Product Name

  • Name

    3-PYRIDAZINECARBALDEHYDE,97%

  • EINECS
  • CAS No. 60170-83-4
  • Article Data5
  • CAS DataBase
  • Density 1.235 g/cm3
  • Solubility
  • Melting Point 47 °C
  • Formula C5H4N2O
  • Boiling Point 300.361 °C at 760 mmHg
  • Molecular Weight 108.1
  • Flash Point 139.901 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes  Xi:Irritant;
  • Molecular Structure Molecular Structure of 60170-83-4 (3-PYRIDAZINECARBALDEHYDE,97%)
  • Hazard Symbols R36/37/38:Irritating to eyes, respiratory system and skin.;
  • Synonyms 3-Pyridazincarbaldehyd;3-pyridazinecarboxaldehyde;pyridazin-3-carbaldehyde;3-FORMYLPYRIDAZINE;3-Pyridazinecarbaldehyde;pyridazine-3-carboxaldehyde;
  • PSA 42.85000
  • LogP 0.28910

Synthetic route

3-(2-phenylethenyl)pyridazine
1135-31-5

3-(2-phenylethenyl)pyridazine

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Conditions
ConditionsYield
With sodium periodate; osmium(VIII) oxide In water; acetone; tert-butyl alcohol at 20℃; for 48h;81%
3-hydroxymethylpyridazine
37444-46-5

3-hydroxymethylpyridazine

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Conditions
ConditionsYield
With selenium(IV) oxide In 1,4-dioxane for 2h; Heating;52%
With manganese(IV) oxide In 1,2-dichloro-ethane at 70℃; for 4h;
pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

4-methylthiosemicarbazide
6610-29-3

4-methylthiosemicarbazide

C7H9N5S
142564-65-6

C7H9N5S

Conditions
ConditionsYield
In methanol Heating;95%
pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

4-(2-pyridylmethyl)thiosemicarbazide
142564-64-5

4-(2-pyridylmethyl)thiosemicarbazide

C12H12N6S
142564-67-8

C12H12N6S

Conditions
ConditionsYield
In methanol Heating;94%
pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

pyridazine-3-carbaldehyde oxime
52348-44-4

pyridazine-3-carbaldehyde oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; potassium carbonate In ethanol; water standing overnight in refrigerator;89%
With hydroxylamine hydrochloride; potassium carbonate In ethanol at 80℃; for 2h;52%
(E)-(2-nitrovinyl)cyclohexane
50598-92-0, 132839-80-6

(E)-(2-nitrovinyl)cyclohexane

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

(S)-2-cyclohexyl-3-nitro-1-(pyridazin-3-yl)propan-1-one
1175052-24-0

(S)-2-cyclohexyl-3-nitro-1-(pyridazin-3-yl)propan-1-one

Conditions
ConditionsYield
With (5R,7R)-7-fluoro-5-isopropyl-2-(perfluorophenyl)-6,7-dihydro-5H-pyrrolo[2,1c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In methanol at 0℃; Stetter reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;88%
(E)-methyl 3-cyanoacrylate
925-56-4

(E)-methyl 3-cyanoacrylate

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Methyl 3-(3-Pyridazinyl)-2-cyanoacrylate
130823-22-2

Methyl 3-(3-Pyridazinyl)-2-cyanoacrylate

Conditions
ConditionsYield
triethylamine In methanol 50-60 deg C, 30 seconds, then r.t., 2h;87%
azepane-1-carbothioic acid hydrazide
6507-37-5

azepane-1-carbothioic acid hydrazide

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Azepane-1-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

Azepane-1-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol for 2h; Heating;86%
pyrrolidine-1-carbothioic acid hydrazide
6499-14-5

pyrrolidine-1-carbothioic acid hydrazide

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Pyrrolidine-1-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

Pyrrolidine-1-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol for 2h; Heating;86%
piperidine-1-carbothioic acid hydrazide
21198-50-5

piperidine-1-carbothioic acid hydrazide

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Piperidine-1-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

Piperidine-1-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol for 2h; Heating;85%
hydrazinecarbodithioic acid methyl ester
5397-03-5

hydrazinecarbodithioic acid methyl ester

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

N'-[1-Pyridazin-3-yl-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester

N'-[1-Pyridazin-3-yl-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester

Conditions
ConditionsYield
In isopropyl alcohol at 65 - 70℃; for 1h;85%
1,1,1,3,3,3-hexafluoropropan-2-yl 2,8-diazaspiro[4.5]decane-8-carboxylate

1,1,1,3,3,3-hexafluoropropan-2-yl 2,8-diazaspiro[4.5]decane-8-carboxylate

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

1,1,1,3,3,3-hexafluoropropan-2-yl 2-(pyridazin-3-ylmethyl)-2,8-diazaspiro[4.5]decane-8-carboxylate

1,1,1,3,3,3-hexafluoropropan-2-yl 2-(pyridazin-3-ylmethyl)-2,8-diazaspiro[4.5]decane-8-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1h;79%
4-allyl-3-thiosemicarbazide
3766-55-0

4-allyl-3-thiosemicarbazide

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

C9H11N5S
142564-66-7

C9H11N5S

Conditions
ConditionsYield
In methanol Heating;74%
(S)-{cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine
1213315-68-4

(S)-{cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine
1414778-35-0

[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

Conditions
ConditionsYield
Stage #1: (S)-{cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine; pyridazine-3 carboxaldehyde With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20 - 35℃; Inert atmosphere;
Stage #2: With potassium carbonate In water; 1,2-dichloro-ethane		73%
3-azabicyclo<3.2.2>nonane-3-thiocarboxylic acid hydrazide
95836-54-7

3-azabicyclo<3.2.2>nonane-3-thiocarboxylic acid hydrazide

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

3-Aza-bicyclo[3.2.2]nonane-3-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

3-Aza-bicyclo[3.2.2]nonane-3-carbothioic acid [1-pyridazin-3-yl-meth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol for 2h; Heating;72%
C12H10ClF3IN3O5S

C12H10ClF3IN3O5S

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

(6-chloropyridin-3-yl)(pyridazin-3-yl)methanone
1426083-00-2

(6-chloropyridin-3-yl)(pyridazin-3-yl)methanone

Conditions
ConditionsYield
With 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; dmap; water In dichloromethane at -40℃; for 16h; Inert atmosphere;63%
1H-indene-1,3(2H)-dione
606-23-5

1H-indene-1,3(2H)-dione

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

2-[(1,3-Dihydroxy-inden-2-ylidene)-pyridazin-3-yl-methyl]-3-hydroxy-inden-1-one

2-[(1,3-Dihydroxy-inden-2-ylidene)-pyridazin-3-yl-methyl]-3-hydroxy-inden-1-one

Conditions
ConditionsYield
With piperidine In methanol for 1.5h; Heating;62%
4,4-dimethylthiosemicarbazide
6926-58-5

4,4-dimethylthiosemicarbazide

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

C8H11N5S
142564-68-9

C8H11N5S

Conditions
ConditionsYield
In methanol Heating;60%
pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

(triphenylphosphoranylidene)acetaldehyde
2136-75-6

(triphenylphosphoranylidene)acetaldehyde

3-(3-Pirydazinyl)-propenal
81398-14-3

3-(3-Pirydazinyl)-propenal

Conditions
ConditionsYield
In benzene at 5℃; for 2h;59%
Methyl diethylphosphonoacetate
1067-74-9

Methyl diethylphosphonoacetate

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

(E)-3-pyridazin-3-yl-acrylic acid methyl ester

(E)-3-pyridazin-3-yl-acrylic acid methyl ester

Conditions
ConditionsYield
Stage #1: Methyl diethylphosphonoacetate With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: pyridazine-3 carboxaldehyde In tetrahydrofuran; mineral oil at 0℃; for 1.5h;		57%
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

ethyl (E)-3-(pyridazin-3-yl)acrylate
130823-25-5

ethyl (E)-3-(pyridazin-3-yl)acrylate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: pyridazine-3 carboxaldehyde In tetrahydrofuran; mineral oil at 0 - 20℃; for 1h;		50.97%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: pyridazine-3 carboxaldehyde In tetrahydrofuran; mineral oil at 20℃; for 1h;		50.97%
With sodium hydride; N,N-dimethyl-formamide at 60℃; for 4h;44%
acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Dimethyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate
130823-27-7

Dimethyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With ammonium hydroxide In methanol for 1h; Heating;49%
pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

Dimethyl malonate
130823-24-4

Dimethyl malonate

Conditions
ConditionsYield
diethylamine In methanol at -10℃; for 5h;45%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-thioxo-4-thiazolidinone
141-84-4

2-thioxo-4-thiazolidinone

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

C14H17N5O2S

C14H17N5O2S

Conditions
ConditionsYield
With acetic acid In methanol for 4h; Reflux; Inert atmosphere;37.1%
...Expand
pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

Dimethyl (3-Pyridazinylmethylene)malonate
130823-23-3

Dimethyl (3-Pyridazinylmethylene)malonate

Conditions
ConditionsYield
diethylamine In dichloromethane for 10h; Ambient temperature;30%
isopropyl acetoacetate
542-08-5

isopropyl acetoacetate

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Diisopropyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate
130823-31-3

Diisopropyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With ammonium hydroxide In methanol for 12h; Heating;28%
malonic acid
141-82-2

malonic acid

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

(E)-3-(pyridazin-3-yl)acrylic acid
123530-64-3

(E)-3-(pyridazin-3-yl)acrylic acid

Conditions
ConditionsYield
With pyridine at 80℃; for 2h;27%
C11H10F3IN2O5S

C11H10F3IN2O5S

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

ethyl 5-(pyridazin-3-yl)-1,3,4-oxadiazole-2-carboxylate

ethyl 5-(pyridazin-3-yl)-1,3,4-oxadiazole-2-carboxylate

Conditions
ConditionsYield
Stage #1: C11H10F3IN2O5S; pyridazine-3 carboxaldehyde With 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; tert-butyl alcohol In 1,2-dichloro-ethane at 0℃; for 0.0833333h; Schlenk technique; Sealed tube; Inert atmosphere;
Stage #2: With N,N,N,N,-tetramethylethylenediamine In 1,2-dichloro-ethane at 0℃; for 10h; Schlenk technique; Sealed tube; Inert atmosphere;		26%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Diethyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate
130823-30-2

Diethyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
With ammonium hydroxide In methanol for 1h; Heating;22%
ethyl aminocrotonate
626-34-6, 7318-00-5, 41867-20-3

ethyl aminocrotonate

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

pyridazine-3 carboxaldehyde
60170-83-4

pyridazine-3 carboxaldehyde

Ethyl Methyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate
130823-32-4

Ethyl Methyl 2,6-Dimethyl-4-(3-pyridazinyl)-1,4-dihydropyridine-3,5-dicarboxylate

Conditions
ConditionsYield
1) EtOH, reflux, 10 min, 2) EtOH, reflux, 2.5h; Yield given. Multistep reaction;
...Expand

3-Pyridazinecarbaldehyde Chemical Properties

Molecule structure of Pyridazine-3-carbaldehyde (CAS NO.60170-83-4):

Molecular Weight: 108.0981 g/mol
Molecular Formula: C5H4N2O 
Density: 1.235 g/cm3 
Boiling Point: 300.361 °C at 760 mmHg 
Flash Point: 139.901 °C
Index of Refraction: 1.581
Molar Refractivity: 29.188 cm3
Molar Volume: 87.547 cm3
Surface Tension: 57.072 dyne/cm
Enthalpy of Vaporization: 54.042 kJ/mol
Vapour Pressure: 0.001 mmHg at 25 °C 
InChI: InChI=1/C5H4N2O/c8-4-5-2-1-3-6-7-5/h1-4H 
InChIKey: YRUFRSUZZACWCW-UHFFFAOYAW 
Product Categories of Pyridazine-3-carbaldehyde (CAS NO.60170-83-4): ALDEHYDE

3-Pyridazinecarbaldehyde Specification

 Pyridazine-3-carbaldehyde (CAS NO.60170-83-4) is also named as 3-pyridazinecarboxaldehyde ; 3-Pyridazinecarbaldehyde, 97% ; 3-Pyridazinecarboxaldehyde (6CI, 9CI) .

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