3-chloropropylamine hydrochloride supplier

Name
1-Amino-3-chloropropane hydrochloride
EINECS 228-474-6
CAS No. 6276-54-6
Article Data4
CAS DataBase
Density 1.004 g/cm3
Solubility
Melting Point 145-150 °C(lit.)
Formula C₃H₉Cl₂N
Boiling Point 130.7 °C at 760 mmHg
Molecular Weight 130.017
Flash Point 32.9 °C
Transport Information
Appearance off-white to yellow-beige crystalline
Safety 26-36/37-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Propylamine,3-chloro-, hydrochloride (6CI,8CI);1-Amino-3-chloropropane hydrochloride;1-Chloro-3-aminopropane hydrochloride;3-Amino-1-chloropropane hydrochloride;3-Aminopropyl chloride hydrochloride;3-Chloro-1-propanamine hydrochloride;
PSA 26.02000
LogP 2.07630

Synthetic route

: 156-87-6
propan-1-ol-3-amine

: 6276-54-6
3-chloropropylamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform at 0℃; Reflux;	93%
With thionyl chloride In chloroform at 0 - 20℃; for 3h; Reflux;	93%
With thionyl chloride In chloroform at 0 - 20℃;

: 3-hydroxypropylamine hydrochloride

: 6276-54-6
3-chloropropylamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 25℃; for 1h;	83%

: 24424-99-5
di-tert-butyl dicarbonate

: 6276-54-6
3-chloropropylamine hydrochloride

: 116861-31-5
tert-butyl N-(3-chloropropyl)carbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate; sodium chloride In chloroform; water for 1.5h; Heating;	100%
With triethylamine In dichloromethane at 0 - 25℃; for 21h;	100%
With triethylamine In chloroform Acylation;	95%

: 6276-54-6
3-chloropropylamine hydrochloride

: 88192-19-2
3-azidopropylamine

Conditions

Conditions	Yield
With sodium azide In water at 80℃; for 15h;	100%
With sodium azide In water at 80℃; for 15h;	100%
With sodium azide In water at 80℃; for 15h;	99%

: 6276-54-6
3-chloropropylamine hydrochloride

: 100-52-7
benzaldehyde

: 1026774-25-3
benzylidene-(3-chloro-1-propylamine)

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 16h;	100%
With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 1h;	83%
With magnesium sulfate; triethylamine In dichloromethane for 12h;

: 6276-54-6
3-chloropropylamine hydrochloride

: 123-11-5
4-methoxy-benzaldehyde

: 4-methoxybenzylidene-(3-chloro-1-propylamine)

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: 4-methoxy-benzaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	100%
With triethylamine In chloroform at 20℃; for 16h;	100%
With magnesium sulfate; triethylamine In dichloromethane for 12h;

: 7791-25-5
sulfuryl dichloride

: 6276-54-6
3-chloropropylamine hydrochloride

: 42065-72-5
(3-chloropropyl)sulfamyl chloride

Conditions

Conditions	Yield
In acetonitrile at 0 - 85℃;	100%

: 6276-54-6
3-chloropropylamine hydrochloride

: 42065-72-5
(3-chloropropyl)sulfamyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride In acetonitrile at 0 - 85℃;	100%
With sulfuryl dichloride In acetonitrile at 85℃; Cooling with ice;	100%
With sulfuryl dichloride In acetonitrile at 85℃; Cooling with ice;	100%

: 6276-54-6
3-chloropropylamine hydrochloride

: 501-53-1
benzyl chloroformate

: 53602-19-0
1-[(benzyloxycarbonyl)amino]-3-chloropropane

Conditions

Conditions	Yield
With sodium hydroxide In water at 0 - 25℃; for 24h;	100%
With sodium hydroxide In water at 0℃; for 12h; Inert atmosphere;	90%
Stage #1: 3-chloropropylamine hydrochloride With sodium hydroxide In water at 0℃; for 0.25h; Schlenk technique; Stage #2: benzyl chloroformate In water at 0℃; for 12h;	2.48 g

: C82H125CoN15O15P

: 6276-54-6
3-chloropropylamine hydrochloride

: C84H133CoN15O15P

Conditions

Conditions	Yield
Stage #1: C82H125CoN15O15P With ammonium bromide; zinc In ethanol for 0.333333h; Inert atmosphere; Stage #2: 3-chloropropylamine hydrochloride In ethyl [2]alcohol for 3h; Inert atmosphere;	100%

: 6276-54-6
3-chloropropylamine hydrochloride

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 3,4-dimethoxybenzylidene-(3-chloro-1-propylamine)

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In chloroform at 20℃;	99%

: 6276-54-6
3-chloropropylamine hydrochloride

: 103-72-0
phenyl isothiocyanate

: 66268-31-3, 133524-17-1, 3420-40-4, 864524-22-1
phenyl(1,3-thiazan-2-yliden)amine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h;	99%

: 6276-54-6
3-chloropropylamine hydrochloride

: 2131-61-5
p-nitrophenyl isothiocyanate

: (4-nitrophenyl)(1,3-thiazan-2-yliden)amine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h;	99%

: 6276-54-6
3-chloropropylamine hydrochloride

: 135-02-4
ortho-anisaldehyde

: 2-methoxybenzylidene-(3-chloro-1-propylamine)

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: ortho-anisaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	99%

: 4122-56-9
methyl o-formylbenzoate

: 6276-54-6
3-chloropropylamine hydrochloride

: 1377966-35-2
methyl 2-[(3-chloropropylimino)methyl]benzoate

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In chloroform at 20℃; for 2h;	99%

: 6276-54-6
3-chloropropylamine hydrochloride

: 2530-87-2
3-Chloropropyltrimethoxysilan

: C9H22ClNO3Si

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With sodium hydroxide In water for 2h; Cooling with ice; Stage #2: 3-Chloropropyltrimethoxysilan In toluene at 100℃; for 24h; Inert atmosphere;	99%

: 6276-54-6
3-chloropropylamine hydrochloride

: 18171-19-2
3-chloropropylmethyldimethoxysilane

: C9H22ClNO2Si

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With ammonium hydroxide for 2.5h; Cooling with ice; Stage #2: 3-chloropropylmethyldimethoxysilane In dimethyl sulfoxide at 120℃; for 12h; Inert atmosphere;	99%

: 13508-63-9
chloropropyl(dimethyl)ethoxysilane

: 6276-54-6
3-chloropropylamine hydrochloride

: C10H24ClNOSi

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With potassium carbonate for 2h; Cooling with ice; Stage #2: chloropropyl(dimethyl)ethoxysilane In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	99%

: 5089-70-3
(3-chloropropyl)triethoxysilane

: 6276-54-6
3-chloropropylamine hydrochloride

: C12H28ClNO3Si

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With potassium hydroxide for 1h; Cooling with ice; Stage #2: (3-chloropropyl)triethoxysilane In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	99%

N2-atmosphere: N2-atmosphere

: 6276-54-6
3-chloropropylamine hydrochloride

: 106-54-7
p-Chlorothiophenol

: 78540-43-9
N-[3-[(4-Chlorophenyl)thio]propyl]amine hydrochloride

Conditions

Conditions	Yield
With sodium ethanolate In ethanol; water	98%

...Expand

: 34619-03-9
tert-butyldicarbonate

: 6276-54-6
3-chloropropylamine hydrochloride

: 116861-31-5
tert-butyl N-(3-chloropropyl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃;	98%
With triethylamine In chloroform at 20℃;	95%

: 6276-54-6
3-chloropropylamine hydrochloride

: 107-13-1
acrylonitrile

: 3-(3-chloro-propylamino)-propionitrile

Conditions

Conditions	Yield
With sodium In ethanol at 25℃; for 8h;	97%

: 6276-54-6
3-chloropropylamine hydrochloride

: 591-31-1
3-methoxy-benzaldehyde

: 3-methoxybenzylidene-(3-chloro-1-propylamine)

Conditions

Conditions	Yield
Stage #1: 3-chloropropylamine hydrochloride With triethylamine In chloroform at 20℃; for 0.0833333h; Stage #2: 3-methoxy-benzaldehyde With magnesium sulfate In chloroform at 20℃; for 16h;	97%
With magnesium sulfate; triethylamine In dichloromethane for 12h;

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 6276-54-6
3-chloropropylamine hydrochloride

: 153652-94-9
3-chloro-N-4,4'-dimethoxytritylpropanamine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 3h;	96%

: 574-66-3
Benzophenone oxime

: 6276-54-6
3-chloropropylamine hydrochloride

: O-(3-aminopropyl)benzophenone oxime

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Alkylation;	96%

: 865998-76-1
1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylic acid

: 6276-54-6
3-chloropropylamine hydrochloride

: N-(3-chloropropyl)-1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxamide

Conditions

Conditions	Yield
Stage #1: 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylic acid With dmap; HATU In DMF (N,N-dimethyl-formamide) at 20℃; for 0.25h; Stage #2: 3-chloropropylamine hydrochloride With triethylamine In DMF (N,N-dimethyl-formamide)	96%

: 6276-54-6
3-chloropropylamine hydrochloride

: 1571-08-0
methyl 4-formylbenzoate

: 4-methoxycarbonylbenzylidene-(3-chloro-1-propylamine)

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 16h;	95%

: 164356-70-1
[CpFe(CO)(CN(CH2)3PPh2)]I

: 6276-54-6
3-chloropropylamine hydrochloride

: [CpFe(CO)(C(NH(CH2)3Cl)NH(CH2)3PPh2)]I

Conditions

Conditions	Yield
With NaOCH2CH3 In ethanol; dichloromethane byproducts: NaCl; (inert atm.); addn. of ethanolic soln. of sodium ethylate to soln. of amine hydrochloride deriv. at room temp., stirring for 10 min, filtration,addn. to CH2Cl2 soln. of iron compd. at room temp., stirring overnight; concg., addn. of diethyl ether, filtration, washing with pentane, dryingin vac., elem. anal.;	95%

: C18H11ClN2O2

: 6276-54-6
3-chloropropylamine hydrochloride

: N-(3‑chloropropyl)-1-(2-chlorophenyl)-9H-β-carboline-3‑carboxamide

Conditions

Conditions	Yield
With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran; methanol at 20℃;	95%

: 6276-54-6
3-chloropropylamine hydrochloride

: 78-84-2
isobutyraldehyde

: N-(2-methyl-1-propylidene)-3-chloropropylamine

Conditions

Conditions	Yield
With magnesium sulfate; triethylamine In dichloromethane for 1h; Ambient temperature;	94%

: 872-85-5
pyridine-4-carbaldehyde

: 6276-54-6
3-chloropropylamine hydrochloride

: (3-Chloro-propyl)-[1-pyridin-4-yl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water for 0.666667h;	94%

: 6276-54-6
3-chloropropylamine hydrochloride

: 147695-56-5
4-bromophenyl isoselenocyanate

: (4-bromophenyl)(1,3-selenazan-2-yliden)amine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h;	94%

3-chloropropylamine hydrochloride Chemical Properties

IUPAC Name: 3-Chloropropan-1-amine
Following is the structure of 3-chloropropylamine hydrochloride (CAS NO.6276-54-6):

Empirical Formula: C₃H₈ClN
Molecular Weight: 93.5553 g/mol
EINECS: 228-474-6
Index of Refraction: 1.435
Molar Refractivity: 24.33 cm³
Molar Volume: 93.1 cm³
Density: 1.004 g/cm³
Flash Point: 32.9 °C
Surface Tension: 30.5 dyne/cm
Melting point: 145-150 °C(lit.)
Enthalpy of Vaporization: 36.84 kJ/mol
Boiling Point: 130.7 °C at 760 mmHg
Vapour Pressure: 9.58 mmHg at 25 °C
Product Categories of 3-chloropropylamine hydrochloride (CAS NO.6276-54-6): omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; omega-Haloalkylamines
Appearance of 3-chloropropylamine hydrochloride (CAS NO.6276-54-6): off-white to yellow-beige crystalline
Canonical SMILES: C(CN)CCl
InChI: InChI=1S/C3H8ClN/c4-2-1-3-5/h1-3,5H2
InChIKey: BZFKSWOGZQMOMO-UHFFFAOYSA-N

3-chloropropylamine hydrochloride Uses

3-chloropropylamine hydrochloride (CAS NO.6276-54-6) , aliphatic amine with halogen, is used in manufacturing other compounds.

3-chloropropylamine hydrochloride Toxicity Data With Reference

3-chloropropylamine hydrochloride (CAS NO.6276-54-6) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

3-chloropropylamine hydrochloride Safety Profile

The Hazard Codes of 3-chloropropylamine hydrochloride(6276-54-6): Xi
The Risk Statements information of 3-chloropropylamine hydrochloride (CAS NO.6276-54-6):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 3-chloropropylamine hydrochloride (CAS NO.6276-54-6):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
36/37: Wear suitable protective clothing and gloves
WGK Germany: 3

3-chloropropylamine hydrochloride Specification

3-chloropropylamine hydrochloride , its cas register number is 6276-54-6. It also can be called 1-Amino-3-chloropropane hydrochloride ; and 3-Chloropropylammonium chloride .
3-chloropropylamine hydrochloride (CAS NO.6276-54-6) could be stable under normal temperatures and pressures. It absorbs moisture or water from the air.It should avoid the condition like incompatible materials, exposure to moist air or water. It is not compatible with strong oxidizing agents. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, carbon monoxide, carbon dioxide. However, its hazardous polymerization will not occur.

Product Name

1-Amino-3-chloropropane hydrochloride

Synthetic route

3-chloropropylamine hydrochloride Chemical Properties

3-chloropropylamine hydrochloride Uses

3-chloropropylamine hydrochloride Toxicity Data With Reference

3-chloropropylamine hydrochloride Safety Profile

3-chloropropylamine hydrochloride Specification

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