4-BIPHENYLACETIC ACID supplier

Name
4-Biphenylacetic acid
EINECS 227-233-2
CAS No. 5728-52-9
Article Data93
CAS DataBase
Density 1.165 g/cm³
Solubility 39.27mg/L(25 oC)
Melting Point 159-160 °C(lit.)
Formula C₁₄H₁₂O₂
Boiling Point 389.8 °C at 760 mmHg
Molecular Weight 212.248
Flash Point 286.6 °C
Transport Information UN 2811 6.1/PG 3
Appearance Off-white powder
Safety 26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
Risk Codes 23/25-36/37/38-25-36/37/38/63-20/21/22
Molecular Structure
Hazard Symbols T, Xn
Synonyms 4-Biphenylaceticacid (8CI);Acetic acid, (4-biphenylyl)- (6CI,7CI);([1,1'-Biphenyl]-4-yl)acetic acid;2-(Biphenyl-4-yl)acetic acid;4-Biphenylylaceticacid;4-Carboxymethylbiphenyl;4-Phenylphenylacetic acid;BPAA;Cl 83544;L 141;Seltouch;Traxam;p-Biphenylacetic acid;p-Biphenylylacetic acid;
PSA 37.30000
LogP 2.98070

Synthetic route

: 98-80-6
phenylboronic acid

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With sodium carbonate; Pd-complex on fluorous reversed silica gel In water at 80℃; for 16h; Suzuki reaction;	100%
With carbon-doped cobalt; C118H94N4O7P8; palladium diacetate; sodium carbonate In tetrahydrofuran; water at 20 - 60℃; for 14h; Suzuki Coupling; Inert atmosphere;	100%
With palladium diacetate; potassium carbonate In water; toluene at 65℃; for 20h; Solvent; Suzuki-Miyaura Coupling;	100%

: 59793-29-2
methyl 2-(1,1'-biphenyl-4-yl)acetate

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With methanol; potassium hydroxide for 10h; Reflux;	99%
With water; sodium hydroxide at 70℃; for 4h;	75.5%
With sodium hydroxide In methanol for 4h; Ambient temperature; Yield given;
With water; sodium hydroxide at 20℃; for 3h;	2.56 g

: 31603-77-7
4-biphenylacetonitrile

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With water; potassium hydroxide In ethylene glycol at 120℃; for 16h;	97.6%
With hydrogenchloride
With water; sodium hydroxide for 4h; Time; Reflux;
With sodium hydroxide In water; butan-1-ol at 100℃; for 8h; Temperature;

: 143-66-8
sodium tetraphenyl borate

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With sodium carbonate; palladium on activated charcoal In water for 1h; Suzuki reaction; Heating;	96%

: 1878-66-6
4-chlorophenylacetic Acid

: potassium phenyltrifluoborate

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With choline chloride; palladium diacetate; sodium carbonate; glycerol at 100℃; for 5h; Suzuki-Miyaura Coupling;	95%
With C16H16Cl2N2O4Pd2; tetrabutylammomium bromide; potassium carbonate In water at 100℃; under 749.884 Torr; for 0.25h; Microwave irradiation; Darkness; Inert atmosphere;	86%

: 14062-23-8
4-biphenylylacetic acid ethyl ester

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
Stage #1: 4-biphenylylacetic acid ethyl ester With potassium hydroxide In water for 0.5h; Reflux; Stage #2: With hydrogenchloride In water	94%
With potassium hydroxide In 1,4-dioxane; water for 18h; Reflux;	76%

: 3418-30-2
2-Chlormethyl-2--<1.3>dioxolan

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With copper(l) iodide; zinc diacetate at 155℃; for 1.5h;	92.6%

: tert-butyl 4-biphenylacetylenyl ether

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With water; triethylamine In toluene at 75℃; for 12h; Inert atmosphere;	92%

: 5428-57-9
2-biphenyl-4-yl-1-morpholin-4-yl-ethanethione

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide for 0.0166667h; microwave irradiation;	90%
With potassium hydroxide 1.) EtOH, reflux; 2.) 100 deg C, 2 h;	79.7%
With sodium hydroxide In methanol; water for 8h; Reflux; Large scale;	78.2%

: C14H9O3(1-)*Na(1+)

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
Stage #1: C14H9O3(1-)*Na(1+) With hydrazine hydrate; sodium hydroxide In water at 80 - 100℃; for 17h; Stage #2: With hydrogenchloride In water pH=3; Temperature;	87.4%

: 2996-92-1
phenyl trimethylsiloxane

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide; 4,4'-dichlorobenzophenone oxime-derived palladacycle at 120℃; for 1.5h; Hiyama coupling;	84%
With 3-benzyl-1-(2-hydroxy-2-phenylethyl)imidazolium chloride; palladium diacetate; sodium hydroxide In water at 120℃; for 1h; Hiyama Coupling; Microwave irradiation;	81%
With 3-benzyl-1-(2-hydroxy-2-phenylethyl)imidazolium chloride; water; palladium diacetate; sodium hydroxide at 120℃; for 1h; Hiyama coupling; Microwave irradiation;	67%

: 1878-66-6
4-chlorophenylacetic Acid

: 98-80-6
phenylboronic acid

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; tetra(n-butyl)ammonium hydroxide; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate In N,N-dimethyl-formamide at 130℃; for 0.333333h; Suzuki-Miyaura coupling; Microwave irradiation;	82%
Stage #1: 4-chlorophenylacetic Acid; phenylboronic acid With sodium hydroxide In water at 20℃; for 0.0333333h; Suzuki-Miyaura Coupling; Inert atmosphere; Stage #2: With sodium (η3-allyl)(1,3-bis(2,6-diisopropyl-4-sulfonatophenyl)imidazol-2-ylidene)chloridopalladate(II) In water at 60℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	82.9%
With tetrabutylammomium bromide; potassium carbonate; di-μ-chlorobis[5-hydroxy-2-[1-(hydroxyimino)ethyl]phenyl]palladium(II) dimer In water for 2.5h; Suzuki cross-coupling; Heating;	50 % Chromat.
With phenone oxime-derived palladacycle; tetrabutylammomium bromide; potassium carbonate In water for 2.5h; Suzuki coupling; Heating;	50 % Spectr.

: 1667-11-4
biphenyl-4-methylchloride

: 201230-82-2
carbon monoxide

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry; Stage #2: biphenyl-4-methylchloride With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;	80%

: 124-38-9
carbon dioxide

: 1-([1,1'-biphenyl]-4-yl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; sodium carbonate; caesium carbonate In N,N-dimethyl-formamide at 25 - 30℃; under 760.051 Torr; for 26h; Schlenk technique; Glovebox; Irradiation; Sealed tube;	80%

: 140-89-6
potassium ethyl xanthogenate

: 210578-21-5
Biphenyl-4-yl-acetic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester

A: 5728-52-9
(4-biphenylyl)acetic acid

B: Dithiocarbonic acid O-ethyl ester S-(5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl) ester

Conditions

Conditions	Yield
With sodium dithionite In tetrahydrofuran; water	A 52% B 78%

...Expand

: 1878-66-6
4-chlorophenylacetic Acid

: 2996-92-1
phenyl trimethylsiloxane

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; palladium(II) acetylacetonate; 3,9-bis(2,4-tBu-PhO)tetraoxa-3,9-diphosphaspiro[5.5]undecane In xylene at 80℃; Hiyama coupling;	78%

: 124-38-9
carbon dioxide

: 91954-74-4
4-phenylbenzylidene hydrazine

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction;	77%

: 591-50-4
iodobenzene

: C8H6KO2(1-)*K(1+)

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
In ammonia for 5h; Phenylation; Irradiation;	73%

: 64-18-6
formic acid

: 1667-11-4
biphenyl-4-methylchloride

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium diacetate In N,N-dimethyl-formamide at 115℃; for 12h; Inert atmosphere;	73%

: 124-38-9
carbon dioxide

: 1202236-78-9
2-([1,1'-biphenyl]-4-ylmethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With potassium ethoxide In 1,4-dioxane at 100℃; for 24h;	70%

: 124-38-9
carbon dioxide

: 127292-60-8
1-([1,1’-biphenyl]-4-yl)-N,N-dimethylmethanamine

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; sodium carbonate; caesium carbonate; methyl trifluoromethanesulfonate In N,N-dimethyl-formamide at 20℃; for 36h; Irradiation;	63%

: 124-38-9
carbon dioxide

: 1533458-00-2
biphenyl-4-ylmethyl 2-methoxyacetate

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With manganese; dichlorobis(trimethylphosphine)nickel In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 24h; Schlenk technique;	60%

: 50-00-0
formaldehyd

: 92-52-4
biphenyl

: 124-38-9
carbon dioxide

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
Stage #1: formaldehyd; biphenyl With hydrogenchloride; phosphoric acid; acetic acid In water at 85℃; for 24h; Stage #2: carbon dioxide With iodine; magnesium In ethyl bromide; diethyl ether at 38℃; for 2.25h; Cooling with ice;	53.24%

...Expand

: 99-90-1
para-bromoacetophenone

: 98-80-6
phenylboronic acid

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
Stage #1: para-bromoacetophenone; phenylboronic acid With potassium carbonate In tetrahydrofuran for 2h; Inert atmosphere; Stage #2: With morpholine; sulfur for 8h; Reflux;	44.82%

: 1667-11-4
biphenyl-4-methylchloride

: 124-38-9
carbon dioxide

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With samarium; chloro-trimethyl-silane; tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; under 760.051 Torr; for 2h; Electrochemical reaction; Cooling with ice;	43%

: 447465-00-1
biphenyl-4-yl-(toluene-4-sulfonyl)-acetic acid ethyl ester

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
Stage #1: biphenyl-4-yl-(toluene-4-sulfonyl)-acetic acid ethyl ester With magnesium; mercury dichloride In methanol at 20 - 50℃; for 24h; Stage #2: With potassium hydroxide In methanol at 20℃; for 24h; Further stages.;	30%

: 108-86-1
bromobenzene

: 90111-58-3
2-[4-(dihydroxyboranyl)phenyl]acetic acid

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In 1,4-dioxane; water at 100℃; for 1h; Suzuki-Miyaura Coupling; Inert atmosphere;	18%

: 450-52-2
4-phenylmandelic acid

: 5728-52-9
(4-biphenylyl)acetic acid

Conditions

Conditions	Yield
With phosphorus; iodine; acetic acid

: 5728-52-9
(4-biphenylyl)acetic acid

: 39889-69-5
biphenyl-4-yl-acetyl chloride

Conditions

Conditions	Yield
With thionyl chloride In benzene at 78 - 80℃; for 2.5h;	100%
With thionyl chloride In N,N-dimethyl-formamide; benzene at 20℃; for 5h;	97%
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 0 - 10℃; for 16h; Reflux;	90%

: 67-56-1
methanol

: 5728-52-9
(4-biphenylyl)acetic acid

: 59793-29-2
methyl 2-(1,1'-biphenyl-4-yl)acetate

Conditions

Conditions	Yield
With TEA; (2-chloro-1-pyridinio)-(Wang resin) triflate In dichloromethane for 0.25h;	100%
With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)pyridinium trifluoromethanesulfonate; triethylamine In dichloromethane at 20℃; for 0.5h;	100%
With thionyl chloride at 0 - 20℃; for 0.5h;	100%

: 4518-10-9
Methyl 3-aminobenzoate

: 5728-52-9
(4-biphenylyl)acetic acid

: 3-(2-biphenyl-4-yl-acetyl-amino)-benzoic acid methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	100%

: 5728-52-9
(4-biphenylyl)acetic acid

: 79-37-8
oxalyl dichloride

: 39889-69-5
biphenyl-4-yl-acetyl chloride

Conditions

Conditions	Yield
In N-methyl-acetamide; benzene	100%

: 5728-52-9
(4-biphenylyl)acetic acid

: 1013028-77-7
tetrakis(Nγ-trichloroethoxycarbonyl)polymyxin B (2-10) hydrochloride

: 1013028-99-3
4-biphenylacetyl-tetrakis(Nγ-trichloroethoxycarbonyl)polymyxin B (2-10)

Conditions

Conditions	Yield
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 5h; pH=7.8;	100%

: 5728-52-9
(4-biphenylyl)acetic acid

: 77-78-1
dimethyl sulfate

: 59793-29-2
methyl 2-(1,1'-biphenyl-4-yl)acetate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene for 4h; Cooling with ice;	100%

: 5728-52-9
(4-biphenylyl)acetic acid

: 2-([1,1'-biphenyl]-4-yl)acetic acid-d2

Conditions

Conditions	Yield
With water-d2; sodium hydroxide at 120℃; for 12h; Inert atmosphere;	100%

: 5728-52-9
(4-biphenylyl)acetic acid

: 149-73-5
trimethyl orthoformate

: 59793-29-2
methyl 2-(1,1'-biphenyl-4-yl)acetate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol for 4h; Reflux; Inert atmosphere;	99%
Stage #1: (4-biphenylyl)acetic acid With toluene-4-sulfonic acid In methanol for 1h; Reflux; Stage #2: trimethyl orthoformate In methanol for 2h; Reflux;	99.3%

: 5728-52-9
(4-biphenylyl)acetic acid

: 37729-18-3
2-(biphenyl-4-yl)ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 5h; Heating;	99%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Inert atmosphere;	99%
Stage #1: (4-biphenylyl)acetic acid With sodium tetrahydroborate In tetrahydrofuran at 20 - 30℃; for 0.666667h; Stage #2: With iodine In tetrahydrofuran at 20 - 30℃; for 2h; Product distribution / selectivity;	98.5%

: 5728-52-9
(4-biphenylyl)acetic acid

: 100-39-0
benzyl bromide

: 111363-79-2
benzyl 2-([1,1'-biphenyl]-4-yl)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	99%

: 5728-52-9
(4-biphenylyl)acetic acid

: tert-butyl (2,2-difluoro-3-hydroxypropyl)carbamate

: C22H25F2NO4

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 16h;	99%

: 5728-52-9
(4-biphenylyl)acetic acid

: 109-89-7
diethylamine

: 2-([1,1'-biphenyl]-4-yl)-N,N-diethylacetamide

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;	99%

: 5728-52-9
(4-biphenylyl)acetic acid

: 115-20-8
1,1,1-trichloroethanol

: 2,2,2-trichloroethyl 2-([1,1'-biphenyl]-4-yl)acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 23℃; for 15h; Inert atmosphere;	99%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; Inert atmosphere;

: 5728-52-9
(4-biphenylyl)acetic acid

: 59793-29-2
methyl 2-(1,1'-biphenyl-4-yl)acetate

Conditions

Conditions	Yield
With hydrogenchloride In methanol; ethyl acetate; Petroleum ether	98%
With sulfuric acid In formic acid for 6h; Reflux;

: 5728-52-9
(4-biphenylyl)acetic acid

: 10269-01-9
3-bromobenzylamine

: 1572927-05-9
2-([1,1'-biphenyl]-4-yl)-N-(3-bromobenzyl)acetamide

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 0 - 20℃;	98%

: 5728-52-9
(4-biphenylyl)acetic acid

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: C21H25NO4

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;	98%

: 5728-52-9
(4-biphenylyl)acetic acid

: 2-bromo-3-methyl-N-methylaniline

: 2-([1,1'-biphenyl]-4-yl)-N-(2-bromo-3-methylphenyl)-N-methylacetamide

Conditions

Conditions	Yield
With tributyl-amine; 2-chloro-1-methyl-pyridinium iodide In toluene at 90℃; for 14h; Inert atmosphere;	97%

: 5728-52-9
(4-biphenylyl)acetic acid

: 62-53-3
aniline

: 848175-28-0
2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;	97%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 0 - 20℃;	90%

: 5728-52-9
(4-biphenylyl)acetic acid

: 645-58-9
4-methoxyphenethylamine hydrochloride

: 2-[(1,1'-biphenyl)-4-yl]-N-(4-methoxyphenethyl)acetamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In acetonitrile at 25℃;	97%

: 5728-52-9
(4-biphenylyl)acetic acid

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 935886-64-9
felbinac trometamol

Conditions

Conditions	Yield
at 50℃; for 0.5h; Product distribution / selectivity;	96%

: 5728-52-9
(4-biphenylyl)acetic acid

: 2564-83-2, 45842-10-2
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

: 2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)-2-(4-(trifluoromethyl)phenyl)acetic acid

Conditions

Conditions	Yield
With N4,N4,N7,N7-tetramethyl-1,10-phenanthroline-4,7-diamine; iron(II) acetate In tetrahydrofuran at 60℃; for 24h; Molecular sieve; Inert atmosphere; Schlenk technique; chemoselective reaction;	95%

: 5728-52-9
(4-biphenylyl)acetic acid

: 108-95-2
phenol

: biphenyl-4-ylacetic acid phenyl ester

Conditions

Conditions	Yield
Stage #1: (4-biphenylyl)acetic acid With phosphoric acid; trifluoroacetic anhydride In acetonitrile at 25℃; for 0.5h; Stage #2: phenol In acetonitrile at 25℃; for 20h;	95%

: 5728-52-9
(4-biphenylyl)acetic acid

: 1020672-00-7
C16H14BrNO4

: 1020671-83-3
C30H22BrNO4

Conditions

Conditions	Yield
With dmap; potassium carbonate; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 80℃; for 6h;	94%

4-BIPHENYLACETIC ACID Chemical Properties

Name ：4-Biphenylacetic acid
Synonyms ：BIPHENYL-4-ACETIC ACID;FELBINAC;CI 83544;4-PHENYLPHENYLACETIC ACID;4-CARBOXYMETHYLBIPHENYL;4-BIPHENYLACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;P-BIPHENYLACETIC ACID

Molecular Structure ：

Molecular Formula ：C₁₄H₁₂O₂
Molecular Weight ：212.25
CAS Registry Number ：5728-52-9
Melting point ：156-160 ^oC
EINECS ：227-233-2
The compound 4-biphenylacetic acid is known and its preparation described in the literature, F. Blicke, et al., J. Am. Chem. Soc., 65, 1725 (1943). U.S. Pat. No. 3,784,704 also discloses the preparation of 4-biphenylacetic acid, and its usein producing long lasting amelioration of pain in warm-blooded animals. French Pat. No. 7,166M, patented Feb. 23, 1970, reports that 4-biphenylacetic acid possesses anti-inflammatory, antipyretic and analgesic activity.

4-BIPHENYLACETIC ACID Uses

4-Biphenylacetic acid can be useful, as an antithrombotic agent, in the treatment of well known thrombotic conditions resulting from platelet aggregation. 4-Biphenylacetic acid can be useful in reducing transient ischemic attacks of the brain and possibly the heart. 4-Biphenylacetic acid may also be useful extrinsically in preventing the clotting of shed and/or stored blood and it iscontemplated that its use as a platelet inhibitor extends both in vivo and in vitro platelet aggregation inhibition. 4-Biphenylacetic acid may be merely added to blood in vitro to prevent or inhibit platelet aggregation.

4-BIPHENYLACETIC ACID Toxicity Data With Reference

1.	orl-rat LD50:410 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.
2.	ipr-rat LD50:495 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.
3.	scu-rat LD50:148 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.
4.	orl-mus LD50:675 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.
5.	ipr-mus LD50:508 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.
6.	scu-mus LD50:730 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.
7.	scu-dog LD50:320 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.
8.	scu-rbt LD50:1280 mg/kg	KSRNAM Kiso to Rinsho. Clinical Report. 20 (1986),2107.

4-BIPHENYLACETIC ACID Safety Profile

Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes.
T: Toxic
R25 ：Toxic if swallowed.
R36/37/38 : Irritating to eyes, respiratory system and skin.
S26 ：In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28 ：After contact with skin, wash immediately with plenty of soap-suds.
S36/37 : Wear suitable protective clothing and gloves.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Product Name

4-Biphenylacetic acid

Synthetic route

4-BIPHENYLACETIC ACID Chemical Properties

4-BIPHENYLACETIC ACID Uses

4-BIPHENYLACETIC ACID Toxicity Data With Reference

4-BIPHENYLACETIC ACID Safety Profile

Related Products

Hot Products