	78%

: 93-51-6
2-Methoxy-4-methylphenol

: 1194-02-1
4-fluorobenzonitrile

: 897036-73-6
4-(2-methoxy-4-methylphenoxy)benzonitrile

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl acetamide at 100℃; for 30h;	99%

: 93-51-6
2-Methoxy-4-methylphenol

: 394-47-8
2-fluorobenzonitrile

: 928302-73-2
2-(2-methoxy-4-methyl-phenoxy)-benzonitrile

Conditions

Conditions	Yield
With caesium carbonate In dimethyl amine at 100℃; for 30h;	99%

: 546-68-9
titanium(IV) isopropylate

: 93-51-6
2-Methoxy-4-methylphenol

: 1394844-98-4
[(2-methoxy-4-methylphenoxy)2Ti(isopropoxy)2]

Conditions

Conditions	Yield
In cyclohexane at 20℃; Inert atmosphere; Schlenk technique;	99%

: 93-51-6
2-Methoxy-4-methylphenol

: 124-38-9
carbon dioxide

: 4386-42-9
2-hydroxy-3-methoxy-5-methylbenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-Methoxy-4-methylphenol; carbon dioxide With potassium carbonate at 200℃; under 41372.9 Torr; for 4.5h; Kolbe-Schmitt reaction; Autoclave; Stage #2: With hydrogenchloride In water at 20℃; pH=1;	98%
With potassium carbonate at 200℃; under 41371.8 Torr; for 4h; Carboxylation; Kolbe-Schmitt carboxylation;

: 67-56-1
methanol

: 1629-58-9
4-penten-3-one

: 93-51-6
2-Methoxy-4-methylphenol

: (1SR,4SR,7SR)-3,3-dimethoxy-5-methyl-7-propionylbicyclo[2.2.2]oct-5-en-2-one

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene at 20℃; for 1h;	98%

...Expand

: 93-51-6
2-Methoxy-4-methylphenol

: 4648-54-8
trimethylsilylazide

: 132114-79-5
(4-methyl-2-methoxyphenoxy)trimethylsilane

Conditions

Conditions	Yield
tetrabutylammomium bromide at 30℃; for 4h;	98%

: 93-51-6
2-Methoxy-4-methylphenol

: 1795-48-8
Isopropyl isocyanate

: 956219-14-0
C12H17NO3

Conditions

Conditions	Yield
With dmap In tetrahydrofuran Heating;	98%

: 93-51-6
2-Methoxy-4-methylphenol

: 100-39-0
benzyl bromide

: 78136-55-7
1-(benzyloxy)-2-methoxy-4-methylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 18h; Reflux;	98%
With potassium carbonate In acetonitrile for 18h; Reflux;	98%
With potassium carbonate In acetone at 50℃; for 12h; Inert atmosphere;	96%
Stage #1: 2-Methoxy-4-methylphenol With sodium hydride In DMF (N,N-dimethyl-formamide) at 0℃; for 0.5h; Stage #2: benzyl bromide With tetrabutylammomium bromide In DMF (N,N-dimethyl-formamide) at 0 - 20℃;

: 5162-44-7
1-bromo-4-butene

: 93-51-6
2-Methoxy-4-methylphenol

: 1140923-64-3
1-(but-3-enyloxy)-2-methoxy-4-methylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 12h; Reflux;	98%

: 93-51-6
2-Methoxy-4-methylphenol

: 2436-85-3
2-N,N-Dimethylaminonaphthalene

: 2-(2-(dimethylamino)naphthalen-1-yl)-6-methoxy-4-methylphenol

Conditions

Conditions	Yield
With iron(III) chloride; di-tert-butyl peroxide; trifluoroacetic acid at 20℃; for 24h; chemoselective reaction;	98%
With 1,1,1,3',3',3'-hexafluoro-propanol; periodic acid In nitromethane; N,N-dimethyl-formamide at 20℃; for 0.5h;	34%

: 50-00-0
formaldehyd

: 93-51-6
2-Methoxy-4-methylphenol

: 1620-70-8
2,2'-dihydroxy-3,3'-dimethoxy-5,5'-dimethyl-diphenylmethane

Conditions

Conditions	Yield
With sodium hydroxide for 2.5h; Dimerization;	97%
With zinc(II) acetate dihydrate for 16h; Inert atmosphere; Reflux; regioselective reaction;	41%
With zinc(II) acetate dihydrate for 16h; Reflux; Inert atmosphere;	41%
With zinc diacetate

: 93-51-6
2-Methoxy-4-methylphenol

: 3,3'-dimethoxy-5,5'-dimethylbiphenyl-2,2'-diol

Conditions

Conditions	Yield
With copper diacetate; ethylene glycol at 75℃; for 12h; Green chemistry;	97%

: 93-51-6
2-Methoxy-4-methylphenol

: 1045821-71-3
N-[(trifluoromethyl)sulfanyl]aniline

: 2-methoxy-4-methyl-5-(trifluoromethylthio)phenol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane at 20℃; regioselective reaction;	97%

: 93-51-6
2-Methoxy-4-methylphenol

: 74-88-4
methyl iodide

: 494-99-5
1,2-dimethoxy-4-methylbenzene

Conditions

Conditions	Yield
Stage #1: 2-Methoxy-4-methylphenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Sealed tube; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 60℃; Sealed tube;	96%
With sodium hydroxide In N,N-dimethyl acetamide at 25℃; Rate constant;

: 67-56-1
methanol

: 1629-58-9
4-penten-3-one

: 93-51-6
2-Methoxy-4-methylphenol

: (1R,4R)-3,3-Dimethoxy-5-methyl-7-propionyl-bicyclo[2.2.2]oct-5-en-2-one

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene at 20℃; Diels-Alder reaction;	96%
With isosorbide dinitrate	88%

...Expand

: 93-51-6
2-Methoxy-4-methylphenol

: 106-54-7
p-Chlorothiophenol

: 2-methoxy-4-methyl-6-((4-nitrophenyl)thio)phenol

Conditions

Conditions	Yield
With nitronium tetrafluoborate; oxygen In sulfolane at 20℃; for 24h; Sealed tube;	96%

: 93-51-6
2-Methoxy-4-methylphenol

: 79-03-8
propionyl chloride

: 91970-98-8
hydroxy-5 methoxy-4 methyl-2 propiophenone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane at 20℃; for 2h;	95%

: 93-51-6
2-Methoxy-4-methylphenol

: 88-10-8
N,N-diethylcarbamyl chloride

: 628339-15-1
N,N-diethyl-1-carbamyloxy-2-methoxy-4-methylbenzene

Conditions

Conditions	Yield
Stage #1: 2-Methoxy-4-methylphenol With sodium hydride In tetrahydrofuran at 20℃; for 2h; Stage #2: N,N-diethylcarbamyl chloride In tetrahydrofuran at 20℃; for 8h;	95%
With sodium hydride In tetrahydrofuran at 20℃;	95%

2-Methoxy-4-methylphenol Chemical Properties

MF: C₈H₁₀O₂
MW: 138.16
EINECS: 202-252-9
2-METHOXY-p-CRESOL(93-51-6),its melting point is 5 °C(lit.),boiling point is 221-222 °C(lit.);density is 1.092 g/mL at 25 °C(lit.) , Following is the molecular structure of 2-METHOXY-p-CRESOL(93-51-6):

2-Methoxy-4-methylphenol Uses

2-METHOXY-p-CRESOL(93-51-6) can be used for spice, pharmaceutical and other organic intermediates.

2-Methoxy-4-methylphenol Toxicity Data With Reference

1.	sce-hmn:lyms 500 µmol/L	MUREAV Mutation Research. 206 (1988),17.
2.	orl-rat LD50:740 mg/kg	FOMDAK Folia Medica. 32 (1991),309.
3.	ivn-mus LD50:76 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 164 (1966),30.

RTECS :GP1755000

2-Methoxy-4-methylphenol Consensus Reports

Reported in EPA TSCA Inventory.

2-Methoxy-4-methylphenol Safety Profile

A poison by intravenous route. Appears to be at least moderately toxic. An irritant to skin and eyes. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Othersafty informations about 2-METHOXY-p-CRESOL(93-51-6):
Hazard Codes : Xn,Xi (Harmful;Irritant)
Risk Statements :
R22:Harmful if swallowed
R36/37/38 :Irritating to eyes, respiratory system and skin
Safety Statements :
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical a
S36:Wear suitable protective clothing
S24/25 :Avoid contact with skin and eyes
RIDADR :2810
WGK Germany: 3

Product Name

2-Methoxy-4-methylphenol

Synthetic route

2-Methoxy-4-methylphenol Chemical Properties

2-Methoxy-4-methylphenol Uses

2-Methoxy-4-methylphenol Toxicity Data With Reference

2-Methoxy-4-methylphenol Consensus Reports

2-Methoxy-4-methylphenol Safety Profile

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