4-Formylbenzenesulfonamide supplier

Name
Benzenesulfonamide, 4-formyl- (9CI)
EINECS
CAS No. 3240-35-5
Article Data28
CAS DataBase
Density 1.424 g/cm³
Solubility
Melting Point 118-120 °C
Formula C₇H₇NO₃S
Boiling Point 392.7 °C at 760 mmHg
Molecular Weight 185.203
Flash Point 191.3 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms p-(Aminosulfonyl)benzaldehyde;4-Sulfamoylbenzaldehyde;Benzenesulfonamide,p-formyl- (7CI,8CI);p-Formylbenzenesulfonamide;p-Sulfamoylbenzaldehyde;
PSA 85.61000
LogP 1.92760

Synthetic route

: 3119-02-6
4-cyanobenzenesulfonamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With formic acid; aluminum nickel Stephen reduction;	86%
With hydrogenchloride; diethyl ether und anschliessenden Behandeln mit einer Loesung von Zinn(II)-chlorid und Chlorwasserstoff in Aether;
With formic acid; nickel for 1h; Heating;
With formic acid

: 67472-44-0
4-(hydroxymethyl)benzenesulfonamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With Dess-Martin periodane In acetonitrile at 80℃; for 2h;	83%
With dipyridinium dichromate In tetrahydrofuran for 2h; Molecular sieve;	55%
With pyridinium chlorochromate In dichloromethane; acetone	53%

: 796072-77-0
(4-(N-acetylsulfamoyl)phenyl)methylene diacetate

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With sulfuric acid In ethanol; water at 90℃; for 3h; Sealed tube;	80%

: 179057-35-3
N-methoxy-N-methyl-(4-sulfamoyl)benzamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 20 - 50℃; for 7h; Reduction;	52%

: 99856-72-1
4-[bis(acetyloxy)methyl]benzenesulfonamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With sulfuric acid; water In methanol Reflux;	40%
With sulfuric acid In ethanol; water for 2h; Reflux;	12%
With hydrogenchloride
With sulfuric acid
Stage #1: 4-[bis(acetyloxy)methyl]benzenesulfonamide With ethanol; sulfuric acid; water for 2.5h; Heating / reflux; Stage #2: With potassium carbonate In water; ethyl acetate

: N-methoxy-N-methyl-4-sulfonamidobenzamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With LiAlH4 In tetrahydrofuran; methanol; chloroform	16%

: 70-55-3
toluene-4-sulfonamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
Trennung durch Ueberfuehren in das Anil;
Multi-step reaction with 2 steps 1: chromium(III) oxide; sulfuric acid / acetic acid / 5 - 10 °C 2: sulfuric acid; water / methanol / Reflux View Scheme
Multi-step reaction with 2 steps 1: chromium(VI) oxide; sulfuric acid / 2.5 h / 0 - 5 °C 2: sulfuric acid / water; ethanol / 3 h / 90 °C / Sealed tube View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid; chromium(VI) oxide / 4 h / 5 - 10 °C / Cooling with ice 2: sulfuric acid / water; ethanol / 2 h / Reflux View Scheme

N-<α,α-diacetoxy-toluene-sulfonyl-(4)>-acetamide: N-<α,α-diacetoxy-toluene-sulfonyl-(4)>-acetamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With hydrogenchloride

N-<4-sulfamoyl-benzyl>-hexamethylenetetraminium chloride: N-<4-sulfamoyl-benzyl>-hexamethylenetetraminium chloride

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With acetic acid

: 70-55-3
toluene-4-sulfonamide

sodium p-toluenesulfonic acid chloroamide: sodium p-toluenesulfonic acid chloroamide

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With water

: 63-74-1
sulfanilamide

docosen-(13c)-oyl chloride: docosen-(13c)-oyl chloride

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: NaNO2; HCl 1.2: 53 percent / aq. CuSO4 2.1: 86 percent / Ni-Al; 75 percent aq. HCO2H View Scheme

: 138-41-0
4-(aminosulfonyl)-benzoic acid

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 73 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH2Cl2 / 6 h / 20 °C 2: 52 percent / LiAlH4 / tetrahydrofuran / 7 h / 20 - 50 °C View Scheme
Multi-step reaction with 2 steps 1.1: diborane / tetrahydrofuran / 18.5 h / 0 - 20 °C 1.2: 1.5 h / 0 °C / Reflux 2.1: Dess-Martin periodane / acetonitrile / 2 h / 80 °C View Scheme

: 69232-47-9
(4-(chlorosulfonyl)phenyl)methylene diacetate

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH3 2: aqueous ethanol.H2SO4 View Scheme

: 98-59-9
p-toluenesulfonyl chloride

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2SO4; CrO3 2: NH3 3: aqueous ethanol.H2SO4 View Scheme

: 85822-16-8
4-formylbenzene-1-sulfonyl chloride

: 3240-35-5
4-formyl-benzenesulfonamide

Conditions

Conditions	Yield
With ammonia In tetrahydrofuran at 20℃; for 3h;
With ammonia In 1,4-dioxane; dichloromethane at 20℃; for 3h;

: 3240-35-5
4-formyl-benzenesulfonamide

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: C15H17N7O4S2*ClH

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%

: 3240-35-5
4-formyl-benzenesulfonamide

: 71682-97-8
3-(3,4-difluorophenyl)-3-oxopropanenitrile

: 4-(2-cyano-3-(3,4-difluorophenyl)-3-oxopropyl)benzenesulfonamide

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline In ethanol at 60℃; for 0.5h;	98%

: 3240-35-5
4-formyl-benzenesulfonamide

: 33977-11-6
5-chloro-2-methoxybenzoylhydrazide

: C15H14ClN3O4S

Conditions

Conditions	Yield
With acetic acid In ethanol for 15h; Reflux;	96%

: 3240-35-5
4-formyl-benzenesulfonamide

: 104-96-1
4-methylsulfanylaniline

: 4-methylthio-N-(4-sulfamoylbenzylidene)aniline

Conditions

Conditions	Yield
	95%

: 3240-35-5
4-formyl-benzenesulfonamide

: 614-16-4
Benzoylacetonitrile

: 4-(2-cyano-3-oxo-3-phenylpropyl)benzenesulfonamide

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline In ethanol at 60℃; for 0.5h;	94%

: 3240-35-5
4-formyl-benzenesulfonamide

: 67472-44-0
4-(hydroxymethyl)benzenesulfonamide

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol	92%

: 3240-35-5
4-formyl-benzenesulfonamide

: 915364-11-3
6-amino-4-cyclopentylaminoquinoline-3-carbonitrile

: 4-({[3-cyano-4-(cyclopentylamino)quinolin-6-yl]amino}methyl)benzenesulfonamide

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid In ethanol at 25 - 30℃; pH=4;	86%

: 3240-35-5
4-formyl-benzenesulfonamide

: 104-94-9
4-methoxy-aniline

: 4-methoxy-N-(4-sulfamoylbenzylidene)aniline

Conditions

Conditions	Yield
	85%
In methanol at 150℃; for 0.0833333h;	76%

: 3240-35-5
4-formyl-benzenesulfonamide

: 2591-86-8
N-Formylpiperidine

: 4-formyl-N-[(E)-piperidin-1-ylmethylidene]benzenesulfonamide

Conditions

Conditions	Yield
With oxalyl dichloride In dichloromethane at 0 - 20℃; for 3h;	84%

: 3240-35-5
4-formyl-benzenesulfonamide

: 106-49-0
p-toluidine

: N-(4-sulfamoylbenzylidene)-4-methylaniline

Conditions

Conditions	Yield
	82%
In methanol at 150℃; for 0.0833333h;	66%

: 3240-35-5
4-formyl-benzenesulfonamide

: 1-cyclopropyl-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one-3-carboxylic acid-(2-thioxo-1,3-thiazolidin-4-one-3-yl)amide

: 1-cyclopropyl-6-fluoro-7-(4-methylpiperazin-1-yl)quinolin-4(1H)-one-3-carboxylic acid-(2-sulfanylidene-5-p-sulfamoylphenylmethylidene-1,3-thiazolidin-4-one-3-yl)amide

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 12h; Reflux;	80.3%

: 3240-35-5
4-formyl-benzenesulfonamide

: C21H22FN5O4S2

: ofloxacin(5-p-sulfonamidobenzylidene-rhodanine-3-yl)amide

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 12h; Reflux;	78.2%

: 3240-35-5
4-formyl-benzenesulfonamide

: 3-([1,1'-biphenyl]-3-yl)-3-oxopropanenitrile

: 4-(3-([1,1'-biphenyl]-3-yl)-2-cyano-3-oxopropyl)benzenesulfonamide

Conditions

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline In ethanol at 60℃; for 0.5h;	78%

: 3240-35-5
4-formyl-benzenesulfonamide

: 20870-78-4
5-bromo-2-indolin-2-one

: 1261153-01-8
(E)-5-bromo-3-[[4-(sulfamoyl)phenyl]methylene]indolin-2-one

Conditions

Conditions	Yield
With sodium acetate In acetic acid for 4h; Knoevenagel condensation; Reflux;	77.8%

: 3240-35-5
4-formyl-benzenesulfonamide

: 6315-89-5
3,4-dimethoxyaniline

: C15H16N2O4S

Conditions

Conditions	Yield
In methanol at 150℃; for 0.0833333h;	76%

: 3240-35-5
4-formyl-benzenesulfonamide

: 123-30-8
4-amino-phenol

: C13H12N2O3S

Conditions

Conditions	Yield
In methanol at 150℃; for 0.0833333h;	75%

: 3240-35-5
4-formyl-benzenesulfonamide

: 106-47-8
4-chloro-aniline

: 4-chloro-N-(4-sulfamoylbenzylidene)aniline

Conditions

Conditions	Yield
	72%

: 3240-35-5
4-formyl-benzenesulfonamide

: 371-40-4
4-fluoroaniline

: 4-fluoro-N-(4-sulfamoylbenzylidene)aniline

Conditions

Conditions	Yield
In methanol at 150℃; for 0.0833333h;	72%
	25%

: 3240-35-5
4-formyl-benzenesulfonamide

: C21H23F2N5O3S2

: C28H28F2N6O5S3

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 12h; Reflux;	68%

: 3240-35-5
4-formyl-benzenesulfonamide

: 1986-47-6, 2208-35-7, 2337-86-2, 4548-34-9, 37388-05-9, 54779-58-7, 61-81-4
tranylcypromine hydrochloride

: 4-((((1S*,2R*)-2-phenylcyclopropyl)amino)methyl)benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: 4-formyl-benzenesulfonamide; tranylcypromine hydrochloride With acetic acid In 1,2-dichloro-ethane at 20℃; for 2h; Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane	68%

: 3240-35-5
4-formyl-benzenesulfonamide

: 619-45-4
4-methoxycarbonyl aniline

: C15H14N2O4S

Conditions

Conditions	Yield
In methanol at 150℃; for 0.0833333h;	65%

: 3240-35-5
4-formyl-benzenesulfonamide

: levofloxacin(rhodanine-3-yl)-amide

: levofloxacin (2-thio-5-sulfonamidophenyl-2-methylidene-thiazolidin-4-one-3-yl)-amide

Conditions

Conditions	Yield
With sodium acetate; acetic acid for 12h; Reflux;	64.5%

: 3240-35-5
4-formyl-benzenesulfonamide

: 42753-75-3
methyl 5-amino-2-hydroxybenzoate

: C15H14N2O5S

Conditions

Conditions	Yield
In methanol at 150℃; for 0.0833333h;	64%

: 3240-35-5
4-formyl-benzenesulfonamide

: 455-14-1
4-trifluoromethylphenylamine

: C14H11F3N2O2S

Conditions

Conditions	Yield
In methanol at 150℃; for 0.0833333h;	63%

: 3240-35-5
4-formyl-benzenesulfonamide

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1261152-97-9
(E)-5-fluoro-3-[[4-(sulfamoyl)phenyl]methylene]indolin-2-one

Conditions

Conditions	Yield
With sodium acetate In acetic acid for 4h; Knoevenagel condensation; Reflux;	62.9%

: 3240-35-5
4-formyl-benzenesulfonamide

: 20870-79-5
5-nitrooxindole

: 1261153-02-9
(E)-5-nitro-3-[[4-(sulfamoyl)phenyl]methylene]indolin-2-one

Conditions

Conditions	Yield
With sodium acetate In acetic acid for 4h; Knoevenagel condensation; Reflux;	62.3%

: 3240-35-5
4-formyl-benzenesulfonamide

: 57420-88-9
3-(2,6-dimethylphenoxy)propylamine

: 4-((3-(2,6-dimethylphenoxy)propylamino)methyl)benzenesulfonamide hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-formyl-benzenesulfonamide; 3-(2,6-dimethylphenoxy)propylamine In methanol at 20℃; Inert atmosphere; Stage #2: With sodium tetrahydroborate In methanol at 20℃; Inert atmosphere; Stage #3: With hydrogenchloride In methanol; water	62%

4-Formylbenzenesulfonamide Specification

The Benzenesulfonamide,4-formyl- is an organic compound with the formula C₇H₇NO₃S. The IUPAC name of this chemical is 4-formylbenzenesulfonamide. With the CAS registry number 3240-35-5, it is also named as 4-sulfamoylbenzaldehyde. Besides, its molecular weight is 185.20 and it belongs to the class of Sulfonamide.

Physical properties about Benzenesulfonamide,4-formyl- are: (1)ACD/LogP: 0.20; (2)ACD/LogD (pH 5.5): 0.2; (3)ACD/LogD (pH 7.4): 0.2; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 30.51; (7)ACD/KOC (pH 7.4): 30.38; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 62.83 Å²; (12)Index of Refraction: 1.594; (13)Molar Refractivity: 44.16 cm³; (14)Molar Volume: 130 cm³; (15)Polarizability: 17.5×10^-24cm³; (16)Surface Tension: 58.8 dyne/cm; (17)Density: 1.424 g/cm³; (18)Flash Point: 191.3 °C; (19)Enthalpy of Vaporization: 64.24 kJ/mol; (20)Boiling Point: 392.7 °C at 760 mmHg; (21)Vapour Pressure: 2.25E-06 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(N)c1ccc(C=O)cc1
(2)InChI: InChI=1/C7H7NO3S/c8-12(10,11)7-3-1-6(5-9)2-4-7/h1-5H,(H2,8,10,11)
(3)InChIKey: PCPUKVSTMLHXQF-UHFFFAOYAZ

Product Name

Benzenesulfonamide, 4-formyl- (9CI)

Synthetic route

4-Formylbenzenesulfonamide Specification

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