3-Bromo-5-chlorophenol supplier

Name
3-Bromo-5-chlorophenol
EINECS
CAS No. 56962-04-0
Article Data13
CAS DataBase
Density 1.788g/cm3
Solubility
Melting Point 66-70℃
Formula C6H4BrClO
Boiling Point 258.397oC at 760 mmHg
Molecular Weight 207.454
Flash Point 110.075oC
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Phenol, 3-bromo-5-chloro-;3-bromo-5-chloro-phenol;3-Brom-5-chlor-phenol;2-AMINO-5-(2-PYRIDYL)-1,3,4-OXADIAZOLE;
PSA 20.23000
LogP 2.80810

Synthetic route

: 174913-12-3
1-bromo-3-chloro-5-methoxybenzene

: 56962-04-0
3-bromo-5-chlorophenol

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chloro-5-methoxybenzene With lithium iodide In 2,4,6-trimethyl-pyridine at 170℃; for 4h; Stage #2: With hydrogenchloride In 2,4,6-trimethyl-pyridine; water at 20℃;	94%
With hydrogen bromide; acetic acid In water at 120℃; for 40h;
Stage #1: 1-bromo-3-chloro-5-methoxybenzene With boron tribromide In dichloromethane at 20℃; Stage #2: With water In dichloromethane at 20℃;
Stage #1: 1-bromo-3-chloro-5-methoxybenzene With boron tribromide In dichloromethane at 20℃; Stage #2: With water In dichloromethane at 20℃;

: 108-37-2
1-bromo-3-chlorobenzene

: 56962-04-0
3-bromo-5-chlorophenol

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chlorobenzene With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 20℃; for 18h; Inert atmosphere; Stage #2: With Oxone In water; acetone for 0.166667h;	81%
Stage #1: 1-bromo-3-chlorobenzene With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 20℃; for 18h; Inert atmosphere; Stage #2: With Oxone In water; acetone for 0.166667h;	81%
Stage #1: 1-bromo-3-chlorobenzene With 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; (η5-indenyl)(η4-1,5-cyclooctadiene)iridium(I); 1,2-bis(dimethylphosphanyl)ethane at 150℃; for 3.5h; Inert atmosphere; Stage #2: With Oxone; water In acetone Cooling with ice;	62%
Multi-step reaction with 2 steps 1: 1,2-bis(dimethylphosphino)ethane; (indenyl)Ir(1,5-cyclooctadiene) / 3.5 h / 150 °C 2: aq. oxone / acetone / 0.12 h / 25 °C View Scheme
Multi-step reaction with 2 steps 1: 1,2-bis(dimethylphosphanyl)ethane / 150 °C 2: oxone; water / acetone / 0.12 h / 25 °C View Scheme

: 210992-77-1
3-chloro-5-(4-methoxybenzyloxy)bromobenzene

: 56962-04-0
3-bromo-5-chlorophenol

Conditions

Conditions	Yield
With methanesulfonic acid; 1,3-Dimethoxybenzene In toluene at 10℃;	81%

: 87504-69-6
3-chloro-2,4,5,6-tetrabromophenol

A: 108-86-1
bromobenzene

B: 56962-04-0
3-bromo-5-chlorophenol

Conditions

Conditions	Yield
With aluminium trichloride; benzene

: 883195-40-2
3-amino-5-chlorophenol

: 56962-04-0
3-bromo-5-chlorophenol

: 7446-70-0
aluminium trichloride

: 87504-69-6
3-chloro-2,4,5,6-tetrabromophenol

: 71-43-2
benzene

A: 108-86-1
bromobenzene

B: 56962-04-0
3-bromo-5-chlorophenol

...Expand

: 2-(3-bromo-5-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 56962-04-0
3-bromo-5-chlorophenol

Conditions

Conditions	Yield
With Oxone In acetone at 25℃; for 0.116667h;
With Oxone In water; acetone at 0 - 25℃; for 0.15 - 0.25h;
With Oxone; sodium hydroxide; sodium hydrogencarbonate In water; acetone at 0℃; for 0.25h;
With Oxone; sodium hydroxide In water; acetone at 0℃; for 0.283333 - 0.333333h;
With oxone; water In acetone at 25℃; for 0.116667h;

: 108-43-0
3-monochlorophenol

: 56962-04-0
3-bromo-5-chlorophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iron powder; bromine 2: aluminium chloride; benzene View Scheme

: 33863-76-2
1-bromo-3-chloro-5-fluorobenzene

: 56962-04-0
3-bromo-5-chlorophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tetrahydrofuran / 40 °C 1.2: 60 °C 2.1: methanesulfonic acid; 1,3-Dimethoxybenzene / toluene / 10 °C View Scheme
Multi-step reaction with 2 steps 1.1: N,N-dimethyl-formamide / 20 °C 2.1: boron tribromide / dichloromethane / 20 °C 2.2: 20 °C View Scheme

: 1155847-43-0
4-chloro-3-fluoropicolinonitrile

: 56962-04-0
3-bromo-5-chlorophenol

: 1155847-61-2
3-(3-bromo-5-chlorophenoxy)-4-chloropyridine-2-carbonitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 0.333333h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 0.166667h;

: C31H28Br4O3

: 56962-04-0
3-bromo-5-chlorophenol

: C55H40Br4Cl4O7

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 6h; Inert atmosphere; Schlenk technique;	95%

: 56962-04-0
3-bromo-5-chlorophenol

: 1,3-bis(bromomethyl)-5-benzyloxybenzene

: C27H20Br2Cl2O3

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 6h; Inert atmosphere; Schlenk technique;	93%

: 56962-04-0
3-bromo-5-chlorophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1392196-71-2
(3-bromo-5-chloro-phenoxy)-tert-butyl-dimethyl-silane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 25℃; for 15h;	92%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃;	33 g

: 75-30-9
2-iodo-propane

: 56962-04-0
3-bromo-5-chlorophenol

: 1-bromo-3-chloro-5-isopropoxybenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h;	91%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h;	91%

: 56962-04-0
3-bromo-5-chlorophenol

: 100-39-0
benzyl bromide

: 1187966-48-8
1-benzyloxy-3-bromo-5-chloro-benzene

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 2h; Reflux;	90%

: 930836-30-9
(chlorodifluoromethylsulfonyl)benzene

: 56962-04-0
3-bromo-5-chlorophenol

: 1004112-67-7
1-bromo-3-chloro-5-(difluoromethoxy)benzene

Conditions

Conditions	Yield
With potassium hydroxide In acetonitrile at 50℃; for 5h;	89%

: 56962-04-0
3-bromo-5-chlorophenol

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 1-(tert-butyl) 2-methyl (2S,4S)-4-(3-bromo-5-chlorophenoxy)pyrrolidine-1,2-dicarboxylate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	87%

: 3209-22-1
1,2-Dichloro-3-nitrobenzene

: 56962-04-0
3-bromo-5-chlorophenol

: 1034474-41-3
2-(3-bromo-5-chlorophenoxy)-1-chloro-3-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 2h; Inert atmosphere;	85.4%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 2h;

: 56962-04-0
3-bromo-5-chlorophenol

: 3282-30-2
pivaloyl chloride

: 3-bromo-5-chlorophenyl pivalate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃;	85%

: 109-99-9
tetrahydrofuran

: 56962-04-0
3-bromo-5-chlorophenol

: 3-chloro-5-(tetrahydrofuran-2-yl)phenol

Conditions

Conditions	Yield
With bis(acetylacetonate)nickel(II); 5,5'-dimethyl-2,2'-bipyridine; (4-methoxyphenyl)(4-(trifluoromethyl)phenyl)methanone; sodium carbonate at 20℃; for 72h; Schlenk technique; Inert atmosphere; Irradiation; chemoselective reaction;	84%

: 2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

: 56962-04-0
3-bromo-5-chlorophenol

: benzyl (2-(2-(2-(3-bromo-5-chlorophenoxy)ethoxy)ethoxy)ethyl)carbamate

Conditions

Conditions	Yield
Stage #1: 3-bromo-5-chlorophenol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	84%

: 1493-13-6
trifluorormethanesulfonic acid

: 56962-04-0
3-bromo-5-chlorophenol

: 3-bromo-5-chlorophenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	82%

: 591-50-4
iodobenzene

: 56962-04-0
3-bromo-5-chlorophenol

: 1620783-10-9
1-bromo-3-chloro-5-phenyloxybenzene

Conditions

Conditions	Yield
With 18-crown-6 ether; copper; potassium carbonate In N,N-dimethyl-formamide at 120℃;	81%

: 56962-04-0
3-bromo-5-chlorophenol

: 6258-60-2
p-methoxybenzylmercaptan

: C14H13ClO2S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; nickel dichloride at 110℃; for 2h;	80%

: 1345336-82-4
4,5-dichloro-N-(methoxybenzyl)-2-nitroaniline

: 56962-04-0
3-bromo-5-chlorophenol

: 1345336-85-7
5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one Heating; Inert atmosphere;	74%

: 56962-04-0
3-bromo-5-chlorophenol

: 6482-24-2
2-Bromoethyl methyl ether

: 1-bromo-3-chloro-5-(2-methoxyethoxyl)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 18h;	70%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 100℃; for 18h;	70%
With caesium carbonate In acetonitrile at 80℃; for 12h;	17 g
With caesium carbonate In acetonitrile at 80℃; for 12h;	17 g
With caesium carbonate In acetonitrile at 80℃; for 12h;	17 g

: 372-48-5
2-fluoropyridine

: 56962-04-0
3-bromo-5-chlorophenol

: 2-(3-bromo-5-chlorophenoxy)pyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 140℃; for 6h; Ullmann Condensation; Microwave irradiation;	65%

: 56962-04-0
3-bromo-5-chlorophenol

: 82560-12-1
3-tert-butyl-1H-pyrazole-5-amine

: 3-(5-amino-3-tert-butyl-pyrazol-1-yl)-5-chloro-phenol

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine In toluene at 110℃; for 24h; Microwave irradiation; Inert atmosphere;	62%
With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate In toluene at 110℃; for 24h; Inert atmosphere; Microwave irradiation;	62%

: 33863-76-2
1-bromo-3-chloro-5-fluorobenzene

: 56962-04-0
3-bromo-5-chlorophenol

: C12H6Br2Cl2O

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 180℃; for 16h;	60%

: 56962-04-0
3-bromo-5-chlorophenol

: 1-cyclohexyl-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt

: 3-chloro-5-cyclohexylphenol

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; manganese; 4,4'-Dimethoxy-2,2'-bipyridin In 1-methyl-pyrrolidin-2-one at 20℃; for 20h; Inert atmosphere; chemoselective reaction;	51%

: (6-(4-(dimethylamino)piperidin-1-yl)pyridin-3-yl)boronic acid

: 56962-04-0
3-bromo-5-chlorophenol

: 3-chloro-5-{6-[4-(dimethylamino)piperidin-1-yl]pyridin-3-yl}phenol

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 90℃; Inert atmosphere; Schlenk technique;	50%

: 109-01-3
1-methyl-piperazine

: 56962-04-0
3-bromo-5-chlorophenol

: 3-chloro-5-(4-methylpiperazin-1-yl)phenol

Conditions

Conditions	Yield
With palladium diacetate; lithium hexamethyldisilazane; 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane In toluene at 80℃; Inert atmosphere;	45%

: (1-(4-(3,4-dichlorophenyl)-5-(isopropylthio)thiazol-2-yl)-5-(methoxycarbonyl)-3-methyl-1H-pyrazol-4-yl)boronic acid

: 56962-04-0
3-bromo-5-chlorophenol

: C24H20Cl3N3O3S2

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 85℃; for 16h; Inert atmosphere;	41%

: 50-00-0
formaldehyd

: 56962-04-0
3-bromo-5-chlorophenol

: 3-bromo-5-chloro-4-(hydroxymethyl)phenol

Conditions

Conditions	Yield
With water; sodium hydroxide at 45℃;	31%

: 56962-04-0
3-bromo-5-chlorophenol

: 73183-34-3
bis(pinacol)diborane

: 960388-56-1
3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Conditions

Conditions	Yield
With water; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,2-dimethoxyethane at 150℃; for 0.25h;	28%
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane; water at 150℃; for 0.25h; Irradiation in a microwave;	28%
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane; water at 150℃; for 0.25h; Microwave irradiation;	28%
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane at 150℃; for 0.25h; Microwave irradiation;	28%

: 56962-04-0
3-bromo-5-chlorophenol

: 98-80-6
phenylboronic acid

: 1620783-10-9
1-bromo-3-chloro-5-phenyloxybenzene

Conditions

Conditions	Yield
With copper diacetate; triethylamine In dichloromethane at 20℃; for 3h; Molecular sieve;	20%

3-Bromo-5-chlorophenol Chemical Properties

Molecular Structure of 3-Bromo-5-chlorophenol (CAS NO.56962-04-0):

Systematic Name: 3-Bromo-5-chlorophenol
Molecular Formula: C₆H₄BrClO
Molecular Weight: 207.45
CAS Registry Number: 56962-04-0
H bond acceptors: 1
H bond donors: 1
Freely Rotating Bonds: 1
Index of Refraction: 1.619
Molar Refractivity: 40.72 cm³
Molar Volume: 115.999 cm³
Surface Tension: 50.126 dyne/cm
Density: 1.788 g/cm³
Flash Point: 110.075 °C
Enthalpy of Vaporization: 51.602 kJ/mol
Boiling Point: 258.397 °C at 760 mmHg
Vapour Pressure: 0.009 mmHg at 25 °C
SMILES: Oc1cc(Br)cc(Cl)c1
InChI: InChI=1/C6H4BrClO/c7-4-1-5(8)3-6(9)2-4/h1-3,9H
InChIKey: GMGWXLPFRHYWAS-UHFFFAOYAJ
Product Categories: Bromine Compounds; Chlorine Compounds; Phenols

3-Bromo-5-chlorophenol Specification

3-Bromo-5-chlorophenol (CAS NO.56962-04-0), its Synonym is Phenol, 3-bromo-5-chloro- .

Product Name

3-Bromo-5-chlorophenol

Synthetic route

3-Bromo-5-chlorophenol Chemical Properties

3-Bromo-5-chlorophenol Specification

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