2-Methyl-2-butanol supplier

Name
tert-Amyl alcohol
EINECS 200-908-9
CAS No. 75-85-4
Article Data199
CAS DataBase
Density 0.811 g/cm³
Solubility 120 g/L (20 °C) in water
Melting Point -12 °C
Formula C₅H₁₂O
Boiling Point 102 °C at 760 mmHg
Molecular Weight 88.1497
Flash Point 21.1 °C
Transport Information UN 1105 3/PG 2
Appearance colourless liquid with a camphor-like odour
Safety 46
Risk Codes 11-20-37/38
Molecular Structure
Hazard Symbols F,Xn
Synonyms tert-Pentylalcohol (8CI);1,1-Dimethyl-1-propanol;2-Ethyl-2-propanol;2-Hydroxy-2-methylbutane;2-Methyl-2-hydroxybutane;Amylenehydrate;Dimethylethylcarbinol;Ethyldimethylcarbinol;NSC 25498;tert-Amylalcohol;tert-Pentanol;
PSA 20.23000
LogP 1.16730

Synthetic route

: 115-19-5
2-methyl-but-3-yn-2-ol

A: 75-85-4
tert-Amyl alcohol

B: 115-18-4
2-methyl-3-buten-2-ol

Conditions

Conditions	Yield
With hydrogen; copper-palladium; silica gel In ethanol at 25℃; under 760 Torr; Kinetics;	A n/a B 98%
With hydrogen; palladium dichloride In N,N-dimethyl-formamide under 18751.5 Torr; for 0.3h; Product distribution; Ambient temperature; various time;	A 2% B 91%
With hydrogen; nickel dihydroxide; Ni(C17H35COO)2 In toluene at 40℃; Product distribution; Kinetics; other catalyst. Object of study: selectivity;	A 41.6% B 85.5%

: 115-19-5
2-methyl-but-3-yn-2-ol

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With sodium tetrahydroborate; hydrogen; nickel dichloride In isopropyl alcohol at 60℃; under 760.051 Torr; for 7h;	90%
With hydrogen; palladium membrane at 29.9℃; Kinetics; electrochemical reduction;
With alkali durch elektrolytische Reduktion an Platinkathoden;

: 6689-16-3
2-methyl-2-trimethylsiloxybutane

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With nano magnetic sulfated zirconia (Fe3O4 at ZrO2/SO42-) In neat (no solvent) at 20℃; for 0.416667h; Green chemistry;	80%

: 97-94-9
triethyl borane

: 67-64-1
acetone

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; N,N-dimethyl-formamide for 7h; Ambient temperature; electrolysis with Pt/Cu electrodes;	76%

: 78-78-4
methylbutane

A: 563-80-4
3-methyl-butan-2-one

B: 75-85-4
tert-Amyl alcohol

C: 96-17-3, 57456-98-1
2-Methylbutyraldehyde

D: 598-75-4
3-methyl-2-butanol

Conditions

Conditions	Yield
With [2,2]bipyridinyl; Ba; trifluoroacetic acid In dichloromethane at 20℃; for 0.0333333h;	A 11% B 70% C 4.5% D n/a
With [2,2]bipyridinyl; Ba; trifluoroacetic acid In dichloromethane at 20℃; for 0.0333333h; Product distribution;	A 11% B 70% C 4.5% D n/a

...Expand

: 563-46-2
2-Methyl-1-butene

: 64-19-7
acetic acid

A: 75-85-4
tert-Amyl alcohol

B: 661-53-0
2-fluoro-2-methylbutane

C: 625-16-1
tert-amyl acetate

Conditions

Conditions	Yield
With hydrogenchloride; water at 25℃; Kinetics;	A 70% B 25% C n/a

...Expand

: 54269-84-0
1,1-dimethyl-1-(2-propenyloxy)-propane

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; titanium tetrachloride In tetrahydrofuran for 8h; Ambient temperature;	49%

: 78-78-4
methylbutane

A: 75-85-4
tert-Amyl alcohol

B: 64-19-7
acetic acid

C: 67-64-1
acetone

Conditions

Conditions	Yield
With N-hydroxyphthalimide; air; cobalt(II) acetate In benzonitrile at 100℃; under 7600 Torr; for 8h; Oxidation;	A 21% B 15% C 32%

...Expand

: 1927-66-8
2-(1,1-dimethyl-propoxy)-tetrahydropyran

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With acid-washed bentonite In acetone at 40 - 50℃;	10%

: 558-30-5
2-methyl-1,2-epoxypropane

: 2999-74-8
dimethylmagnesium

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With diethyl ether

: 1758-32-3, 1758-33-4, 3266-23-7, 6189-41-9, 21490-63-1, 63864-69-7, 103110-88-9
2,3-epoxybutane

: 75-16-1
methylmagnesium bromide

: 75-85-4
tert-Amyl alcohol

: 5076-19-7
trimethyloxirane

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride

: 67-56-1
methanol

: 594-38-7
2-iodo-2-methylbutane

A: 75-85-4
tert-Amyl alcohol

B: 74-88-4
methyl iodide

Conditions

Conditions	Yield
at 100℃;

...Expand

: 513-35-9
2-methyl-but-2-ene

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With sulfuric acid at 50℃;
With sulfuric acid at 120℃; under 7355.08 - 11032.6 Torr;
With ammonium sulfate; sulfuric acid at 0℃;

: 60-29-7
diethyl ether

: 28276-08-6
1,1-dimethylpropylmagnesium chloride

: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
ausser Dimethyl-aethyl-essigsaeure;

...Expand

: 594-36-5
2-methyl-2-butylchloride

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With glyceride alkali salt; water Hydrolysis;
With sodium hydroxide Hydrolysis.in Gegenwart von fettsauren Alkalisalzen;

: 115-18-4
2-methyl-3-buten-2-ol

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With alkali durch elektrolytische Reduktion an Platinkathoden;
With hydrogen; palladium at 20℃; under 760 Torr; Rate constant; effect of solvent (methanol, cyclohexane) on hydrogenation;
With hydrogen; palladium at 20℃; under 735.5 Torr; Rate constant; effects of solvent on hydrogenation of title compound;

: 762-64-1
1-diazo-2,2-dimethylpropane

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With sulfuric acid

: 78-78-4
methylbutane

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With hydrogen bromide at 165℃;
With 3,3-dimethyldioxirane In acetone Rate constant; Ambient temperature;

: 507-36-8
2-bromo-2-methylbutane

: 623-11-0
1-methyl-4-nitrosobenzene

A: 75-85-4
tert-Amyl alcohol

B: 513-35-9
2-methyl-but-2-ene

Conditions

Conditions	Yield
at 35℃; Hydrolysis;
at 45℃; Hydrolysis;

...Expand

: 507-36-8
2-bromo-2-methylbutane

A: 75-85-4
tert-Amyl alcohol

B: 513-35-9
2-methyl-but-2-ene

Conditions

Conditions	Yield
Hydrolysis;

: 594-38-7
2-iodo-2-methylbutane

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With potassium hydroxide

: 19781-24-9
3,3-dimethyl-2-pentanol

A: 75-85-4
tert-Amyl alcohol

B: 20669-04-9
3,3-dimethyl-2-pentanone

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

: 66793-92-8
isopropyl-tert-pentyl-carbinol

A: 75-85-4
tert-Amyl alcohol

B: 34575-34-3
2,4,4-trimethyl-hexan-3-one

Conditions

Conditions	Yield
With chromium(VI) oxide; acetic acid

: 4111-08-4
2-hydroxy-2-methyl-butyronitrile

: 75-16-1
methylmagnesium bromide

: 75-85-4
tert-Amyl alcohol

: 4111-08-4
2-hydroxy-2-methyl-butyronitrile

: methyl magnesium (1+); bromide

A: 75-85-4
tert-Amyl alcohol

B: 109916-61-2, 133645-41-7, 560-24-7
3-hydroxy-3-methyl-pentan-2-one

C: 78-93-3
butanone

...Expand

: 24675-20-5
2-methyl-butan-2-ol; zirconium (IV)-compound

A: 75-85-4
tert-Amyl alcohol

B: 591-95-7
penta-1,2-diene

Conditions

Conditions	Yield
at 250 - 320℃; under 175 - 760 Torr; Pyrolysis;

: 544-97-8
dimethyl zinc(II)

: 79-03-8
propionyl chloride

: 75-85-4
tert-Amyl alcohol

: 28276-08-6
1,1-dimethylpropylmagnesium chloride

: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

: 75-85-4
tert-Amyl alcohol

: 28276-08-6
1,1-dimethylpropylmagnesium chloride

: 75-85-4
tert-Amyl alcohol

Conditions

Conditions	Yield
With oxygen Zersetzung des Reaktionsproduktes mit Wasser;

: 75-85-4
tert-Amyl alcohol

: 594-36-5
2-methyl-2-butylchloride

Conditions

Conditions	Yield
With bismuth(III) chloride In tetrachloromethane at 25℃; for 0.0833333h;	100%
With hydrogenchloride In water at 20℃; for 0.05h;	98%
With chloro-trimethyl-silane; dimethyl sulfoxide for 0.166667h;	88%

: 75-85-4
tert-Amyl alcohol

: 32115-55-2
N,N-Dimethylcarbamidsaeure-trimethylsilylester

: 6689-16-3
2-methyl-2-trimethylsiloxybutane

Conditions

Conditions	Yield
at 100℃; for 15h;	100%
at 69.9℃; Mechanism; Rate constant; Kinetics; var. time and temp.;

: 75-85-4
tert-Amyl alcohol

: 79-04-9
chloroacetyl chloride

: 5439-30-5
2-methylbut-2-yl chloroacetate

Conditions

Conditions	Yield
With pyridine In diethyl ether at 0℃;	100%

: 75-85-4
tert-Amyl alcohol

: 52177-63-6
4-methylthiophenyl chloroformate

: tert-amyl p-methylthiophenyl carbonate

Conditions

Conditions	Yield
With pyridine In dichloromethane	100%

: 75-85-4
tert-Amyl alcohol

: Fe{Nb(OCH(CH3)2)6}3

: Fe{Nb(OCH(CH3)2)2(OC(CH3)2C2H5)4}3

Conditions

Conditions	Yield
In tert-Amyl alcohol byproducts: isopropanol; anhydrous conditions; refluxing (48 h, distn. off of i-PrOH); solvent removal (vac.); elem. anal.;	99.5%

: 75-85-4
tert-Amyl alcohol

: 71-43-2
benzene

: 2049-95-8
tery-amylbenzene

Conditions

Conditions	Yield
With aluminum (III) chloride; iron(III) chloride at 0 - 5℃; for 6h; Large scale;	99.4%
With AlCl2
With iron(III) chloride
With aluminium trichloride

: 75-85-4
tert-Amyl alcohol

: K{hexaisopropoxytantalate}

: bis(tri-t-amyloxy-tri-isopropoxy-tantalate)iron(II)

Conditions

Conditions	Yield
under N2; elem. anal.;	99.3%

: 75-85-4
tert-Amyl alcohol

: 108-24-7
acetic anhydride

: 625-16-1
tert-amyl acetate

Conditions

Conditions	Yield
With erbium(III) chloride at 50℃; for 3.5h;	99%
cerium triflate In acetonitrile at 20℃; for 24h;	98%
With Methylenediphosphonic acid at 20℃; for 3.5h; neat (no solvent);	97%

: 75-85-4
tert-Amyl alcohol

: 1-(2-bromo-6-fluorophenyl)-1-methylsiletane

: 8-fluoro-1-methyl-1-(tert-pentyloxy)-1,2,3,4-tetrahydrobenzo[b]siline

Conditions

Conditions	Yield
With bis(tri-t-butylphosphine)palladium(0); N,N-diethyl-1,1,1-trimethylsilanamine at 80℃; for 24h; Inert atmosphere; Schlenk technique;	99%

: 75-85-4
tert-Amyl alcohol

: 94370-87-3
tert-amyl hypobromite

Conditions

Conditions	Yield
With bromine; mercury(II) oxide In pentane for 1h; Product distribution; Ambient temperature; other tertiary and secondary alcohols;	98.5%

: 43112-38-5
3-(trimethylsilyl)-2-oxazolidinone

: 75-85-4
tert-Amyl alcohol

: 6689-16-3
2-methyl-2-trimethylsiloxybutane

Conditions

Conditions	Yield
chloro-trimethyl-silane at 0℃; for 0.0333333h;	98%

: 75-85-4
tert-Amyl alcohol

: nickel tantalum isopropoxide

: Ni(2+)*2Ta(5+)*8OC(CH2CH3)(CH3)2(1-)*4OCH(CH3)2(1-) = Ni[Ta(OC(CH2CH3)(CH3)2)4(OCH(CH3)2)2]2

Conditions

Conditions	Yield
In benzene byproducts: isopropanol; moisture excluded; excess alcohol added to soln. of nickel tantalum isopropoxide; refluxed over a fractionating column; isopropanol liberated was continuously fractionated out with benzene between 72-80°C; excess of solvent removed under reduced pressure and compd. dried; elem. anal.;	98%

: 5765-44-6
5-methylisoxazole

: 75-85-4
tert-Amyl alcohol

: 4878-36-8
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid

: 1431937-50-6
1-(2-methyl-2-butyl-carbamoyl)prop-1-en-2-yl 3,5-diamino-6-chloropyrazine-2-carboxylate

Conditions

Conditions	Yield
Stage #1: 5-methylisoxazole; tert-Amyl alcohol With trifluorormethanesulfonic acid In N,N-dimethyl-formamide for 1h; Cooling with ice; Stage #2: 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid With triethylamine In N,N-dimethyl-formamide at 20℃; for 2h; Cooling with ice;	98%
Stage #1: 5-methylisoxazole; tert-Amyl alcohol With trifluorormethanesulfonic acid Cooling with ice; Stage #2: 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid With triethylamine In N,N-dimethyl-formamide at 25℃; for 2h; Cooling with ice;	98%

...Expand

: 75-85-4
tert-Amyl alcohol

: {iron(II)((μ-isopropoxy)3Nb(isopropoxy)3)2}

: bis(tri-t-amyloxy-tri-isopropoxy-niobate)iron(II)

Conditions

Conditions	Yield
In benzene byproducts: isopropanol; Excess of 2,2'-dimethylpentanol is added to a benzene soln. of the starting complex, the mixt. is refluxed for 5 h (N2).; The liberated isopropanol is removed azeotropically (72-80°C) till no isopropanol is detected in the destillate, the volatiles are stripped off in vacuo, the resulting complex is recrystallized from n-hexane (-10 to -15°C), elem. anal.;	97.5%

: 75-85-4
tert-Amyl alcohol

: tert-butyltin tris(dimethylamide)

: C19H42O3Sn

Conditions

Conditions	Yield
With oxygen In isopropyl alcohol at 20℃; under 51.7162 - 103.432 Torr; Schlenk technique; Cooling with ice;	97.3%
Glovebox; Inert atmosphere; Sealed tube;	97.3%
With 2,2',2''-triaminotriethylamine In pentane for 2h; Schlenk technique; Cooling with ice; Glovebox;	435 g

: 75-85-4
tert-Amyl alcohol

: 6343-16-4, 24425-58-9, 38447-89-1, 51252-31-4
bicyclo<2.2.1>hept-5,6-ene-2α,3β-dicarbonitrile

: (1S,2R,3R,4R)-Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid bis-[(1,1-dimethyl-propyl)-amide]

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 12h; Ritter reaction;	97%

: 75-85-4
tert-Amyl alcohol

: 463934-08-9
methanesulfonic acid 3-(naphthalen-2-oxy)-1-propyl ester

A: 894085-83-7
2-[3-(2-methyl-2-butoxy)propoxy]naphthalene

B: 398-53-8
2-(3-fluoro-n-propoxy)naphthalene

Conditions

Conditions	Yield
With rubidium fluoride; polystyrene-supported 1-n-hexyl-3-methylimidazolium BF4 at 90℃; for 1.5h;	A 2 % Spectr. B 97%
With cesium fluoride at 80℃; for 2.5 - 6h; Product distribution / selectivity;	A 4% B 93%
With cesium fluoride at 80℃; for 6h;	A 5 % Spectr. B 93%

...Expand

: 1-(3-p-toluenesulfonyloxypropyl)-4-nitroimidazole

: 75-85-4
tert-Amyl alcohol

A: C11H19N3O3

B: 1-(3-fluoropropyl)-4-nitro-1H-imidazole

Conditions

Conditions	Yield
With cesium fluoride; polystyrene-supported 1-n-hexyl-3-methylimidazolium BF4 at 80℃; for 1h;	A n/a B 97%

...Expand

: 75-85-4
tert-Amyl alcohol

: nickel niobium isopropoxide

: Ni(2+)*2Nb(5+)*4OCH(CH3)2(1-)*8OC(CH2CH3)(CH3)2(1-) = Ni[Nb(OCH(CH3)2)2(OC(CH2CH3)(CH3)2)4]2

Conditions

Conditions	Yield
In benzene byproducts: isopropanol; moisture excluded; excess alcohol added to soln. of nickel niobium isopropoxide; refluxed over a fractionating column; isopropanol liberated was continuously fractionated out with benzene between 72-80°C; excess of solvent removed under reduced pressure and compd. dried; elem. anal.;	97%

: 75-85-4
tert-Amyl alcohol

: 2-methylbutan-2-ol (lithium salt)

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at 0 - 22℃; for 1h; Inert atmosphere;	97%
With lithium In hexane Inert atmosphere; Schlenk technique; Reflux;	77.8%

: 75-85-4
tert-Amyl alcohol

: 88477-42-3
RbOC(Me)2Et

Conditions

Conditions	Yield
With rubidium In n-heptane Inert atmosphere; Schlenk technique; Reflux;	96.7%
With rubidium In tetrahydrofuran for 48h; Inert atmosphere; Reflux;	92.5%

: 75-85-4
tert-Amyl alcohol

: 507-36-8
2-bromo-2-methylbutane

Conditions

Conditions	Yield
With hydrogen bromide at 50℃; for 0.25h;	96.5%
With hydrogen bromide; lithium bromide at -10℃; for 2h;	91%
With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine In dichloromethane at 20℃; for 0.15h; Appel Halogenation;	85%

: 75-85-4
tert-Amyl alcohol

: 54237-96-6
2-Chloromethyl-1,3-dioxepane

: 1634-04-4
tert-butyl methyl ether

: 107-21-1
ethylene glycol

: 69814-56-8
2-methylene-1,3-dioxepane

Conditions

Conditions	Yield
With potassium hydroxide	96.3%

...Expand

: 75-85-4
tert-Amyl alcohol

: 622-58-2
p-Tolylisocyanate

: 40083-80-5
tert-pentyl p-tolyl carbamate

Conditions

Conditions	Yield
at 120℃; for 0.5h; Mechanism;	96%
at 120℃; for 0.5h;	96%
copper(II) 2-ethylhexanoate In benzene Heating;

: 75-85-4
tert-Amyl alcohol

: 7677-24-9
trimethylsilyl cyanide

: 6689-16-3
2-methyl-2-trimethylsiloxybutane

Conditions

Conditions	Yield
at 25℃; for 0.0833333h;	96%

: 75-85-4
tert-Amyl alcohol

: 939-26-4
2-bromomethylnaphthyl bromide

A: C16H20O

B: 55831-11-3
2-(fluoromethyl)naphthalene

Conditions

Conditions	Yield
With cesium fluoride; polystyrene-supported 1-n-hexyl-3-methylimidazolium BF4 at 80℃; for 0.5h;	A n/a B 96%

...Expand

: 75-85-4
tert-Amyl alcohol

: (dimethylamino)titanatrane

: 137516-03-1
(CH3)2C2H5COTi(OCH2CH2)3N

Conditions

Conditions	Yield
In dichloromethane byproducts: HN(CH3)2; under Ar, stirring at room temp. for 10 min;; layering with pentane, cooling to -25°C, standing overnight, elem. anal.;;	96%

: 75-85-4
tert-Amyl alcohol

: 75-36-5
acetyl chloride

: 625-16-1
tert-amyl acetate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 24h;	95%
With sodium carbonate; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 3h; Heating;	80%
With diethyl ether; magnesium

: 75-85-4
tert-Amyl alcohol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 6689-16-3
2-methyl-2-trimethylsiloxybutane

Conditions

Conditions	Yield
With aluminium(III) triflate at 20℃; for 1.11667h;	95%
With copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 20℃; for 2.5h;	93%
With nano magnetic sulfated zirconia (Fe3O4 at ZrO2/SO42-) In neat (no solvent) at 20℃; for 0.5h; Green chemistry;	82%

2-Methyl-2-butanol Specification

The IUPAC name of 2-Methyl-2-butanol is 2-methylbutan-2-ol. With the CAS registry number 75-85-4, it is also named as tert-Amyl alcohol. The product's category is Organics. Besides, it is colourless liquid with a camphor-like odour, which should be sealed in a cool, dark and ventilated place. It is light sensitive, and incompatible with strong oxidizing agents. In addition, its molecular formula is C₅H₁₂O and molecular weight is 88.15.

The other characteristics of this product can be summarized as: (1)EINECS: 200-908-9; (2)ACD/LogP: 1.04; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.04; (5)ACD/LogD (pH 7.4): 1.04; (6)ACD/BCF (pH 5.5): 3.64; (7)ACD/BCF (pH 7.4): 3.64; (8)ACD/KOC (pH 5.5): 87.73; (9)ACD/KOC (pH 7.4): 87.73; (10)#H bond acceptors: 1; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 2; (13)Index of Refraction: 1.406; (14)Molar Refractivity: 26.71 cm³; (15)Molar Volume: 108.6 cm³; (16)Surface Tension: 25 dyne/cm; (17)Density: 0.811 g/cm³; (18)Flash Point: 21.1 °C; (19)Melting point: -12 °C; (20)Water solubility: 120 g/L (20 °C); (21)Enthalpy of Vaporization: 39.77 kJ/mol; (22)Boiling Point: 102 °C at 760 mmHg; (23)Vapour Pressure: 19.2 mmHg at 25 °C.

Preparation of 2-Methyl-2-butanol: this chemical can be prepared by Acetone and Acetylene. This reaction will occur by ethynylation and hydrogenation.

Uses of 2-Methyl-2-butanol: this chemical possesses sedative, hypnotic, and anticonvulsant effects in humans. It is a cosolvent of cellulose esters, cellulose ethers, dope, varnish, mineral flotation agent, acridine and nitro spray. Moreover, it can react with Diketene to get Acetoacetic acid tert-pentyl ester.

This reaction needs 4-Dimethylaminopyridine and Tetrahydrofuran at temperature of 20 °C for 5 min. The yield is 73 %.

When you are using this chemical, please be cautious about it as the following: it is highly flammable. It is also harmful by inhalation. And it is irritating to respiratory system and skin. If swallowed, please seek medical advice immediately and show this container or label.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CCC(C)(C)O
(2)InChI: InChI=1S/C5H12O/c1-4-5(2,3)6/h6H,4H2,1-3H3
(3)InChIKey: MSXVEPNJUHWQHW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	parenteral	4gm/kg (4000mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 296, 1935.
man	LDLo	unreported	441mg/kg (441mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intravenous	610mg/kg (610mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 330, 1962.
mouse	LD50	subcutaneous	2100mg/kg (2100mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 161, 1955.
mouse	LDLo	intraperitoneal	2gm/kg (2000mg/kg)		Skandinavisches Archiv fuer Physiologie. Vol. 79, Pg. 258, 1938.
mouse	LDLo	oral	2500mg/kg (2500mg/kg)		"Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit	LD50	oral	2028mg/kg (2028mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE CARDIAC: PULSE RATE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972.
rat	LCLo	inhalation	5700ppm/6H (5700ppm)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. OTS0536478,
rat	LD50	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: ATAXIA	Science. Vol. 116, Pg. 663, 1952.
rat	LDLo	intraperitoneal	1530mg/kg (1530mg/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 1, 1945.
rat	LDLo	rectal	1400mg/kg (1400mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 36, 1933.
rat	LDLo	subcutaneous	1400mg/kg (1400mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 36, 1933.

Product Name

tert-Amyl alcohol

Synthetic route

2-Methyl-2-butanol Specification

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