Product Name

  • Name

    4-Ethylbenzenesulfonamide

  • EINECS 680-161-7
  • CAS No. 138-38-5
  • Article Data14
  • CAS DataBase
  • Density 1.225 g/cm3
  • Solubility
  • Melting Point 111 °C
  • Formula C8H11NO2S
  • Boiling Point 329.658 °C at 760 mmHg
  • Molecular Weight 185.247
  • Flash Point 153.172 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 138-38-5 (4-Ethylbenzenesulfonamide)
  • Hazard Symbols Xi
  • Synonyms Benzenesulfonamide,p-ethyl- (6CI,7CI,8CI);4-Ethylbenzenesulfonamide;EBSA;NSC 9909;p-Ethylbenzenesulfonamide;
  • PSA 68.54000
  • LogP 2.67750

Synthetic route

triethyl borane
97-94-9

triethyl borane

4-bromo-benzenesulfonic acid amide
701-34-8

4-bromo-benzenesulfonic acid amide

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In tetrahydrofuran Suzuki coupling; Inert atmosphere; Reflux; chemoselective reaction;88%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In tetrahydrofuran Suzuki-Miyaura cross-coupling; Inert atmosphere; Reflux;88%
4-Ethyl-N-isopropylidene-benzenesulfonamide
110955-51-6

4-Ethyl-N-isopropylidene-benzenesulfonamide

A

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

B

acetone
67-64-1

acetone

Conditions
ConditionsYield
With water for 1h; Heating;A 77%
B n/a
1-Ethyl-3-trimethylsilylbenzol
17988-51-1

1-Ethyl-3-trimethylsilylbenzol

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With chlorure d'aluminium; chlorure de sulfamoyle In dichloromethane for 15h; Ambient temperature;38%
p-ethylbenzenesulfonyl chloride
16712-69-9

p-ethylbenzenesulfonyl chloride

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With ammonia at 20 - 100℃;9.5%
With ammonia
With ammonium hydroxide at 40℃; for 0.5h;
With ammonium hydroxide for 2h; Large scale;450 kg
With pyridine; ammonium hydroxide In dichloromethane at 0 - 20℃; for 4h;
ethylbenzene
100-41-4

ethylbenzene

A

4,4'-sulfonylbis(1-ethylbenzene)
66294-51-7

4,4'-sulfonylbis(1-ethylbenzene)

B

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With chlorosulphuric acid; chloroform Erwaermen des Reaktionsprodukts mit Ammoniumcarbonat;
1-ethyl-benzene-sulfonyl fluoride-(4)

1-ethyl-benzene-sulfonyl fluoride-(4)

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With ammonia
N-chloro-N-sodio-p-ethylbenzenesulfonamide

N-chloro-N-sodio-p-ethylbenzenesulfonamide

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With sodium hydroxide; D-Fructose In water at 29.85℃; Kinetics; Further Variations:; pH-values; Reagents; ionic strength values;
2-Ethyl-1,4-bis-trimethylsilanyl-benzene
128254-32-0

2-Ethyl-1,4-bis-trimethylsilanyl-benzene

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / acide trifluoroacetique / CCl4 / 15 h / Heating
2: 38 percent / chlorure d'aluminium, chlorure de sulfamoyle / CH2Cl2 / 15 h / Ambient temperature
View Scheme
ammonium hydroxide
1336-21-6

ammonium hydroxide

p-ethylbenzenesulfonyl chloride
16712-69-9

p-ethylbenzenesulfonyl chloride

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With sulfuric acid; trichlorophosphate In ethylbenzene; water
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

[1,1'-biphenyl]-2,2'-iodonium trifluoromethanesulfonate
189999-35-7

[1,1'-biphenyl]-2,2'-iodonium trifluoromethanesulfonate

9-((4-ethylphenyl)sulfonyl)-9H-carbazole
1469876-05-8

9-((4-ethylphenyl)sulfonyl)-9H-carbazole

Conditions
ConditionsYield
With copper diacetate; sodium carbonate In ethylene glycol; isopropyl alcohol at 90℃; for 16h; Inert atmosphere;100%
With copper diacetate; sodium carbonate; ethylene glycol In isopropyl alcohol at 85℃; for 16h; Ullmann Condensation; Inert atmosphere;74%
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

p-chlorphenylisocyanate
104-12-1

p-chlorphenylisocyanate

N-([(4-chlorophenyl)amino]carbonyl)-4-ethylbenzenesulfonamide
102607-92-1

N-([(4-chlorophenyl)amino]carbonyl)-4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With sodium hydroxide In acetone92%
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

triethylamine
121-44-8

triethylamine

(E)-N,N-diethyl-N'-((4-ethylphenyl)sulfonyl)formimidamide

(E)-N,N-diethyl-N'-((4-ethylphenyl)sulfonyl)formimidamide

Conditions
ConditionsYield
With N-Bromosuccinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 25℃; for 4h; Darkness;91%
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

A

benzhydryl ether
574-42-5

benzhydryl ether

B

C21H21NO2S

C21H21NO2S

Conditions
ConditionsYield
With acidic mesoporous zeolite β-catalyst In 1,2-dichloro-ethane at 80℃; for 6h; Inert atmosphere;A n/a
B 91%
...Expand
morpholine
110-91-8

morpholine

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

(E)-4-ethyl-N-(morpholinomethylene)benzenesulfonamide

(E)-4-ethyl-N-(morpholinomethylene)benzenesulfonamide

Conditions
ConditionsYield
With copper(I) bromide In dimethyl sulfoxide at 100℃; for 24h; Schlenk technique; stereoselective reaction;91%
4-ethylbiphenyl
5707-44-8

4-ethylbiphenyl

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

N-(1-([1,1'-biphenyl]-4-yl)ethyl)-4-ethylbenzenesulfonamide

N-(1-([1,1'-biphenyl]-4-yl)ethyl)-4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With tetrabutylammonium tetrafluoroborate In 1,2-dichloro-ethane at 20℃; for 2.5h; Electrochemical reaction; Inert atmosphere; regioselective reaction;84%
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

cyclohexanone
108-94-1

cyclohexanone

4-Ethylbenzolsulfanilid
64329-90-4

4-Ethylbenzolsulfanilid

Conditions
ConditionsYield
With 1,10-Phenanthroline; palladium(II) trifluoroacetate; oxygen In toluene at 140℃; for 40h;79%
p-ethylbenzenesulfonyl chloride
16712-69-9

p-ethylbenzenesulfonyl chloride

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

4-ethyl-N-[(4-ethylphenyl)sulfonyl]benzenesulfonamide

4-ethyl-N-[(4-ethylphenyl)sulfonyl]benzenesulfonamide

Conditions
ConditionsYield
With dmap; triethylamine In toluene at 70℃; for 12h;79%
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

(3R,4S)-1-(4-methylphenyl)-3-(3-p-toluenesulfonate-n-propyl)-4-(4-nitrophenyl)-2-azetidinone

(3R,4S)-1-(4-methylphenyl)-3-(3-p-toluenesulfonate-n-propyl)-4-(4-nitrophenyl)-2-azetidinone

(3R,4S)-1-(4-methylphenyl)-3-[3-(4-ethylbenzenesulfonamido)propyl]-4-(4-nitrophenyl)-2-azetidinone

(3R,4S)-1-(4-methylphenyl)-3-[3-(4-ethylbenzenesulfonamido)propyl]-4-(4-nitrophenyl)-2-azetidinone

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 90℃; for 12h;78%
Togni's reagent II
887144-94-7

Togni's reagent II

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

C9H10F3NO2S

C9H10F3NO2S

Conditions
ConditionsYield
With sodium decatungstate; sulfuric acid; copper dichloride In water; acetonitrile at 20 - 30℃; for 12h; Irradiation; regioselective reaction;77%
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

Eudesmic acid
118-41-2

Eudesmic acid

4,5,6-trimethoxy-2-(4-ethylphenylsulfonyl)isoindoline-1-one

4,5,6-trimethoxy-2-(4-ethylphenylsulfonyl)isoindoline-1-one

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In chlorobenzene at 110℃; for 12h; Pummerer Sulfoxide Rearrangement; Inert atmosphere;73%
...Expand
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

N-(tert-butyldimethylsilyl)-4-ethylbenzene-1-sulfonamide

N-(tert-butyldimethylsilyl)-4-ethylbenzene-1-sulfonamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 18h;71.8%
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

(1R,2R,4S,5S,6R)-6-Bromomethyl-3-oxa-tricyclo[3.2.1.02,4]octane

(1R,2R,4S,5S,6R)-6-Bromomethyl-3-oxa-tricyclo[3.2.1.02,4]octane

(1R,2S,3S,6S,7R)-4-(4-Ethyl-benzenesulfonyl)-4-aza-tricyclo[4.2.1.03,7]nonan-2-ol

(1R,2S,3S,6S,7R)-4-(4-Ethyl-benzenesulfonyl)-4-aza-tricyclo[4.2.1.03,7]nonan-2-ol

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In benzene for 1h; Heating;70%
4-bromo-2-trifluoromethyl-aniline
445-02-3

4-bromo-2-trifluoromethyl-aniline

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

N-(4-amino-3-(trifluoromethyl)phenyl)-4-ethylbenzenesulfonamide

N-(4-amino-3-(trifluoromethyl)phenyl)-4-ethylbenzenesulfonamide

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine at 70℃; for 20h;46%
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine at 70℃; for 20h;
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

N-(1-(2-((2-methoxy-4-methylphenyl)sulfonamido)-1-(3-methoxyphenyl)-2-oxoethyl)indolin-4-yl)-N-((4-methoxyphenyl)sulfonyl)glycine

N-(1-(2-((2-methoxy-4-methylphenyl)sulfonamido)-1-(3-methoxyphenyl)-2-oxoethyl)indolin-4-yl)-N-((4-methoxyphenyl)sulfonyl)glycine

2-(4-((N-(2-((4-ethylphenyl)sulfonamido)-2-oxoethyl)-4-methoxyphenyl)sulfonamido)indolin-1-yl)-N-((2-methoxy-4-methylphenyl)sulfonyl)-2-(3-methoxyphenyl)acetamide

2-(4-((N-(2-((4-ethylphenyl)sulfonamido)-2-oxoethyl)-4-methoxyphenyl)sulfonamido)indolin-1-yl)-N-((2-methoxy-4-methylphenyl)sulfonyl)-2-(3-methoxyphenyl)acetamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 40℃; for 4h;45%
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

Cyclohexyl isocyanate
3173-53-3

Cyclohexyl isocyanate

DK37
965-82-2

DK37

Conditions
ConditionsYield
Stage #1: 4-ethylbenzenesulfonamide With potassium carbonate In acetone for 1.5h; Heating;
Stage #2: Cyclohexyl isocyanate for 16h; Heating;		29.9%
9-hydroxyxanthene
90-46-0

9-hydroxyxanthene

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

4-ethyl-benzenesulfonic acid xanthen-9-ylamide

4-ethyl-benzenesulfonic acid xanthen-9-ylamide

Conditions
ConditionsYield
With acetic acid
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

4-acetylbenzenesulfonamide
1565-17-9

4-acetylbenzenesulfonamide

Conditions
ConditionsYield
With magnesium(II) nitrate; potassium permanganate; acetone
With chromium(VI) oxide; acetic acid for 3h; Ambient temperature; Yield given;
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

acrylonitrile
107-13-1

acrylonitrile

4-ethyl-benzenesulfonic acid-[bis-(2-cyano-ethyl)-amide]
100720-12-5

4-ethyl-benzenesulfonic acid-[bis-(2-cyano-ethyl)-amide]

Conditions
ConditionsYield
With N-benzyl-trimethylammonium hydroxide
4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl N-p-ethylbenzene-sulphonyl-formimidate
100981-70-2

ethyl N-p-ethylbenzene-sulphonyl-formimidate

Conditions
ConditionsYield
at 110℃; for 2h;
cis,trans-2,5-dimethoxytetrahydrofuran
696-59-3

cis,trans-2,5-dimethoxytetrahydrofuran

4-ethylbenzenesulfonamide
138-38-5

4-ethylbenzenesulfonamide

1-(4-Ethyl-benzenesulfonyl)-1H-pyrrole
891392-78-2

1-(4-Ethyl-benzenesulfonyl)-1H-pyrrole

Conditions
ConditionsYield
With acetic acid

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