4-Bromophthalic anhydride supplier

Name
4-Bromophthalic anhydride
EINECS 201-707-9
CAS No. 86-90-8
Article Data27
CAS DataBase
Density 1.911
Solubility
Melting Point 107 °C
Formula C₈H₃BrO₃
Boiling Point 361.8 °C at 760 mmHg
Molecular Weight 227.014
Flash Point 172.6 °C
Transport Information
Appearance off-white to white powder
Safety S26; S36/37/39
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols C
Synonyms Phthalicanhydride, 4-bromo- (6CI,7CI,8CI);4-Bromo-1,2-benzenedicarboxylic anhydride;5-Bromo-1,3-isobenzofurandione;1,3-Isobenzofurandione,5-bromo-;
PSA 43.37000
LogP 1.75970

Synthetic route

: 6968-28-1
4-bromophthalic acid

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
With acetic anhydride for 2h; Heating;	97%
With acetic anhydride at 140℃; for 2h;	84%
With acetic anhydride at 140℃; for 2h;	84%

: 6941-75-9
5-Bromoisoindoline-1,3-dione

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
With urea at 140℃; for 0.333333h;	87%

: 85-44-9
phthalic anhydride

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; bromine; sodium hydroxide In water at 45 - 80℃; for 11.7h; Catalytic behavior; Reagent/catalyst; Temperature;	85.4%
Stage #1: phthalic anhydride With bromine; sodium hydroxide In water at 90℃; for 6h; Stage #2: With thionyl chloride In water at 0℃; Reflux;	79%
Stage #1: phthalic anhydride With bromine; sodium hydroxide In water at 90℃; for 12h; Inert atmosphere; Stage #2: With thionyl chloride for 5h; Reflux; Inert atmosphere;	71%

: 118728-51-1, 145551-79-7
5-brom-7-oxa-bicyclo<2.2.1>hept-5-en-2-exo,3-cis-dicarbonsaeureanhydrid

: 10035-10-6, 12258-64-9
hydrogen bromide

: 64-19-7
acetic acid

: 86-90-8
4-bromophthalic anhydride

...Expand

: 583-71-1
4-bromo-o-xylene

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. KMnO4; Na2CO3; aliquat 336 / 0.75 h / Heating 2: Ac2O / 4 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 67 percent / potassium hydroxide, potassium permanganate / H2O / 7 h 2: Ac2O / 4 h / Heating View Scheme
Stage #1: 4-bromo-o-xylene With pyridine; potassium permanganate In water for 24h; Reflux; Stage #2: With acetic anhydride for 22h; Reflux;

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: alkaline potassium permanganate 2: durch Destillation View Scheme

: 67832-11-5
4-bromo-2-methylbenzonitrile

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: alcoholic NaOH-solution 2: alkaline potassium permanganate 3: durch Destillation View Scheme

: 583-75-5
4-Bromo-2-methylaniline

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: durch Austausch von NH2 gegen CN 2: alcoholic NaOH-solution 3: alkaline potassium permanganate 4: durch Destillation View Scheme

: 118-45-6
4-chlorophthalic anhydride

: 7439-89-6
iron

: 86-90-8
4-bromophthalic anhydride

Conditions

Conditions	Yield
With bromine In chlorobenzene

: 86-90-8
4-bromophthalic anhydride

: 76240-49-8
6-bromo-2,3-dihydrophthalazine-1,4-dione

Conditions

Conditions	Yield
Stage #1: 4-bromophthalic anhydride With acetic acid at 125℃; for 1h; Stage #2: With hydrazine hydrate at 125℃; for 0.5h;	100%
Stage #1: 4-bromophthalic anhydride With acetic acid at 125℃; for 1h; Stage #2: With hydrazine hydrate at 125℃; for 0.583333h;	100%
Stage #1: 4-bromophthalic anhydride With hydrazine hydrate Inert atmosphere; Stage #2: With hydrogenchloride In water for 24h; Reflux; Inert atmosphere;	96%

: 394248-90-9
3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)aniline

: 86-90-8
4-bromophthalic anhydride

: 515877-85-7
5-bromo-2-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-isoindole-1,3-dione

Conditions

Conditions	Yield
With EDC resin In dichloromethane for 12h;	100%

: 86-90-8
4-bromophthalic anhydride

: 171011-37-3
4-bromo-2-(hydroxymethyl)benzyl alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; zinc(II) chloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	100%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 17.5h;	94%
Stage #1: 4-bromophthalic anhydride With diisobutylaluminium hydride In toluene at 20℃; under 760.051 Torr; for 1.5h; Cooling with ice; Stage #2: With hydrogenchloride In water; toluene at 0 - 20℃; for 1h;	91%

: 86-90-8
4-bromophthalic anhydride

: 99-31-0
5-aminoisophthalic acid

: C16H8BrNO6

Conditions

Conditions	Yield
Stage #1: 4-bromophthalic anhydride; 5-aminoisophthalic acid In N,N-dimethyl acetamide at 60 - 100℃; for 1h; Stage #2: With pyridine; acetic anhydride In N,N-dimethyl acetamide for 2h;	100%

: 86-90-8
4-bromophthalic anhydride

: 6941-75-9
5-Bromoisoindoline-1,3-dione

Conditions

Conditions	Yield
With formamide at 200℃; for 2h;	99%
With choline chloride; urea at 140℃; for 1h; Green chemistry;	99%
With formamide for 4h; Reflux;	94%

: 86-90-8
4-bromophthalic anhydride

: 111-26-2
hexan-1-amine

: 299963-46-5
5-bromo-2-hexylisoindoline-1,3-dione

Conditions

Conditions	Yield
In toluene for 18h; Reflux;	99%
With propionic acid at 130℃; for 72h;	96%
With acetic acid for 4h;

: 86-90-8
4-bromophthalic anhydride

: 63-74-1
sulfanilamide

: C14H9BrN2O4S

Conditions

Conditions	Yield
With acetic acid for 19h; Reflux;	97%

: 86-90-8
4-bromophthalic anhydride

: 56-12-2
4-amino-n-butyric acid

: 299964-12-8
4-(5-bromo-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid

Conditions

Conditions	Yield
With acetic acid at 100℃; for 3h;	96.7%
With triethylamine In toluene for 24h; Reflux;	68%
With triethylamine In toluene for 24h; Reflux;

: 86-90-8
4-bromophthalic anhydride

: 74-89-5
methylamine

: 90224-73-0
5-bromo-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione

Conditions

Conditions	Yield
With sodium acetate; acetic acid In water for 6h; Inert atmosphere; Reflux;	96%
In water; toluene at 130℃; for 12h; Dean-Stark; Inert atmosphere;	90%
In water; toluene for 9h; Reflux;	88%

: 86-90-8
4-bromophthalic anhydride

: 610-35-5
4-hydroxyphthalic acid

Conditions

Conditions	Yield
Stage #1: 4-bromophthalic anhydride With copper(l) chloride; potassium hydroxide In water; dimethyl sulfoxide at 25℃; for 0.166667h; Inert atmosphere; Stage #2: In water; dimethyl sulfoxide at 130℃; for 24h; Inert atmosphere; Stage #3: With hydrogenchloride In water; dimethyl sulfoxide pH=1 - 2; Reagent/catalyst; Temperature;	95.3%

: 86-90-8
4-bromophthalic anhydride

: 100-46-9
benzylamine

: 82104-06-1
2-benzyl-5-bromoisoindoline-1,3-dione

Conditions

Conditions	Yield
	95%
With acetic acid at 130℃; for 4h; Inert atmosphere;	89%
With acetic acid at 130℃; for 4h; Inert atmosphere;	89%
	56%

: 86-90-8
4-bromophthalic anhydride

: 28004-54-8
2-amino-5-styryl-1,3,4-thiadiazole

: C18H10BrN3O2S

Conditions

Conditions	Yield
With acetic acid at 120℃; Molecular sieve;	95%

: 86-90-8
4-bromophthalic anhydride

: 93-05-0
N,N-diethylaniline

: 5-bromo-2-(4-(diethylamino)phenyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
In acetic acid at 118℃;	95%

: 86-90-8
4-bromophthalic anhydride

: 24666-56-6
rac-α-aminoglutarimide hydrochloride

: 26166-92-7
5-bromo-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Conditions

Conditions	Yield
With sodium acetate; acetic acid Heating / reflux;	93%
With sodium acetate In acetic acid at 20 - 80℃; for 16h;	92%
With sodium acetate; acetic acid at 115℃; for 16h;	91.6%
With potassium acetate; acetic acid at 90℃; for 12h;	60%
With sodium acetate; acetic acid at 120℃; for 5h;

: 86-90-8
4-bromophthalic anhydride

: 62-53-3
aniline

: 82104-66-3
5-bromo-2-phenylisoindoline-1,3-dione

Conditions

Conditions	Yield
With acetic acid at 120℃; Molecular sieve;	92%
With acetic acid at 120℃; for 1h; Molecular sieve; Microwave irradiation;	86%
	75%
With acetic acid Reflux;	73%

: 86-90-8
4-bromophthalic anhydride

: 73183-34-3
bis(pinacol)diborane

: 849677-21-0
C14H15BO5

Conditions

Conditions	Yield
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In dimethyl sulfoxide at 80℃; for 10h;	92%

: 86-90-8
4-bromophthalic anhydride

: 74-86-2
acetylene

: 129808-00-0
5,5'-(ethyne-1,2-diyl)bis(isobenzofuran-1,3-dione)

Conditions

Conditions	Yield
With copper(l) iodide; bis(triphenylylphosphine)palladium(II) dichloride; triethylamine; triphenylphosphine In toluene at 80℃; Temperature; Pressure; Solvent; Time; Neutral conditions;	92%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine In toluene at 80℃; Concentration; Inert atmosphere; Large scale;	80%

: 86-90-8
4-bromophthalic anhydride

: 106-40-1
4-bromo-aniline

: 5-bromo-2-(4-bromophenyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 30h;	92%
With acetic acid Reflux;	82%

: 86-90-8
4-bromophthalic anhydride

: 104-94-9
4-methoxy-aniline

: 82104-71-0
5-bromo-2-(4-methoxyphenyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With acetic acid at 120℃; Molecular sieve;	91%
With acetic acid at 120℃; for 1h; Molecular sieve; Microwave irradiation;	80%
	67%

: 86-90-8
4-bromophthalic anhydride

: 75-31-0
isopropylamine

: 351996-68-4
5-bromo-2-isopropylisoindoline-1,3-dione

Conditions

Conditions	Yield
With isoquinoline In 3-methyl-phenol at 20 - 200℃; for 10h; Inert atmosphere;	91%
With acetic acid for 1.5h; Inert atmosphere; Reflux;	80%

: 67-56-1
methanol

: 86-90-8
4-bromophthalic anhydride

: 87639-57-4
4-bromophthalic Acid Dimethyl Ester

Conditions

Conditions	Yield
With sulfuric acid at 80℃; for 16h;	90%
With sulfuric acid

: 86-90-8
4-bromophthalic anhydride

: 616-24-0
3-aminopentane

: 4-bromo-2-(1-ethylpropyl)phthalimide

Conditions

Conditions	Yield
In acetic acid at 120 - 180℃; for 0.333333h; Microwave irradiation; Sealed tube;	90%

: 86-90-8
4-bromophthalic anhydride

: 124-41-4
sodium methylate

: 1885-13-8
4-methoxyphthalic acid

Conditions

Conditions	Yield
With Methyl formate; copper(l) chloride In methanol at 150℃; for 16h; Inert atmosphere;	90%

: 86-90-8
4-bromophthalic anhydride

: 501-65-5
diphenyl acetylene

: 3-bromo-5,6,7,8-tetraphenyl-1-naphthoic acid

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; tetrabutylammomium bromide In N,N-dimethyl-formamide at 100℃; for 12h; Sealed tube;	90%

: 86-90-8
4-bromophthalic anhydride

: 2353-44-8
(+/-)-α-aminoglutarimide

: 26166-92-7
5-bromo-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Conditions

Conditions	Yield
With sodium acetate; acetic acid at 120℃; for 5h;	90%
With sodium acetate; acetic acid at 120℃; for 5h;	90%
With sodium acetate; acetic acid Reflux; Inert atmosphere;	82%
With sodium acetate; acetic acid at 75℃; for 12h; Inert atmosphere;	82%
With triethylamine In acetonitrile at 80℃; for 12h;	81%

: 86-90-8
4-bromophthalic anhydride

: 455-14-1
4-trifluoromethylphenylamine

: 5-bromo-2-(4-(trifluoromethyl)phenyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With acetic acid Reflux;	88%
In N,N-dimethyl-formamide at 150℃; for 24h; Inert atmosphere;	80%
In N,N-dimethyl-formamide for 24h; Inert atmosphere; Reflux;	70%
In N,N-dimethyl-formamide for 24h; Inert atmosphere; Reflux;	68%

: 86-90-8
4-bromophthalic anhydride

: 19341-56-1
n-butylguanidine hydrochloride

: 2,2'-((butylimino)methylene)bis(5-bromoisoindoline-1,3-dione)

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 50℃; for 5h; Reagent/catalyst; Inert atmosphere;	86%

4-Bromophthalic anhydride Chemical Properties

Molecular Structure of 4-Bromophthalic anhydride (CAS NO.86-90-8):

IUPAC Name: 5-bromo-2-benzofuran-1,3-dione
Empirical Formula: C₈H₃BrO₃
Molecular Weight: 227.0116
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 43.37 ?2
Index of Refraction: 1.651
Molar Refractivity: 43.37 cm³
Molar Volume: 118.7 cm³
Surface Tension: 62.7 dyne/cm
Density: 1.911 g/cm³
Flash Point: 172.6 °C
EINECS: 201-707-9
Melting Point: 107 °C
Enthalpy of Vaporization: 60.77 kJ/mol
Boiling Point: 361.8 °C at 760 mmHg
Vapour Pressure: 2.02E-05 mmHg at 25°C
InChI
InChI=1/C8H3BrO3/c9-4-1-2-5-6(3-4)8(11)12-7(5)10/h1-3H
Smiles
O1C(c2cc(Br)ccc2C1=O)=O
Product Categories: Phthalic Acids, Esters and Derivatives; Furan&Benzofuran

4-Bromophthalic anhydride Safety Profile

Safety information of 4-Bromophthalic anhydride (CAS NO.86-90-8):
Hazard Codes: C
Risk Statements:
6/37/38: Irritating to eyes, respiratory system and skin
Safety Statements:
6: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection

4-Bromophthalic anhydride Specification

4-Bromophthalic anhydride , with CAS number of 86-90-8, can be called 4-Bromophthalic acid anhydride ; 1,3-Isobenzofurandione,5-bromo- ; Timtec-bb sbb008534 ; 5-Bromo-1,3-isobenzofurandione ; 4-Bromo-1,2-benzenedicarboxylic anhydride . It is an off-white to white powder.

Product Name

4-Bromophthalic anhydride

Synthetic route

4-Bromophthalic anhydride Chemical Properties

4-Bromophthalic anhydride Safety Profile

4-Bromophthalic anhydride Specification

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