3,4,5-Trimethoxyphenol supplier

Name
3,4,5-Trimethoxyphenol
EINECS 211-387-2
CAS No. 642-71-7
Article Data49
CAS DataBase
Density 1.152 g/cm³
Solubility
Melting Point 146-149 °C
Formula C₉H₁₂O₄
Boiling Point 313.1 °C at 760 mmHg
Molecular Weight 184.192
Flash Point 143.2 °C
Transport Information
Appearance light yellow to brown crystalline powder
Safety 37/39-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 3,4,5-Trimethoxyphenol;Antiarol;
PSA 47.92000
LogP 1.41800

Synthetic route

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With cesiumhydroxide monohydrate; t-BuBrettPhos; C44H62NO5PPdS; water In 1,4-dioxane at 20℃; for 18h; Inert atmosphere;	91%

: 105205-66-1
2-(3,4,5-Trimethoxy-phenyl)-propan-2-ol

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With sodium perborate; boron trifluoride diethyl etherate In tetrahydrofuran at 0℃; for 1.5h;	87%
With dihydrogen peroxide; toluene-4-sulfonic acid In tetrahydrofuran at 22℃; for 4h;	73%
With sodium perborate; boron trifluoride diethyl etherate In tetrahydrofuran at 20℃;

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxy-benzaldehyde With dibutyl ether; bis[3,5-bis(trifluoromethyl)diphenyl] diselenide In 2,2,2-trifluoroethanol at 20℃; for 0.25h; Baeyer-Villiger oxidation; Stage #2: With potassium hydroxide In methanol for 2h; Further stages.;	85%
With dihydrogen peroxide; 3,5-bis(perfluorooctyl)phenyl butylselenide In 1,2-dichloro-ethane at 80℃;	75%
Stage #1: 3,4,5-trimethoxy-benzaldehyde With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane; water at 20℃; for 1h; Stage #2: With potassium carbonate In methanol at 20℃; for 0.5h;	70%

: 24313-88-0
3,4,5-Trimethoxyaniline

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
Stage #1: 3,4,5-Trimethoxyaniline With sulfuric acid; sodium nitrite In water at 10 - 15℃; Stage #2: With sulfuric acid; copper(II) sulfate at 100℃; for 2h;	80%
Stage #1: 3,4,5-Trimethoxyaniline With tetrafluoroboric acid In water at 20℃; for 0.0333333h; Stage #2: With sodium nitrite In water at 0℃; for 0.5h; Stage #3: With copper(I) oxide; copper(II) sulfate In water at 0 - 20℃; for 0.5h;	76%
Diazotization.Kochen der Loesung mit Schwefelsaeure;
With sulfuric acid; copper(II) sulfate; sodium nitrite at 20 - 60℃; for 1.25h;	0.95 g
Stage #1: 3,4,5-Trimethoxyaniline With tetrafluoroboric acid In tetrahydrofuran Stage #2: With sodium nitrite In tetrahydrofuran; water at -5 - 0℃; Stage #3: With sulfuric acid; water; sodium sulfate at 70℃;	2.3 g

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With rongalite In ethanol; water at 20℃; for 8h; Irradiation;	77%

: 1408323-52-3
1-phenyl-2-(3,4,5-trimethoxyphenoxy)ethanone

A: 642-71-7
3,4,5-trimethoxyphenol

B: 4,5,6-trimethoxy-3-phenylbenzofuran

Conditions

Conditions	Yield
With gallium(III) triflate In nitromethane at 25℃; for 5h; Catalytic behavior; Solvent; Inert atmosphere;	A 12% B 48%

: CF3O3S(1-)*C18H22IO3(1+)

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With water; sodium acetate; copper(l) chloride In N,N-dimethyl-formamide at 40℃; for 2h; Inert atmosphere; Sealed tube;	42%

: 15233-65-5
2,6-dimethoxy-1,4-hydroquinone

: 77-78-1
dimethyl sulfate

A: 642-71-7
3,4,5-trimethoxyphenol

B: 5333-45-9
1,2,3,5-tetramethoxybenzene

Conditions

Conditions	Yield
With sodium hydroxide

...Expand

: 15233-65-5
2,6-dimethoxy-1,4-hydroquinone

: 74-88-4
methyl iodide

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With potassium hydroxide

: 63591-70-8
2',4',5,5',6,7-hexamethoxyflavone

A: 642-71-7
3,4,5-trimethoxyphenol

B: 22248-14-2
6-hydroxy-2,3,4-trimethoxyacetophenone

C: 490-64-2
asaronic acid

D: 55162-39-5
6-hydroxy-2,3,4-trimethoxybenzoic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 120h; Heating;

...Expand

: 58235-51-1
2,4,6,3',4',5'-hexamethoxydiphenyl ether

A: 500-99-2
3,5-dimethoxyphenol

B: 621-23-8
1,2,3-trimethoxybenzene

C: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With ammonia; sodium at -70℃; Product distribution;

...Expand

: 51318-84-4
trifuhalol-A-octamethyl ether

A: 500-99-2
3,5-dimethoxyphenol

B: 621-23-8
1,2,3-trimethoxybenzene

C: 642-71-7
3,4,5-trimethoxyphenol

D: 4,3'-dihydroxy-2,6,4',5'-tetramethoxydiphenyl ether

E: 4-hydroxy-2,6,3',4',5'-pentamethoxydiphenyl ether

Conditions

Conditions	Yield
With ammonia; sodium at -70℃; Product distribution;

...Expand

: 82479-17-2
1-Phenyl-5-(3,4,5-trimethoxy-phenoxy)-1H-tetrazole

A: 5378-52-9
phenyl-1H-tetrazole

B: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With tetraethylammonium bromide In water; N,N-dimethyl-formamide electrolysis;	A n/a B 40 % Chromat.

: 17742-46-0
acetic acid 3,4,5-trimethoxy-phenyl ester

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With potassium hydroxide In ethanol Heating;

: 29137-74-4
Methoxy-(1,2,6-trimethoxy-4-oxo-cyclohexa-2,5-dienyl)-acetic acid ethyl ester

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With hydrogenchloride

: 94687-12-4
<2-Hydroxy-4.5.6-trimethoxy-phenyl>-<2.4.5-trimethoxy-benzyl>-keton

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water at 180℃;

: 15233-65-5
2,6-dimethoxy-1,4-hydroquinone

: 77-78-1
dimethyl sulfate

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With sodium hydroxide

: 15233-65-5
2,6-dimethoxy-1,4-hydroquinone

: 77-78-1
dimethyl sulfate

A: 642-71-7
3,4,5-trimethoxyphenol

B: 20491-92-3
2,4,6-trimethoxyphenol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 3h; Heating;	A 120 mg B 100 mg

...Expand

: 77-78-1
dimethyl sulfate

: 1-β-D-glucopyranosyloxy-3,5-dimethoxy-4-hydroxybenzene

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With potassium hydroxide; potassium carbonate 1.) Me2CO, reflux, 6 h, 2.) MeOH, reflux; Multistep reaction;

: 64554-43-4
5,6,7-trimethoxy-2-methyl-3-(3,4,5-trimethoxy-phenyl)-chromen-4-one

concentrated alkaline solution: concentrated alkaline solution

A: 642-71-7
3,4,5-trimethoxyphenol

B: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

Conditions

Conditions	Yield
at 180℃;

...Expand

: 7732-18-5
water

: 50901-35-4
5,6,7-trimethoxy-3-(3',4',5'-trimethoxyphenyl)-4H-chromen-4-one

methanolic KOH-solution: methanolic KOH-solution

A: 642-71-7
3,4,5-trimethoxyphenol

B: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

Conditions

Conditions	Yield
at 180℃;

...Expand

: 7664-93-9
sulfuric acid

: 24313-88-0
3,4,5-Trimethoxyaniline

sodium nitrite: sodium nitrite

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
Eintraegen die Diazoniumsalzloesung in siedend heisse 50prozentige Schwefelsaeure;

...Expand

irigenintrimethyl ether: irigenintrimethyl ether

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With potassium hydroxide at 180℃;

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

A: 642-71-7
3,4,5-trimethoxyphenol

B: 30225-76-4
3,4,5-trimethoxyphenyl formate

Conditions

Conditions	Yield
With dibutyl ether; bis[3,5-bis(trifluoromethyl)diphenyl] diselenide In 2,2,2-trifluoroethanol at 20℃; for 0.25h; Baeyer-Villiger oxidation;

: 143287-98-3
3,4,5-trimethoxyphenyl trifluoromethanesulfonate

A: 634-36-6
1,2,3-trimethoxybenzene

B: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
With methanol; ammonium bicarbonate; magnesium; palladium on activated charcoal at 20℃; for 24h;

: 143287-98-3
3,4,5-trimethoxyphenyl trifluoromethanesulfonate

A: 634-36-6
1,2,3-trimethoxybenzene

B: 642-71-7
3,4,5-trimethoxyphenol

C: 56772-00-0
3,3’,4,4’,5,5’-hexamethoxy-1,1’-biphenyl

Conditions

Conditions	Yield
With methanol; ammonia; magnesium; palladium on activated charcoal at 20℃; for 1.5h;

...Expand

: 1916-07-0
3,4,5-trimethoxybenzoic acid methyl ester

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: magnesium / diethyl ether / Heating 1.2: diethyl ether / Heating 2.1: BF3Et2O; NaBO34H2O / tetrahydrofuran / 20 °C View Scheme

: 530-55-2
2,6-dimethoxy-p-quinone

: 642-71-7
3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium dithionite 2: 120 mg / K2CO3 / acetone / 3 h / Heating View Scheme
Multi-step reaction with 2 steps 1: Reduktion 2: KOH View Scheme
Multi-step reaction with 3 steps 1: Cu 3: HCl View Scheme
Multi-step reaction with 3 steps 1: Cu 2: HCl 3: aq. NaOH View Scheme

: 642-71-7
3,4,5-trimethoxyphenol

: 530-55-2
2,6-dimethoxy-p-quinone

Conditions

Conditions	Yield
With bis-[(trifluoroacetoxy)iodo]benzene In water; acetonitrile for 0.166667h; Ambient temperature;	100%
With tetrakis-[4-(diacetoxyiodo)phenyl]methane In acetonitrile at 20℃; for 0.5h;	96%
With oxygen; copper dichloride In water; ethyl acetate at 70℃; for 3h;	92%

: 67-56-1
methanol

: 642-71-7
3,4,5-trimethoxyphenol

: 57197-13-4
3,4,4,5-Tetramethoxy-2,5-cyclohexadien-1-one

Conditions

Conditions	Yield
With potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile for 0.166667h; Ambient temperature;	100%
With 1,3,5,7-tetrakis-(4-(diacetoxyiodo)phenyl)adamantane at 20℃; for 0.166667h;	100%
With thallium(III) nitrate

: 64-17-5
ethanol

: 642-71-7
3,4,5-trimethoxyphenol

: 57197-20-3
4-ethoxy-3,4,5-trimethoxycyclohexa-2,5-dienone

Conditions

Conditions	Yield
With potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile for 0.166667h; Ambient temperature;	100%
With thallium(III) nitrate

: 642-71-7
3,4,5-trimethoxyphenol

: 63930-81-4
ethoxy-(4-methylpiperazin-1-yl)methane

: 2,6-bis-(4-methylpiperazin-1-ylmethyl)-3,4,5-trimethoxyphenol

Conditions

Conditions	Yield
In acetonitrile for 20h; Heating;	100%

: 642-71-7
3,4,5-trimethoxyphenol

: 190001-40-2
tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate

: 1-((3,4,5-trimethoxyphenoxy)methyl)carbonyl-4-(t-butoxycarbonyl)piperazine

Conditions

Conditions	Yield
With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene	100%
Stage #1: 3,4,5-trimethoxyphenol With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.333333h; Stage #2: tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate In N,N-dimethyl-formamide; toluene at 20℃; for 2h;	100%
Stage #1: 3,4,5-trimethoxyphenol With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.333333h; Stage #2: tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate In N,N-dimethyl-formamide; toluene at 20℃; for 2h;	100%

: 642-71-7
3,4,5-trimethoxyphenol

: 106-96-7
propargyl bromide

: 1,2,3-trimethoxy-5-(prop-2-yn-1-yloxy)benzene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; toluene at 20℃; for 7h; Inert atmosphere;	100%
With potassium carbonate In acetone at 50℃; for 5h;	95%
With potassium carbonate In acetone for 10h; Reflux;
Stage #1: 3,4,5-trimethoxyphenol With potassium carbonate In acetone at 70℃; for 0.5h; Stage #2: propargyl bromide In acetone at 70℃; for 8h;

: 642-71-7
3,4,5-trimethoxyphenol

: 108-24-7
acetic anhydride

: 17742-46-0
acetic acid 3,4,5-trimethoxy-phenyl ester

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxyphenol With triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: acetic anhydride In dichloromethane at 20℃; for 6h;	99%
Stage #1: 3,4,5-trimethoxyphenol With triethylamine In dichloromethane at 20℃; for 0.25h; Stage #2: acetic anhydride In dichloromethane at 20℃; for 6h;	99%
With sodium acetate at 110℃; for 2h;	99%

: 642-71-7
3,4,5-trimethoxyphenol

: 102-92-1
Cinnamoyl chloride

: 89329-20-4
3,4,5-trimethoxyphenylcinnamate

Conditions

Conditions	Yield
With pyridine In benzene for 1h; Heating;	99%

: 642-71-7
3,4,5-trimethoxyphenol

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 267901-34-8
5,6,7-trimethoxy-4-(4-methoxyphenyl)-3,4-dihydrochromen-2-one

Conditions

Conditions	Yield
With trifluoroacetic acid for 23h;	99%
With trifluoroacetic acid; palladium diacetate In dichloromethane at 20℃; for 10h; Cyclization; hydroarylation;	90%

: 642-71-7
3,4,5-trimethoxyphenol

: 329008-88-0
2-allyloxy-4-chloromethyl-1-methoxy-benzene

: 329008-89-1
5-(3-Allyloxy-4-methoxy-benzyloxy)-1,2,3-trimethoxy-benzene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 18h;	99%

: 642-71-7
3,4,5-trimethoxyphenol

: 98799-41-8
2-iodo-3,4,5-trimethoxybenzoic acid

: 3',4',5'-trimethoxyphenyl 2-iodo-3,4,5-trimethoxybenzoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;	99%

: 480427-00-7
2-(4-bromo-phenyl)-5,7-dimethyl-4-[1H-1,2,4]triazol-1-yl-imidazo[5,1-f][1,2,4]triazine

: 642-71-7
3,4,5-trimethoxyphenol

: 480425-78-3
2-(4-bromo-phenyl)-5,7-dimethyl-4-(3,4,5-trimethoxy-phenoxy)-imidazo[5,1-f][1,2,4]triazine

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxyphenol With potassium tert-butylate In tetrahydrofuran for 0.5h; Stage #2: 2-(4-bromo-phenyl)-5,7-dimethyl-4-[1H-1,2,4]triazol-1-yl-imidazo[5,1-f][1,2,4]triazine In tetrahydrofuran at 70℃; for 3h;	99%

: 642-71-7
3,4,5-trimethoxyphenol

: 2373-80-0
3,4-(methylenedioxy)cinnamic acid

: 4-(benzo[d][1,3]dioxol-5-yl)-5,6,7-trimethoxychroman-2-one

Conditions

Conditions	Yield
With acetyl chloride at 25℃; for 10h; Inert atmosphere;	99%

: 642-71-7
3,4,5-trimethoxyphenol

: C11H11NO3

: C18H19NO5

Conditions

Conditions	Yield
With chloro-trimethyl-silane; 1,3-bis(2,4,6-trimethylphenyl)-2-iodoimidazolium triflate In chloroform at 25℃; for 24h; Inert atmosphere;	99%

: 642-71-7
3,4,5-trimethoxyphenol

: 106-95-6
allyl bromide

: 150571-99-6
1-(allyloxy)-3,4,5-trimethoxybenzene

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 23℃; for 1h; Alkylation;	98%
With potassium carbonate In acetone Williamson Ether Synthesis; Reflux;	30%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;

: 642-71-7
3,4,5-trimethoxyphenol

: 98-59-9
p-toluenesulfonyl chloride

: 312299-66-4
3,4,5-trimethoxyphenyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane for 2.25h; Inert atmosphere;	98%
With pyridine; dmap In dichloromethane	84%

: 358-23-6
trifluoromethylsulfonic anhydride

: 642-71-7
3,4,5-trimethoxyphenol

: 143287-98-3
3,4,5-trimethoxyphenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	98%
With potassium phosphate In toluene at 0 - 20℃;	97%
With potassium phosphate In water; toluene at 0 - 20℃;	97%

: 1-O-acetyl-3,4-di-O-benzyl-2,6-dideoxy-α-D-glucoside

: 642-71-7
3,4,5-trimethoxyphenol

: C29H34O7

Conditions

Conditions	Yield
With tetrafluoroboric acid; 1-hexyl-3-methylimidazolium tetrafluoroborate at 25℃; under 2 Torr; for 1h;	98%

: 642-71-7
3,4,5-trimethoxyphenol

: 77-78-1
dimethyl sulfate

: 5333-45-9
1,2,3,5-tetramethoxybenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone Inert atmosphere;	98%

: 642-71-7
3,4,5-trimethoxyphenol

: 127-09-3
sodium acetate

: 17742-46-0
acetic acid 3,4,5-trimethoxy-phenyl ester

Conditions

Conditions	Yield
In acetic anhydride at 110℃; for 2h; Inert atmosphere;	98%

: 642-71-7
3,4,5-trimethoxyphenol

: 741265-23-6
2-(5-chloro-2-methyl-phenylamino)-6-trifluoromethyl-nicotinic acid

: 3,4,5-trimethoxyphenyl 2-((5-chloro-2-methylphenyl)amino)-6-(trifluoromethyl)nicotinate

Conditions

Conditions	Yield
Stage #1: 2-(5-chloro-2-methyl-phenylamino)-6-trifluoromethyl-nicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 0.5h; Stage #2: 3,4,5-trimethoxyphenol In acetonitrile at 20℃; for 24h;	98%

: 642-71-7
3,4,5-trimethoxyphenol

: 67-63-0
isopropyl alcohol

: 57197-21-4
4-isopropoxy-3,4,5-trimethoxycyclohexa-2,5-dienone

Conditions

Conditions	Yield
With potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene In acetonitrile for 0.166667h; Ambient temperature;	97%
With thallium(III) nitrate

: 642-71-7
3,4,5-trimethoxyphenol

: 124-63-0
methanesulfonyl chloride

: 3,4,5-trimethoxyphenyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine at 20℃; for 19h;	96%
With triethylamine In dichloromethane at 0℃; for 0.5h;	59%

: 1028981-50-1
diethyl 2-(2-(phenylethynyl)benzylidene)malonate

: 642-71-7
3,4,5-trimethoxyphenol

: (E)-ethyl 7-benzylidene-1,2,3-trimethoxy-6-oxo-6,6a,7,11b-tetrahydroindeno[2,1-c]chromene-6a-carboxylate

Conditions

Conditions	Yield
With tin(II) trifluoromethanesulfonate In 1,2-dichloro-ethane at 100℃; for 8h; Sealed tube; stereoselective reaction;	96%

: 1866-39-3
4-methylcinnamic acid

: 642-71-7
3,4,5-trimethoxyphenol

: 5,6,7-trimethoxy-4-(p-tolyl)chroman-2-one

Conditions

Conditions	Yield
With acetyl chloride at 48℃; for 24h; Inert atmosphere;	96%

: 642-71-7
3,4,5-trimethoxyphenol

: 4-azido-3,4,5-trimethoxycyclohexa-2,5-dien-1-one

Conditions

Conditions	Yield
With Amberlyst A26-resin bound iodine azide In acetonitrile at 20℃; for 2.5h; Catalytic behavior; Inert atmosphere;	96%

: 642-71-7
3,4,5-trimethoxyphenol

: 108-24-7
acetic anhydride

: 22248-14-2
6-hydroxy-2,3,4-trimethoxyacetophenone

Conditions

Conditions	Yield
Stage #1: 3,4,5-trimethoxyphenol; acetic anhydride With boron trifluoride diethyl etherate at 0 - 60℃; for 3h; Stage #2: With water; triethylamine at 20℃; for 1h;	95%
With boron trifluoride diethyl etherate at 0 - 60℃; for 3h;	95%
Stage #1: 3,4,5-trimethoxyphenol; acetic anhydride With zinc(II) chloride In nitromethane Friedel-Crafts reaction; Stage #2: With sodium hydrogencarbonate In nitromethane Further stages.;	91%

: 642-71-7
3,4,5-trimethoxyphenol

: 73438-28-5
(RS)-1-chloro-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-2-ol

: 68576-86-3
Enciprazine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 6h; Reflux;	95%

: 642-71-7
3,4,5-trimethoxyphenol

: dimethyl 2-((fluoromethyl)(phenyl)-l4-sulfaneylidene)malonate

: 5-(fluoromethoxy)-1,2,3-trimethoxybenzene

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 40℃; for 0.5h; Schlenk technique; Inert atmosphere;	95%

: 375-72-4
Nonafluorobutanesulfonyl fluoride

: 642-71-7
3,4,5-trimethoxyphenol

: 3,4,5-trimethoxyphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Inert atmosphere;	95%

3,4,5-Trimethoxyphenol Specification

The IUPAC name of 3,4,5-Trimethoxyphenol is 3,4,5-trimethoxyphenol. With the CAS registry number 642-71-7, it is also named as Phenol, 3,4,5-trimethoxy-. The product's categories are Aromatic Phenols; Organic Building Blocks; Oxygen Compounds; Phenols. Besides, it is light yellow to brown crystalline powder, which should be stored in sealed containers in a cool, dry place away from oxidizing agents. In addition, its molecular formula is C₉H₁₂O₄ and molecular weight is 184.19.

The other characteristics of this product can be summarized as: (1)EINECS: 211-387-2; (2)ACD/LogP: 1.07; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.07; (5)ACD/LogD (pH 7.4): 1.07; (6)ACD/BCF (pH 5.5): 3.82; (7)ACD/BCF (pH 7.4): 3.81; (8)ACD/KOC (pH 5.5): 90.89; (9)ACD/KOC (pH 7.4): 90.46; (10)#H bond acceptors: 4; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 4; (13)Polar Surface Area: 36.92 Å²; (14)Index of Refraction: 1.514; (15)Molar Refractivity: 48.17 cm³; (16)Molar Volume: 159.8 cm³; (17)Polarizability: 19.09×10^-24cm³; (18)Surface Tension: 36.2 dyne/cm; (19)Density: 1.152 g/cm³; (20)Flash Point: 143.2 °C; (21)Melting point: 146-149 °C; (22)Enthalpy of Vaporization: 57.62 kJ/mol; (23)Boiling Point: 313.1 °C at 760 mmHg; (24)Vapour Pressure: 0.000276 mmHg at 25 °C.

Preparation of 3,4,5-Trimethoxyphenol: this chemical can be prepared by 2-(3,4,5-trimethoxy-phenyl)-propan-2-ol.

This reaction NaBO₃^.4H₂O, BF₃^.Et₂O and tetrahydrofuran at temperature of 0 °C for 1.5 hours. The yield is 87 %.

Uses of 3,4,5-Trimethoxyphenol: it can react with acetic acid anhydride to get 5-acetoxy-1,2,3-trimethoxy-benzene.

This reaction needs AcONa at temperature of 110 °C for 2 hours. The yield is 96 %.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: COC1=CC(=CC(=C1OC)OC)O
(2)InChI: InChI=1S/C9H12O4/c1-11-7-4-6(10)5-8(12-2)9(7)13-3/h4-5,10H,1-3H3
(3)InChIKey: VTCDZPUMZAZMSB-UHFFFAOYSA-N

Product Name

3,4,5-Trimethoxyphenol

Synthetic route

3,4,5-Trimethoxyphenol Specification

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