Conditions | Yield |
---|---|
Stage #1: nicotinic acid With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -50℃; for 0.5h; Metallation; Stage #2: carbon dioxide In tetrahydrofuran; hexane Substitution; | 73% |
Conditions | Yield |
---|---|
With Iron(III) nitrate nonahydrate; tetrabutylammomium bromide; nitric acid In water at 60℃; for 16h; | 71% |
Stage #1: isoquinoline With acetic acid In water at 20℃; for 0.25h; Stage #2: With ozone In water at 20 - 25℃; for 6h; | 45% |
With alkaline permanganate solution |
Conditions | Yield |
---|---|
Stage #1: pyridine-4-carboxylic acid With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -50 - -25℃; for 0.5h; Metallation; Stage #2: carbon dioxide In tetrahydrofuran; hexane Substitution; | 65% |
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane; water for 48h; Heating; | 54.5% |
3-aza-2,4-cyclopentadiene
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With polymer-bound monoester of acetylenedicarboxylic acid In dimethyl sulfoxide for 72h; Heating; behaviour of various aza- and diaza-cyclopentadienones as dienes or dienophiles; hydrolysis of the polymer-bound product; | 54.3% |
Conditions | Yield |
---|---|
With potassium permanganate | |
In water Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode; | 56 % Chromat. |
isoquinoline
A
3,4-pyridinecarboxylic acid
B
benzene-1,2-dicarboxylic acid
Conditions | Yield |
---|---|
With ozone; acetic acid |
Conditions | Yield |
---|---|
With permanganate(VII) ion |
pyridine-3,4-dicarboxylic acid 3-methyl ester
A
pyridine
B
methyl 3-pyridinecarboxylate
C
3,4-pyridinecarboxylic acid
D
4-(methoxycarbonyl)nicotinic acid
Conditions | Yield |
---|---|
beim Erhitzen ueber den Schmelzpunkt; |
pyridine-2,3,4-tricarboxylic acid
acetic anhydride
acetic acid
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
at 170 - 190℃; |
pyridine-2,3,4-tricarboxylic acid
A
3,4-pyridinecarboxylic acid
B
pyridine-2,3,4-tricarboxylic acid-3,4-anhydride
Conditions | Yield |
---|---|
at 110 - 115℃; under 20 Torr; |
pyridine-2,4,5-tricarboxylic acid
acetic anhydride
acetic acid
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
at 160℃; im Rohr; |
Conditions | Yield |
---|---|
at 140℃; im Rohr; |
pyridine-2,3,4,6-tetracarboxylic acid
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With nitrobenzene |
Conditions | Yield |
---|---|
With nitric acid |
Conditions | Yield |
---|---|
With nitric acid |
Conditions | Yield |
---|---|
With nitric acid | |
With nitric acid |
(R)-[(1S,2S,4S)-5-Eth-(Z)-ylidene-1-aza-bicyclo[2.2.2]oct-2-yl]-(6-methoxy-quinolin-4-yl)-methanol
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With nitric acid |
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With alkaline permanganate solution |
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride at 240 - 250℃; im Rohr; |
3,4-pyridinecarboxylic acid
2-(3-ethyl-[4]pyridyl)-propane-1,3-diol
3,4-pyridinecarboxylic acid
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With acetic anhydride; acetic acid | |
at 170 - 190℃; | |
With acetic acid |
3,4-pyridinecarboxylic acid
2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione
Conditions | Yield |
---|---|
Stage #1: 3,4-pyridinecarboxylic acid With acetic anhydride for 1h; Reflux; Stage #2: With hydrazine hydrate for 4h; Reflux; | 98.6% |
TETRAHYDROFURFURYLAMINE
3,4-pyridinecarboxylic acid
2-((tetrahydrofuran-2-yl)methyl)-2H-pyrrolo[3,4-c]pyridine-1,3-dione
Conditions | Yield |
---|---|
for 0.0333333h; Microwave irradiation; | 98% |
Conditions | Yield |
---|---|
With acetic anhydride for 0.75h; Heating; | 96% |
With acetic anhydride for 2h; Heating; | 76% |
With acetic anhydride | 76% |
Conditions | Yield |
---|---|
Stage #1: 3,4-pyridinecarboxylic acid With acetic anhydride at 140 - 150℃; Stage #2: With acetamide at 140℃; for 3h; | 95.1% |
Stage #1: 3,4-pyridinecarboxylic acid With acetic anhydride at 140℃; for 16h; Stage #2: With acetamide at 140℃; for 8h; | 68% |
Multi-step reaction with 2 steps 1: acetic anhydride / 0.08 h / Heating 2: urea / 0.33 h / 150 - 160 °C View Scheme |
Conditions | Yield |
---|---|
for 0.0666667h; Microwave irradiation; | 94% |
Conditions | Yield |
---|---|
for 0.0833333h; Microwave irradiation; | 94% |
Conditions | Yield |
---|---|
for 0.0666667h; Microwave irradiation; | 92% |
Conditions | Yield |
---|---|
With phosphorus pentachloride at 180℃; for 2h; | 91% |
With thionyl chloride for 18h; Reflux; | |
With thionyl chloride In N,N-dimethyl-formamide for 5h; Reflux; | |
With thionyl chloride; N,N-dimethyl-formamide for 2h; Reflux; |
Conditions | Yield |
---|---|
In water High Pressure; metal compd. and ligand (1:1) heated at 180°C for 3 d; cooled to room temp., crystd., elem. anal.; | 90% |
Conditions | Yield |
---|---|
for 0.05h; Microwave irradiation; | 90% |
3,4-pyridinecarboxylic acid
water
copper diacetate
praseodymium(3+) acetate
Conditions | Yield |
---|---|
Stage #1: 3,4-pyridinecarboxylic acid; water; copper diacetate Stage #2: praseodymium(3+) acetate With sodium acetate; sodium hydroxide pH=11; pH-value; Concentration; | 90% |
Conditions | Yield |
---|---|
for 0.0666667h; Microwave irradiation; | 88% |
Conditions | Yield |
---|---|
With thionyl chloride for 3h; Reflux; | 87.8% |
With sulfuric acid | 80.3% |
With sulfuric acid at 25 - 100℃; for 16h; | 73% |
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With triethylamine In water High Pressure; mixt. Zn(NO3)2*6H2O, pyridine-3,4-dicarboxylic acid, triethylamine, and water were heated in Teflon reactor at 160°C for 5 days; react. mixt. was cooled to room temp. at rate 10°C/h; elem. anal.; | 87% |
With HCl; 1,2-bis(4-pyridyl)ethane In water High Pressure; Zn:H2pydc:bpe:1:1:0.5 molar ratio, pH adjusted to 3, heated at 160°C for 4 d; cooled to room temp., crysts. filtered; elem. anal., TGA; | 47.1% |
3,4-pyridinecarboxylic acid
Pyridine-3,4-dicarboxylic acid N-oxide
Conditions | Yield |
---|---|
With tetrahexylammonium chloride; dihydrogen peroxide; <(Ph2PO2)(WO(O2)2)2> In toluene at 90℃; for 5h; | 85% |
With dihydrogen peroxide; 34> In toluene at 90℃; for 6h; | 82% |
3,4-pyridinecarboxylic acid
1,4-bis(imidazol-l-yl-methyl)benzene
Conditions | Yield |
---|---|
With sodium hydroxide In water at 160℃; for 72h; Autoclave; High pressure; | 85% |
Conditions | Yield |
---|---|
With triethylamine In water High Pressure; mixed with Zn:H2PDB:4,4'-bipy:triethylamine=1:1:1:2 molar ratio in H2O, hydrothermally heated at 160°C for 120 h at pH=5.0-4.7; elem. anal., XRD; | 83% |
3,4-pyridinecarboxylic acid
water
zinc(II) acetate dihydrate
N,N’-di(3-pyridyl)adipoamide
Conditions | Yield |
---|---|
at 120℃; for 48h; Autoclave; High pressure; | 82% |
Conditions | Yield |
---|---|
Stage #1: 3,4-pyridinecarboxylic acid With sodium hydrogencarbonate In water at 100℃; Stage #2: 1,2-bis(4'-pyridyl)ethane; cadmium(II) nitrate tetrhydrate; water In ethanol at 20℃; for 336h; Sealed tube; | 82% |
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 168h; | 82% |
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With NaOH In water High Pressure; lanthanide salt, org. compd., NaOH and H2O mixed in teflon reactor, heated at 180°C for 6 d; cooled to room temp. (5 K/h), washed with water, dried, elem. anal.; | 80% |
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With NaOH In water High Pressure; lanthanide salt, org. compd., NaOH and H2O mixed in teflon reactor, heated at 180°C for 6 d; cooled to room temp. (5 K/h), washed with water, dried, elem. anal.; | 78% |
methanol
1,2-bis(4'-pyridyl)ethane
3,4-pyridinecarboxylic acid
water
Conditions | Yield |
---|---|
Stage #1: 3,4-pyridinecarboxylic acid With sodium hydrogencarbonate In water at 100℃; Stage #2: methanol; 1,2-bis(4'-pyridyl)ethane; cadmium(II) nitrate tetrhydrate; water at 20℃; for 336h; Sealed tube; | 76% |
3,4-pyridinecarboxylic acid
di-tert-butyl dicarbonate
Conditions | Yield |
---|---|
With sodium hydroxide In hydrogenchloride; water | 75% |
3,4-pyridinecarboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; | 75% |
Conditions | Yield |
---|---|
With NaOH In water High Pressure; lanthanide salt, org. compd., NaOH and H2O mixed in teflon reactor, heated at 180°C for 6 d; cooled to room temp. (5 K/h), washed with water, dried, elem. anal.; | 73% |
3,4-pyridinecarboxylic acid
2,2-dimethoxy-propane
dimethyl 3,4-pyridinedicarboxylate
Conditions | Yield |
---|---|
With thionyl chloride In methanol for 24h; Heating; | 72% |
Stage #1: 3,4-pyridinecarboxylic acid With thionyl chloride In methanol at 20℃; for 0.25h; Stage #2: 2,2-dimethoxy-propane In methanol Reflux; | 46% |
3,4-pyridinecarboxylic acid
di-tert-butyltin dichloride
sodium hydroxide
Conditions | Yield |
---|---|
In methanol byproducts: NaCl, H2O; NaOH (4 mmol) was added to MeOH soln. of a ligand (2 mmol); the resulting soln. was refluxed for 2 h; the methanolic soln. of Sn-contg. compd. (2 mmol) was added; the resulting soln. was refluxed for another 2 h; slow evapn. of the solvent at room temp.; the solid was sepd. by filtration and washed with dry methanol; elem. anal.; | 72% |
[2,2]bipyridinyl
3,4-pyridinecarboxylic acid
[Zn(pyridine-3,4-dicarboxylate)(2,2'-bipyridine)](n)
Conditions | Yield |
---|---|
In water High Pressure; under autogenous pressure at 140°C for 5 d; cooled to room temp. at a rate of 10°C/h; elem. anal.; | 72% |
The IUPAC name of Pyridine-3,4-dicarboxylic acid is pyridine-3,4-dicarboxylic acid. With the CAS registry number 490-11-9, it is also named as Chinchomeronic acid. The product's categories are Pyridine; Pyridine Derivative; Pyridine Series; Carboxylic Acids; Carboxylic Acids. Besides, it is white to slightly beige fine crystalline powder, which should be stored away from oxides. In addition, its molecular formula is C7H5NO4 and molecular weight is 167.12.
The other characteristics of this product can be summarized as: (1)EINECS: 207-705-4; (2)ACD/LogP: -0.80; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -4.35; (5)ACD/LogD (pH 7.4): -4.94; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 5; (11)#H bond donors: 2; (12)#Freely Rotating Bonds: 2; (13)Index of Refraction: 1.627; (14)Molar Refractivity: 38.2 cm3; (15)Molar Volume: 107.7 cm3; (16)Surface Tension: 83.5 dyne/cm; (17)Density: 1.551 g/cm3; (18)Flash Point: 273.6 °C; (19)Melting Point: 262 °C; (20)Enthalpy of Vaporization: 84.6 kJ/mol; (21)Boiling Point: 528.8 °C at 760 mmHg; (22)Vapour Pressure: 5.21E-12 mmHg at 25 °C.
Preparation of Pyridine-3,4-dicarboxylic acid: this chemical can be prepared by Pyrrol-3-one.
This reaction needs Polymer-bound monoester of acetylenedicarboxylic acid and Dimethylsulfoxide by heating for 3 days. The yield is 54.3 %.
Uses of Pyridine-3,4-dicarboxylic acid: this chemical is used in organic synthesis. Moreover, it can be used to produce Pyridine-3,4-dicarboxylic acid anhydride.
This reaction needs Ac2O by heating for 45 min. The yield is 96 %.
When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing to avoid contact with skin and eyes.
People can use the following data to convert to the molecule structure.
(1)SMILES: c1cncc(c1C(=O)O)C(=O)O
(2)InChI: InChI=1/C7H5NO4/c9-6(10)4-1-2-8-3-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)
(3)InChIKey: MUYSADWCWFFZKR-UHFFFAOYAA
(4)Std. InChI: InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-3-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)
(5)Std. InChIKey: MUYSADWCWFFZKR-UHFFFAOYSA-N
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View