Product Name

  • Name

    4-Isopropylaniline

  • EINECS 202-797-2
  • CAS No. 99-88-7
  • Article Data63
  • CAS DataBase
  • Density 0.989
  • Solubility insoluble
  • Melting Point -63 ºC
  • Formula C9H13 N
  • Boiling Point 226-228 ºC
  • Molecular Weight 135.209
  • Flash Point 92 ºC
  • Transport Information
  • Appearance light brown clear liquid
  • Safety S36/37
  • Risk Codes R20/21/22   
  • Molecular Structure Molecular Structure of 99-88-7 (4-Isopropylaniline)
  • Hazard Symbols
  • Synonyms Cumidine(6CI,7CI,8CI); 1-Amino-4-isopropylbenzene; 4-(1-Methylethyl)benzenamine;4-(2-Propyl)aniline; 4-Amino-1-isopropylbenzene; 4-Aminocumene;4-Aminoisopropylbenzene; 4-Isopropylaniline; 4-Isopropylbenzenamine;4-Isopropylphenylamine; NSC 7198; [4-(1-Methylethyl)phenyl]amine; p-Cumidine;p-Isopropylaniline; b-(4-Aminophenyl)propane
  • PSA 26.02000
  • LogP 2.97340

Synthetic route

4-nitrocumene
1817-47-6

4-nitrocumene

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With triethylamine In water at 80℃; for 2h; Inert atmosphere; Green chemistry; chemoselective reaction;99%
With borane-ammonia complex In methanol; water at 49.84℃; for 0.1h; Catalytic behavior;99%
With nickel; ammonium chloride In water at 80 - 90℃; for 1.5h;96%
(4-isopropylphenyl)boronic acid
16152-51-5

(4-isopropylphenyl)boronic acid

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With copper(I) oxide; ammonium hydroxide; air In methanol at 20℃; for 12h;88%
1,2-Bis(4-isopropylphenyl)diazene
15887-26-0

1,2-Bis(4-isopropylphenyl)diazene

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With perchloric acid In isopropyl alcohol; acetonitrile at 25℃; for 0.8h; pH=2; Inert atmosphere; Irradiation;88%
isopropylmagnesium bromide
920-39-8

isopropylmagnesium bromide

p-aminoiodobenzene
540-37-4

p-aminoiodobenzene

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In tetrahydrofuran -78 deg C, 10 min, reflux, 24 h;87%
N-Isopropylaniline
768-52-5

N-Isopropylaniline

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With aluminum oxide; aluminium trichloride for 0.0583333h; microwave irradiation;87%
2-(4-bromophenyl)propane
586-61-8

2-(4-bromophenyl)propane

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With ammonium hydroxide; L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate In 1-methyl-pyrrolidin-2-one at 110℃; for 20h;87%
1-chloro-4-isopropylbenzene
2621-46-7

1-chloro-4-isopropylbenzene

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With ammonium sulfate; bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate at 100 - 110℃; for 12h;81%
4-isopropylphenylhydrazine
63693-65-2

4-isopropylphenylhydrazine

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With 4,4'-di-tert-butylbiphenyl; lithium; nickel dichloride In tetrahydrofuran at 20℃; Reduction;72%
Isopropylbenzene
98-82-8

Isopropylbenzene

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

meta-iso-propyl aniline
5369-16-4

meta-iso-propyl aniline

C

2-isopropylaniline
643-28-7

2-isopropylaniline

Conditions
ConditionsYield
With tris-(2-chloro-ethyl)-amine; trifluorormethanesulfonic acid; trifluoroacetic acid In chloroform at 25℃; for 5h;A 37%
B 9%
C 48%
aniline
62-53-3

aniline

isopropyl alcohol
67-63-0

isopropyl alcohol

A

propene
187737-37-7

propene

B

4-Isopropylaniline
99-88-7

4-Isopropylaniline

C

N-Isopropylaniline
768-52-5

N-Isopropylaniline

D

2-isopropylaniline
643-28-7

2-isopropylaniline

Conditions
ConditionsYield
With Ce-Y zeolite at 300℃; Product distribution; var. zeolites, temp., and flow rate;A n/a
B 1.9%
C 4%
D 10.7%
Isopropylbenzene
98-82-8

Isopropylbenzene

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

2-isopropylaniline
643-28-7

2-isopropylaniline

Conditions
ConditionsYield
With nitric acid man faellt mit Wasser das rohe Nitrocumol als Oel aus und reduziert es mit Schwefelammon in alkoh. Loesung;
With sulfuric acid; nitric acid man faellt mit Wasser das rohe Nitrocumol als Oel aus und reduziert es mit Zink und Salzsaeure;
Stage #1: Isopropylbenzene With nitric acid at 10℃; for 0.166667h; Flow reactor;
Stage #2: In toluene at 100℃; under 30003 Torr; Flow reactor; Overall yield = 76.79 %Chromat.;
A 59.4 %Chromat.
B 16.7 %Chromat.
N-Isopropylaniline
768-52-5

N-Isopropylaniline

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
With cobalt(II) chloride at 250℃;
With zinc dibromide at 250℃;
With cadmium(II) chloride at 250℃;
4,4'-(1-methyl-ethane-1,1-diyl)-bis-aniline
2479-47-2

4,4'-(1-methyl-ethane-1,1-diyl)-bis-aniline

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
With nickel at 200℃; under 36775.4 Torr; Hydrogenation;
With nickel; cyclohexanol at 200℃;
aniline
62-53-3

aniline

isopropyl alcohol
67-63-0

isopropyl alcohol

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

N,4-diisopropylaniline

N,4-diisopropylaniline

Conditions
ConditionsYield
With zinc(II) chloride at 260℃;
propane
74-98-6

propane

aniline
62-53-3

aniline

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

meta-iso-propyl aniline
5369-16-4

meta-iso-propyl aniline

C

2-isopropylaniline
643-28-7

2-isopropylaniline

Conditions
ConditionsYield
With oxygen In gaseous matrix at 80℃; Irradiation;A 35 % Spectr.
B 2 % Spectr.
C 63 % Spectr.
With oxygen In gaseous matrix at 80℃; Irradiation;A 35 % Spectr.
B n/a
C n/a
propane
74-98-6

propane

aniline
62-53-3

aniline

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

meta-iso-propyl aniline
5369-16-4

meta-iso-propyl aniline

C

N-Isopropylaniline
768-52-5

N-Isopropylaniline

D

2-isopropylaniline
643-28-7

2-isopropylaniline

Conditions
ConditionsYield
at 40℃; Mechanism; Product distribution; Irradiation; intramolecular selectivity in the gas-phase alkylation and acetylation of aniline by charged electrophiles;
4,4'-(1-methyl-ethane-1,1-diyl)-bis-aniline
2479-47-2

4,4'-(1-methyl-ethane-1,1-diyl)-bis-aniline

nickel

nickel

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
at 200℃; under 36775.4 Torr; Hydrogenation;
4,4'-(1-methyl-ethane-1,1-diyl)-bis-aniline
2479-47-2

4,4'-(1-methyl-ethane-1,1-diyl)-bis-aniline

cyclohexanol
108-93-0

cyclohexanol

nickel

nickel

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
at 225℃;
4-nitro-cumene

4-nitro-cumene

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With nickel; isopropyl alcohol at 100℃; under 58840.6 Torr; Hydrogenation;
With hydrogenchloride; tin
With hydrogenchloride; iron
N-Isopropylaniline
768-52-5

N-Isopropylaniline

cadmium chloride

cadmium chloride

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
at 250℃;
N-Isopropylaniline
768-52-5

N-Isopropylaniline

cobalt (II)-chloride

cobalt (II)-chloride

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
at 250℃;
N-Isopropylaniline
768-52-5

N-Isopropylaniline

zinc bromide

zinc bromide

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

aniline
62-53-3

aniline

Conditions
ConditionsYield
at 250℃;
hydrogenchloride
7647-01-0

hydrogenchloride

N-(4-iso-propylphenyl)benzamide
100990-57-6

N-(4-iso-propylphenyl)benzamide

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
at 150℃;
N-Isopropylaniline
768-52-5

N-Isopropylaniline

A

propene
187737-37-7

propene

B

4-Isopropylaniline
99-88-7

4-Isopropylaniline

C

aniline
62-53-3

aniline

D

2-isopropylaniline
643-28-7

2-isopropylaniline

Conditions
ConditionsYield
Ce-Y zeolite In hexane at 30℃; Product distribution; Further Variations:; Catalysts; Temperatures; other alkyl aniline; Isomerization; dealkylation;
N-(4-isopropylphenyl)-N',N'-dimethylurea
34123-59-6

N-(4-isopropylphenyl)-N',N'-dimethylurea

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

dimethyl amine
124-40-3

dimethyl amine

Conditions
ConditionsYield
With sulfuric acid In methanol; water at 80 - 90℃; Kinetics; Further Variations:; Temperatures;
N-(4-isopropylphenyl)-N',N'-dimethylurea
34123-59-6

N-(4-isopropylphenyl)-N',N'-dimethylurea

A

N,N-dimethylcarbamic acid
7260-94-8

N,N-dimethylcarbamic acid

B

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 90℃; Kinetics; Further Variations:; Temperatures; pH-values;
N-(4-isopropylphenyl)-N',N'-dimethylurea
34123-59-6

N-(4-isopropylphenyl)-N',N'-dimethylurea

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
With Arthrobacter sp. N2 In various solvent(s) pH=6.6; Kinetics;
aniline
62-53-3

aniline

isopropyl alcohol
67-63-0

isopropyl alcohol

A

4-Isopropylaniline
99-88-7

4-Isopropylaniline

B

N-Isopropylaniline
768-52-5

N-Isopropylaniline

C

2-isopropylaniline
643-28-7

2-isopropylaniline

Conditions
ConditionsYield
Li-Y zeolite at 350℃; Product distribution; Further Variations:; Catalysts; Temperatures;
Isopropylbenzene
98-82-8

Isopropylbenzene

Raney nickel

Raney nickel

4-Isopropylaniline
99-88-7

4-Isopropylaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HNO3, H2SO4 / nitromethane
2: H2 / PtO2 / ethanol
View Scheme
4-Isopropylaniline
99-88-7

4-Isopropylaniline

acetic anhydride
108-24-7

acetic anhydride

N-(4-iso-propylphenyl)acetamide
5702-74-9

N-(4-iso-propylphenyl)acetamide

Conditions
ConditionsYield
In dichloromethane at 20℃; Inert atmosphere;100%
With ZnAl2O4 nanoparticles at 20℃; for 0.05h; Neat (no solvent);96%
In neat (no solvent) at 20℃; for 0.05h;96%
dimethoxyacetaldehyde
51673-84-8

dimethoxyacetaldehyde

4-Isopropylaniline
99-88-7

4-Isopropylaniline

N-[(2,2-dimethoxyethyl)amino]-4-(2-propyl)aniline
205192-94-5

N-[(2,2-dimethoxyethyl)amino]-4-(2-propyl)aniline

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 760 Torr; for 18h;100%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

diethyl 2-ethoxymethylenemalonate
87-13-8

diethyl 2-ethoxymethylenemalonate

diethyl 4-i-propylanilinomethylenemalonate
64321-60-4

diethyl 4-i-propylanilinomethylenemalonate

Conditions
ConditionsYield
at 130℃; for 2h;100%
at 120℃; for 4h; Inert atmosphere;
2-(1H-pyrrol-1-yl)benzaldehyde
31739-56-7

2-(1H-pyrrol-1-yl)benzaldehyde

4-Isopropylaniline
99-88-7

4-Isopropylaniline

N-[4-(1-methylethyl)phenyl]-(2-(pyrrol-1-yl)phenylmethylen)amine

N-[4-(1-methylethyl)phenyl]-(2-(pyrrol-1-yl)phenylmethylen)amine

Conditions
ConditionsYield
at 20℃;100%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

[(2-{6-[(methyloxy)carbonyl]-3-phenyl-1H-indol-1-yl}ethyl)oxy]acetic acid
1198592-03-8

[(2-{6-[(methyloxy)carbonyl]-3-phenyl-1H-indol-1-yl}ethyl)oxy]acetic acid

methyl 1-{2-[(2-{[4-(1-methylethyl)phenyl]amino}-2-oxoethyl)oxy]ethyl}-3-phenyl-1H-indole-6-carboxylate
1198592-04-9

methyl 1-{2-[(2-{[4-(1-methylethyl)phenyl]amino}-2-oxoethyl)oxy]ethyl}-3-phenyl-1H-indole-6-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h;100%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide
50978-45-5

3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

N-[4-(propan-2-yl)phenyl]formamide
5279-58-3

N-[4-(propan-2-yl)phenyl]formamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 0.25h; chemoselective reaction;100%
2-chloro-6-methoxyquinazoline
850424-11-2

2-chloro-6-methoxyquinazoline

4-Isopropylaniline
99-88-7

4-Isopropylaniline

N-(4-isopropylphenyl)-6-methoxyquinazolin-2-amine
1374336-64-7

N-(4-isopropylphenyl)-6-methoxyquinazolin-2-amine

Conditions
ConditionsYield
In ethanol at 80℃; for 16h;100%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

2-chloro-5-methoxyquinoline
160893-07-2

2-chloro-5-methoxyquinoline

N-(4-isopropylphenyl)-5-methoxyquinolin-2-amine

N-(4-isopropylphenyl)-5-methoxyquinolin-2-amine

Conditions
ConditionsYield
In neat (no solvent) at 160℃;100%
In neat (no solvent) at 160℃;
4-Isopropylaniline
99-88-7

4-Isopropylaniline

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

(4-isopropylphenyl)boronic acid
16152-51-5

(4-isopropylphenyl)boronic acid

Conditions
ConditionsYield
With tert.-butylnitrite In acetonitrile at 0 - 80℃; for 2h;99.8%
With tert.-butylnitrite In acetonitrile at 0 - 80℃; for 2h;99.8%
formic acid
64-18-6

formic acid

4-Isopropylaniline
99-88-7

4-Isopropylaniline

N-[4-(propan-2-yl)phenyl]formamide
5279-58-3

N-[4-(propan-2-yl)phenyl]formamide

Conditions
ConditionsYield
for 16h; Reflux;99%
With choline chloride*2SnCl2 at 70℃; for 0.333333h;97%
With choline chloride*2SnCl2 at 70℃;97%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

pivaloyl chloride
3282-30-2

pivaloyl chloride

N-(4-isopropylphenyl)pivalamide
448250-70-2

N-(4-isopropylphenyl)pivalamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;99%
With TEA In dichloromethane at 0 - 25℃; for 3h; Acylation;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Trimethylacetic acid In dichloromethane at 20℃; for 18h;
4-Isopropylaniline
99-88-7

4-Isopropylaniline

dicyclohexyl-carbodiimide
538-75-0

dicyclohexyl-carbodiimide

N-(p-isopropylphenyl)-N',N''-dicyclohexylguanidine

N-(p-isopropylphenyl)-N',N''-dicyclohexylguanidine

Conditions
ConditionsYield
[(Me3Si)2N]3Yb(μ-Cl)Li(THF)3 In dichloromethane at 40℃; for 4h;99%
With C23H40AlN In toluene at 25℃; for 1h; Inert atmosphere; Schlenk technique;92%
With [Cp*2(Me)Zr(μ-O)Zr(NMe2)2(μ-O)Zr(Me)Cp*2] In benzene-d6 at 110℃; for 12h; Temperature; Reagent/catalyst; Time; Inert atmosphere;
cis,trans-2,5-dimethoxytetrahydrofuran
696-59-3

cis,trans-2,5-dimethoxytetrahydrofuran

4-Isopropylaniline
99-88-7

4-Isopropylaniline

1-(4-(iso-propyl)phenyl)-1H-pyrrole
166963-93-5

1-(4-(iso-propyl)phenyl)-1H-pyrrole

Conditions
ConditionsYield
In acetic acid; ethyl acetate99%
In acetic acid; ethyl acetate99%
In acetic acid for 1.5h; Heating / reflux;99%
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

4-Isopropylaniline
99-88-7

4-Isopropylaniline

(4-isopropylphenyl){(E)-[4-(trifluoromethyl)phenyl]methylene}amine
884600-73-1

(4-isopropylphenyl){(E)-[4-(trifluoromethyl)phenyl]methylene}amine

Conditions
ConditionsYield
Stage #1: 4-Trifluoromethylbenzaldehyde; 4-Isopropylaniline In water at 20℃; for 2h;
Stage #2: In dichloromethane; water for 0.333333h;
99%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

2-Iodobenzoyl chloride
609-67-6

2-Iodobenzoyl chloride

2-iodo-N-(4-isopropylphenyl)benzamide
331270-10-1

2-iodo-N-(4-isopropylphenyl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 3h;99%
With triethylamine In dichloromethane
With pyridine In dichloromethane at 0 - 20℃;
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

4-Isopropylaniline
99-88-7

4-Isopropylaniline

ethyl 2-((4-isopropylphenyl)amino)acetate
890169-52-5

ethyl 2-((4-isopropylphenyl)amino)acetate

Conditions
ConditionsYield
With sodium dithionite; myoglobin mutant H64V,V68A In aq. phosphate buffer pH=8.0; Reagent/catalyst; chemoselective reaction;99%
With sodium dithionite; Bacillus megaterium cytochrome P450 variant H2-5-F10 In aq. phosphate buffer at 20℃; for 12h; pH=8; Enzymatic reaction;59%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

indole-2,3-dione
91-56-5

indole-2,3-dione

C17H16N2O

C17H16N2O

Conditions
ConditionsYield
In methanol Reflux;99%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

benzyl alcohol
100-51-6

benzyl alcohol

N-benzyl-4-isopropylaniline

N-benzyl-4-isopropylaniline

Conditions
ConditionsYield
With C55H43ClN5P2Ru(1+)*Cl(1-); potassium hydroxide In toluene at 140℃; for 2h; Sealed tube;99%
With C17H18IrN3O; caesium carbonate at 120℃; for 20h; Inert atmosphere;93%
With tetrakis[3,5-bis(trifluoromethyl)phenyl]boric acid bis(diethyl ether) complex; C32H63CoNP2Si(2+) In toluene for 48h; Molecular sieve; Reflux; Inert atmosphere; chemoselective reaction;90%
With 9-N-methylamino-1-oxophenalene; potassium tert-butylate In toluene at 130℃; for 18h; Inert atmosphere;81%
With [(NH-C3H5)Tr(NHP(iPr)2)2CoCl2]; potassium tert-butylate In toluene at 80℃; for 24h;76%
potassium cyanate
590-28-3

potassium cyanate

4-Isopropylaniline
99-88-7

4-Isopropylaniline

3-[4-(1-methylethyl)]phenylurea
56046-17-4

3-[4-(1-methylethyl)]phenylurea

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 2h; Inert atmosphere;99%
3-bromo-3-methyl-2-indolinone
2406-05-5

3-bromo-3-methyl-2-indolinone

4-Isopropylaniline
99-88-7

4-Isopropylaniline

(R)-3-((4-isopropylphenyl)amino)-3-methylindolin-2-one

(R)-3-((4-isopropylphenyl)amino)-3-methylindolin-2-one

Conditions
ConditionsYield
Stage #1: 3-bromo-3-methyl-2-indolinone With nickel(II) tetrafluoroborate hexahydrate; C42H66N4O8 In ethyl acetate at 35℃; for 0.583333h;
Stage #2: With N-ethyl-N,N-diisopropylamine In ethyl acetate at 0℃; for 0.166667h;
Stage #3: 4-Isopropylaniline In ethyl acetate at 0℃; for 24h; enantioselective reaction;
99%
methyl 2-bromomethylbenzoate
2417-73-4

methyl 2-bromomethylbenzoate

4-Isopropylaniline
99-88-7

4-Isopropylaniline

2-(4-isopropylphenyl)isoindolin-1-one

2-(4-isopropylphenyl)isoindolin-1-one

Conditions
ConditionsYield
at 140℃; for 2h;98.35%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

4-Isopropylaniline
99-88-7

4-Isopropylaniline

4-isopropylphenylisocyanate
31027-31-3

4-isopropylphenylisocyanate

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 70 - 83℃;98.2%
With triethylamine In benzene Substitution; dehydrochlorination; Heating;66.2%
With triethylamine In dichloromethane at 0 - 20℃; for 0.0833333h;
4-Isopropylaniline
99-88-7

4-Isopropylaniline

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

4-Chloro-N-(4-isopropyl-phenyl)-benzamide

4-Chloro-N-(4-isopropyl-phenyl)-benzamide

Conditions
ConditionsYield
With pyridine for 24h; Ambient temperature;98%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-Isopropylaniline
99-88-7

4-Isopropylaniline

4-isopropyl-N-tert-butoxycarbonylaniline
164226-14-6

4-isopropyl-N-tert-butoxycarbonylaniline

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 25℃; for 17h; Inert atmosphere;98%
With choline chloride; urea at 50℃; Green chemistry;95%
With 3a,6a-diphenylglycoluril In ethanol at 25 - 30℃; for 0.333333h; Catalytic behavior; Reagent/catalyst;95%
With triethylamine In tetrahydrofuran at 25℃; for 17h; Inert atmosphere;67%
With dmap In dichloromethane at 20℃; for 0.5h;
4-Isopropylaniline
99-88-7

4-Isopropylaniline

1-azido-4-isopropylbenzene

1-azido-4-isopropylbenzene

Conditions
ConditionsYield
Stage #1: 4-Isopropylaniline With hydrogenchloride; sodium nitrite In water; ethyl acetate at 0℃; for 1h;
Stage #2: With sodium azide In water; ethyl acetate at 20℃; for 4h;
98%
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 20℃; for 1h;96%
Stage #1: 4-Isopropylaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 2h;
Stage #2: With sodium azide In water at 0 - 20℃;
94%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

diisopropyl-carbodiimide
693-13-0

diisopropyl-carbodiimide

N-(p-isopropylphenyl)-N',N''-diisopropylguanidine

N-(p-isopropylphenyl)-N',N''-diisopropylguanidine

Conditions
ConditionsYield
[(Me3Si)2N]3Yb(μ-Cl)Li(THF)3 In tetrahydrofuran at 60℃; for 4h;98%
With C23H40AlN In toluene at 25℃; for 1h; Inert atmosphere; Schlenk technique;89%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

p-chlorobenzoylphenylacetylene
16616-42-5

p-chlorobenzoylphenylacetylene

(Z)-3-(4-isopropylphenylamino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one
1025784-68-2

(Z)-3-(4-isopropylphenylamino)-1-(4-chlorophenyl)-3-phenylprop-2-en-1-one

Conditions
ConditionsYield
at 80℃; for 1h; Michael addition;98%
4-Isopropylaniline
99-88-7

4-Isopropylaniline

N,N-Dimethylcarbamoyl chloride
79-44-7

N,N-Dimethylcarbamoyl chloride

N-(4-isopropylphenyl)-N',N'-dimethylurea
34123-59-6

N-(4-isopropylphenyl)-N',N'-dimethylurea

Conditions
ConditionsYield
With sodium carbonate; sodium iodide In hexane at 50℃; for 16h; pH=7;98%
With triethylamine In dichloromethane at 0 - 20℃; for 24h;
4-Isopropylaniline
99-88-7

4-Isopropylaniline

o-phthalic dicarboxaldehyde
643-79-8

o-phthalic dicarboxaldehyde

1-p-isopropylphenylimino-2-p-isopropylphenylisoindoline
1093076-04-0

1-p-isopropylphenylimino-2-p-isopropylphenylisoindoline

Conditions
ConditionsYield
With formic acid In diethyl ether at 20℃; for 12h; Inert atmosphere;98%

4-IsopropylAniline Chemical Properties

Product Name:4-Isopropylaniline.
The MF of 4-Isopropylaniline(99-88-7) is C9H13N.

                                      
The MW of 4-Isopropylaniline(99-88-7) is 135.21.
Synonyms:4-AMINO-1-ISOPROPYLBENZENE;4-AMINOCUMENE;4-AMINOCUMOL;4-ISOPROPYLANILINE;AKOS BBS-00003562;CUMIDENE;CUMIDINE;P-ISOPROPYLANILINE
EINECS: 202-797-2
Mol File: 99-88-7.mol
MP:-63 °C
FP:198 °F  
BP:226-227 °C745 mm Hg(lit.)
Density:0.989 g/mL at 25 °C(lit.)
Refractive index:n20/D 1.543(lit.)
Water Solubility:insoluble
Sensitive:Light Sensitive
Merck:14,2620
BRN:1930544
CAS DataBase Reference:99-88-7(CAS DataBase Reference)
NIST Chemistry Reference:99-88-7(NIST)

4-IsopropylAniline Uses

The 4-Isopropylaniline(99-88-7) is used as an intermediate herbicide isoproturon,medicine and pesticide intermediates.

4-IsopropylAniline Toxicity Data With Reference

  • RTECS#: CAS# 99-88-7: None listed
    LD50/LC50: RTECS: Not available. 
    Carcinogenicity: 4-Isopropylaniline - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
    Other: The toxicological properties have not been fully investigated.

4-IsopropylAniline Safety Profile

Safety information of 4-Isopropylaniline(99-88-7):
Hazard Codes:Xi,Xn
Risk Statements:36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin ;
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed ;
Safety Statements:26-36/37
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice ;
S36/37:Wear suitable protective clothing and gloves ;
WGK Germany:2
Hazard Note:Irritant
HS Code:29214980

4-IsopropylAniline Specification

It is air sensitive and light sensitive.Incompatibilities with strong oxidizing agents, strong acids.Hazardous decomposition products are carbon monoxide, oxides of nitrogen, carbon dioxide.
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