4-Bromobenzaldehyde supplier

Name
4-Bromobenzaldehyde
EINECS 214-365-0
CAS No. 1122-91-4
Article Data635
CAS DataBase
Density 1.577 g/cm³
Solubility insoluble in water
Melting Point 55-58 °C
Formula C₇H₅BrO
Boiling Point 244 °C at 760 mmHg
Molecular Weight 185.02
Flash Point 108.9 °C
Transport Information
Appearance white crystalline solid
Safety 26-36/37-36/37/39-22
Risk Codes 22-36/37/38-43
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Benzaldehyde,p-bromo- (6CI,8CI);1-Bromo-4-formylbenzene;4-Formylbromobenzene;4-Formylphenyl bromide;NSC 21638;p-Bromobenzaldehyde;
PSA 17.07000
LogP 2.26160

Synthetic route

: 873-75-6
4-bromobenzenemethanol

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With dinitrogen tetraoxide; ferric nitrate for 0.08h; Ambient temperature; further oxidizing agent, further conditions and solvents;	100%
With butyltriphenylphosphonium chlorochromate In acetonitrile for 0.333333h; Heating;	100%
With 1H-imidazole; sodium periodate; manganese(III)-porphyrin complex immobilized on polystyrene In water; acetonitrile at 20℃; for 0.75h;	100%

: 55605-27-1
(4-bromophenyl)methylenediacetate

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With [NO(1+)18-crown-6H(NO3)2(1-)]; silica gel In dichloromethane at 20℃; for 0.0833333h;	100%
With caro's acid; silica gel In dichloromethane for 1.4h; Heating;	98%
With potassium tert-butylate; 3-Dimethylaminophenol In tetrahydrofuran for 0.0833333h;	97%

: 83521-65-7
2-(4-bromophenyl)-1,3-dithiolane

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With pyridine hydrogenfluoride; Selectfluor In dichloromethane at 20℃;	100%
With bromine; dimethyl sulfoxide In chloroform at 20℃; for 0.0666667h;	97%
With silica gel; ferric nitrate In hexane at 50℃; for 0.25h;	94%

: (E)-1-(4-bromobenzylidene)semicarbazide

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With caro's acid; silica gel In dichloromethane for 0.0833333h; Heating;	100%

: 2039-82-9
1-bromo-4-ethenyl-benzene

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 75℃; for 6h;	100%
With eosin Y; oxygen In dimethyl sulfoxide at 20℃; for 10h; Irradiation; Green chemistry;	95%
With oxygen at 110℃; for 12h; Green chemistry;	92%

: 100-52-7
benzaldehyde

A: 1122-91-4
4-bromo-benzaldehyde

B: 6630-33-7
ortho-bromobenzaldehyde

Conditions

Conditions	Yield
With sulfuric acid; C18H16Br4N2O3V; dihydrogen peroxide; potassium bromide In methanol; water at 20℃; for 2.33333h; Catalytic behavior;	A 100% B n/a

: 873-75-6
4-bromobenzenemethanol

: 98-95-3
nitrobenzene

A: 1122-91-4
4-bromo-benzaldehyde

B: 5877-51-0
N-(4-bromobenzylidene)aniline

Conditions

Conditions	Yield
With α,α,α-trifluorotoluene; titanium(IV) oxide In dodecane under 750.075 Torr; for 3h; Darkness; Inert atmosphere; Irradiation;	A n/a B 100%

...Expand

: 5798-75-4
Ethyl 4-bromobenzoate

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
Stage #1: Ethyl 4-bromobenzoate With morpholine; diisobutylaluminium hydride In tetrahydrofuran; hexane at 0℃; for 3.16667h; Inert atmosphere; Stage #2: With diisobutylaluminium hydride In tetrahydrofuran; hexane at 0℃; for 0.166667h; Inert atmosphere;	99%
With H2SiEt2; C15H27Br2CoN3; potassium tert-butylate In toluene at 50℃; for 12h; Inert atmosphere; Glovebox; Sealed tube;	51%
With naphthalene In tetrahydrofuran; hexane at 0℃; for 3h;	83 % Chromat.

: 873-75-6
4-bromobenzenemethanol

: 1774-35-2
di(p-tolyl) sulfoxide

A: 620-94-0
di-(p-tolyl)sulfane

B: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With per-rhenic acid In toluene for 17h; Reflux;	A 99% B 98%

...Expand

: C16H17BrO2

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With silica-OSO3H; silica gel In toluene at 60 - 70℃; for 1h;	98%
With tetrachlorosilane; silica gel In toluene at 60 - 70℃; for 1h;	92%
With potassium sulfate; potassium hydrogensulfate; potassium peroxomonosulfate; aluminium trichloride In acetonitrile Heating;

: 87199-17-5
4-formylphenylboronic acid,

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile at 80℃; for 12h;	98%
With 1,10-Phenanthroline; oxygen; potassium bromide; copper(ll) bromide In N,N-dimethyl-formamide at 130℃; for 20h;	80%

: 25062-46-8, 40979-16-6, 34158-73-1
4-bromobenzaldehyde oxime

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With quinolinium dichromate(VI) In acetonitrile for 0.5h; Heating;	97%
With potassium permanganate; 1-n-butyl-3-methylimidazolim bromide at 20℃; for 0.283333h; Ionic liquid; chemoselective reaction;	97%
With aluminum(III) nitrate nonahydrate; sodium bromide In dichloromethane at 20℃; for 6.75h;	96%

: 16917-42-3
4-bromobenzaldehyde phenylhydrazone

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With quinolinium dichromate(VI) In acetonitrile for 1h; Heating;	97%
With water; silica gel; bis(trimethylsilyl)chromate In chloroform for 0.15h; Heating;	97%
With quinolinium dichromate In acetonitrile for 0.266667h; Heating;	92%

: 86605-93-8
(4-bromobenzyloxy)trimethylsilane

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With NTPPPODS In acetonitrile for 0.05h; Reflux;	97%
With cetyltrimethylammonium peroxodisulphate In acetonitrile for 0.166667h; Reflux;	95%
With zinc dichromate(VI) at 20℃;	93%

: 5892-99-9
4-bromo-N,N-diethylbenzamide

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With zirconocene dichloride; lithium tri-t-butoxyaluminum hydride In tetrahydrofuran at 20℃; for 0.0333333h; Product distribution / selectivity;	96%
With zirconocene dichloride; lithium tri-t-butoxyaluminum hydride In tetrahydrofuran at 20℃; for 0.0333333h; Solvent; Inert atmosphere;	96%

: 336182-29-7
4-bromo-N-isopropyl-benzamide

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 4-bromo-N-isopropyl-benzamide With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at 0℃; for 0.333333h; Inert atmosphere; Stage #2: With 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 0 - 20℃; for 6.16667h; Inert atmosphere; Stage #3: With hydrogenchloride In dichloromethane; water at 20℃; Inert atmosphere;	96%

: 623-00-7
4-bromobenzenecarbonitrile

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With lithium diisobutylmorpholinoaluminum hydride In tetrahydrofuran; hexane at 0℃; for 0.5h;	95%
With calcium bis(hypophosphite); calcium acetate; nickel(II) acetate tetrahydrate In ethanol; water at 100℃; for 23h; Sealed tube;	90%
With sodium hydride; zinc(II) chloride In tetrahydrofuran; mineral oil at 40℃; for 0.5h; Inert atmosphere; Sealed tube;	80%
With hydrogenchloride; diethyl ether; tin(ll) chloride anschliessenden Hydrolyse;

: 106-37-6
1.4-dibromobenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 1.4-dibromobenzene With n-butyllithium; isopropylmagnesium chloride In tetrahydrofuran; hexane at 0 - 5℃; for 1h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 1h; Further stages.;	95%
Stage #1: 1.4-dibromobenzene With tri-n-butyllithium magnesate complex In toluene at 0℃; for 5h; Stage #2: N,N-dimethyl-formamide In toluene at 0℃; for 0.5h; Stage #3: With citric acid at 20℃;	84%
Stage #1: 1.4-dibromobenzene With n-butyllithium In diethyl ether; hexane at -78℃; for 3.25h; Stage #2: N,N-dimethyl-formamide In diethyl ether; hexane at -78 - 23℃; for 2.5h;	72%

: 5877-51-0
N-(4-bromobenzylidene)aniline

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With tetrachlorosilane In acetonitrile at 20℃; for 6h;	95%

: 17100-68-4
2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With N-Bromosuccinimide; β‐cyclodextrin In acetone at 20℃; for 0.5h;	95%
With NTPPPODS In acetonitrile for 0.133333h; Reflux;	93%
With potassium permanganate; tetrachlorosilane In acetonitrile at 20℃; for 0.116667h;	90%

: 16917-42-3
(E)-1-(4-bromobenzylidene)-2-phenylhydrazine

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With caro's acid; silica gel In dichloromethane for 1.41667h; Heating;	95%

: 10602-01-4
p-bromobenzaldehyde 1,3-dioxolane

: 76-05-1
trifluoroacetic acid

A: 667-32-3
2-hydroxyethyl trifluoroacetate

B: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
In chloroform at 25℃; for 10h;	A n/a B 95%

...Expand

: 120445-43-4, 14066-66-1
2-(4-bromobenzylidene)hydrazinecarboxamide

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With quinolinium monofluorochromate(VI) In acetonitrile for 2.5h; Heating;	94%
With benzyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.166667h; Heating;	93%
With NTPPPODS In water; acetonitrile for 0.333333h; Reflux;	93%

: 114021-98-6
(4-Bromo-phenyl)-phenylamino-methanesulfonic acid; compound with methylamine

A: 1122-91-4
4-bromo-benzaldehyde

B: 113360-52-4
(4-Bromo-phenyl)-phenylamino-methanesulfonic acid; compound with phenylamine

Conditions

Conditions	Yield
With hydrogenchloride for 24h;	A n/a B 94%

: 1562381-84-3
(E)-N-(4-(4-bromophenyl)but-3-en-1-yn-1-yl)-N-methylmethanesulfonamide

: 586-96-9
Nitrosobenzene

A: 1562381-21-8
N-methyl-N-(methylsulfonyl)-N'-phenylpropiolimidamide

B: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With zinc trifluoromethanesulfonate In 1,2-dichloro-ethane at 60℃; for 2h; Inert atmosphere;	A 94% B 94%

...Expand

: 21757-86-8
1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol

A: 35549-94-1
p-bromophenyl-α-chloroacetic acid

B: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With potassium hydroxide In water at 0℃; for 48h;	A 93% B 0.34 g
With potassium hydroxide In water at 0℃; for 48h; Product distribution;	A 93% B 0.34 g

: 147441-51-8, 147441-52-9, 77853-37-3
2-(4-bromophenyl)-1,3-oxathiolane

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With tetrafluoroboric acid; mercury(II) oxide In tetrahydrofuran Ambient temperature;	93%
With tetrafluoroboric acid; mercury(II) oxide In tetrahydrofuran Product distribution; Ambient temperature; various 1,3-oxathiolanes;	93%
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 1.5h;	90%
With eosin Y disodium salt In acetonitrile at 20℃; for 3h; Catalytic behavior; Reagent/catalyst; Solvent; Irradiation;	80%

: 589-17-3
p-bromobenzyl chloride

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With water; sodium hydroxide at 20℃; for 0.0666667h; Microwave irradiation;	93%
With (NH4)4[ZnMo6O18(OH)6]; oxygen In water; acetonitrile at 60℃; under 760.051 Torr; for 12h;	87%
With dihydrogen peroxide; vanadia; Aliquat 336 In water for 15h; Heating;	85%

: 37580-82-8, 126082-50-6, 24133-54-8
1,2-bis(4-bromophenyl)ethane-1,2-diol

: 1122-91-4
4-bromo-benzaldehyde

Conditions

Conditions	Yield
With dimanganese decacarbonyl In toluene at 120℃; Sealed tube;	93%
With oxygen; cetyltrimethylammonim bromide In water at 20℃; under 760.051 Torr; for 5h; Irradiation; Green chemistry;	85%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In trifluoroacetic acid at 30℃; for 0.1h;	82%
With dichlorobis(dimethylsulfoxide)dioxomolybdenum(VI); dimethyl sulfoxide at 130℃; for 0.166667h; Sealed tube; Microwave irradiation; Green chemistry; chemoselective reaction;	91 %Spectr.
With oxygen In methanol at 140℃; under 2250.23 Torr; for 3h; Autoclave;

: 107-21-1
ethylene glycol

: 1122-91-4
4-bromo-benzaldehyde

: 10602-01-4
p-bromobenzaldehyde 1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 100 - 110℃; for 5h;	100%
With toluene-4-sulfonic acid In toluene at 110℃; for 12h;	100%
With toluene-4-sulfonic acid In toluene Reflux;	98%

: 1122-91-4
4-bromo-benzaldehyde

: 100-65-2
N-Phenylhydroxylamine

: 24720-81-8, 94664-73-0
α-(4-bromo)-N-phenylnitrone

Conditions

Conditions	Yield
With methanesulfonic acid In ethanol at 20℃;	100%
With hydrogenchloride In ethanol; water for 0.0833333h;	85%
With clay for 2h; Ambient temperature;	75%

: 1122-91-4
4-bromo-benzaldehyde

: 873-75-6
4-bromobenzenemethanol

Conditions

Conditions	Yield
With hydrogen; Et4N In 1,2-dimethoxyethane at 100℃; under 38000 Torr; for 13h;	100%
With tri-n-butyl-tin hydride In methanol; diethyl ether for 4h; Reduction; Heating;	100%
With hydrogen; phosphotungstic acid 44-hydrate; [Fe(C5H4P(i-Pr)2)2Rh(C8H12)]BF4 In water; isopropyl alcohol at 20℃; under 5171.62 Torr; for 16h;	100%

: 16532-79-9
4-Bromophenylacetonitrile

: 1122-91-4
4-bromo-benzaldehyde

: 33731-82-7
1,2-bis(4-bromophenyl)-1-cyanovinylene

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 1.5h;	100%
With sodium hydroxide In ethanol at 20℃; for 1h;	91%
With sodium hydroxide In methanol

: 1122-91-4
4-bromo-benzaldehyde

: 292638-85-8
acrylic acid methyl ester

: 7560-50-1, 71093-79-3, 58045-41-3
methyl (2E)-3-(4-formylphenyl)acrylate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; C12H12N4O2Pd(2+)*2Cl(1-); potassium carbonate In water at 75 - 80℃; for 0.5h; Solvent; Heck Reaction; Sonication; Green chemistry;	100%
With polystyrene-supported palladacycle catalyst; sodium acetate In N,N-dimethyl acetamide at 100℃; for 10h; Heck reaction;	99%
With sodium acetate; palladium diacetate In 1-methyl-pyrrolidin-2-one at 115 - 120℃; for 1h; Heck reaction; Inert atmosphere;	99%

: 1122-91-4
4-bromo-benzaldehyde

: 536-74-3
phenylacetylene

: 57341-98-7
4-(phenylethynyl)benzaldehyde

Conditions

Conditions	Yield
Stage #1: 4-bromo-benzaldehyde With 5% Pd/C; triethylamine; triphenylphosphine for 0.0833333h; Sonogashira Cross-Coupling; Sealed tube; Sonication; Stage #2: phenylacetylene for 3h; Sealed tube;	100%
With water; potassium carbonate In 1-methyl-pyrrolidin-2-one at 135℃; for 24h; Catalytic behavior; Sonogashira Cross-Coupling;	99%
With C19H16ClNPdS; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 1h; Solvent; Reagent/catalyst; Sonogashira Cross-Coupling;	99%

: 1122-91-4
4-bromo-benzaldehyde

: 149-73-5
trimethyl orthoformate

: 24856-58-4
1,1-dimethoxy-1-(4-bromophenyl)methane

Conditions

Conditions	Yield
Yb-Amberlyst XN-1010 In dichloromethane	100%
With Yb(III)-coordinated adamantane-based porous polymer In methanol at 20℃; for 12h; Catalytic behavior; Reagent/catalyst;	100%
With amberlyst-15 In acetonitrile for 2.5h; electroosmos;	99.7%

: 3949-36-8
3-acetylcoumarin

: 1122-91-4
4-bromo-benzaldehyde

: 107126-88-5
1-(3'-coumarinyl)-3-(4''-bromophenyl)-2-propen-1-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol Reflux;	100%
With ZnS/g-C3N4 nanocomposite In ethanol for 1h; Claisen-Schmidt Condensation; Reflux; Green chemistry;	91%
With piperidine In ethanol Claisen-Schmidt Condensation; Reflux;	75%

: 104-94-9
4-methoxy-aniline

: 1122-91-4
4-bromo-benzaldehyde

: 28115-12-0
N-(4-bromobenzylidene)-4-methoxyaniline

Conditions

Conditions	Yield
for 6h; Ambient temperature;	100%
With sulfuric acid In neat (no solvent) Microwave irradiation; Sealed tube; Green chemistry;	92%
In dichloromethane at 20℃; for 16h; Inert atmosphere; Molecular sieve;	92%

: 104-94-9
4-methoxy-aniline

: 1122-91-4
4-bromo-benzaldehyde

: 28115-12-0
(E)-1-(4-bromophenyl)-N-(4-methoxyphenyl)methanimine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane Inert atmosphere;	100%
With tris(2,2,2-trifluoroethyl) borate In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	92%
In ethanol at 20℃; Inert atmosphere;	81%

: 1663-39-4
tert-Butyl acrylate

: 1122-91-4
4-bromo-benzaldehyde

: 208036-26-4
(E)-t-butyl 4-formylcinnamate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h; Heck-Mizoroki reaction;	100%
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine Heating;	91%
With palladium on silica; triethylamine In N,N-dimethyl-formamide for 0.2h; Heck Reaction; Microwave irradiation; Green chemistry;	89%

: 126983-41-3
6-chloro-2-[1-methyl-2-(2-thienylmethylene)hydrazino]quinoxaline-4-oxide

: 1122-91-4
4-bromo-benzaldehyde

: 128960-28-1
2-<2-(p-bromobenzylidene)-1-methylhydrazino>-6-chloroquinoxaline 4-oxide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h; Heating;	100%

: 126983-41-3
6-chloro-2-[1-methyl-2-(2-thienylmethylene)hydrazino]quinoxaline-4-oxide

: 1122-91-4
4-bromo-benzaldehyde

: 128960-28-1
2-<2-(p-bromobenzylidene)-1-methylhydrazino>-6-chloroquinoxaline 4-oxide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h; Heating;	100%

: 1122-91-4
4-bromo-benzaldehyde

: 6285-64-9
phenylazomalonamamidine hydrochloride

: 81976-29-6
2,8-Bis-(4-bromo-phenyl)-1,7-dihydro-purin-6-one

Conditions

Conditions	Yield
at 170℃; for 1h;	100%

: 1122-91-4
4-bromo-benzaldehyde

: 6285-64-9
phenylazomalonamamidine hydrochloride

: 81990-66-1
2-{N-[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-carbamimidoyl}-2-phenylazo-acetamide; hydrochloride

Conditions

Conditions	Yield
at 120℃; for 0.25h;	100%

: 1122-91-4
4-bromo-benzaldehyde

: 75-64-9
tert-butylamine

: 62058-76-8
N-(4-bromobenzylidene)-2-methylpropan-2-amine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 4h;	100%
With 4 A molecular sieve for 24h; Ambient temperature;	97%
With titanium tetrachloride In diethyl ether; toluene at 0℃; for 0.25h; Glovebox; Inert atmosphere; Schlenk technique;	86%
at 100℃; Schlenk technique;
In 1,2-dichloro-ethane at 70℃; for 4h; Glovebox;

: 1122-91-4
4-bromo-benzaldehyde

: 74-89-5
methylamine

: 35003-56-6
1-(4-bromophenyl)-N-methylmethanimine

Conditions

Conditions	Yield
In methanol; dichloromethane for 18h; Molecular sieve;	100%
at 80℃; for 1h;
In methanol; dichloromethane at 20℃; for 12h; Molecular sieve; Inert atmosphere;

: 1122-91-4
4-bromo-benzaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 24393-53-1, 136265-11-7, 15795-20-7
ethyl (E)-3-(4-bromophenyl)-2-propenoate

Conditions

Conditions	Yield
In dichloromethane at 22℃; for 16h; Wittig reaction;	100%
In toluene Wittig reaction;	100%
In toluene at 20℃; for 0.5h;	97%

: 1122-91-4
4-bromo-benzaldehyde

: 1066-54-2
trimethylsilylacetylene

: 77123-57-0
4-[(trimethylsilyl)ethynyl]bezaldehyde

Conditions

Conditions	Yield
With copper(l) iodide; diisopropylamine; polymer-supp. 11-(2-[Pd(OAc)2]-1-Mes-3-imidazolyl)undecanol In tetrahydrofuran at 20℃; for 2h; Sonogashira coupling;	100%
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine In tetrahydrofuran at 20℃; Inert atmosphere;	100%
Stage #1: 4-bromo-benzaldehyde With 5% Pd/C; triethylamine; triphenylphosphine for 0.0833333h; Sonogashira Cross-Coupling; Sealed tube; Sonication; Stage #2: trimethylsilylacetylene for 3h; Sealed tube;	100%

: 1122-91-4
4-bromo-benzaldehyde

: 504-63-2
trimethyleneglycol

: 61568-51-2
2-(4-bromophenyl)-1,3-dioxane

Conditions

Conditions	Yield
With Amberlyst 15 In benzene for 3h; Heating;	100%
With boron trifluoride diethyl etherate In toluene for 4.5h; Acetalization; Heating;	96%
With boron trifluoride diethyl etherate In toluene at 100℃; for 4.5h;	96%

: 1122-91-4
4-bromo-benzaldehyde

: 25062-46-8, 34158-73-1, 40979-16-6
4-bromobenzaldehyde Oxime

Conditions

Conditions	Yield
With pyridine; hydroxylamine hydrochloride In ethanol	100%
With hydroxylamine hydrochloride In ethanol	100%
With hydroxylamine hydrochloride; sodium acetate In methanol; water Reflux;	100%

: 1122-91-4
4-bromo-benzaldehyde

: 4254-18-6
1,2-bis(4-bromophenyl)-2-hydroxyethan-1-one

Conditions

Conditions	Yield
With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine In ethanol at 20℃; for 60h;	100%
With sodium cyanide In ethanol; water for 0.333333h; Heating;	91.8%
With sodium cyanide In methanol; water for 0.5h; Reflux;	90%

: 141-32-2
acrylic acid n-butyl ester

: 1122-91-4
4-bromo-benzaldehyde

: 169479-49-6
butyl (E)-4-formylcinnamate

Conditions

Conditions	Yield
With 2-n-butyl-1,1,1,3,3-tetramethylguanidine acetate; palladium dichloride at 140℃; for 0.25h;	100%
With sodium acetate In ISOPROPYLAMIDE	100%
With sodium acetate In ISOPROPYLAMIDE	100%

: 292638-84-7
styrene

: 1122-91-4
4-bromo-benzaldehyde

: 32555-96-7
4-styrylbenzaldehyde

Conditions

Conditions	Yield
With triethylamine; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 150℃; for 24h; Catalytic behavior; Reagent/catalyst; Heck Reaction; Inert atmosphere;	100%
With 2-n-butyl-1,1,1,3,3-tetramethylguanidine acetate; palladium dichloride at 140℃; for 0.25h;	99%
With 1,3-bis-(2-ethoxybenzyl)-3,4,5,6-tetrahydropyrimidinium chloride; palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide at 80℃; for 4h; Heck reaction; stereoselective reaction;	99%

: 1122-91-4
4-bromo-benzaldehyde

: 37580-82-8, 126082-50-6, 24133-54-8
1,2-bis(4-bromophenyl)ethane-1,2-diol

Conditions

Conditions	Yield
With aluminium; potassium hydroxide In methanol at 0℃; for 1h; Inert atmosphere;	100%
With 2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester; Cu(5-(4-fluorosulfonyl)amino-3-(2-pyridyl)-pyrazole)((rac)-2,2′-bis(diphenylphosphino)-1,1′-binaphthalene)BF4 In tetrahydrofuran for 18h; Pinacol Rearrangement; Irradiation;	99%
With bis(cyclopentadienyl)-titanium(III) chloride In tetrahydrofuran at -78 - 20℃;	91%

: 1122-91-4
4-bromo-benzaldehyde

: 109-77-3
malononitrile

: 2826-24-6
4-bromobenzylidenemalononitrile

Conditions

Conditions	Yield
With polyethylenimine functionalized Si-MCM-41 grafted on surfacemodified graphene oxide In tetrahydrofuran; benzene for 0.5h; Knoevenagel Condensation;	100%
With 3-(1-piperazino)propyl functionalised silica gel In acetonitrile Knoevenagel condensation;	99.9%
With 3-(1-piperazino)propyl-functionalised silica gel In acetonitrile Knoevenagel reaction; electroosmotic flow;	99.9%

: 134-32-7
1-amino-naphthalene

: 1122-91-4
4-bromo-benzaldehyde

: 116401-74-2
[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-naphthalen-1-yl-amine

Conditions

Conditions	Yield
for 2h; Ambient temperature;	100%
In benzene Reflux;

4-Bromobenzaldehyde Consensus Reports

Reported in EPA TSCA Inventory.

4-Bromobenzaldehyde Specification

The IUPAC name of 4-Bromobenzaldehyde is 4-bromobenzaldehyde. With the CAS registry number 1122-91-4, it is also named as Benzaldehyde, p-bromo-. The product's categories are Fine Chemical & Intermediates; Aromatic Aldehydes & Derivatives (substituted); Benzaldehyde; Benzaldehyde (Building Blocks for Liquid Crystals); Bifunctional Compounds (Building Blocks for Liquid Crystals); Building Blocks for Liquid Crystals; Functional Materials; Aldehydes; C7; Carbonyl Compounds. Besides, it is white crystalline solid, which should be stored in sealed container in a cool, dry place. And you should ensure that the workplaces have good ventilated or exhaust devices. In addition, its molecular formula is C₇H₅BrO and molecular weight is 185.02.

The other characteristics of this product can be summarized as: (1)EINECS: 214-365-0; (2)ACD/LogP: 2.57; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 2.57; (5)ACD/LogD (pH 7.4): 2.57; (6)ACD/BCF (pH 5.5): 53.02; (7)ACD/BCF (pH 7.4): 53.02; (8)ACD/KOC (pH 5.5): 597.02; (9)ACD/KOC (pH 7.4): 597.02; (10)#H bond acceptors: 1; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 1; (13)Index of Refraction: 1.61; (14)Molar Refractivity: 40.69 cm³; (15)Molar Volume: 117.2 cm³; (16)Surface Tension: 44.4 dyne/cm; (17)Density: 1.577 g/cm³; (18)Flash Point: 108.9 °C; (19)Melting Point: 55-58 °C; (20)Enthalpy of Vaporization: 48.11 kJ/mol; (21)Boiling Point: 244 °C at 760 mmHg; (22)Vapour Pressure: 0.0311 mmHg at 25 °C.

Preparation of 4-Bromobenzaldehyde: please add Bromine to Parabromotoluene at the temperature of 105-110 °C. And then the temperature should be rose to 150 °C. Afterwards, please add Calcium carbonate and water to stir. After heating and reflux for 15 min, it would be hydrolyzed. And you can obtain this chemical after steam distillation.

Uses of 4-Bromobenzaldehyde: this chemical is used as intermediate of pharmaceutical and dyes. It is also used in organic synthesis. Furthermore, it can be used to produce 4-Bromo-benzoic acid.

This reaction needs 30percent Hydrogen peroxide, 5 molpercent Benzeneseleninic acid and Tetrahydrofuran by heating for 7 hours. The yield is 97 %.

When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed. Please do not breathe dust. It is also irritating to eyes, respiratory system and skin. Moreovewr, it may cause sensitization by skin contact. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=Cc1ccc(Br)cc1
(2)InChI: InChI=1/C7H5BrO/c8-7-3-1-6(5-9)2-4-7/h1-5H
(3)InChIKey: ZRYZBQLXDKPBDU-UHFFFAOYAH
(4)Std. InChI: InChI=1S/C7H5BrO/c8-7-3-1-6(5-9)2-4-7/h1-5H
(5)Std. InChIKey: ZRYZBQLXDKPBDU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	389mg/kg (389mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(12), Pg. 19, 1979.
mouse	LD50	oral	1230mg/kg (1230mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(12), Pg. 19, 1979.

Product Name

4-Bromobenzaldehyde

Synthetic route

4-Bromobenzaldehyde Consensus Reports

4-Bromobenzaldehyde Specification

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