3-Fluorobenzyl chloride supplier

Name
3-Fluorobenzyl chloride
EINECS 207-264-8
CAS No. 456-42-8
Article Data27
CAS DataBase
Density 1.191 g/cm³
Solubility 40 g/L (20 °C) in water
Melting Point 34.5-36 °C
Formula C₇H₆ClF
Boiling Point 173.3 °C at 760 mmHg
Molecular Weight 144.576
Flash Point 58.9 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 26-36/37/39-45
Risk Codes 34-37
Molecular Structure
Hazard Symbols C
Synonyms a-Chloro-m-fluorotoluene;Toluene,a-chloro-m-fluoro- (6CI,7CI,8CI);1-(Chloromethyl)-3-fluorobenzene;3-Fluorophenylmethylchloride;NSC 60720;m-Fluorobenzyl chloride;a-Chloro-3-fluorotoluene;
PSA 0.00000
LogP 2.56450

Synthetic route

: 352-70-5
m-Fluorotoluene

: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
With methanol; tetrachloromethane; iron(II) chloride tetrahydrate; formamide at 180℃; for 6h; Reagent/catalyst; Inert atmosphere; Sealed tube; Autoclave; chemoselective reaction;	35%
at 147℃; Irradiation.Einleiten von Chlor;
at 147℃; Einleiten von Chlor;

: 352-70-5
m-Fluorotoluene

A: 402-64-2
1-dichloromethyl-3-fluoro-benzene

B: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
Chlorierung;

: 456-47-3
3-fluoro-benzenemethanol

: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
With pyridine; thionyl chloride

: 28490-56-4
1-fluoro-3-(iodomethyl)benzene

: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G;	28 % Spectr.

: 65108-06-7
m-fluorobenzyl ion

: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
With tertiary butyl chloride In gaseous matrix at 600℃; chloride affinity;

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G;	65 % Spectr.

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
With pyridine; tributyltin chloride at 50℃; Thermodynamic data; Equilibrium constant; Δ G;	65 % Spectr.

: 394-54-7
1-(1-chloro-2,2,2-trifluoroethyl)-4-chlorobenzene

: 65108-06-7
m-fluorobenzyl ion

A: 128408-33-3
C8H5ClF3(1+)

B: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

...Expand

: 191402-55-8
1-(1-Chloro-2,2,2-trifluoro-ethyl)-3-methyl-benzene

: 65108-06-7
m-fluorobenzyl ion

A: 128408-28-6
C9H8F3(1+)

B: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

...Expand

: 81577-13-1
1-(1-Chloro-2,2,2-trifluoro-ethyl)-4-fluoro-benzene

: 65108-06-7
m-fluorobenzyl ion

A: 128408-32-2
C8H5F4(1+)

B: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

...Expand

: 2-Chloro-4-(1-chloro-2,2,2-trifluoro-ethyl)-1-methyl-benzene

: 65108-06-7
m-fluorobenzyl ion

A: 128408-27-5
C9H7ClF3(1+)

B: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
at 69.85℃; Thermodynamic data; chloride-transfer;

...Expand

3-fluoro-toluene-vapour: 3-fluoro-toluene-vapour

: 456-42-8
m-fluorobenzyl chloride

Conditions

Conditions	Yield
With chlorine

: 1178094-73-9
(Z)-6-methoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one

: 456-42-8
m-fluorobenzyl chloride

: 1250364-30-7
(Z)-1-(3-fluorobenzyl)-4-((6-methoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride

Conditions

Conditions	Yield
In acetonitrile Reflux;	100%

: 1250364-18-1
(Z)-6-ethoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one

: 456-42-8
m-fluorobenzyl chloride

: 1250364-43-2
(Z)-1-(3-fluorobenzyl)-4-((6-ethoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride

Conditions

Conditions	Yield
In acetonitrile Reflux;	100%

: 1250364-19-2
(Z)-6-propoxy-2-(pyridin-4-ylmethylene)benzofuran-3(2H)-one

: 456-42-8
m-fluorobenzyl chloride

: 1250364-55-6
(Z)-1-(3-fluorobenzyl)-4-((6-propoxy-3-oxobenzofuran-2(3H)-ylidene)methyl)pyridinium chloride

Conditions

Conditions	Yield
In acetonitrile Reflux;	100%

: 68-11-1
mercaptoacetic acid

: 456-42-8
m-fluorobenzyl chloride

: 2-(3-fluorobenzylthio)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 20℃; for 1h;	98.1%

: 124-38-9
carbon dioxide

: 456-42-8
m-fluorobenzyl chloride

: 331-25-9
(3-fluorophenyl)acetic acid

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; manganese; palladium diacetate; magnesium chloride In N,N-dimethyl-formamide under 760.051 Torr; for 12h; Inert atmosphere; Schlenk technique;	96%

: 456-42-8
m-fluorobenzyl chloride

: 214326-07-5
C19H22Cl3NO3

: 214325-98-1
C26H27Cl3FNO3

Conditions

Conditions	Yield
With potassium carbonate In ethanol Heating;	95%

: 123-08-0
4-hydroxy-benzaldehyde

: 456-42-8
m-fluorobenzyl chloride

: 66742-57-2
4-(3-fluoro-benzyloxy)-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In ethanol for 5.41667h; Product distribution / selectivity; Heating / reflux;	95%
With sodium hydroxide In ethanol for 6.75h; Product distribution / selectivity; Heating / reflux;	95%
With potassium carbonate; sodium iodide In ethanol for 5.41667h; Product distribution / selectivity; Heating / reflux;	95%

: 456-42-8
m-fluorobenzyl chloride

: 128564-78-3
(E)-3-(pyridin-4-ylmethylene)indolin-2-one

: 1621102-53-1
(E)-1-(3-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride

Conditions

Conditions	Yield
In acetonitrile at 60 - 70℃;	95%

: 137-07-5
2-amino-benzenethiol

: 456-42-8
m-fluorobenzyl chloride

: 1629-07-8
2-(3-fluorophenyl)benzo[d]thiazole

Conditions

Conditions	Yield
With pyridine; sulfur at 130℃; for 20h; Inert atmosphere;	95%

: 88-73-3
2-Chloronitrobenzene

: 456-42-8
m-fluorobenzyl chloride

: 1629-07-8
2-(3-fluorophenyl)benzo[d]thiazole

Conditions

Conditions	Yield
With N-methylcyclohexylamine; sulfur at 110℃; for 24h; Sealed tube; Inert atmosphere;	95%

: 436-77-1, 10172-02-8, 33889-68-8, 38769-07-2, 53834-87-0, 119478-08-9
demethyltetrandrine

: 456-42-8
m-fluorobenzyl chloride

: C44H45FN2O6*2HCl

Conditions

Conditions	Yield
Stage #1: demethyltetrandrine; m-fluorobenzyl chloride With tetrabutylammomium bromide In water at 120℃; for 1h; Sonication; Stage #2: With hydrogenchloride In water Reagent/catalyst; Solvent; Temperature; Molecular sieve;	94.77%

: 76352-25-5
2-amino-4-methoxy-N-(8-azabicyclo<3,2,1>oct-3 β-yl)-5-pyrimidine carboxamide

: 456-42-8
m-fluorobenzyl chloride

: 84922-97-4
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(3-fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide

Conditions

Conditions	Yield
With potassium carbonate In acetone for 36h; Heating;	94%

: 456-42-8
m-fluorobenzyl chloride

: 251940-05-3
1-(4-fluoro-phenyl)-2-(tetrahydro-pyrimidin-2-ylidene)-ethanone

: 3-(3'-fluorophenyl)-1-(4'-fluoro-phenyl)-2-(tetrahydropyrimidin-2'-ylidene)-propan-1-one

Conditions

Conditions	Yield
In toluene at 65℃; for 2h;	94%

: 16101-63-6
6,7-dimethoxyisoquinoline-1(2H)-one

: 456-42-8
m-fluorobenzyl chloride

: 2-(3-fluorobenzyl)-6,7-dimethoxyisoquinolin-1(2H)-one

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;	93.1%

: 82100-30-9
1-phenyl-2-(tetrahydropyrimidin-2(1H)-ylidene)ethan-1-one

: 456-42-8
m-fluorobenzyl chloride

: 3-(3'-fluoro-phenyl)-1-phenyl-2-(tetrahydropyrimidin-2'-ylidene)-propan-1-one

Conditions

Conditions	Yield
In toluene at 60℃; for 2h;	93%

: 1146443-78-8
N,2,5-trimethoxy-N-methylbenzamide

: 456-42-8
m-fluorobenzyl chloride

: 1097077-65-0
1-(2,5-dimethoxyphenyl)-2-(3-fluorophenyl)ethanone

Conditions

Conditions	Yield
Stage #1: m-fluorobenzyl chloride With magnesium In diethyl ether at 0 - 20℃; for 4h; Stage #2: N,2,5-trimethoxy-N-methylbenzamide In tetrahydrofuran; diethyl ether at 0℃; for 1h;	93%
Stage #1: m-fluorobenzyl chloride With iodine; magnesium In tetrahydrofuran at 0℃; Stage #2: N,2,5-trimethoxy-N-methylbenzamide In tetrahydrofuran at 0℃; for 1h;

: 2‐amino‐4‐(pyridin‐4‐yl)‐5‐oxo‐4H,5H‐pyrano[3,2‐c]chromene‐3‐carbonitrile

: 456-42-8
m-fluorobenzyl chloride

: 4-(2-amino-3-cyano-5-oxo-4,5-dihydropyrano[3,2-c]chromen-4-yl)-1-(3-fluorobenzyl)pyridinium chloride

Conditions

Conditions	Yield
With potassium iodide In acetonitrile Reflux;	93%

: 22841-91-4
8-chloro-[1,2,4]triazolo[4,3-a]pyridine-3(2H)-thione

: 456-42-8
m-fluorobenzyl chloride

: 8-chloro-3-((3-fluorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 90℃; for 0.25h; Microwave irradiation;	93%
With sodium hydroxide In N,N-dimethyl-formamide at 90℃; for 0.25h; Microwave irradiation;	81%

: 615-43-0
2-iodophenylamine

: 456-42-8
m-fluorobenzyl chloride

: 1629-07-8
2-(3-fluorophenyl)benzo[d]thiazole

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; sodium carbonate; sulfur In dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; Inert atmosphere;	93%

: 27386-01-2
2-methylamino-5-mercapto-1,3,4-thiadiazole

: 456-42-8
m-fluorobenzyl chloride

: 97773-03-0
2-(3-fluorobenzylthio)-5-methylamino-1,3,4-thiadiazole

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 0.5h; Ambient temperature;	92%

: 95-92-1
oxalic acid diethyl ester

: 456-42-8
m-fluorobenzyl chloride

: 3-(3-fluorophenyl)-2-oxopropionic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: m-fluorobenzyl chloride With magnesium In diethyl ether for 0.166667h; Heating; Stage #2: oxalic acid diethyl ester In diethyl ether at 20℃; for 2h; Grignard reaction;	92%

: 918156-44-2
CH3C6H3OCHCNC(CONH)

: 456-42-8
m-fluorobenzyl chloride

: CH3C6H3OCHCNC(CON)CH2C6H4F

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 12h;	92%

: 13115-24-7
N-methylacetohydroxamic acid

: 456-42-8
m-fluorobenzyl chloride

: 1352918-96-7
N-((3-fluorobenzyl)oxy)-N-methylacetamide

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 12h; Inert atmosphere;	92%

: 300-57-2
allylbenzene

: 456-42-8
m-fluorobenzyl chloride

: 1419174-93-8
1-(2-benzylallyl)-3-fluorobenzene

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; trans-bis(dicyclohexylphenylphosphine)(2-methylphenyl)nickel(II) chloride; triethylamine In dichloromethane at 20℃; for 4h; Heck Reaction; regioselective reaction;	92%

: 95-25-0
5-chloro-2-benzoxazolinone

: 456-42-8
m-fluorobenzyl chloride

: 5-chloro-3-(3-fluorobenzyl)benzo[d]oxazol-2(3H)-one

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-benzoxazolinone With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 1h; Stage #2: m-fluorobenzyl chloride In N,N-dimethyl-formamide at 60℃; for 7h;	92%

: 62-53-3
aniline

: 456-42-8
m-fluorobenzyl chloride

: 83444-26-2
N-(3-fluorobenzyl)aniline

Conditions

Conditions	Yield
With sodium carbonate at 110℃; for 1h;	90%

: 367-12-4
2-fluorophenol

: 456-42-8
m-fluorobenzyl chloride

: C13H10F2O

Conditions

Conditions	Yield
With sodium In ethanol for 2h; Heating;	90%

: 1214839-99-2
(3R,6S)-hexahydrofuro[3,2-b]furan-3,6-diol

: 456-42-8
m-fluorobenzyl chloride

: (3R,6S)-3,6-Bis-(3-fluoro-benzyloxy)-hexahydro-furo[3,2-b]furan

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide In xylene at 125℃; for 0.0833333h; Alkylation; microwave irradiation;	90%

: 107165-83-3
1-(4-chlorophenyl)-2-(tetrahydropyrimidin-2(1H)-ylidene)ethan-1-one

: 456-42-8
m-fluorobenzyl chloride

: 1-(4'-chloro-phenyl)-3-(3'-fluoro-phenyl)-2-(tetrahydropyrimidin-2'-ylidene)-propan-1-one

Conditions

Conditions	Yield
In toluene at 65℃; for 3h;	90%

: 456-42-8
m-fluorobenzyl chloride

: 5401-94-5
5-nitroindazole

A: 529508-58-5
1-(3-fluorobenzyl)-5-nitro-1H-carbazole

B: 202197-31-7
1-(3-fluorobenzyl)-1H-indazol-5-ylamine

Conditions

Conditions	Yield
With Ki; potassium carbonate In water; N,N-dimethyl-formamide	A 33% B 90%

...Expand

3-Fluorobenzyl chloride Chemical Properties

Molecular Formula m-Fluorobenzyl chloride(456-42-8) : C₇H₆ClF
Formula Weight m-Fluorobenzyl chloride(456-42-8) : 144.57
Molecular Structure:

Boiling point: 176-177 °C
density : 1.194 g/mL at 25 °C(lit.)
refractive index : n20/D 1.511(lit.)
Flash point : 138 °F
WATER Solubility of m-Fluorobenzyl chloride: 40 g/L (20 °C)

3-Fluorobenzyl chloride Uses

M-Fluorobenzyl chloride(456-42-8) is For R&D use only.

3-Fluorobenzyl chloride Toxicity Data With Reference

ACUTE EFFECTS:
Corrosive
May be harmful by ingestion and inhalation.
Material is irritating to mucous membranes and upper respiratory tract.
To the best of our knowledge, the toxicological properties of m-Fluorobenzyl chloride have not been fully determined.

3-Fluorobenzyl chloride Safety Profile

The Hazard Codes of m-Fluorobenzyl chloride (456-42-8) :

C
The Risk Statements information of m-Fluorobenzyl chloride (456-42-8) :
34: Causes burns
37: Irritating to the respiratory system
The Safety Statements information of m-Fluorobenzyl chloride(456-42-8) :
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR : UN 2920 8/PG 2
WGK Germany : 3
Hazard Note : Corrosive/Lachrymatory
Hazard Class : 3
Packing Group : III

Product Name

3-Fluorobenzyl chloride

Synthetic route

3-Fluorobenzyl chloride Chemical Properties

3-Fluorobenzyl chloride Uses

3-Fluorobenzyl chloride Toxicity Data With Reference

3-Fluorobenzyl chloride Safety Profile

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