4-Isopropylphenol supplier

Name
4-Isopropylphenol
EINECS 202-798-8
CAS No. 99-89-8
Article Data135
CAS DataBase
Density 0.987 g/cm³
Solubility Slightly soluble in water, soluble in ethanol and ethyl ether
Melting Point 59-62 ºC
Formula C₉H₁₂O
Boiling Point 208.6 °C at 760 mmHg
Molecular Weight 136.194
Flash Point 95.3 °C
Transport Information UN 2430
Appearance white to beige crystalline solid
Safety 26-36/37/39-45-61
Risk Codes 22-34-43-52/53
Molecular Structure
Hazard Symbols C
Synonyms Phenol,p-isopropyl- (8CI);4-(1-Methylethyl)phenol;4-Isopropylphenol;Australol;NSC1888;p-Cumenol;p-Isopropylphenol;
PSA 20.23000
LogP 2.51560

Synthetic route

: 4132-79-0
4-isopropyl-phenetole

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.5h; Microwave irradiation; Inert atmosphere;	99%
With hydrogen iodide

: 4132-48-3
1-methoxy-4-(1-methylethyl)benzene

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 220℃; for 0.666667h; Inert atmosphere; Microwave irradiation;	98%
With trimethylsilyl iodide at 105 - 114℃; for 0.25h; Microwave irradiation; Inert atmosphere;	92%
With tetrachlorosilane; borontrifluoride acetic acid; lithium iodide In toluene; acetonitrile at 70℃; for 10h;	89%
With hydrogen iodide

: 16152-51-5
(4-isopropylphenyl)boronic acid

: 7722-84-1
dihydrogen peroxide

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique;	97%

: 25237-77-8
(4-isopropylphenoxy)trimethylsilane

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0666667h; Green chemistry;	96%
With poly (ethylene glycol)-sulfonated sodium montmorillonite nanocomposite In methanol at 20℃; for 0.166667h;	91%

: 28530-35-0
4-propoxycumene

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 200 - 220℃; for 0.5h; Microwave irradiation; Inert atmosphere;	96%

: 16152-51-5
(4-isopropylphenyl)boronic acid

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With dihydrogen peroxide In ethanol at 20℃; for 0.166667h;	96%
With iron(III) oxide; oxygen In tetrahydrofuran Irradiation;	95%
With iron(III) oxide; oxygen In tetrahydrofuran at 20℃; Irradiation;	95%

: 1338215-41-0
[2-(4-isopropylphenoxy)ethyl]trimethylsilane

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
Stage #1: [2-(4-isopropylphenoxy)ethyl]trimethylsilane With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere; Stage #2: With water In N,N-dimethyl-formamide Inert atmosphere;	88%

: 41485-62-5
4-isopropylphenyl lithium

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With titanium(IV) isopropylate; tert.-butylhydroperoxide In diethyl ether at -78℃; for 12h;	80%

: 4-hydroxy-4-isopropylcyclohexa-2,5-dien-1-one

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With sodium hydride; bis(pinacol)diborane In 1,2-dichloro-ethane at 70℃; for 12h; Inert atmosphere;	77%

: 127-91-3
(1R,5R)-(+)-β-pinene

A: 99-89-8
4-Isopropylphenol

B: 77982-63-9
nopinone

Conditions

Conditions	Yield
Stage #1: (1R,5R)-(+)-β-pinene With ozone In methanol Stage #2: With iron(III) chloride hexahydrate In methanol at 60℃; for 2h;	A 15% B 70%

: aluminium isopropoxide

: 2216-51-5
(-)-menthol

: 108-95-2
phenol

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

C: 2741-16-4
isopropoxybenzene

D: 618-45-1
3-isopropylhydroxybenzene

Conditions

Conditions	Yield
at 120℃; for 15h;	A 64% B 23% C 10% D 3%

...Expand

: 100-18-5
1,4-bis(1-methylethyl)benzene

A: 99-89-8
4-Isopropylphenol

B: 123-31-9
hydroquinone

Conditions

Conditions	Yield
Stage #1: 1,4-bis(1-methylethyl)benzene With N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile); oxygen In acetonitrile at 75℃; under 760.051 Torr; for 20h; Stage #2: With sulfuric acid In acetonitrile at 75℃; for 4h; Further stages.;	A 33% B 61%

: 67-63-0
isopropyl alcohol

: 108-95-2
phenol

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

C: 644-35-9
5-propylphenol

D: 2078-54-8
2,6-diisopropylphenol

Conditions

Conditions	Yield
With supercritical water at 399.84℃; for 1h; Kinetics; Further Variations:; Time;	A 57.9% B 2.4% C 6.9% D 5.9%

...Expand

: allyl 1-isopropyl-4-oxocyclohexa-2,5-dienecarboxylate

A: 99-89-8
4-Isopropylphenol

B: 71029-37-3
1-(allyloxy)-4-isopropylbenzene

C: 74663-59-5
2-allyl-4-isopropylphenol

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In toluene at 110℃; for 0.5h; Inert atmosphere;	A 44% B 8% C 48%

...Expand

: 67-63-0
isopropyl alcohol

: 108-95-2
phenol

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

C: 2078-54-8
2,6-diisopropylphenol

D: 2741-16-4
isopropoxybenzene

Conditions

Conditions	Yield
With HMCM-49/MCM-41 composite at 180℃; under 760.051 Torr; for 1h; Flow reactor;	A 41.6% B 13.3% C n/a D n/a

...Expand

: aluminium isopropoxide

: 2216-51-5
(-)-menthol

: 108-95-2
phenol

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

C: 618-45-1
3-isopropylhydroxybenzene

Conditions

Conditions	Yield
at 160℃; for 15h;	A 37% B 26% C 37%

...Expand

: 67-63-0
isopropyl alcohol

: 108-95-2
phenol

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

C: 2078-54-8
2,6-diisopropylphenol

D: 2934-07-8
2,4,6-triisopropylphenol

Conditions

Conditions	Yield
With HMCM-49 at 180℃; under 760.051 Torr; for 1h; Flow reactor;	A 35.5% B 9.4% C n/a D n/a

...Expand

: 18412-75-4
(4-isopropylbenzyl)trimethylsilane

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With sodium persulfate; oxygen In acetonitrile at 55℃; for 20h;	33%

: 98-82-8
Isopropylbenzene

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

C: 617-94-7
1-methyl-1-phenylethyl alcohol

D: 618-45-1
3-isopropylhydroxybenzene

Conditions

Conditions	Yield
With pyridine-2-carbaldehyde; 2-(Aminomethyl)pyridine; iron(II) trifluoromethanesulfonate acetonitrile disolvate; dihydrogen peroxide In acetonitrile at 25℃; for 1.5h; chemoselective reaction;	A 7% B n/a C 6% D n/a
With VO(O2)(picolinato)(H2O)2 In acetonitrile at 20℃; Product distribution; Mechanism;

...Expand

: 80-05-7
BPA

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
bei der Destillation;
With palladium on activated charcoal
With copper oxide-chromium oxide; hydrogen at 220 - 230℃; under 132391 Torr;

: 80-05-7
BPA

A: 99-89-8
4-Isopropylphenol

B: 108-95-2
phenol

Conditions

Conditions	Yield
Hydrogenolyse;
at 160℃; under 7600 - 15200 Torr; Hydrogenation.in Gegenwart eines wismuthaltigen Nickel-, Kobalt- oder Kupfer-Katalysators;

: 2741-16-4
isopropoxybenzene

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With dihydroxodifluoroboric acid bei Siedetemperatur;
With aluminium trichloride

: 99-88-7
4-Isopropylaniline

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite Erwaermen der erhaltenen Diazoniumsalz-Loesung auf 50-60grad;
via p-cumenediazonium salt; Multistep reaction;
With sulfuric acid; sodium nitrite Erwaermen der erhaltenen Diazoniumsalz-Loesung auf 50-60grad;

: 31589-71-6
2-hydroxy-5-isopropylbenzoic acid

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With hydrogenchloride at 180℃;

: 98-49-7
1-(4-isopropyl-phenyl)-1-methyl-ethyl hydroperoxide

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With sulfuric acid
With sulfuric acid

: 1095-03-0
triphenylborane

: 106-94-5
propyl bromide

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With aluminium trichloride anschliessendes Behandeln mit H2O;

: 67-63-0
isopropyl alcohol

: 108-95-2
phenol

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With phosphoric acid at 95 - 130℃;
With iron(III) chloride at 120 - 130℃;
With boron trifluoride

...Expand

: 67-63-0
isopropyl alcohol

: 108-95-2
phenol

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With boron trifluoride
With aluminium trichloride; Petroleum ether at 110 - 120℃;
With iron(III) chloride at 120 - 130℃;

: 80-05-7
BPA

: 108-93-0
cyclohexanol

: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With hydrogenation catalyst at 220 - 230℃;

: 71-23-8
propan-1-ol

: 108-95-2
phenol

A: 88-69-7
2-(1-methylethyl)phenol

B: 99-89-8
4-Isopropylphenol

Conditions

Conditions	Yield
With boron trifluoride
With phosphoric acid at 95 - 130℃;
With boric acid Erhitzen des Reaktionsprodukts mit wenig H2SO4 und anschliessend mit H2O;

...Expand

: 99-89-8
4-Isopropylphenol

: 106-96-7
propargyl bromide

: 1-isopropyl-4-(prop-2-yn-1-yloxy)benzene

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile	100%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	92%
With potassium carbonate In acetone for 4h; Reflux;	80.3%

: 99-89-8
4-Isopropylphenol

: 100-39-0
benzyl bromide

: 28530-42-9
1-(benzyloxy)-4-isopropylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 12h; Reflux; Sealed tube;	100%
Stage #1: 4-Isopropylphenol With potassium carbonate In N,N-dimethyl-formamide for 2h; Inert atmosphere; Stage #2: benzyl bromide In N,N-dimethyl-formamide at 60℃; for 12h;
With tetra-(n-butyl)ammonium iodide; potassium hydroxide In acetonitrile for 2h;
With tetra-(n-butyl)ammonium iodide; potassium hydroxide In acetonitrile for 1h; Cooling;

: 4548-45-2
2-chloro-5-nitropyridine

: 99-89-8
4-Isopropylphenol

: 76893-56-6
2-(4-isopropylphenoxy)-5-nitropyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;	99%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;	99%
With sodium hydroxide; tetrabutyl-ammonium chloride In water; benzene at 56℃; for 0.25h;	71%

: 99-89-8
4-Isopropylphenol

: 35787-71-4
thianthrene cation radical perchlorate

: 5-(2-Hydroxy-5-isopropyl-phenyl)-thianthren-5-ium; perchlorate

Conditions

Conditions	Yield
In acetonitrile for 18h;	99%

: 99-89-8
4-Isopropylphenol

: 122-60-1
Phenyl glycidyl ether

: 1260374-16-0
1-(4'-isopropylphenoxy)-3-phenoxypropan-2-ol

Conditions

Conditions	Yield
With 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine supported on polystyrene (PS-BEMP; PS = 200-400 mesh polystyryl with 2percent of divinylbenzene) at 60℃; for 18h; Neat (no solvent); regioselective reaction;	99%
With 1,4-bis(4-vinylphenoxy)benzene crosslinked polystyrene functionalized with 1,5,7-triazabicyclo[4.4.0]dec-5-ene In neat (no solvent) at 60℃; for 18h; Reagent/catalyst; Green chemistry;

: 99-89-8
4-Isopropylphenol

: 935-02-4
2-cyano-1-phenylacetylene

: 1395087-33-8
(Z)-3-(4-isopropylphenoxy)-3-phenylacrylonitrile

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 20 - 25℃; for 12h; optical yield given as %de;	99%

: 99-89-8
4-Isopropylphenol

: C20H13ClF2S

: C38H35ClO2S

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	99%

: 99-89-8
4-Isopropylphenol

: 696-29-7
(1-methylethyl)-cyclohexane

Conditions

Conditions	Yield
With hydrogen In dodecane at 200℃; under 15001.5 Torr; for 2h;	98.2%

: 99-89-8
4-Isopropylphenol

: 74-88-4
methyl iodide

: 4132-48-3
1-methoxy-4-(1-methylethyl)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	98%
Stage #1: 4-Isopropylphenol With potassium carbonate In acetone Stage #2: methyl iodide In acetone Further stages.;	98%
With sodium hexamethyldisilazane In tetrahydrofuran at 20℃; for 23h; Inert atmosphere;	83%

: 99-89-8
4-Isopropylphenol

: 58456-88-5
2-iodo-4-(1-methylethyl)phenol

Conditions

Conditions	Yield
With N-iodo-succinimide; toluene-4-sulfonic acid In dichloromethane at 20℃;	98%
Stage #1: 4-Isopropylphenol With ammonium iodide In methanol at 0℃; for 0.0333333h; Stage #2: With potassium phosphate In methanol for 0.0833333h;	90%
With N-iodo-succinimide In various solvent(s) at 27℃; for 0.666667h;	89%

: 99-89-8
4-Isopropylphenol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 25237-77-8
(4-isopropylphenoxy)trimethylsilane

Conditions

Conditions	Yield
With 3-methyl-1-sulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0333333h; Neat (no solvent);	98%
With succinimide-N-sulfonic acid In acetonitrile at 20℃; for 0.0333333h; chemoselective reaction;	98%
With 1,3-disulfonic acid imidazolium hydrogen sulfate In neat (no solvent) at 20℃; for 0.0333333h; Green chemistry;	98%

: 99-89-8
4-Isopropylphenol

: 1493-27-2
ortho-nitrofluorobenzene

: 640766-56-9
1-(4-isopropylphenoxy)-2-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h; Inert atmosphere;	98%
Stage #1: 4-Isopropylphenol With potassium tert-butylate In tetrahydrofuran for 1h; Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran

: 99-89-8
4-Isopropylphenol

: 105-36-2
ethyl bromoacetate

: 14062-21-6
(4-isopropylphenyl)acetic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 48h;	98%

: 99-89-8
4-Isopropylphenol

: 4784-77-4, 39616-19-8, 29576-14-5
(E)-1-Bromo-2-butene

: 104395-27-9
(E)-1-(but-2-en-1-yloxy)-4-isopropylbenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 6h; Heating;	97%

: 99-89-8
4-Isopropylphenol

: 1638114-19-8
C18H20O3

Conditions

Conditions	Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; N,N'-di-tert-butylethylenediamine; oxygen In dichloromethane at 20 - 23℃; under 760.051 Torr; for 4h;	97%
With tetrakis(actonitrile)copper(I) hexafluorophosphate; N,N'-di-tert-butylethylenediamine; oxygen In dichloromethane at 23℃; under 760.051 Torr; for 4h; Reagent/catalyst;	92%
With N,N'-di-tert-butylethylenediamine; oxygen; copper(II) acetate monohydrate In dichloromethane at 25℃; under 1520.1 Torr; for 4h; Catalytic behavior; Glovebox;	87%

: 99-89-8
4-Isopropylphenol

: 100-35-6
2-(diethylamino)ethyl chloride

: 57586-09-1
1-(2-Diethylaminoethoxy)-4-isopropyl-benzol

Conditions

Conditions	Yield
	96%

: 99-89-8
4-Isopropylphenol

: 11-amino-6-chloro-9-mercapto-5H-naphtho[2,1-b]pyrimido[5,4-e][1,4]oxazin-5-one

: 11-amino-9-mercapto-6-(4-isopropylphenoxy)-8,10-diaza-5H-benzo[a]phenoxazin-5-one

Conditions

Conditions	Yield
With palladium diacetate; tert-butyl XPhos In toluene at 100 - 110℃; for 7h; Inert atmosphere;	96%

: 99-89-8
4-Isopropylphenol

: 1576-10-9
4-isopropyl-2-nitrophenol

Conditions

Conditions	Yield
With nitric acid; copper(II) nitrate In water at 20 - 25℃; for 2h;	95.1%
With Eu-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h;	87%
With nitrourea; silica-gel-supported sulfuric acid In dichloromethane at 20℃; for 3.83333h; regioselective reaction;	77%

: 99-89-8
4-Isopropylphenol

: 1194-02-1
4-fluorobenzonitrile

: 4-(4-isopropylphenoxy)benzonitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 14h; Alkylation;	95%

: 99-89-8
4-Isopropylphenol

: 108-24-7
acetic anhydride

: 2664-32-6
4-isopropylphenyl acetate

Conditions

Conditions	Yield
With rice husk ash at 80℃; for 0.25h; Green chemistry;	95%
With rice-husk-supported FeCl3 nano particles In neat (no solvent) at 80℃; for 1h;	93%
With H3[P(Mo3O10)4]*nH2O at 20℃; for 0.05h;	87%

: 50-00-0
formaldehyd

: 99-89-8
4-Isopropylphenol

: 68591-07-1
2-hydroxy-5-isopropylbenzaldehyde

Conditions

Conditions	Yield
With triethylamine; magnesium chloride In acetonitrile at 70℃; for 2h;	95%
With magnesia In neat (no solvent) for 0.283333h; Microwave irradiation; regioselective reaction;	75%
With triethylamine; magnesium chloride In tetrahydrofuran for 6h; Reflux;	75%

: 99-89-8
4-Isopropylphenol

: 75-65-0
tert-butyl alcohol

: 7597-97-9
2-(tert-butyl)-4-isopropylphenol

Conditions

Conditions	Yield
With sulfuric acid; acetic acid at 40℃; for 24h; Inert atmosphere;	95%
With sulfuric acid at 20℃; for 1h; Inert atmosphere;	42%

: 626-05-1
2,6-Dibromopyridine

: 99-89-8
4-Isopropylphenol

: 2,6-bis(4-isopropylphenoxy)pyridine

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate In 1-methyl-pyrrolidin-2-one at 160℃; for 24h; Inert atmosphere; Schlenk technique;	95%

: 99-89-8
4-Isopropylphenol

: 591-50-4
iodobenzene

: 201230-82-2
carbon monoxide

: 13936-99-7
4-isopropylphenyl benzoate

Conditions

Conditions	Yield
With dicarbonyl(acetylacotonato)rhodium(I); triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 120℃; for 48h; Inert atmosphere; Autoclave; Schlenk technique;	95%
With palladium diacetate; potassium carbonate at 100℃; under 5250.53 Torr; for 3h; Catalytic behavior;	50 %Chromat.

...Expand

4-Isopropylphenol Consensus Reports

Reported in EPA TSCA Inventory.

4-Isopropylphenol Standards and Recommendations

DOT Classification: 6.1; Label: KEEP AWAY FROM FOOD

4-Isopropylphenol Specification

The IUPAC name of p-Isopropylphenol is 4-propan-2-ylphenol. With the CAS registry number 99-89-8, it is also named as 1-Hydroxy-4-isopropylbenzene. It is white to beige crystalline solid which is slightly soluble in water, soluble in ethanol and ethyl ether. In addition, thischemical is toxic and flammable. When heated to decomposition it emits acrid smoke and fumes. So the storage environment should be ventilate, low-temperature and dry. Keep p-Isopropylphenol separate from oxidant.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.82; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.82; (4)ACD/LogD (pH 7.4): 2.82; (5)ACD/BCF (pH 5.5): 81.99; (6)ACD/BCF (pH 7.4): 81.86; (7)ACD/KOC (pH 5.5): 815.63; (8)ACD/KOC (pH 7.4): 814.34; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.525; (13)Molar Refractivity: 42.31 cm³; (14)Molar Volume: 137.9 cm³; (15)Polarizability: 16.77×10^-24 cm³; (16)Surface Tension: 35.7 dyne/cm; (17)Enthalpy of Vaporization: 46.3 kJ/mol; (18)Vapour Pressure: 0.147 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Tautomer Count: 2; (21)Exact Mass: 136.088815; (22)MonoIsotopic Mass: 136.088815; (23)Topological Polar Surface Area: 20.2; (24)Heavy Atom Count: 10; (25)Complexity: 90.9.

Preparation of p-Isopropylphenol: It can be obtained by C9H11Li. This reaction needs reagent tBuOOH and Ti(OiPr)₄ and solvent diethyl ether at temperature of -78 °C. The reaction time is 12 hours. The yield is 80%.

Uses of p-Isopropylphenol: It is used in organic synthesis. For example: it can react with trichloromethane to get 2-hydroxy-5-isopropyl-benzaldehyde. This reaction which is Reimer-Tiemann reaction needs reagent sodium hydroxide and solvent ethanol and H₂O at temperature of 70 °C.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful if swallowed, but also harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. It may cause sensitization by skin contact and may cause burns. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) And people should avoid release it to the environment.

People can use the following data to convert to the molecule structure.
1. SMILES:Oc1ccc(cc1)C(C)C
2. InChI:InChI=1/C9H12O/c1-7(2)8-3-5-9(10)6-4-8/h3-7,10H,1-2H3

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	40mg/kg (40mg/kg)	BEHAVIORAL: SLEEP	Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
mouse	LD50	oral	875mg/kg (875mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(1), Pg. 94, 1981.
mouse	LDLo	intraperitoneal	250mg/kg (250mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 339, 1953.

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