4-Acetylbiphenyl supplier

Name
4-Acetylbiphenyl
EINECS 202-202-6
CAS No. 92-91-1
Article Data799
CAS DataBase
Density 1.053 g/cm³
Solubility insoluble in water
Melting Point 152-155 °C(lit.)
Formula C₁₄H₁₂O
Boiling Point 326 °C at 760 mmHg
Molecular Weight 196.249
Flash Point 139.9 °C
Transport Information
Appearance Off-white to beige powder
Safety 22-24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 4-Phenylacetophenone;Acetophenone,4'-phenyl- (6CI,7CI,8CI);Acetophenone, p-phenyl- (4CI);(1-[1,1'-Biphenyl]-4-yl)ethanone;1,1'-Biphenyl-4-yl methyl ketone;1-(4-Phenylphenyl)ethanone;1-Acetyl-4-phenylbenzene;1-Biphenyl-4-ylethanone;4-Acetyl-1,1'-biphenyl;4-Biphenylyl methyl ketone;4-Ethanoylbiphenyl;4'-Phenylacetophenone;Methyl 4-biphenylyl ketone;NSC1875;p-Acetylbiphenyl;p-Phenylacetophenone;1-(1,1'-biphenyl-4-yl)ethanone;1-(4-Biphenylyl)ethanone;1-(Biphenyl-4-yl)ethanon;4-Acetylbiphenyl;4-biphenylcarboxaldehyde;ethanone, 1-[1,1'-biphenyl]-4-yl-;
PSA 17.07000
LogP 3.55620

Synthetic route

: 5707-44-8
4-ethylbiphenyl

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With magnesium(II) perchlorate; oxygen; 9,10-Dicyanoanthracene In acetonitrile for 3h; Thermodynamic data; Mechanism; Rate constant; Irradiation; with and without singlet oxygen senzitizers, in less polar solvents; addition of 1,4-diazabicyclo<2.2.2>octane; ΔG; fluorescence quenching rate const.; var. biphenyls and terphenyls;	100%
With hydrogen bromide; dihydrogen peroxide In dichloromethane; water at 20℃; for 12h;	85%
With air; Ag/AgBr/TiO2 nanotubes In neat (no solvent) at 20℃; for 12h; Irradiation; Green chemistry;	84%

: 99-91-2
para-chloroacetophenone

: 98-80-6
phenylboronic acid

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With potassium phosphate; catacxium A; palladium diacetate In toluene at 100℃; for 20h; Suzuki cross-coupling reaction;	100%
With potassium phosphate; N,N-diisopropyl 2-dicyclohexylphosphino-4-phenylbenzamide; tris(dibenzylideneacetone)dipalladium (0) In tetrahydrofuran at 65℃; for 4h; Suzuki cross-coupling reaction;	100%
With 1,4-diaza-bicyclo[2.2.2]octane; caesium carbonate; palladium diacetate In N,N-dimethyl-formamide at 110℃; for 17h; Suzuki-Miyaura cross-coupling;	100%

: 99-90-1
para-bromoacetophenone

: 98-80-6
phenylboronic acid

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With potassium carbonate; {1,3-di[(R)-1-PhEt]imidazolin-2-ylidene}(PPh3)PdI2 In xylene at 130℃; for 13h; Suzuki-Miyaura cross-coupling reaction;	100%
With tetrabutylammomium bromide; potassium carbonate; quasi polymeric 4-pyridine-aldoxime Pd(II)-catalyst at 120℃; for 0.333333h; Suzuki-Miyaura reaction; microwave irradiation;	100%
With 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole; tris(dibenzylideneacetone)dipalladium (0) In toluene at 65℃; for 2h; Suzuki coupling;	100%

: 3562-73-0
1-(4-phenyl-phenyl)-1-ethanol

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; acetophenone oxime; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate at 20℃;	100%
With dinitrogen monoxide; dioxo(tetramesitylporphyrinato)ruthenium(VI) In 1,2-dichloro-ethane at 120℃; under 7600 Torr; for 7.5h;	100%
With dinitrogen monoxide; dioxo(tetramesitylporphyrinato)ruthenium(VI) In 1,2-dichloro-ethane at 120℃; under 7500.6 Torr; for 7.5h;	100%

: 960-16-7
tributylphenylstannane

: 99-90-1
para-bromoacetophenone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
{1,3-di[(R)-1-PhEt]imidazolin-2-ylidene}(PCPh)PdI2 In toluene at 110℃; for 17h; Stille reaction;	100%
With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; poly(ethylene glycol)-400; palladium diacetate In water at 80℃; for 10h; Stille coupling;	100%
With potassium carbonate; trans-(1,3-di(1'-(R)-phenylethyl)imidazolin-2-ylidene)(tricyclohexylphosphine)palladium(II) diiodide In toluene at 110℃; for 17h; Stille cross coupling;	99%

: 6135-51-9
2-([1,1'-biphenyl]-4-yl)-2-methyl-1,3-dioxolane

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate; (3,4-dimethoxyphenyl)methanol for 0.0333333h;	100%
With n-butyltriphenylphosphonium peroxodisulfate In acetonitrile for 2.5h; Heating;	99%
With K5 In acetone for 0.166667h; Heating;	97%

: 13329-40-3
4-Iodoacetophenone

: tetrabutylammonium triphenyldifluorosilicate

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
bis(η3-allyl-μ-chloropalladium(II)) In N,N-dimethyl-formamide at 95℃; for 21h;	100%

: 13329-40-3
4-Iodoacetophenone

: 98-80-6
phenylboronic acid

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With trihexyl(tetradecyl)phosphonium chloride; potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In toluene at 50℃; for 1h; Suzuki cross-coupling;	100%
Stage #1: 4-Iodoacetophenone With tetrakis(triphenylphosphine) palladium(0) In 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide at 20 - 110℃; Suzuki coupling; Inert atmosphere; Ionic liquid; Stage #2: phenylboronic acid With triethylamine In 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide; water at 20 - 110℃; Suzuki coupling; Ionic liquid; Inert atmosphere;	100%
With potassium carbonate In ethanol; water at 20℃; for 0.5h; Suzuki-Miyaura reaction; in air;	100%

: 591-50-4
iodobenzene

: 149104-90-5
4-acetylphenylboronic acid

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 100℃; for 4h; Suzuki Coupling; High pressure; Green chemistry;	100%
With potassium carbonate In ethanol at 80℃; for 12h; Suzuki-Miyaura coupling; Inert atmosphere;	99%
With potassium carbonate In ethanol at 80℃; for 12h; Suzuki coupling; Inert atmosphere;	99%

: 108-86-1
bromobenzene

: 149104-90-5
4-acetylphenylboronic acid

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With tri-tert-butyl phosphine; palladium diacetate; potassium hydroxide In tetrahydrofuran; water at 24℃; for 0.0833333h; Suzuki-Miyaura Coupling; Flow reactor;	100%
With C24H30N4O7; potassium carbonate; palladium dichloride In water at 20℃; for 1.5h; Suzuki coupling;	99%
With potassium carbonate In water at 25℃; for 18h; Suzuki-Miyaura Coupling;	99%

: 99-90-1
para-bromoacetophenone

: 98-80-6
phenylboronic acid

A: 92-91-1
biphenyl-4-acetaldehyde

B: 146175-56-6
bromoboronate

Conditions

Conditions	Yield
With K2CO3; diiodo(1,3-di[(R)-1-phenylethyl]imidazolin-2-ylidene)(triphenylphosphino)palladium(II) In xylene the mixt. in xylene was heated at 130°C for 13 h (N2); H2O was added, the aq. phase was extd. with diethyl ether, the organic phase was dried over MgSO4;	A 100% B n/a
With K2CO3; di-μ-iodobis(1,3-di[(R)-1-phenylethyl]imidazolin-2-ylidene)diiododipalladium(II) In xylene the mixt. in xylene was heated at 130°C for 14 h (N2); H2O was added, the aq. phase was extd. with diethyl ether, the organic phase was dried over MgSO4;	A 99% B n/a

...Expand

: 960-16-7
tributylphenylstannane

: 99-90-1
para-bromoacetophenone

A: 92-91-1
biphenyl-4-acetaldehyde

B: 1461-23-0
tributyltin bromide

Conditions

Conditions	Yield
diiodo(1,3-di[(R)-1-phenylethyl]imidazolin-2-ylidene)(triphenylphosphino)palladium(II) In toluene toluene, 110°C, 17 h (N2); H2O was added, the aq. phase was extd. with diethyl ether, the organic phase was dried over MgSO4;	A 100% B n/a
diiodo(1,3-di-tert-butylimidazolin-2-ylidene)(triphenylphosphino)palladium(II) In toluene toluene, 110°C, 17 h (N2); H2O was added, the aq. phase was extd. with diethyl ether, the organic phase was dried over MgSO4;	A 72% B n/a
diiodo(1,3-di[(R)-1-phenylethyl]imidazolin-2-ylidene)(tri-o-tolylphosphino)palladium(II) In toluene toluene, 110°C, 17 h (N2); H2O was added, the aq. phase was extd. with diethyl ether, the organic phase was dried over MgSO4;	A 65% B n/a

...Expand

: 99-90-1
para-bromoacetophenone

: 98-80-6
phenylboronic acid

immobilized 4-bromobenzoic acid: immobilized 4-bromobenzoic acid

A: 92-91-1
biphenyl-4-acetaldehyde

B: 586-76-5
4-Bromobenzoic acid

C: 92-92-2
biphenyl-4-carboxylic acid

Conditions

Conditions	Yield
Stage #1: para-bromoacetophenone; phenylboronic acid; immobilized 4-bromobenzoic acid With potassium carbonate In water; N,N-dimethyl-formamide Stage #2: With potassium hydroxide In ethanol; water	A 100% B 19% C 81%

...Expand

: 2996-92-1
phenyl trimethylsiloxane

: 99-90-1
para-bromoacetophenone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With Br(1-)*C24H31BrN5O6Pd(1+); sodium hydroxide In water at 160℃; for 2h; Hiyama coupling; Sealed tube;	99%
With potassium fluoride; propylene glycol; chloro-[2-(9-phenyl-1,10-phenanthrolin-2-yl)phenyl]palladium In dichloromethane at 100℃; for 12h; Hiyama Coupling; Inert atmosphere;	99%
With sodium hydroxide; 4,4'-dichlorobenzophenone oxime-derived palladacycle at 120℃; under 7500.6 Torr; for 0.166667h; Hiyama coupling; microwave irradiation;	98%

: 2996-92-1
phenyl trimethylsiloxane

: 99-91-2
para-chloroacetophenone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With 3-(dicyclohexylphosphino)-2-(2-methoxyphenyl)-1-methyl-1-H-indole; tetrabutyl ammonium fluoride; palladium diacetate In water at 110℃; for 3h; Hiyama Coupling; Schlenk technique; Inert atmosphere; Sealed tube;	99%
With tBu2P-N=P(iBuPCH2CH2)3N; tetrabutyl ammonium fluoride; palladium diacetate In 1,4-dioxane at 80℃; for 1.5h; Hiyama coupling; Inert atmosphere;	95%
With tetrabutyl ammonium fluoride; palladium(II) acetylacetonate; 3,9-bis(2,4-tBu-PhO)tetraoxa-3,9-diphosphaspiro[5.5]undecane In xylene at 80℃; Hiyama coupling;	93%

: 195064-80-3
(1-biphenyl-4-yl-ethoxy)-trimethyl-silane

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With n-butyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.25h; Heating;	99%
With aluminium trichloride; tetramethylammonium chlorochromate In acetonitrile for 0.916667h; Heating;	96%
With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In dichloromethane for 0.0833333h; microwave irradiation;	92%

: 64101-67-3
4-acetylphenyl p-toluenesulfonate

: 98-80-6
phenylboronic acid

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With trans-chloro(1-naphthyl)bis-(triphenylphosphine)nickel(II); tricyclohexylphosphine tetrafluoroborate; potassium carbonate In water; toluene at 20℃; for 24h; Suzuki-Miyaura cross-coupling reaction; Inert atmosphere;	99%
With potassium phosphate; Ni(1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene)[P(OPh)3]2 In tetrahydrofuran at 70℃; for 18h; Suzuki-Miyaura Coupling; Sealed tube;	96%
With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; tricyclohexylphosphine In 1,4-dioxane at 130℃; Suzuki cross-coupling;	95%

: 143-66-8
sodium tetraphenyl borate

: 99-90-1
para-bromoacetophenone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With sodium hydroxide; palladium diacetate In water at 110℃; for 2h; Suzuki-type reaction;	99%
With tetrabutylammomium bromide; potassium carbonate In water at 120℃; for 0.25h; Suzuki cross-coupling reaction; Microwave irradiation; solid phase reaction;	95%
With sodium carbonate; palladium dichloride In methanol at 20℃; for 0.5h; Suzuki-Miyaura cross-coupling reaction;	93%

: 99-91-2
para-chloroacetophenone

poly(phenylmethylsiloxane): poly(phenylmethylsiloxane)

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
Stage #1: poly(phenylmethylsiloxane) With tetrabutyl ammonium fluoride In 1,4-dioxane at 20℃; for 1h; Stage #2: para-chloroacetophenone; (bis(tricyclohexyl)phosphine)palladium(II) dichloride In 1,4-dioxane at 100℃;	99%

: 4406-72-8
2-phenyl[1,3,2]dioxaborolane

: 13329-40-3
4-Iodoacetophenone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With potassium phosphate; aluminum oxide; ruthenium In 1,2-dimethoxyethane; water at 60℃; for 12h; Suzuki-Miyaura-type cross coupling reaction;	99%

: 99-90-1
para-bromoacetophenone

: potassium phenyltrifluoborate

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With water; palladium diacetate; sodium carbonate at 80℃; for 2h; Time; Suzuki Coupling; Green chemistry;	99%
With palladium diacetate; sodium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In water at 80℃; for 2h; Suzuki-Miyaura Coupling;	99%
With C14H21B10ClN2O2Pd*H2O; potassium carbonate In water at 110℃; for 10h; Reagent/catalyst; Suzuki Coupling;	99%

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 99-90-1
para-bromoacetophenone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With caesium carbonate In methanol at 60℃; for 24h; Suzuki-Miyaura reaction; Inert atmosphere;	99%
With potassium carbonate In water; N,N-dimethyl-formamide at 80℃; Suzuki-Miyaura cross-coupling reaction; Inert atmosphere;	99%
With potassium phosphate; (C5H5FeC5H3C(CH3)NC6H4CH3)PdCl(tricyclohexylphosphine); potassium acetate In 1,4-dioxane; water at 100℃; for 3h; Suzuki coupling; Inert atmosphere;	92%

: 64101-66-2
4’-benzenesulfoxyacetophenone

: 98-80-6
phenylboronic acid

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With potassium phosphate; (NC5H3(N2C7H4(CH2)3CH3)2)NiBr(1+)*Br(1-)=Ni(NC5H3(N2C7H4(CH2)3CH3)2)Br2; triphenylphosphine In 1,4-dioxane at 100℃; for 24h; Suzuki-Miyaura coupling;	99%

: 28179-30-8
1‐([1,1'‐biphenyl]‐4‐yl)‐2,2‐dibromoethan‐1‐one

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With sodium hydrogen telluride In ethyl acetate for 1h; Ambient temperature;	98%

: 135-73-9
2-Bromo-4'-phenylacetophenone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; meso-5,10,15,20-tetraphenyl-21-monothiaporphyrin; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 22℃; for 18h; Irradiation;	98%
With trimethylsilyl iodide In chloroform Ambient temperature; or reflux;	95%
With chloro-trimethyl-silane; sodium iodide In acetonitrile for 3h; Ambient temperature;	93%

: 7746-51-2
4-phenylacetophenone-4-nitrophenylhydrazone

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With quinolinium dichromate(VI) In acetonitrile for 2h; Heating;	98%
With benzyltriphenylphosphonium dichromate; silica gel for 0.25h;	94%
With 3-carboxypyridinium chlorochromate In acetonitrile for 2h; Heating;	84%
With Oxone; water; potassium hydrogencarbonate In acetone for 0.666667h; Heating;	58%

: 75408-89-8
4-acetylbiphenyl oxime

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; benzyltriphenylphosphonium chlorochromate In acetonitrile for 0.416667h; Heating;	98%
With 1,4-dibenzyl-1,4-diazoniabicyclo[2.2.2]octane chlorochromate In acetonitrile for 0.25h; Heating;	97%
With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In acetonitrile for 1.25h; Heating;	92%

: 108446-63-5
1-(1-biphenyl-4-yl-ethylidene)-2-phenylhydrazine

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With 1-benzyl-4-aza-1-azoniabiyclo<2.2.2>octane peroxodisulfate In acetonitrile for 0.833333h; Heating;	98%
With benzyltriphenylphosphonium dichromate In acetonitrile for 0.416667h; Oxidation; Heating;	98%
With quinolinium dichromate(VI) In acetonitrile for 0.75h; Heating;	98%

: 13329-40-3
4-Iodoacetophenone

: 5747-23-9
2-phenyl-1,3,2-benzodioxaborole

: 92-91-1
biphenyl-4-acetaldehyde

Conditions

Conditions	Yield
With potassium carbonate; aluminum oxide; ruthenium In 1,2-dimethoxyethane; water at 80℃; for 12h; Suzuki-Miyaura-type cross coupling reaction;	98%

: 92-91-1
biphenyl-4-acetaldehyde

: 135-73-9
2-Bromo-4'-phenylacetophenone

Conditions

Conditions	Yield
With bromine In 1,4-dioxane; diethyl ether for 0.5h; Ambient temperature;	100%
With phenyltrimethylammonium bromide dibromide In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	100%
With pol(vinylphenyltrimethylammoniumtribromide) resin In methanol; water at 65℃; for 1h;	97%

: 92-91-1
biphenyl-4-acetaldehyde

: 95-92-1
oxalic acid diethyl ester

: 41350-17-8
ethyl 3-(4-phenylbenzoyl)-2-ketopropionate

Conditions

Conditions	Yield
Stage #1: biphenyl-4-acetaldehyde With lithium hexamethyldisilazane In tetrahydrofuran; dichloromethane at -78℃; for 0.75h; Stage #2: oxalic acid diethyl ester In tetrahydrofuran; dichloromethane at 0 - 20℃; for 16h; Stage #3: With water; ammonium chloride In tetrahydrofuran; dichloromethane	100%
With sodium ethanolate In benzene for 4.5h; Ambient temperature;	70%
With sodium
Stage #1: oxalic acid diethyl ester With sodium ethanolate In toluene for 0.166667h; Cooling with ice; Stage #2: biphenyl-4-acetaldehyde In toluene for 4h; Cooling with ice;
With sodium In diethyl ether at 20 - 40℃;

: 92-91-1
biphenyl-4-acetaldehyde

: 104-88-1
4-chlorobenzaldehyde

: 13662-60-7
4-Chloro-4'-phenylchalcone

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 35 - 40℃; for 2.5h;	100%
With sodium hydroxide In ethanol
With sodium hydroxide In ethanol; water for 0.5h; Heating;

: 92-91-1
biphenyl-4-acetaldehyde

: 75408-89-8
4-acetylbiphenyl oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In ethanol; water Reflux;	100%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water at 95℃;	100%
	96%

: 92-91-1
biphenyl-4-acetaldehyde

: 6326-64-3
1,3,5-tris(1,1'-biphenyl-4-yl)benzene

Conditions

Conditions	Yield
With trichloro(trifluoromethanesulfonato)titanium(IV) at 90 - 100℃; for 10h;	99%
With phosphomolybdic acid In ethanol for 4h; Reflux;	92%
With para-dodecylbenzenesulfonic acid In neat (no solvent) at 130℃; for 3h; Green chemistry;	92%

: 92-91-1
biphenyl-4-acetaldehyde

: 5707-44-8
4-ethylbiphenyl

Conditions

Conditions	Yield
With hydrogenchloride; palladium 10% on activated carbon; zinc In water at 50℃;	99%
With chlorobenzene In methanol at 40℃; for 4h; Sealed tube; Green chemistry; chemoselective reaction;	99%
With palladium 10% on activated carbon; hydrogen In ethanol at 100℃; under 760.051 - 1520.1 Torr; for 24h; Reagent/catalyst;	99%

: 92-91-1
biphenyl-4-acetaldehyde

: 3562-73-0
1-(4-phenyl-phenyl)-1-ethanol

Conditions

Conditions	Yield
With sodium tetrahydroborate; Dowex1-x8 In tetrahydrofuran for 2.8h; Heating;	99%
With sodium tetrahydroborate In tetrahydrofuran for 1.8h; Heating; ultrasound irradiation;	99%
With diethoxymethylane; iron(II) acetate In tetrahydrofuran at 65℃; for 24h;	99%

: 92-91-1
biphenyl-4-acetaldehyde

: 10426-00-3
1,2-Di-biphenyl-1,2-dimethyl-1,2-ethandiol

Conditions

Conditions	Yield
With 2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester; Cu(5-(4-fluorosulfonyl)amino-3-(2-pyridyl)-pyrazole)((rac)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene)BF4 In tetrahydrofuran for 18h; Pinacol Rearrangement; Irradiation;	99%
With lithium amalgam; (S,S)-(+)-N,N,N',N'-tetramethyl-1,4-diamino-2,3-dimethoxybutane for 20h; Ambient temperature;	86%
With samarium diiodide In tetrahydrofuran for 2h; Ambient temperature;	48%
With aluminium amalgam

: 92-91-1
biphenyl-4-acetaldehyde

: 3562-73-0, 25675-30-3, 120924-81-4, 150283-02-6
(S)-1-(p-biphenyl)ethanol

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C53H73FeN2O2PS; hydrogen; lithium tert-butoxide In isopropyl alcohol at 25 - 30℃; under 22801.5 Torr; for 12h; Autoclave; enantioselective reaction;	99%
With (mer-[(S,S)-1,5-dimethyl-2,4-bis(4-phenyl-1,3-oxazolin-2-yl)benzene(1-)]Ru(CO)Cl)2(ZnCl2); hydrogen; sodium methylate; (-)-(S)-1-Anthracen-9-ylethanol In isopropyl alcohol at 40℃; under 22801.5 Torr; for 24h; Inert atmosphere; Autoclave; optical yield given as %ee; enantioselective reaction;	98%
With Debaryomyces hansenii P1 at 30℃; for 48h; pH=5.5; Microbiological reaction; enantioselective reaction;	92%

4-Acetylbiphenyl Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

4-Acetylbiphenyl Specification

The Ethanone, 1-(1,1'-biphenyl)-4-yl-, with the CAS registry number 92-91-1 and EINECS registry number 202-202-6, has the systematic name of 1-(biphenyl-4-yl)ethanone. And the molecular formula of this chemical is C₁₄H₁₂O. It is a kind of off-white to beige powder, and belongs to the following product categories: Fine chemical & intermediates; Biphenyl derivatives; API intermediates; Adehydes, Acetals & Ketones. What's more, it is an inhibitor of renieratene, and it is also used in the organic synthesis. In addition, it is used intermediates of liquid crystals.

The physical properties of Ethanone, 1-(1,1'-biphenyl)-4-yl- are as following: (1)ACD/LogP: 3.51; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.51; (4)ACD/LogD (pH 7.4): 3.51; (5)ACD/BCF (pH 5.5): 274.52; (6)ACD/BCF (pH 7.4): 274.52; (7)ACD/KOC (pH 5.5): 1937.02; (8)ACD/KOC (pH 7.4): 1937.02; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 17.07 Å²; (13)Index of Refraction: 1.567; (14)Molar Refractivity: 60.87 cm³; (15)Molar Volume: 186.2 cm³; (16)Polarizability: 24.13×10^-24cm³; (17)Surface Tension: 39.1 dyne/cm; (18)Density: 1.053 g/cm³; (19)Flash Point: 139.9 °C; (20)Enthalpy of Vaporization: 56.82 kJ/mol; (21)Boiling Point: 326 °C at 760 mmHg; (22)Vapour Pressure: 0.000222 mmHg at 25°C.

Uses of Ethanone, 1-(1,1'-biphenyl)-4-yl-: It can react with morpholine to produce 4-(biphenyl-4-yl-thioacetyl)-morpholine. This reaction will need reagent sulfur. The reaction time is 4 minutes with microwave irradiation, and the yield is about 95%.

Ethanone, 1-(1,1'-biphenyl)-4-yl- can react with morpholine to produce 4-(biphenyl-4-yl-thioacetyl)-morpholine

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Do not breathe dust; Avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c2ccc(c1ccccc1)cc2)C
(2)InChI: InChI=1/C14H12O/c1-11(15)12-7-9-14(10-8-12)13-5-3-2-4-6-13/h2-10H,1H3
(3)InChIKey: QCZZSANNLWPGEA-UHFFFAOYAF

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	> 2gm/kg (2000mg/kg)		Medicina Experimentalis. Vol. 11, Pg. 137, 1964.

Product Name

4-Acetylbiphenyl

Synthetic route

4-Acetylbiphenyl Standards and Recommendations

4-Acetylbiphenyl Specification

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