Product Name

  • Name

    4-Acryloylmorpholine

  • EINECS 418-140-1
  • CAS No. 5117-12-4
  • Article Data56
  • CAS DataBase
  • Density 1.122
  • Solubility 1000g/L at 20℃
  • Melting Point -35 ºC
  • Formula C7H11 N O2
  • Boiling Point 296.8 °C at 760 mmHg
  • Molecular Weight 141.17
  • Flash Point >110 ºC
  • Transport Information
  • Appearance
  • Safety S23;S26;S36/37/39
  • Risk Codes R22;R41;R43;R48/22   
  • Molecular Structure Molecular Structure of 5117-12-4 (4-Acryloylmorpholine)
  • Hazard Symbols
  • Synonyms Morpholine,4-(1-oxo-2-propenyl)- (9CI); Morpholine, 4-acryloyl- (6CI,7CI,8CI);1-(Morpholin-4-yl)propenone; 4-Acryloylmorpholine; A-MO; ACMO;Acryloylmorpholine; Kayarad RM 1001; MA 1; MA 1 (amide); N-Acryloylmorpholine;NK Ester A-MO; NSC 162221
  • PSA 29.54000
  • LogP -0.03090

Synthetic route

C11H21NO3

C11H21NO3

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With 10H-phenothiazine; sodium methylate In glycerol at 200℃; Pyrolysis;97%
(+/-)-2-hydroxy-1-morpholinopropan-1-one
27097-66-1

(+/-)-2-hydroxy-1-morpholinopropan-1-one

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With sulfuric acid; acetic anhydride at 550℃; Temperature;96.1%
4-(3-methoxy-propionyl)-morpholine
860248-52-8

4-(3-methoxy-propionyl)-morpholine

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With sodium methylate; 4-methoxy-phenol at 200℃; Pyrolysis;96%
With lithium phosphate at 390℃; Pyrolysis;
β-morpholinyl-N,N-morpholinylpropionic acid amide
3773-84-0

β-morpholinyl-N,N-morpholinylpropionic acid amide

acetic anhydride
108-24-7

acetic anhydride

A

4-acetylmorpholine
1696-20-4

4-acetylmorpholine

B

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
Stage #1: β-morpholinyl-N,N-morpholinylpropionic acid amide; acetic anhydride In toluene at 20 - 80℃; for 2h; Inert atmosphere;
Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol; N-ethyl-N,N-diisopropylamine for 18h; Reagent/catalyst; Temperature; Reflux;
A 84%
B 95%
3-(diethylamino)-1-morpholinopropan-1-one

3-(diethylamino)-1-morpholinopropan-1-one

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
Stage #1: 3-(diethylamino)-1-morpholinopropan-1-one With acetic anhydride In toluene at 20 - 80℃; for 2h; Inert atmosphere;
Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol; triethylamine Reflux;
94%
With 4-methoxy-phenol11.8 g
morpholine
110-91-8

morpholine

acrylic acid anhydride
2051-76-5

acrylic acid anhydride

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With 10H-phenothiazine; sulfuric acid for 2h; Reagent/catalyst; Heating;93.12%
3-(hexyloxy)-1-morpholinopropan-1-one

3-(hexyloxy)-1-morpholinopropan-1-one

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With 10H-phenothiazine; sodium methylate; 4-methoxy-phenol In glycerol at 160℃; Pyrolysis;92%
α-bromomorpholinopropanamide
2620-13-5

α-bromomorpholinopropanamide

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 78℃; for 5h; Temperature;91.5%
1-morpholinopropane-1-one
30668-14-5

1-morpholinopropane-1-one

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With potassium tert-butylate; oxygen; palladium diacetate In dimethyl sulfoxide at 90 - 120℃; under 760.051 Torr; for 36h; Reagent/catalyst; Temperature;90%
morpholine
110-91-8

morpholine

C5H3Cl3O3

C5H3Cl3O3

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With triethylamine at 0 - 3℃; for 2h; Reagent/catalyst; Temperature;89.95%
β-morpholinyl-N,N-morpholinylpropionic acid amide
3773-84-0

β-morpholinyl-N,N-morpholinylpropionic acid amide

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With 10H-phenothiazine; copper(II) bis(trifluoromethanesulfonate) at 135℃; for 2h; Inert atmosphere;89%
With 4-methoxy-phenol8.46 g
With 10H-phenothiazine; sulfuric acid; 4-methoxy-phenol at 180 - 220℃; under 450.045 Torr; for 6h; Reagent/catalyst;
With 10H-phenothiazine In glycerol at 150℃; under 52.5053 Torr; for 0.5h; Reagent/catalyst; Solvent; Inert atmosphere;
2-iodopropionyl morpholine

2-iodopropionyl morpholine

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 85℃; for 3h;88.7%
4-acetylmorpholine
1696-20-4

4-acetylmorpholine

formaldehyd
50-00-0

formaldehyd

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With sodium hydroxide at 85 - 90℃;85.5%
With potassium tert-butylate In water at 120℃; for 3h; Reagent/catalyst; Temperature;20.7%
β-morpholinyl-N,N-morpholinylpropionic acid amide
3773-84-0

β-morpholinyl-N,N-morpholinylpropionic acid amide

benzyl bromide
100-39-0

benzyl bromide

A

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

B

4-benzyl-morpholine
10316-00-4

4-benzyl-morpholine

Conditions
ConditionsYield
Stage #1: β-morpholinyl-N,N-morpholinylpropionic acid amide; benzyl bromide In toluene at 20 - 80℃; for 2h; Inert atmosphere;
Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol; triethylamine for 12h; Reflux;
A 77%
B 84%
morpholine
110-91-8

morpholine

acrylic acid
79-10-7

acrylic acid

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With 4-methoxy-phenol; trichlorophosphate In dichloromethane at 0 - 5℃; for 1h; Reagent/catalyst; Concentration; Solvent;81%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 12h;21%
β-ethoxy-N-morpholinylpropionamide

β-ethoxy-N-morpholinylpropionamide

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate); hydroquinone at 100℃; for 10h; Inert atmosphere;80%
morpholine
110-91-8

morpholine

acryloyl chloride
814-68-6

acryloyl chloride

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With triethylamine In dichloromethane 1 h, 0 deg C then 1 h, room temp.;78%
With triethylamine 1.) 0 deg C, 1 h; 2.) r.t., 1 h;78%
In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;63%
morpholine acrylate

morpholine acrylate

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With phosphorus pentoxide In N,N-dimethyl-formamide at 135℃; Temperature; Solvent;77.6%
morpholin hydrochloride
10024-89-2

morpholin hydrochloride

acryloyl chloride
814-68-6

acryloyl chloride

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
In dichloromethane 1.) 0 deg C, 483 min; 2.) 25 deg C, 1 h;76%
acrylic acid
79-10-7

acrylic acid

3-methyl-1-(morpholin-4-ylcarbonyl)-1H-imidazol-3-ium iodide

3-methyl-1-(morpholin-4-ylcarbonyl)-1H-imidazol-3-ium iodide

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 16h;75%
1,3,5-Trioxan
110-88-3

1,3,5-Trioxan

4-acetylmorpholine
1696-20-4

4-acetylmorpholine

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With sulfuric acid at 120℃; for 3h; Inert atmosphere;28.2%
morpholine
110-91-8

morpholine

acryloyl chloride
814-68-6

acryloyl chloride

A

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

B

β-morpholinyl-N,N-morpholinylpropionic acid amide
3773-84-0

β-morpholinyl-N,N-morpholinylpropionic acid amide

Conditions
ConditionsYield
With triethylamine; benzene
morpholine
110-91-8

morpholine

acetylene
74-86-2

acetylene

CO

CO

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With tetracarbonyl nickel; acrylic acid; toluene
N-(propadienyloxy)morpholine
71145-92-1

N-(propadienyloxy)morpholine

A

morpholine
110-91-8

morpholine

B

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With triethylamine In ethanol for 1h; Heating;A 40 % Chromat.
B 60 % Chromat.
N-prop-2-ynylmorpholine N-oxide
71145-90-9

N-prop-2-ynylmorpholine N-oxide

A

morpholine
110-91-8

morpholine

B

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

C

N-propargylmorpholine
5799-76-8

N-propargylmorpholine

D

3-(3-oxapentane-1,5-diyl)aminoacrylaldehyde
34900-00-0

3-(3-oxapentane-1,5-diyl)aminoacrylaldehyde

Conditions
ConditionsYield
With triethylamine In tert-butyl alcohol at 50 - 79℃; Product distribution; Activation energy; Kinetics; Further Variations:; Solvents; Temperatures; Reagents; pH-values;
2-chloro-1-(4-morpholino)propan-1-one
54022-76-3

2-chloro-1-(4-morpholino)propan-1-one

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 70℃; for 8h;569 g
3-(dioctadecylamino)propionylmorpholine

3-(dioctadecylamino)propionylmorpholine

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
With 4-methoxy-phenol19.2 g
morpholine
110-91-8

morpholine

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

acrylic acid
79-10-7

acrylic acid

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Conditions
ConditionsYield
Stage #1: morpholine; acrylic acid methyl ester With 2,6-di-tert-butyl-4-methyl-phenol at 20 - 55℃; for 3h; Inert atmosphere;
Stage #2: With sodium methylate In methanol at 55 - 75℃; for 6.5h;
Stage #3: acrylic acid With 2,6-di-tert-butyl-4-methyl-phenol In 5,5-dimethyl-1,3-cyclohexadiene at 140 - 145℃; for 2h;
S-1-butyl-S'-(α-methyl-α'-acetic acid)trithiocarbonate
480436-46-2

S-1-butyl-S'-(α-methyl-α'-acetic acid)trithiocarbonate

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

C78H124N10O22S3

C78H124N10O22S3

Conditions
ConditionsYield
With 2,2’-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride In 1,4-dioxane; water at 70℃; for 2h; Inert atmosphere;99%
With 4,4'-dicyano-4,4'-azo-di-valeric acid In 1,4-dioxane; water at 70℃; for 24h;
pyrrolidine
123-75-1

pyrrolidine

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

1-morpholino-3-(pyrrolidin-1-yl)propan-1-one
99991-64-7

1-morpholino-3-(pyrrolidin-1-yl)propan-1-one

Conditions
ConditionsYield
In dichloromethane for 1h; Inert atmosphere; Reflux;98%
With [DABCO-PDO][OAc] In neat (no solvent) at 20℃; for 2h; Michael Addition; Green chemistry;90%
With triethylamine In water at 20℃; for 2h; Michael Addition; Green chemistry;89%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

3-chloro-8-methyl-6-trifluoromethylsulfonyloxy-8H-quino[4,3,2-kl]acridine
410533-71-0

3-chloro-8-methyl-6-trifluoromethylsulfonyloxy-8H-quino[4,3,2-kl]acridine

(E)-3-(3-chloro-8-methyl-8H-quino[4,3,2-kl]acridin-6-yl)acrylic acid (morpholin-1-yl)amide
410533-78-7

(E)-3-(3-chloro-8-methyl-8H-quino[4,3,2-kl]acridin-6-yl)acrylic acid (morpholin-1-yl)amide

Conditions
ConditionsYield
With triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 18h; Heck reaction;98%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

phenylacetylene
536-74-3

phenylacetylene

C15H17NO2
1453502-78-7

C15H17NO2

Conditions
ConditionsYield
With C29H26N2O5Ru; sodium acetate In 1,4-dioxane at 100℃; for 96h; Inert atmosphere;98%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

5,5'-dibromo-2,2'-bisthiophene
4805-22-5

5,5'-dibromo-2,2'-bisthiophene

4,4′-{2,2′-bithiene-5,5′-diylbis-[(1E)-3-oxoprop-1-ene-1,3-diyl]}dimorpholine
1435912-85-8

4,4′-{2,2′-bithiene-5,5′-diylbis-[(1E)-3-oxoprop-1-ene-1,3-diyl]}dimorpholine

Conditions
ConditionsYield
With dichloro{bis[1,1’,1’’-(phosphinetriyl)tripiperidine]}palladium(II); tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 100℃; for 24h; Heck Reaction; Schlenk technique; Glovebox; Inert atmosphere; Green chemistry;98%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

2-benzyl tetrahydropyrrolo[1,2-a]piperazine-1,3,4-trione

2-benzyl tetrahydropyrrolo[1,2-a]piperazine-1,3,4-trione

8-benzyl-7-hydroxy-11-(morpholine-4-carbonyl)-5,8-diazatricyclo[5.2.2.01,5]undecane-6,9-dione

8-benzyl-7-hydroxy-11-(morpholine-4-carbonyl)-5,8-diazatricyclo[5.2.2.01,5]undecane-6,9-dione

Conditions
ConditionsYield
With C33H30N2O In dichloromethane at -78 - -30℃; for 44h; Michael Addition; Inert atmosphere; enantioselective reaction;98%
methanol
67-56-1

methanol

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

carbon monoxide
201230-82-2

carbon monoxide

dimethyl 2-(morpholine-4-carbonyl)succinate

dimethyl 2-(morpholine-4-carbonyl)succinate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; N,N'-bis(2,6-dimethylphenyl)butane-2,3-diimine; toluene-4-sulfonic acid; p-benzoquinone In tetrahydrofuran at 20℃; under 3000.3 Torr; for 67h; Autoclave;98%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

(+/-)-3-(trans-3,4-dimethylpiperidinyl)phenol

(+/-)-3-(trans-3,4-dimethylpiperidinyl)phenol

(+/-)-3-[trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidinyl]-1-(4-morpholinyl)-1-propanone

(+/-)-3-[trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidinyl]-1-(4-morpholinyl)-1-propanone

Conditions
ConditionsYield
In tetrahydrofuran97%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

ethyl (E)-2,2-difluoro-5-morpholino-5-oxopent-3-enoate

ethyl (E)-2,2-difluoro-5-morpholino-5-oxopent-3-enoate

Conditions
ConditionsYield
With copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine In acetonitrile at 80℃; for 12h; Schlenk technique; Inert atmosphere; stereoselective reaction;97%
indole
120-72-9

indole

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

C15H18N2O2

C15H18N2O2

Conditions
ConditionsYield
With potassium tert-butylate In neat (no solvent) at 20℃; for 0.333333h; Michael Addition; Inert atmosphere;96%
tert-butyl 5-iodo-1H-indole-1-carboxylate
374818-66-3

tert-butyl 5-iodo-1H-indole-1-carboxylate

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

t-butyl (E)-5-(3-morpholino-3-oxoprop-1-en-1-yl)-1H-indole-1-carboxylate

t-butyl (E)-5-(3-morpholino-3-oxoprop-1-en-1-yl)-1H-indole-1-carboxylate

Conditions
ConditionsYield
With potassium phosphate; sodium chloride In water; N,N-dimethyl-formamide at 45℃; for 16h; Micellar solution;96%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

3-aminopropyltriethoxysilane
919-30-2

3-aminopropyltriethoxysilane

C16H34N2O5Si

C16H34N2O5Si

Conditions
ConditionsYield
at 70 - 100℃; for 3.16667h;95%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

1-Bromonaphthalene
90-11-9

1-Bromonaphthalene

(E)-1-morpholino-3-(naphthalen-1-yl)prop-2-en-1-one
26163-75-7

(E)-1-morpholino-3-(naphthalen-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
With dichloro{bis[1,1’,1’’-(phosphinetriyl)tripiperidine]}palladium(II); tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 100℃; for 6h; Heck Reaction; Schlenk technique; Glovebox; Inert atmosphere; Green chemistry;95%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

hexan-1-ol
111-27-3

hexan-1-ol

3-(hexyloxy)-1-morpholinopropan-1-one

3-(hexyloxy)-1-morpholinopropan-1-one

Conditions
ConditionsYield
With potassium tert-butylate In neat (no solvent) at 20℃; for 0.333333h; Michael Addition; Inert atmosphere;95%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

(E)-1-morpholino-3-(4-phenoxyphenyl)prop-2-en-1-one
1435912-84-7

(E)-1-morpholino-3-(4-phenoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With dichloro{bis[1,1’,1’’-(phosphinetriyl)tripiperidine]}palladium(II); tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 100℃; for 24h; Heck Reaction; Schlenk technique; Glovebox; Inert atmosphere; Green chemistry;94%
3-phenyl-4-iodo-5-methylisoxazole
31295-66-6

3-phenyl-4-iodo-5-methylisoxazole

N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

(E)-3-(5-methyl-3-phenylisoxazol-4-yl)-1-morpholinoprop-2-en-1-one

(E)-3-(5-methyl-3-phenylisoxazol-4-yl)-1-morpholinoprop-2-en-1-one

Conditions
ConditionsYield
With tetrabutyl-ammonium chloride; sodium carbonate; palladium diacetate In N,N-dimethyl-formamide at 85℃; for 24h; Heck cross-coupling;93%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

tert-butyl 4-(4-chloro-2-methoxyphenyl)-3,6-dihydropyridine-1(2H)-carboxylate
607744-56-9

tert-butyl 4-(4-chloro-2-methoxyphenyl)-3,6-dihydropyridine-1(2H)-carboxylate

tert-butyl 4-{2-methoxy-4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-enyl]phenyl}-3,6-dihydropyridine-1(2H)-carboxylate
607744-57-0

tert-butyl 4-{2-methoxy-4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-enyl]phenyl}-3,6-dihydropyridine-1(2H)-carboxylate

Conditions
ConditionsYield
With N-Methyldicyclohexylamine; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine In 1,4-dioxane at 120℃;93%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

diethyl (N-benzylideneaminomethyl)phosphonate
50917-73-2

diethyl (N-benzylideneaminomethyl)phosphonate

diethyl ((2S,4S,5S)-4-(morpholine-4-carbonyl)-5-phenylpyrrolidine-2-yl)phosphonate
1216933-33-3

diethyl ((2S,4S,5S)-4-(morpholine-4-carbonyl)-5-phenylpyrrolidine-2-yl)phosphonate

Conditions
ConditionsYield
With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; silever triflate; potassium hexamethylsilazane In toluene at 25℃; for 2h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;93%
With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; silver bis(trimethylsilyl)amide In toluene at 25℃; for 2h; Inert atmosphere; optical yield given as %ee; stereoselective reaction;93%
With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; silver bis(trimethylsilyl)amide In toluene at 25℃; enantioselective reaction;93%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

2-bromo-2-methyl-N-phenylbutanamide
1970-59-8

2-bromo-2-methyl-N-phenylbutanamide

C18H24N2O3

C18H24N2O3

Conditions
ConditionsYield
With copper(l) iodide; benzyl tri-n-butylammonium bromide; tris[(2-pyridylmethyl)amine]; diisopropylamine In toluene at 100℃; for 20h; Inert atmosphere;93%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

1,4-bromoiodobenzene
589-87-7

1,4-bromoiodobenzene

2-(4-bromophenyl)-1-morpholinopropan-1-one

2-(4-bromophenyl)-1-morpholinopropan-1-one

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tetramethylammonium formiate; P(p-C6H4F)3 In 1,4-dioxane; water at 80℃; for 4h; Sealed tube;93%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

3-chloro-8-methyl-8H-quino[4,3,2-kl]acridine
410533-61-8

3-chloro-8-methyl-8H-quino[4,3,2-kl]acridine

(E)-3-(8-methyl-8H-quino[4,3,2-kl]acridin-3-yl)acrylic acid (morpholin-4-yl)amide
410533-77-6

(E)-3-(8-methyl-8H-quino[4,3,2-kl]acridin-3-yl)acrylic acid (morpholin-4-yl)amide

Conditions
ConditionsYield
With potassium phosphate; tri-tert-butyl phosphine; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 170℃; for 48h; Heck reaction;92%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

methyl 2-(benzylideneamino)acetate
66646-88-6

methyl 2-(benzylideneamino)acetate

(2R,4S,5S)-methyl 4-(morpholine-4-carbonyl)-5-phenylpyrrolidine-2-carboxylate
1310430-72-8

(2R,4S,5S)-methyl 4-(morpholine-4-carbonyl)-5-phenylpyrrolidine-2-carboxylate

Conditions
ConditionsYield
With (R)-DTBM-segphos; silver trifluoromethanesulfonate; potassium hexamethylsilazane In diethyl ether at 0℃; for 24h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;92%
With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; silver bis(trimethylsilyl)amide In diethyl ether at 0℃; for 24h; Inert atmosphere; optical yield given as %ee; stereoselective reaction;92%
With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; silver bis(trimethylsilyl)amide In diethyl ether at 0℃; for 24h; enantioselective reaction;92%
N-Acryloylmorpholine
5117-12-4

N-Acryloylmorpholine

3-((7-chloro-3-iodoimidazo[1,2-a]pyridin-2-yl)methyl)-1-cyclopropyl-1H-imidazo[4,5-c]pyridin-2(3H)-one
1383080-93-0

3-((7-chloro-3-iodoimidazo[1,2-a]pyridin-2-yl)methyl)-1-cyclopropyl-1H-imidazo[4,5-c]pyridin-2(3H)-one

(E)-3-((7-chloro-3-(3-morpholino-3-oxoprop-1-enyl)imidazo[1,2-a]pyridin-2-yl)methyl)-1-cyclopropyl-1H-imidazo[4,5-c]pyridin-2(3H)-one
1383080-25-8

(E)-3-((7-chloro-3-(3-morpholino-3-oxoprop-1-enyl)imidazo[1,2-a]pyridin-2-yl)methyl)-1-cyclopropyl-1H-imidazo[4,5-c]pyridin-2(3H)-one

Conditions
ConditionsYield
Stage #1: N-Acryloylmorpholine; 3-((7-chloro-3-iodoimidazo[1,2-a]pyridin-2-yl)methyl)-1-cyclopropyl-1H-imidazo[4,5-c]pyridin-2(3H)-one With triphenylphosphine; palladium diacetate In tetrahydrofuran at 80℃; for 2h; Inert atmosphere;
Stage #2: With water for 1h;
92%

4-Acryloylmorpholine Chemical Properties

The molecular structure of 2-Propen-1-one,1-(4-morpholinyl)- (CAS NO.5117-12-4) is

IUPAC Name: 1-Morpholin-4-ylprop-2-en-1-one 
Canonical SMILES: C=CC(=O)N1CCOCC1
Molecular Formula: C7H11 N O2
Molecular Weight: 141.17
Density: 1.074 g/cm3
Melting Point: -35 ºC
Boiling Point: 296.8 °C at 760 mmHg
Flash Point: 133.3 °C
Freely Rotating Bonds: 1
Polar Surface Area: 29.54 Å2
Index of Refraction: 1.477
Molar Refractivity: 37.18 cm3
Molar Volume: 131.4 cm3
Polarizability: 14.74× 10-24 cm3
Surface Tension: 35.9 dyne/cm
Enthalpy of Vaporization: 53.66 kJ/mol
Vapour Pressure: 0.00141 mmHg at 25°C 
The Cas Register Number  of 2-Propen-1-one,1-(4-morpholinyl)- is 5117-12-4. The chemical synonyms of 2-Propen-1-one,1-(4-morpholinyl)- (CAS NO.5117-12-4) are Acryloyl morpholine;4-Acryloylmorpholine ; N-Acryloylmorpholine ; 4-(1-Oxo-2-propenyl)-Morpholine ; N-Acrolylmorpholine ; N-Acrylylmorpholine  ; 4-Acryloylmorpholine,98+% ; Morpholine, 4-(1-oxo-2-propenyl)- . Its product categories are Acrylate ; Acrylic Monomers ; Monomers .

4-Acryloylmorpholine Uses

 2-Propen-1-one,1-(4-morpholinyl)- (CAS NO.5117-12-4) isused as  pharmaceutical intermediate.

4-Acryloylmorpholine Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 22-41-43-48/22 
R22: Harmful if swallowed. 
R41: Risk of serious damage to the eyes. 
R43: May cause sensitization by skin contact. 
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed.
Safety Statements: 23-26-36/37/39 
S23: Do not breathe vapour. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 2

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View