Product Name

  • Name

    2-Thiophenecarbonyl chloride

  • EINECS 226-092-4
  • CAS No. 5271-67-0
  • Article Data26
  • CAS DataBase
  • Density 1.391 g/cm3
  • Solubility
  • Melting Point
  • Formula C5H3ClOS
  • Boiling Point 201.8 °C at 760 mmHg
  • Molecular Weight 146.597
  • Flash Point 75.9 °C
  • Transport Information UN 3265 8/PG 2
  • Appearance clear colourless to yellow-grey liquid
  • Safety 26-36/37/39-45
  • Risk Codes 34-37
  • Molecular Structure Molecular Structure of 5271-67-0 (2-Thiophenecarbonyl chloride)
  • Hazard Symbols CorrosiveC,IrritantXi
  • Synonyms 2-(Chlorocarbonyl)thiophene;2-(Chloroformyl)thiophene;2-Thenoyl chloride;2-Thienylcarbonyl chloride;2-Thiophenecarboxylic acid chloride;2-Thiophenecarboxylic chloride;Thenoyl chloride;Thiophen-2-ylcarbonyl chloride;a-Thenoyl chloride;
  • PSA 45.31000
  • LogP 2.12710

Synthetic route

2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
97%
With thionyl chloride for 2h; Heating;82%
With thionyl chloride; N,N-dimethyl-formamide; sodium hydroxide In ethyl acetate at 58 - 65℃; for 2.5h; Inert atmosphere;81%
thiophene
188290-36-0

thiophene

oxalyl dichloride
79-37-8

oxalyl dichloride

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
With sulfolane at 200℃; under 60006 Torr; for 0.75h; Temperature; Pressure; Reagent/catalyst;93%
N, N-dimethylthiophene-2-carboxamide
30717-57-8

N, N-dimethylthiophene-2-carboxamide

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
With iodine; N,N-dimethyl-formamide; phosphorus trichloride In 1,2-dichloro-ethane at 100℃; for 12h; Schlenk technique; Sealed tube;92%
2-Acetylthiophene
88-15-3

2-Acetylthiophene

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
Stage #1: 2-Acetylthiophene With pyridine; disulfur dichloride In chlorobenzene at 20℃; for 1.75h;
Stage #2: With sulfuryl dichloride In chlorobenzene at 20 - 132℃; for 14.5h; Temperature; Time; Reagent/catalyst;		90%
Stage #1: 2-Acetylthiophene With pyridine; sulfur monochloride at 20℃; for 0.166667h;
Stage #2: at 70℃; for 3h;
Stage #3: at 137℃; for 18h;		86%
With α-picoline; thionyl chloride at 70 - 140℃; for 17.75h; Temperature; Reagent/catalyst;72%
With pyridine; disulfur dichloride at 70 - 137℃; for 21.5h; Concentration; Temperature;86 %Spectr.
Multi-step reaction with 2 steps
1: propionic acid; cobalt(II) nitrate hexahydrate; manganese (II) nitrate tetrahydrate; oxygen / 125 °C / 760.05 Torr
2: N,N-dimethyl-formamide; thionyl chloride; sodium hydroxide / ethyl acetate / 2.5 h / 58 - 65 °C / Inert atmosphere
View Scheme
2-Iodothiophene
3437-95-4

2-Iodothiophene

carbon monoxide
201230-82-2

carbon monoxide

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
With bis(tri-t-butylphosphine)palladium(0); benzyltriphenylphosphonium chloride In toluene at 110℃; under 38002.6 Torr; for 48h; Glovebox; Autoclave; Inert atmosphere;78%
2-Iodothiophene
3437-95-4

2-Iodothiophene

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

A

p-nitrobenzene iodide
636-98-6

p-nitrobenzene iodide

B

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
With (Xantphos)Pd(4-C6H4NO2)(I) In benzene at 90℃; for 20h; Sealed tube; Inert atmosphere;A n/a
B 52%
...Expand
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
With iodine; phosphorus trichloride at 160℃; for 48h; Schlenk technique; Sealed tube;26%
thiophene-2-carboxylic acid methyl ester
5380-42-7

thiophene-2-carboxylic acid methyl ester

A

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

B

glycine nitrile sulfate

glycine nitrile sulfate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / 10 percent aq. HCl / dioxane / 1 h / Heating
2: SOCl2 / 5 h / Heating
View Scheme
N‐methyl‐2‐thiophenecarboxamide
39880-77-8

N‐methyl‐2‐thiophenecarboxamide

A

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

B

glycine nitrile sulfate

glycine nitrile sulfate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96 percent / SOCl2 / 18 h / Heating
2: 97 percent / methanol; tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temperature, 12 h
3: 76 percent / 10 percent aq. HCl / 0.5 h / Ambient temperature
4: 97 percent / 10 percent aq. HCl / dioxane / 1 h / Heating
5: SOCl2 / 5 h / Heating
View Scheme
methyl N-methylthiophene-2-carboximidate
156330-47-1

methyl N-methylthiophene-2-carboximidate

A

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

B

glycine nitrile sulfate

glycine nitrile sulfate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / 10 percent aq. HCl / 0.5 h / Ambient temperature
2: 97 percent / 10 percent aq. HCl / dioxane / 1 h / Heating
3: SOCl2 / 5 h / Heating
View Scheme
N-methylthiophene-2-carboximidoyl chloride
71267-32-8

N-methylthiophene-2-carboximidoyl chloride

A

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

B

glycine nitrile sulfate

glycine nitrile sulfate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97 percent / methanol; tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temperature, 12 h
2: 76 percent / 10 percent aq. HCl / 0.5 h / Ambient temperature
3: 97 percent / 10 percent aq. HCl / dioxane / 1 h / Heating
4: SOCl2 / 5 h / Heating
View Scheme
potassium thiophene-2-carboxylate
33311-43-2

potassium thiophene-2-carboxylate

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane for 3.5h; Cooling with ice; Reflux;
2-thiophenylcarboxylic acid
527-72-0

2-thiophenylcarboxylic acid

oxalyl dichloride
79-37-8

oxalyl dichloride

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;
2-Iodothiophene
3437-95-4

2-Iodothiophene

terephthaloyl chloride
100-20-9

terephthaloyl chloride

A

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

B

4-iodobenzoic acid chloride
1711-02-0

4-iodobenzoic acid chloride

Conditions
ConditionsYield
With (Xantphos)Pd(4-C6H4NO2)(I) In benzene at 110℃; for 20h; Sealed tube; Inert atmosphere;A 92 %Spectr.
B n/a
...Expand
N-chlorosulfonyl-thiophene-2-carboxamide
42839-54-3

N-chlorosulfonyl-thiophene-2-carboxamide

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / dibutyl ether; water / 20 °C
2: hydrogenchloride / dibutyl ether / 7 h / 100 °C
3: N,N-dimethyl-formamide; thionyl chloride / 1.5 h / 65 °C
View Scheme
2-thiophenylcarboxamide
5813-89-8

2-thiophenylcarboxamide

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / dibutyl ether / 7 h / 100 °C
2: N,N-dimethyl-formamide; thionyl chloride / 1.5 h / 65 °C
View Scheme
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Conditions
ConditionsYield
With N-chloro-succinimide; thio-xanthene-9-one In acetonitrile at 20℃; for 7h; Irradiation;
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

α-naphthol
90-15-3

α-naphthol

1-naphthyl thiophen-2-carboxylate
38253-98-4

1-naphthyl thiophen-2-carboxylate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 14h;100%
Stage #1: 2-Thiophenecarbonyl chloride; α-naphthol In tetrahydrofuran at 0 - 20℃;
Stage #2: With triethylamine In tetrahydrofuran for 4h;		99%
Stage #1: 2-Thiophenecarbonyl chloride; α-naphthol With triethylamine In tetrahydrofuran at 0℃; for 4h;
Stage #2: With hydrogenchloride In tetrahydrofuran		99%
With sodium hydroxide
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2-methoxy-phenylamine
90-04-0

2-methoxy-phenylamine

N-(2-methoxyphenyl)-2-thiophenecarboxamide
136340-86-8

N-(2-methoxyphenyl)-2-thiophenecarboxamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
In toluene
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

phenethylamine
64-04-0

phenethylamine

N-(2-phenylethyl)thiophene-2-carboxamide
75690-78-7

N-(2-phenylethyl)thiophene-2-carboxamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 23℃;100%
In dichloromethane for 4h; Ambient temperature;87%
In dichloromethane at 20 - 70℃; for 5h; Alkaline conditions;71%
With morpholinomethyl polystyrene HL In dichloromethane at 20℃;
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2-thiophenecarbonyl azide
2046-39-1

2-thiophenecarbonyl azide

Conditions
ConditionsYield
With sodium azide In water; acetone at 0℃; for 3.5h;100%
With sodium azide In water; acetone for 0.333333h;
With sodium azide
tetrahydrofuran
109-99-9

tetrahydrofuran

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

thiophene-2-carboxylic acid 4-iodo-butyl ester

thiophene-2-carboxylic acid 4-iodo-butyl ester

Conditions
ConditionsYield
With bis(iodozinc)methane at 25℃; Substitution;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

4-[3-aminobenzoyl]-1-methylpiperidine
288156-90-1

4-[3-aminobenzoyl]-1-methylpiperidine

4-[3-(thien-2-ylamidyl)benzoyl]-1-methylpiperidine
288157-82-4

4-[3-(thien-2-ylamidyl)benzoyl]-1-methylpiperidine

Conditions
ConditionsYield
With (piperidinomethyl)-polystyrene In tetrahydrofuran for 18h;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2-amino-4-chloro-6-(2-methoxyphenyl)pyridin trifluoroacetate
925921-91-1

2-amino-4-chloro-6-(2-methoxyphenyl)pyridin trifluoroacetate

N-[4-chloro-6-(2-methoxyphenyl)pyridin-2-yl]thiophene-2-carboxamide
925921-92-2

N-[4-chloro-6-(2-methoxyphenyl)pyridin-2-yl]thiophene-2-carboxamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 16h;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl thiophene-2-carbonylphosphonate
1013942-90-9

dimethyl thiophene-2-carbonylphosphonate

Conditions
ConditionsYield
at 20℃; for 1h;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

methyl 2-(S)-benzyloxycarbonylamino-3-aminopropionate hydrochloride

methyl 2-(S)-benzyloxycarbonylamino-3-aminopropionate hydrochloride

C17H18N2O5S
1210069-24-1

C17H18N2O5S

Conditions
ConditionsYield
With pyridine In dichloromethane at -10℃;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

ethyl 2-((4-methoxyphenyl)imino)-4-(triethylsilyl)but-3-ynoate
1449215-20-6

ethyl 2-((4-methoxyphenyl)imino)-4-(triethylsilyl)but-3-ynoate

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

ethyl 2-(ethyl(4-methoxyphenyl)amino)-2-(thiophen-2-carbonyl)-4-(triethylsilyl)but-3-ynoate
1449215-36-4

ethyl 2-(ethyl(4-methoxyphenyl)amino)-2-(thiophen-2-carbonyl)-4-(triethylsilyl)but-3-ynoate

Conditions
ConditionsYield
Stage #1: ethyl 2-((4-methoxyphenyl)imino)-4-(triethylsilyl)but-3-ynoate; ethylmagnesium bromide In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: 2-Thiophenecarbonyl chloride In tetrahydrofuran at -78 - 20℃; for 0.5h; Inert atmosphere; regioselective reaction;		100%
...Expand
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

benzyl 2,2-dimethyl-3-hydroxypropanoic acid
17701-61-0

benzyl 2,2-dimethyl-3-hydroxypropanoic acid

3-(benzyloxy)-2,2-dimethyl-3-oxopropyl thiophene-2-carboxylate
1379613-69-0

3-(benzyloxy)-2,2-dimethyl-3-oxopropyl thiophene-2-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 2h; Cooling with ice;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

epoxylathyrol

epoxylathyrol

epoxyboetirane R

epoxyboetirane R

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 4h;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

C9H18N2O4*(x)ClH

C9H18N2O4*(x)ClH

methyl 3-(2-thenoylamide)-N-[(1,1-dimethylethoxy)carbonyl]-L-alanine

methyl 3-(2-thenoylamide)-N-[(1,1-dimethylethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water for 0.166667h; Cooling with ice;100%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

N-aminopyridin-1-ium iodide
6295-87-0

N-aminopyridin-1-ium iodide

(pyridin-1-ium-1-yl)(thiophene-2-carbonyl)amide
36048-85-8

(pyridin-1-ium-1-yl)(thiophene-2-carbonyl)amide

Conditions
ConditionsYield
With sodium hydroxide for 24h; Ambient temperature;99.5%
With potassium carbonate In methanol at 20℃; for 72h;98%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

anthranilic acid
118-92-3

anthranilic acid

2-Thiophen-2-yl-4H-3,1-benzoxazin-4-one
26060-06-0

2-Thiophen-2-yl-4H-3,1-benzoxazin-4-one

Conditions
ConditionsYield
With acetic anhydride; triethylamine In ethyl acetate99%
Stage #1: 2-Thiophenecarbonyl chloride; anthranilic acid In N,N-dimethyl acetamide at 7 - 13℃; for 4h; Cooling with ice;
Stage #2: With acetic anhydride In N,N-dimethyl acetamide at 98 - 118℃; for 2h;		95%
With pyridine at 0 - 20℃; for 0.583333h;37%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2-methylmethoxybenzene
578-58-5

2-methylmethoxybenzene

(4-methoxy-3-methylphenyl)(2-thienyl)methanone
56824-67-0

(4-methoxy-3-methylphenyl)(2-thienyl)methanone

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane for 0.75h; < 12 deg C;99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2-Chloroaniline
95-51-2

2-Chloroaniline

N-(2-chlorophenyl)thiophene-2-carboxamide
136340-94-8

N-(2-chlorophenyl)thiophene-2-carboxamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 24h;99%
In toluene
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2-bromoaniline
615-36-1

2-bromoaniline

thiophene-2-carboxylic acid (2-bromophenyl)amide
136340-96-0

thiophene-2-carboxylic acid (2-bromophenyl)amide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 24h;99%
In tetrahydrofuran at 20℃; for 24h;96%
With triethylamine In dichloromethane at 0 - 20℃;84%
In toluene
With triethylamine In dichloromethane at 20℃; for 3h;
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

thiophen-2-carboxylic anhydride
25569-97-5

thiophen-2-carboxylic anhydride

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In toluene for 3h; Heating;99%
With zinc In N,N-dimethyl-formamide; pentane at 20℃; for 20h; Inert atmosphere; Schlenk technique;33%
With water; triethylamine In acetone at 20℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2,2-dimethyl-3-butyne
917-92-0

2,2-dimethyl-3-butyne

(E)-4,4-dimethyl-1-(thiophen-2-yl)pent-2-en-1-one

(E)-4,4-dimethyl-1-(thiophen-2-yl)pent-2-en-1-one

Conditions
ConditionsYield
Stage #1: 3,3-Dimethylbut-1-yne With polymethylhydrosiloxane; trifuran-2-yl-phosphane; trimethyltin fluoride; tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 2h;
Stage #2: 2-Thiophenecarbonyl chloride In tetrahydrofuran at 65℃; for 2h; Stille reaction;		99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

4-Isopropyl-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one
22123-18-8

4-Isopropyl-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one

(4-isopropyl-3-methyl-1-phenyl-1H-pyrazol-5-yl) 2-thiophenecarboxylate

(4-isopropyl-3-methyl-1-phenyl-1H-pyrazol-5-yl) 2-thiophenecarboxylate

Conditions
ConditionsYield
With triethylamine In chloroform for 1h; Heating;99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

N-(tert-butyl)thiophene-2-carboxamide
90642-98-1

N-(tert-butyl)thiophene-2-carboxamide

Conditions
ConditionsYield
99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

benzyl alcohol
100-51-6

benzyl alcohol

benzyl thiophen-2-ylcarbamate
64307-10-4

benzyl thiophen-2-ylcarbamate

Conditions
ConditionsYield
Stage #1: 2-Thiophenecarbonyl chloride With pyridine; trimethylsilylazide In N,N-dimethyl-formamide at 20℃; Curtius rearrangement; Microflow reaction; Inert atmosphere;
Stage #2: benzyl alcohol With acetic acid In N,N-dimethyl-formamide at 110℃; Microflow reaction; Inert atmosphere;		99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

10-Undecen-1-ol
112-43-6

10-Undecen-1-ol

2-thiophenecarboxylic acid, undec-10-enyl ester
959051-71-9

2-thiophenecarboxylic acid, undec-10-enyl ester

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

1-hydrazino-4-(4-methoxyphenyl)-5H-2,3-benzodiazepine
943101-01-7

1-hydrazino-4-(4-methoxyphenyl)-5H-2,3-benzodiazepine

3-(2-furyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-a][2,3]benzodiazepine hydrochloride

3-(2-furyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-a][2,3]benzodiazepine hydrochloride

Conditions
ConditionsYield
In 1,4-dioxane for 1h; Reflux;99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

2,2-diphenyl-4-pentenylamine
53001-06-2

2,2-diphenyl-4-pentenylamine

C22H21NOS

C22H21NOS

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

5-bromo-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine

5-bromo-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine

(4-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridin-1(2H)-yl)(thiophen-2-yl)methanone

(4-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-5,6-dihydropyridin-1(2H)-yl)(thiophen-2-yl)methanone

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;99%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

(R)-2-[4-(4-fluorobenzyloxy)-3-methoxybenzylamino]-2-phenylacetamide

(R)-2-[4-(4-fluorobenzyloxy)-3-methoxybenzylamino]-2-phenylacetamide

N-((R)-carbamoylphenylmethyl)-N-[4-(4-fluorobenzyloxy)-3-methoxybenzyl]-2-thienamide

N-((R)-carbamoylphenylmethyl)-N-[4-(4-fluorobenzyloxy)-3-methoxybenzyl]-2-thienamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1h;99%
2-methyl-1-buten-4-ol
763-32-6

2-methyl-1-buten-4-ol

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

3-methylbut-3-en-1-yl thiophene-2-carboxylate

3-methylbut-3-en-1-yl thiophene-2-carboxylate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere;99%
With dmap; triethylamine In dichloromethane at 20℃;90%
With dmap; triethylamine In dichloromethane at 0 - 20℃;83%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

(phen)(PPh3)Cu(heptafluoroisopropyl)

(phen)(PPh3)Cu(heptafluoroisopropyl)

C8H3F7OS

C8H3F7OS

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 21 - 23℃; for 24h; Inert atmosphere;99%

2-Thiophenecarbonyl chloride Specification

1. Introduction of 2-Thiophenecarbonylchloride
2-Thiophenecarbonyl chloride with the CAS registry number of 5271-67-0, is also named as 2-Thenoyl chloride. The systematic name of 2-Thiophenecarbonylchloride is thiophene-2-carbonyl chloride. The product's categories are Acidhalide; Thiophene & Benzothiophene; Heterocyclic Compounds. Besides, it is clear colourless to yellow-grey liquid, which should be sealed in a dark, cool, dry place at 2-8 °C. In addition, its molecular formula is C5H3ClOS and molecular weight is 146.59.

2. Properties of 2-Thiophenecarbonylchloride
The other characteristics of 2-Thiophenecarbonyl chloride can be summarized as: (1)EINECS: 226-092-4; (2)ACD/LogP: 1.89; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.89; (5)ACD/LogD (pH 7.4): 1.89; (6)ACD/BCF (pH 5.5): 16.01; (7)ACD/BCF (pH 7.4): 16.01; (8)ACD/KOC (pH 5.5): 253.39; (9)ACD/KOC (pH 7.4): 253.39; (10)#H bond acceptors: 1; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 1; (13)Polar Surface Area: 45.31 Å2; (14)Index of Refraction: 1.576; (15)Molar Refractivity: 34.88 cm3; (16)Molar Volume: 105.3 cm3; (17)Polarizability: 13.82×10-24cm3; (18)Surface Tension: 45.9 dyne/cm; (19)Density: 1.391 g/cm3; (20)Flash Point: 75.9 °C; (21)Enthalpy of Vaporization: 43.81 kJ/mol; (22)Boiling Point: 201.8 °C at 760 mmHg; (23)Vapour Pressure: 0.302 mmHg at 25 °C.

3. Structure Descriptors of 2-Thiophenecarbonylchloride
(1)SMILES: ClC(=O)c1sccc1
(2)InChI: InChI=1/C5H3ClOS/c6-5(7)4-2-1-3-8-4/h1-3H
(3)InChIKey: QIQITDHWZYEEPA-UHFFFAOYAG
(4)Std. InChI: InChI=1S/C5H3ClOS/c6-5(7)4-2-1-3-8-4/h1-3H
(5)Std. InChIKey: QIQITDHWZYEEPA-UHFFFAOYSA-N

4. Safety Information of 2-Thiophenecarbonylchloride
When you are using this chemical, please be cautious about it as the following: it is toxic to aquatic organisms. It also irritates to respiratory system. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection. Moreover, in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

5. Preparation of 2-Thiophenecarbonylchloride
2-Thiophenecarbonylchloride can be prepared by thiophene-2-carboxylic acid.



The yield is 97 %.

6. Use of 2-Thiophenecarbonylchloride
2-Thiophenecarbonylchloride can react with diazomethane to get 2-diazo-1-thiophen-2-yl-ethanone.


The yield is 60 %.

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