Product Name

  • Name

    4'-Hydroxypropiophenone

  • EINECS 200-743-2
  • CAS No. 70-70-2
  • Article Data72
  • CAS DataBase
  • Density 1.104 g/cm3
  • Solubility 0.34 g/l (15 °C) in water
  • Hazard Symbols HarmfulXn, IrritantXi
  • Synonyms POP;Paroxon;Paroxypropion;Propiophenone,4'-hydroxy- (8CI);Propiophenone, p-hydroxy- (3CI);1-(4-Hydroxyphenyl)-1-propanone;1-(p-Hydroxyphenyl)-1-propanone;4-Propanoylphenol;4-Propionylphenol;Paroxypropione;B 360;Bio-fren;Ethyl 4-hydroxyphenyl ketone;Ethyl p-hydroxyphenyl ketone;Frenantol;Frenohypon;Frenon;Frenormon;H 365;Hypophenon;Hypostat;Ibiopopp;Mepal;NSC 2834;NSC 33949;
  • PSA 37.30000
  • LogP 1.98490

Synthetic route

propionyl chloride
79-03-8

propionyl chloride

phenol
108-95-2

phenol

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With trifluorormethanesulfonic acid at 0 - 20℃; for 1h; Friedel-Crafts acylation; regiospecific reaction;99%
With aluminium trichloride In dichloromethane Friedel-Crafts acylation;53%
man verseift das Propionat mit alkoh. Kalilauge;
1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)propan-1-one

1-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)propan-1-one

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With cerium (IV) sulfate tetrahydrate In methanol at 130℃; for 0.333333h; Temperature; Microwave irradiation;94%
4-benzyloxypropiophenone
4495-66-3

4-benzyloxypropiophenone

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With hydrogen; nickel In isopropyl alcohol at 60℃; under 3102.9 Torr; 20-24 h;92%
With trifluoroacetic acid
4-{[(tert-butyl)(diphenyl)silyl]oxy}-3-methoxybenzaldehyde
69405-03-4

4-{[(tert-butyl)(diphenyl)silyl]oxy}-3-methoxybenzaldehyde

1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)propan-1-one
134136-83-7

1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)propan-1-one

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With cerium (IV) sulfate tetrahydrate In methanol at 130℃; for 0.333333h; Microwave irradiation; chemoselective reaction;92%
4-Methoxypropiophenone
121-97-1

4-Methoxypropiophenone

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
Stage #1: 4-Methoxypropiophenone With 1-n-butyl-3-methylimidazolim bromide at 220℃; under 9000.9 Torr; for 0.666667h; Inert atmosphere; Sealed tube; Microwave irradiation;
Stage #2: With hydrogenchloride; water pH=1;
90%
With hydrogen bromide; acetic acid In water at 100℃; for 18h; Heating / reflux;70%
With Pyridine hydrobromide at 240℃; for 0.25h;60%
1-(4-(prop-2-yn-1-yloxy)phenyl)propan-1-one
192067-89-3

1-(4-(prop-2-yn-1-yloxy)phenyl)propan-1-one

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 28℃; for 19h;87%
With Pd-catalyst In water; N,N-dimethyl-formamide
4-hydroxy-α-ethylbenzylalcohol
22805-42-1

4-hydroxy-α-ethylbenzylalcohol

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With C6H4MoNO7(1-)*C19H42N(1+); oxygen In water at 100℃; for 20h; Green chemistry; chemoselective reaction;81%
phenyl propionate
637-27-4

phenyl propionate

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With trifluorormethanesulfonic acid at 0 - 20℃; for 4.5h; Inert atmosphere;80%
With trifluorormethanesulfonic acid at 0 - 20℃; for 4.5h;80%
With aluminium trichloride In nitrobenzene at 30℃; for 24h; Fries rearrangement;60%
propionic acid
802294-64-0

propionic acid

phenol
108-95-2

phenol

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
Stage #1: propionic acid With trifluoromethylsulfonic anhydride at 20 - 60℃;
Stage #2: phenol at 60℃; for 0.166667h; regiospecific reaction;
80%
With zinc(II) chloride
With boron trifluoride
With PPA
4'-Bromopropiophenone
10342-83-3

4'-Bromopropiophenone

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With nickel(II) bromide trihydrate; water; 1-(2,2-diphenyl-2λ4,3λ4-[1,3,2]diazaborolo[4,5,1-ij]quinolin-1(2H)-yl)-3-phenylpropan-1-one; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine In dimethyl sulfoxide at 25℃; for 22h; Irradiation;80%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

4-Hydroxyacetophenone
99-93-4

4-Hydroxyacetophenone

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With ammonium peroxydisulfate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In water at 110℃; for 3h; Inert atmosphere; Sealed tube;73%
phenyl propionate
637-27-4

phenyl propionate

A

1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With aluminium trichloride In chlorobenzene at 106℃; under 760 Torr; for 0.05h; Irradiation; microwave oven;A 28%
B 62%
With carbon disulfide; aluminium trichloride Erhitzen des Reaktionsgemisches auf 190grad;
With carbon disulfide; aluminium trichloride bei Siedetemperatur und anschliessend Abdestillieren des Schwefelkohlenstoffs und Erhitzen auf 140-150grad;
With aluminium trichloride; n-heptane Erhitzen des Reaktionsgemisches auf 190grad;
phenyl propionate
637-27-4

phenyl propionate

A

1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

C

phenol
108-95-2

phenol

Conditions
ConditionsYield
With β‐cyclodextrin In water at 25℃; for 1h; Product distribution; Quantum yield; Irradiation; various times, effect of oxygen, without cyclodextrin;A 16.49%
B 9.16%
C n/a
1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

A

phenyl propionate
637-27-4

phenyl propionate

B

2-chloro-1-(2-hydroxyphenyl)-1-propanone
74316-25-9

2-chloro-1-(2-hydroxyphenyl)-1-propanone

C

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
iron(III) chloride at 170℃; for 24h; Mechanism; Product distribution;A 8.7%
B 5.9%
C 0.7%
diethyl ether
60-29-7

diethyl ether

dibutyl ether
142-96-1

dibutyl ether

N, N-diethyl-4-hydroxybenzamide
79119-31-6

N, N-diethyl-4-hydroxybenzamide

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

N, N-diethyl-4-hydroxybenzamide
79119-31-6

N, N-diethyl-4-hydroxybenzamide

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With diethyl ether; dibutyl ether Erhitzen des vom Diaethylaether befreiten Reaktionsgemisches auf Siedetemperatur und anschliessende Hydrolyse;
4-t-amylphenol
80-46-6

4-t-amylphenol

propionic acid
802294-64-0

propionic acid

A

1-(2-hydroxy-5-tert-pentyl-phenyl)-propan-1-one
859059-71-5

1-(2-hydroxy-5-tert-pentyl-phenyl)-propan-1-one

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With boron trifluoride
propionic acid
802294-64-0

propionic acid

phenol
108-95-2

phenol

A

1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With boron trifluoride Erwaermen des Reaktionsgemisches auf 75grad;
With boron trifluoride und Erwaermen des Reaktionsgemisches auf 75grad;
pyridine hydrochloride
628-13-7

pyridine hydrochloride

4-Methoxypropiophenone
121-97-1

4-Methoxypropiophenone

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-propionylphenyl benzoate
96187-97-2

4-propionylphenyl benzoate

A

N-butylbenzamide
2782-40-3

N-butylbenzamide

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With N-butylamine In benzene for 0.4h; Ambient temperature; Yield given;
4-propionylphenyl benzoate
96187-97-2

4-propionylphenyl benzoate

N-butylamine
109-73-9

N-butylamine

A

N-butylbenzamide
2782-40-3

N-butylbenzamide

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
In benzene for 0.4h; Ambient temperature; Yields of byproduct given;
1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)propan-1-one
134136-83-7

1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)propan-1-one

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
With potassium carbonate; [2.2.2]cryptande In acetonitrile at 55℃; for 2h; Yield given;
With tetrabutyl ammonium fluoride In tetrahydrofuran
pyridine hydrochloride
628-13-7

pyridine hydrochloride

1-<4-ethoxy-phenyl>-propanone-(1)

1-<4-ethoxy-phenyl>-propanone-(1)

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

boron trifluoride
7637-07-2

boron trifluoride

propionic acid
802294-64-0

propionic acid

phenol
108-95-2

phenol

A

1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
at 73 - 75℃;
at 75℃;
2-bromo-(4'-hydroxyphenyl)-propan-1-one
53946-87-5

2-bromo-(4'-hydroxyphenyl)-propan-1-one

acetic acid
64-19-7

acetic acid

zinc-powder

zinc-powder

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

carbon disulfide
75-15-0

carbon disulfide

aluminium trichloride
7446-70-0

aluminium trichloride

phenyl propionate
637-27-4

phenyl propionate

A

1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
Erhitzen des vom Loesungsmittel befreiten Reaktionsgemisches auf 135-140grad;
aluminium trichloride
7446-70-0

aluminium trichloride

n-heptane
142-82-5

n-heptane

phenyl propionate
637-27-4

phenyl propionate

A

1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
at 80 - 90℃; Product distribution;
aluminium trichloride
7446-70-0

aluminium trichloride

phenyl propionate
637-27-4

phenyl propionate

1,1,2,2-tetrachloroethane
79-34-5

1,1,2,2-tetrachloroethane

A

1-(2-Hydroxy-phenyl)-propan-1-on
610-99-1

1-(2-Hydroxy-phenyl)-propan-1-on

B

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
at 95℃; Product distribution;
tetrachloromethane
56-23-5

tetrachloromethane

bis-[1-(4-hydroxy-phenyl)-propylidene]-hydrazine
84234-15-1

bis-[1-(4-hydroxy-phenyl)-propylidene]-hydrazine

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

Conditions
ConditionsYield
in siedendem Xylol, nach laengerer Dauer;
triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)propan-1-one
134136-88-2

1-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)propan-1-one

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 20℃; for 14h;100%
With 1H-imidazole In N,N-dimethyl-formamide for 3h;99%
pivaloyl chloride
3282-30-2

pivaloyl chloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

p-(trimethylacetoxy)propiophenone
120703-45-9

p-(trimethylacetoxy)propiophenone

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 2h;100%
Stage #1: 4-hydroxypropiophenone With sodium hydride In tetrahydrofuran; mineral oil
Stage #2: pivaloyl chloride In tetrahydrofuran; mineral oil for 2h;
100%
benzyl bromide
100-39-0

benzyl bromide

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-benzyloxypropiophenone
4495-66-3

4-benzyloxypropiophenone

Conditions
ConditionsYield
With potassium carbonate In acetone Heating / reflux;100%
With potassium carbonate In acetone Heating / reflux;100%
With potassium carbonate In acetone Heating / reflux;100%
O-ethylhydroxylamine hydrochloride
3332-29-4

O-ethylhydroxylamine hydrochloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

(E)-1-(4-hydroxyphenyl)propan-1-one-O-ethylketoxime

(E)-1-(4-hydroxyphenyl)propan-1-one-O-ethylketoxime

Conditions
ConditionsYield
With sodium acetate In ethanol at 80℃; for 4h;99%
With sodium acetate at 80℃; for 2h;
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
72824-04-5

2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-(3-hydroxyhex-5-en-3-yl)phenol

4-(3-hydroxyhex-5-en-3-yl)phenol

Conditions
ConditionsYield
With indium iodide In tetrahydrofuran at 40℃; for 24h;98%
tetramethlyammonium chloride
75-57-0

tetramethlyammonium chloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-Methoxypropiophenone
121-97-1

4-Methoxypropiophenone

Conditions
ConditionsYield
With potassium carbonate In 1,2-dimethoxyethane at 145℃; for 0.416667h; Microwave irradiation; Inert atmosphere; Sealed vessel;98%
With potassium carbonate at 150 - 160℃; for 4h;81%
ethylene glycol
107-21-1

ethylene glycol

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

2-ethyl-2-(4-hydroxyphenyl)-1,3-dioxolane
89723-36-4

2-ethyl-2-(4-hydroxyphenyl)-1,3-dioxolane

Conditions
ConditionsYield
With Triisopropoxymethan; cerium triflate In hexane at 25℃; for 2.5h;98%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

C33H48O5

C33H48O5

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 10 - 20℃; for 2h; Temperature; Concentration;97.3%
allyl bromide
106-95-6

allyl bromide

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

allyl 4-propionylphenyl ether
2089-23-8

allyl 4-propionylphenyl ether

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 12h;97%
at 75 - 90℃; for 6h; Substitution;89.4%
With sodium hydroxide
ethyl bromoacetate
105-36-2

ethyl bromoacetate

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

ethyl 2-(4-propionylphenoxy)acetate
51828-70-7

ethyl 2-(4-propionylphenoxy)acetate

Conditions
ConditionsYield
With potassium carbonate In acetone for 4h; Heating / reflux;97%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 3h;94%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 3h;94%
With potassium carbonate In toluene for 48h; Reflux;
p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-{4-[(4-methoxybenzyl)oxy]phenyl}propan-1-one
935859-44-2

1-{4-[(4-methoxybenzyl)oxy]phenyl}propan-1-one

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In butanone at 20 - 60℃; for 12h;96%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 12h; Inert atmosphere;
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

ethyl 2-(4-propionylphenoxy)acetate
51828-70-7

ethyl 2-(4-propionylphenoxy)acetate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 18h;95%
4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

O-(4-bromophenyl)hydroxylamine
65440-82-6

O-(4-bromophenyl)hydroxylamine

(E/Z)-1-(4-hydroxyphenyl)-1-propanone O-(4-bromophenyl)oxime

(E/Z)-1-(4-hydroxyphenyl)-1-propanone O-(4-bromophenyl)oxime

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 20℃; for 2h;94%
4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

trimethyleneglycol
504-63-2

trimethyleneglycol

2-ethyl-2-(4-hydroxyphenyl)-1,3-dioxane
1171247-83-8

2-ethyl-2-(4-hydroxyphenyl)-1,3-dioxane

Conditions
ConditionsYield
With Triisopropoxymethan; cerium triflate In hexane at 25℃; for 6h;94%
1-iodo-butane
542-69-8

1-iodo-butane

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-(4-butoxyphenyl)propan-1-one
5736-90-3

1-(4-butoxyphenyl)propan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;93%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-propionyl-phenyl methanesulfonate
929431-57-2

4-propionyl-phenyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 5℃; for 1.5h;93%
2-chloro-N,N-diethylethylamine hydrochloride
869-24-9

2-chloro-N,N-diethylethylamine hydrochloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-(4-(2-(diethylamino)ethoxy)phenyl)propan-1-one
92726-49-3

1-(4-(2-(diethylamino)ethoxy)phenyl)propan-1-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Heating;92%
With potassium carbonate In butanone
iodomethane-d3
865-50-9

iodomethane-d3

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-(4-(methoxy-d3)phenyl)propan-1-one

1-(4-(methoxy-d3)phenyl)propan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;92%
benzyl chloride
100-44-7

benzyl chloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-benzyloxypropiophenone
4495-66-3

4-benzyloxypropiophenone

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Reflux;91.5%
With potassium carbonate In acetone Heating;
With sodium hydroxide
1-(2-chloroethyl)pyrrolidine hydrochloride
7250-67-1

1-(2-chloroethyl)pyrrolidine hydrochloride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propan-1-one

1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propan-1-one

Conditions
ConditionsYield
With potassium carbonate In acetone for 6h; Heating;91%
With potassium carbonate In acetone at 60℃; for 6h;72%
4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

2-bromo-(4'-hydroxyphenyl)-propan-1-one
53946-87-5

2-bromo-(4'-hydroxyphenyl)-propan-1-one

Conditions
ConditionsYield
With pyridinium hydrobromide perbromide; acetic acid at 20℃; for 3.08333h; Product distribution / selectivity;90%
With pyridinium hydrobromide perbromide; acetic acid at 20℃; for 3h;66%
With bromine In chloroform; ethyl acetate61.3%
4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-n-Propylphenol
645-56-7

4-n-Propylphenol

Conditions
ConditionsYield
palladium on activated charcoal In ethanol at 34℃; under 37503 Torr; for 0.833333h;90%
With palladium on activated charcoal; ethanol Hydrogenation;
With methanol; copper oxide-chromium oxide at 115 - 125℃; under 161812 - 176522 Torr; Hydrogenation;
4-chloro-2,3-(hexamethylene)quinoline
25866-35-7

4-chloro-2,3-(hexamethylene)quinoline

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-[4-(6,7,8,9,10,11-Hexahydro-cycloocta[b]quinolin-12-yloxy)-phenyl]-propan-1-one
108154-92-3

1-[4-(6,7,8,9,10,11-Hexahydro-cycloocta[b]quinolin-12-yloxy)-phenyl]-propan-1-one

Conditions
ConditionsYield
at 140℃; for 24h;90%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

4-propionylphenol trifluoromethanesulfonate
87241-55-2

4-propionylphenol trifluoromethanesulfonate

Conditions
ConditionsYield
With 2,6-dimethylpyridine; dmap In dichloromethane for 2h; Ambient temperature;90%
With dmap In dichloromethane at -20 - 20℃; Inert atmosphere;90%
With pyridine In dichloromethane at 0 - 20℃;88%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;88%
With 2,6-dimethylpyridine; dmap In dichloromethane at 20℃; for 2h;14 g
1-bromo-hexane
111-25-1

1-bromo-hexane

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

1-(4-(hexyloxy)phenyl)propan-1-one
5736-96-9

1-(4-(hexyloxy)phenyl)propan-1-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 85℃;90%

4'-Hydroxypropiophenone Chemical Properties

Molecule structure of Paroxypropione (CAS NO.70-70-2):


IUPAC Name: 1-(4-Hydroxyphenyl)propan-1-one
Molecular Formula: C9H10O2
Molecular Weight: 150.174500 g/mol
Melting Point: 36-38 °C(lit.)
Density: 1.104 g/cm3 
Melting Point: 36-38 °C(lit.)
Boiling Point: 152-154 °C at 26 mm Hg(lit.)
Flash Point: >230 °F
Index of Refraction: 1.542
Molar Refractivity: 42.79 cm3
Molar Volume: 135.9 cm3
Surface Tension: 42.6 dyne/cm
Methanol Solubility: 0.1 g/mL, clear
Water Solubility: 0.34 g/l (15 °C) 
XLogP3: 2
H-Bond Donor: 1
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Tautomer Count: 7
Exact Mass: 150.06808
MonoIsotopic Mass: 150.06808
Topological Polar Surface Area: 37.3
Heavy Atom Count: 11 
Canonical SMILES: CCC(=O)C1=CC=C(C=C1)O
InChI: InChI=1S/C9H10O2/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
InChIKey: RARSHUDCJQSEFJ-UHFFFAOYSA-N
EINECS: 202-815-9
Product Categories: Acetophenone Series; Aromatic Propiophenones (substituted); C9; Carbonyl Compounds; Ketones

4'-Hydroxypropiophenone Uses

 Paroxypropione (CAS NO.70-70-2) is used as an intermediates of liquid crystals.

4'-Hydroxypropiophenone Toxicity Data With Reference

1.    

ims-rbt TDLo:1600 mg/kg (female 15-30D post):TER

    AOGNAX    Archivio di Ostetricia e Ginecologia. 66 (1961),286.
2.    

orl-mus LD50:3 mg/kg

    85JDAH    Organophosphorus Pesticides: Organic and Biological Chemistry Eto, M.,Cleveland, OH.: CRC Press, Inc.,1974,197.
3.    

ipr-mus LD50:200 mg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .
4.    

scu-mus LD50:1130 µg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 124 (1960),212.
5.    

par-frg LD50:91 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 124 (1960),212.

4'-Hydroxypropiophenone Consensus Reports

Reported in EPA TSCA Inventory.

4'-Hydroxypropiophenone Safety Profile

Hazard Codes: HarmfulXn, IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 37-24/25-36-26 
S37:Wear suitable gloves. 
S24/25:Avoid contact with skin and eyes. 
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: UH1925000
HS Code: 29145000
Hazardous Substances Data: 70-70-2(Hazardous Substances Data)
Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

4'-Hydroxypropiophenone Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

4'-Hydroxypropiophenone Specification

 Paroxypropione (CAS NO.70-70-2) is also named as 1-(4-Hydroxyphenyl)-1-propanone ; 1-(p-Hydroxyphenyl)-1-propanone ; 4-08-00-00441 (Beilstein Handbook Reference) ; 4-Hydroxypropiophenone ; 4-Propionylphenol ; AI3-03719 ; B 360 ; Ethyl p-hydroxyphenyl ketone ; Frenantol ; Frenohypon ; Frenon ; Frenormon ; H 365 ; Paroxipropiona ; Paroxipropiona [INN-Spanish] ; Paroxon ; Possipione ; Profenone ; Proxiphenon ; Sterofenon ; UNII-X9952001TG ; USAF EK-3302 ; p-Hydroxyphenyl-1-propanone ; p-Hydroxypropiophenone ; p-Oxypropiophenone ; p-Propionylphenol ; p-Propiophenol . Paroxypropione (CAS NO.70-70-2) is white powder. It is slightly soluble in water, soluble in boiling water, with alcohol, ether immiscibility.

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