3-Hydroxypiperidine hydrochloride supplier

Name
3-Hydroxypiperidine hydrochloride
EINECS 264-644-6
CAS No. 64051-79-2
Density 1.016g/cm3
Solubility
Melting Point 192-195 °C
Formula C₅H₁₂ClNO
Boiling Point 191.9 °C at 760 mmHg
Molecular Weight 137.609
Flash Point 104.5 °C
Transport Information
Appearance beige solid.
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 3-Piperidinol,hydrochloride (9CI);piperidin-3-ol hydrochloride;piperidin-3-ol hydrochloride;Piperidin-3-ol hydrochloride (1:1);
PSA 32.26000
LogP 0.86150

Synthetic route

: 64051-79-2
piperidin-3-ol hydrochloride

: 4525-33-1
dimethyl dicarbonate

: 80613-04-3
3-hydroxypiperidine-1-carboxylic acid methyl ester

Conditions

Conditions	Yield
With TEA In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃;

: 369-34-6
3,4-difluoronitrobenzene

: 64051-79-2
piperidin-3-ol hydrochloride

: 916988-48-2
1-(2-fluoro-4-nitrophenyl)-piperidin-3-ol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; for 3h;	100%

: 64051-79-2
piperidin-3-ol hydrochloride

: 501-53-1
benzyl chloroformate

: 95798-22-4
3-hydroxy-piperidine-1-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran; water at 20℃; for 5h;	96%
With triethylamine In dichloromethane at 0℃; for 19h;	95%

: 24424-99-5
di-tert-butyl dicarbonate

: 64051-79-2
piperidin-3-ol hydrochloride

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h;	94%
With sodium hydrogencarbonate In tetrahydrofuran for 14h;	90%
With triethylamine In dichloromethane	88%

: 64051-79-2
piperidin-3-ol hydrochloride

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 267666-12-6
1-(2-nitro-benzenesulfonyl)-piperidin-3-one

Conditions

Conditions	Yield
With potassium carbonate In chloroform; water at 20℃; for 10h; Substitution;	88%

: 64051-79-2
piperidin-3-ol hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 73193-62-1
N-trifluoroacetyl-3-hydroxypiperidine

Conditions

Conditions	Yield
With pyridine In diethyl ether; dichloromethane for 2.5h;	87%

: 64051-79-2
piperidin-3-ol hydrochloride

: 1939-99-7
benzenesulfonyl chloride

: 1-benzenesulfonylmethyl-piperidin-3-one

Conditions

Conditions	Yield
With potassium carbonate In chloroform; water at 20℃; Substitution;	83%

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 96042-30-7
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

: 64051-79-2
piperidin-3-ol hydrochloride

: 405087-57-2
1-[1-(4-Chloro-phenyl)-cyclobutylmethyl]-3-(4-trifluoromethyl-benzyloxy)-piperidine

Conditions

Conditions	Yield
With IPr2NEt In ethyl acetate; Petroleum ether	82%
With IPr2NEt In ethyl acetate; Petroleum ether	82%

...Expand

: 50-00-0
formaldehyd

: 64051-79-2
piperidin-3-ol hydrochloride

: 98-86-2
acetophenone

: (3-hydroxypiperidin-1-yl)-1-phenylpropan-1-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 3h; Addition; Mannich reaction; Heating; alkaline hydrolysis;	77%

...Expand

: 127263-91-6
3-bis(4-fluorophenyl)methoxypiperidine

: 64051-79-2
piperidin-3-ol hydrochloride

: 105-36-2
ethyl bromoacetate

: 200273-74-1
3-bis(4-fluorophenyl)methoxypiperidin-1-yl acetic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In ethyl acetate; acetonitrile	77%

...Expand

: 64051-79-2
piperidin-3-ol hydrochloride

: 98-09-9
benzenesulfonyl chloride

: 267666-10-4
N-benzenesulfonyl-3-piperidone

Conditions

Conditions	Yield
With potassium carbonate In chloroform; water at 20℃; Substitution;	74%

: 14371-10-9
(E)-3-phenylpropenal

: 64051-79-2
piperidin-3-ol hydrochloride

: 1082074-99-4
1-cinnamylpiperidin-3-ol

Conditions

Conditions	Yield
Stage #1: (E)-3-phenylpropenal; piperidin-3-ol hydrochloride In methanol at 20℃; for 1h; Stage #2: With triethylsilane; indium(III) chloride In methanol at 20℃; for 48h;	66%

: (Z)-2-(3,4-dichlorophenyl)-3-(4-(oxiran-2-ylmethoxy)phenyl)acrylonitrile

: 64051-79-2
piperidin-3-ol hydrochloride

: 121-44-8
triethylamine

: triethylammonium (Z)-1-(3-(4-(2-cyano-2-(3,4-dichlorophenyl)vinyl)phenoxy)-2-hydroxypropyl)piperidin-3-olate

Conditions

Conditions	Yield
In ethanol at 120℃; for 0.333333h; Microwave irradiation;	60%

...Expand

: 64051-79-2
piperidin-3-ol hydrochloride

: 4055-39-4
mitomycin A

: 84397-50-2
C20H26N4O6

Conditions

Conditions	Yield
With triethylamine In methanol	58%

: 2622-89-1
diphenylborinic acid

: 64051-79-2
piperidin-3-ol hydrochloride

: 207730-16-3
(N->B)-diphenyl(3-piperidyloxy)borane

Conditions

Conditions	Yield
With NaOH In methanol addn. of NaOH to piperidine derivative, filtration, addn. of B-compd. at-78°C; evapn. under cooling;	57%
With NaOH In benzene addn. of NaOH to piperidine derivative (in H2O), addn. of C6H6, refluxing for 30 min, addn. of slight excess of B-compd. (pptn.); filtration, washing (Et2O), drying;	39%

: 64051-79-2
piperidin-3-ol hydrochloride

: 100-44-7
benzyl chloride

: 14813-01-5
1-benzyl-3-hydroxypiperidine

Conditions

Conditions	Yield
With triethylamine In toluene	56.9%

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 64051-79-2
piperidin-3-ol hydrochloride

: 405087-38-9
1-[1-(4-Chlorophenyl)cyclobutylmethyl]piperidin-3-ol

Conditions

Conditions	Yield
With aqueous KOH; ammonia In ethanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; toluene	54%
With aqueous KOH; ammonia In toluene	54%

: 1635-61-6
5-chloro-2-nitroaniline

: 64051-79-2
piperidin-3-ol hydrochloride

: 5-(3'-hydroxypiperidin-1'-yl)-2-nitroaniline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	54%

: 64051-79-2
piperidin-3-ol hydrochloride

: 350-46-9
4-Fluoronitrobenzene

: 99841-68-6
1-(4-nitrophenyl)piperidin-3-ol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile for 18h; Heating / reflux;	51%
With N-ethyl-N,N-diisopropylamine In acetonitrile for 18h; Heating / reflux;	51%

: 1610520-29-0
7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde

: 64051-79-2
piperidin-3-ol hydrochloride

: 1610521-18-0
7-bromo-2-((3-hydroxypiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one

Conditions

Conditions	Yield
Stage #1: 7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carbaldehyde; piperidin-3-ol hydrochloride With acetic acid In methanol at 20℃; for 0.5h; Stage #2: With 2-picoline borane complex In methanol at 20 - 50℃;	45.9%

: 768-56-9
4-Phenyl-1-butene

: 64051-79-2
piperidin-3-ol hydrochloride

: 1-(2-chloro-4-phenylbutyl)piperidin-3-ol

Conditions

Conditions	Yield
Stage #1: piperidin-3-ol hydrochloride With N-chloro-succinimide; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Sealed tube; Inert atmosphere; Stage #2: 4-Phenylbut-1-ene With trifluoroacetic acid In dichloromethane at 0℃; for 1h; Sealed tube; Inert atmosphere; Irradiation;	45%

: 1355361-72-6
8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylic acid

: 64051-79-2
piperidin-3-ol hydrochloride

: C29H30N2O4S

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 8h; Inert atmosphere; Green chemistry;	32%

: 19260-33-4
4-acetoxybenzyl iodide

: 64051-79-2
piperidin-3-ol hydrochloride

: 121138-45-2
N-p-acetoxybenzyl-3-hydroxypiperidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 1.5h; Ambient temperature;	18%

: 541-41-3
chloroformic acid ethyl ester

: 64051-79-2
piperidin-3-ol hydrochloride

: 73193-61-0
N-carbethoxy-3-piperidinol

Conditions

Conditions	Yield
With triethylamine In dichloromethane

: 88712-56-5, 125185-92-4
1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-pyridine-5-carboxylic acid chloride

: 64051-79-2
piperidin-3-ol hydrochloride

: methyl 3-piperidinyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride

Conditions

Conditions	Yield
In dichloromethane; N,N-dimethyl-formamide for 1.3h; Yield given;

: 64051-79-2
piperidin-3-ol hydrochloride

: 5-Chlorocarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2-cyano-ethyl ester

: 121138-39-4
2-cyanoethyl 3-piperidinyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Conditions

Conditions	Yield
In dichloromethane; N,N-dimethyl-formamide for 4h; Yield given;

: 64051-79-2
piperidin-3-ol hydrochloride

: 57303-04-5
arachidonoyl chloride

: (5Z,8Z,11Z,14Z)-1-(3-Hydroxy-piperidin-1-yl)-icosa-5,8,11,14-tetraen-1-one

Conditions

Conditions	Yield
With pyridine for 0.25h; Ambient temperature; Yield given;

: 64051-79-2
piperidin-3-ol hydrochloride

: 98-59-9
p-toluenesulfonyl chloride

: 220384-68-9
1-(p-toluenesulfonyl)-piperidin-3-ol

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 3h; Ambient temperature;

: 20850-43-5
5-(chloromethyl)-1,3-benzodioxole

: 64051-79-2
piperidin-3-ol hydrochloride

: 1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-3-ol

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 50℃; for 4h;

: 76-83-5
trityl chloride

: 64051-79-2
piperidin-3-ol hydrochloride

: 647863-16-9
(RS)-3-hydroxy-1-N-tritylpiperidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;

3-Hydroxypiperidine hydrochloride Specification

The 3-Hydroxypiperidine hydrochloride, with the CAS registry number 64051-79-2 and EINECS registry number 264-644-6, has the systematic name and IUPAC name of piperidin-3-ol hydrochloride. It belongs to the following product categories: Fine chemical & intermediates; Heterocyclic Compounds; Piperidines. And the molecular formula of this chemical is C₅H₁₂ClNO.

The physical properties of 3-Hydroxypiperidine hydrochloride are as followings: (1)ACD/LogP: -0.64; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.73; (4)ACD/LogD (pH 7.4): -3.37; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 12.47 Å²; (13)Flash Point: 104.5 °C; (14)Enthalpy of Vaporization: 49.82 kJ/mol; (15)Boiling Point: 191.9 °C at 760 mmHg; (16)Vapour Pressure: 0.134 mmHg at 25°C.

Uses of 3-Hydroxypiperidine hydrochloride: It can react with phenylmethanesulfonyl chloride to produce 1-benzenesulfonylmethyl-piperidin-3-one. This reaction will need reagent K₂CO₃, and the solvent H₂O and CHCl₃. The reaction temperature is 20°C, and the yield is about 83%.

3-Hydroxypiperidine hydrochloride can react with phenylmethanesulfonyl chloride to produce 1-benzenesulfonylmethyl-piperidin-3-one

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.OC1CCCNC1
(2)InChI: InChI=1/C5H11NO.ClH/c7-5-2-1-3-6-4-5;/h5-7H,1-4H2;1H
(3)InChIKey: VLECDMDGMKPUSK-UHFFFAOYAY

Product Name

3-Hydroxypiperidine hydrochloride

Synthetic route

3-Hydroxypiperidine hydrochloride Specification

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