4-OCTYLPHENOL supplier | CasNO.1806-26-4

Name
4-N-OCTYLPHENOL
EINECS 217-302-5
CAS No. 1806-26-4
Article Data27
CAS DataBase
Density 0.961 g/mL at 25 °C(lit.)
Solubility
Hazard Symbols 8 UN NO.
Synonyms Phenol,p-octyl- (6CI,7CI,8CI);4-Octylphenol;4-n-Octylphenol;p-(n-Octyl)phenol;p-Octylphenol;
PSA 20.23000
LogP 4.29520

Synthetic route

: 2589-73-3
1-(4-hydroxyphenyl)octanone

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With hydrogenchloride; mercury; zinc	78%
With hydrogenchloride; mercury; zinc	70%
With hydrogenchloride; amalgamated zinc; acetic acid

: 592-41-6
1-hexene

: 1,3-dioxoisoindolin-2-yl 3-(4-hydroxyphenyl)propanoate

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With bis(triphenylphosphine)nickel(II) chloride; magnesium(II) acetate tetrahydrate; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 3h; Schlenk technique; Inert atmosphere; regioselective reaction;	53%

: 62170-25-6
1-(4-methoxyphenyl)octan-1-one

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With potassium hydroxide; hydrazine hydrate; phenol weiteres Reagens: Diaethylenglykol. Erhitzen des Reaktionsprodukts mit wss. HI, Essigsaeure und Acetanhydrid;

: 3307-19-5
1-(4-methoxyphenyl)octane

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid

: 124-13-0
Octanal

: 108-95-2
phenol

A: 1233-26-7
1,1-bis(4-hydroxyphenyl)octane

B: 949-13-3
2-octylphenol

C: 1806-26-4
p-Octylphenol

D: 1-(2-hydroxyphenyl)-1-(4-hydroxyphenyl)octane

E: 1,1-bis(2-hydroxyphenyl)octane

Conditions

Conditions	Yield
With Al3+-exchanged montmorillonite at 100℃; for 48h; Product distribution; Mechanism; other aldehydes and ketones; also AlCl3;

...Expand

: sodium 4-octylphenylazosulfonate

A: 2189-60-8
Octylbenzene

B: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
In water at 25℃; for 7h; Irradiation; Yields of byproduct given. Title compound not separated from byproducts;

: 124-13-0
Octanal

: 108-95-2
phenol

A: 1233-26-7
1,1-bis(4-hydroxyphenyl)octane

B: 949-13-3
2-octylphenol

C: 1806-26-4
p-Octylphenol

D: 1-(2-hydroxyphenyl)-1-(4-hydroxyphenyl)octane

Conditions

Conditions	Yield
With Al(3+)-montmorillonite at 100℃; for 48h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 124-13-0
Octanal

: 108-95-2
phenol

A: 1233-26-7
1,1-bis(4-hydroxyphenyl)octane

B: 1806-26-4
p-Octylphenol

C: 1-(2-hydroxyphenyl)-1-(4-hydroxyphenyl)octane

D: 1,1-bis(2-hydroxyphenyl)octane

Conditions

Conditions	Yield
With Al(3+)-montmorillonite at 100℃; for 48h; Yield given. Further byproducts given. Yields of byproduct given;
With Al(3+)-montmorillonite at 100℃; for 48h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: chloromethyl-phosphonic acid ethyl ester 4-octyl-phenyl ester

A: 1929-42-6
O-ethylchloromethylphosphonic acid

B: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In water at 25℃; Kinetics;

: 16245-79-7
4-octylaniline

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) NaNO2, 3M aq. HCl, 2.) NaOAc, Na2SO3 / 1.) H2O, 0 deg C, 20 min, 2.) H2O, 0 deg C, 16 h 2: H2O / 7 h / 25 °C / Irradiation View Scheme

: 111-64-8
n-octanoic acid chloride

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / nitrobenzene / 0.5 h / 50 °C 2: Zn-Hg, 5 N HCl / ethanol / Heating View Scheme
Multi-step reaction with 2 steps 1: 57 percent / AlCl3 / nitrobenzene / 8 h / Ambient temperature 2: 78 percent / Zn(Hg), HCl View Scheme
Multi-step reaction with 2 steps 1: AlCl3 / CH2Cl2 / 1.) 0 deg C, 30 min; 0 deg C, 30 min; 2.) room temperature, overnight 2: 1.) hydrazine hydrate, 2.) KOH / 1.) diethylene glycol, reflux, 1h; 2.) reflux, 1h View Scheme

: 108-95-2
phenol

perchlorate: perchlorate

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / nitrobenzene / 0.5 h / 50 °C 2: Zn-Hg, 5 N HCl / ethanol / Heating View Scheme

: 124-07-2
Octanoic acid

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 86 percent / SOCl2 2: 60 percent / AlCl3 / nitrobenzene 3: 70 percent / Zn(Hg), HCl View Scheme
Multi-step reaction with 5 steps 1: thionyl chloride / 60 °C / Reflux 2: 70 - 75 °C 3: aluminum (III) chloride / 3.5 h / 20 - 100 °C 4: hydrazine hydrate / diethylene glycol / 2 h / Reflux 5: potassium hydroxide / diethylene glycol / 5 h / 20 - 200 °C View Scheme

: 5457-78-3
phenyl octanoate

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 60 percent / AlCl3 / nitrobenzene 2: 70 percent / Zn(Hg), HCl View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 3.5 h / 20 - 100 °C 2: hydrazine hydrate / diethylene glycol / 2 h / Reflux 3: potassium hydroxide / diethylene glycol / 5 h / 20 - 200 °C View Scheme

: 108-95-2
phenol

m-bromo-toluene: m-bromo-toluene

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 86 percent / SOCl2 2: 60 percent / AlCl3 / nitrobenzene 3: 70 percent / Zn(Hg), HCl View Scheme
Multi-step reaction with 2 steps 1: 57 percent / AlCl3 / nitrobenzene / 8 h / Ambient temperature 2: 78 percent / Zn(Hg), HCl View Scheme

: 108-95-2
phenol

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AlCl3 / CH2Cl2 / 1.) 0 deg C, 30 min; 0 deg C, 30 min; 2.) room temperature, overnight 2: 1.) hydrazine hydrate, 2.) KOH / 1.) diethylene glycol, reflux, 1h; 2.) reflux, 1h View Scheme
Multi-step reaction with 2 steps 1: AlCl3 / 100 - 130 °C 2: amalgamated zinc; concentrated aqueous HCl; glacial acetic acid View Scheme
Multi-step reaction with 2 steps 1: AlCl3 / 100 - 130 °C 2: amalgamated zinc; concentrated aqueous HCl; glacial acetic acid View Scheme
Multi-step reaction with 2 steps 1: zuletzt bei 100grad, und Erwaermen des Reaktionsprodukts mit AlCl3 in Nitrobenzol auf 75grad 2: amalgamated zinc; diluted aqueous HCl / 100 °C View Scheme

: 100-66-3
methoxybenzene

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1,1,2,2-tetrachloro-ethane; AlCl3 2: N2H4+H2O; KOH; phenol / weiteres Reagens: Diaethylenglykol. Erhitzen des Reaktionsprodukts mit wss. HI, Essigsaeure und Acetanhydrid View Scheme

: 100-66-3
methoxybenzene

activated platinum black: activated platinum black

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: HI, AcOH View Scheme

: 111-66-0
oct-1-ene

: 108-95-2
phenol

: 1806-26-4
p-Octylphenol

: 1089700-47-9
C14H22N2O

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With potassium hydroxide In diethylene glycol at 20 - 200℃; for 5h;

: 111-66-0
oct-1-ene

: 108-95-2
phenol

A: 1818-07-1
octyloxybenzene

B: 949-13-3
2-octylphenol

C: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With porous aromatic framework modified by aluminum chloride at 90℃; for 6h; Reagent/catalyst; Temperature; Friedel-Crafts Alkylation; Autoclave;

...Expand

: C14H18O2

: 1806-26-4
p-Octylphenol

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; acetic acid at 80℃; under 7500.75 Torr; for 2h; Pressure; Reagent/catalyst; Autoclave;

: 2969-81-5
4-bromoethylbutanoate

: 1806-26-4
p-Octylphenol

: 1071001-73-4
4-(4-octylphenoxy)butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetone for 18h; Reflux;	100%
With potassium carbonate In acetone Reflux;	71%
With potassium carbonate In acetone for 24h; Heating / reflux;	71%

: 1806-26-4
p-Octylphenol

: 106-89-8
epichlorohydrin

: 4223-17-0
2-[(4-octylphenoxy)methyl]oxirane

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide at 20℃; for 5h;	99%

: 1806-26-4
p-Octylphenol

: trifluoromethanesulfonic anhydride

: 4-octylphenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
Stage #1: p-Octylphenol With pyridine In dichloromethane at -10℃; for 0.0833333h; Inert atmosphere; Stage #2: trifluoromethanesulfonic anhydride In dichloromethane Inert atmosphere;	99%

: 1806-26-4
p-Octylphenol

: 105-36-2
ethyl bromoacetate

: 1621517-92-7
ethyl 2-(4-octylphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 5h; Reflux;	98%
With potassium carbonate In acetone for 5h; Reflux;	98%

: 1806-26-4
p-Octylphenol

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

: 869650-51-1
O-p-octylphenyl N,N-dimethylthiocarbamate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 85℃;	93%

: 1806-26-4
p-Octylphenol

: 124482-92-4
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1275594-48-3
C23H39N2O2P

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.5h; Inert atmosphere;	90%

: 50-00-0
formaldehyd

: 1806-26-4
p-Octylphenol

: 1539-42-0
bis[(2-pyridyl)methyl]amine

: C40H48N6O

Conditions

Conditions	Yield
In ethanol; water for 48h; Reflux;	90%

...Expand

: 1806-26-4
p-Octylphenol

: 1220974-10-6
2-iodo-4-octylphenol

Conditions

Conditions	Yield
With iodine; silver trifluoroacetate In dichloromethane at 0 - 20℃;	87%
With iodine; silver trifluoroacetate at 0 - 20℃; for 1h;	87%

: 741606-45-1
1-oxiranylmethylindole-5-carbonitrile

: 1806-26-4
p-Octylphenol

: 741606-27-9
1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-5-carbonitrile

Conditions

Conditions	Yield
With dmap In dichloromethane at 60℃; for 2h;	85%

: 1806-26-4
p-Octylphenol

: 108-95-2
phenol

: 73318-92-0
2-hydroxy-5-octylbenzaldehyde

Conditions

Conditions	Yield
	85%

: 1806-26-4
p-Octylphenol

: 3282-30-2
pivaloyl chloride

: 4-octylphenyl pivalate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; Sealed tube;	85%

: 1806-26-4
p-Octylphenol

: 60456-23-7
(S)-oxiranemethanol

: 925706-87-2
(R)-2-(4-octylphenoxymethyl)oxirane

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 24h; Mitsunobu reaction;	84%

: 1806-26-4
p-Octylphenol

: 1849-02-1
2-chloro-1-methyl-benzimidazole

: 78765-43-2
1-Methyl-2-(4-octyl-phenoxy)-1H-benzoimidazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 24h; Heating;	83%

: 1806-26-4
p-Octylphenol

: 24777-05-7
2-Nitro-4-octyl-phenol

Conditions

Conditions	Yield
With nitric acid; acetic acid In chloroform for 1.5h; Ambient temperature;	82%
With NaNO3; sulfuric acid In hexane; water; ethyl acetate	68%
With nitric acid; acetic acid

: 1806-26-4
p-Octylphenol

: 814-68-6
acryloyl chloride

: C17H24O2

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	81%

: 1026660-75-2
di-tert-butyl 5-(oxiran-2-ylmethoxy)indole-1,2-carboxylate

: 1806-26-4
p-Octylphenol

: 1026660-76-3
di-tert-butyl 5-[2-hydroxy-3-(4-octylphenoxy)propoxy]indole-1,2-carboxylate

Conditions

Conditions	Yield
With dmap at 40℃; for 48h;	81%

: 1806-26-4
p-Octylphenol

: 205647-74-1
(R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate

: 1643461-35-1
(S)-tert-butyl 2,2-dimethyl-4-[(4-octylphenoxy)methyl]oxazolidine-3-carboxylate

Conditions

Conditions	Yield
Stage #1: p-Octylphenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: (R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate In N,N-dimethyl-formamide; mineral oil at 70℃; for 3h;	81%

: 1806-26-4
p-Octylphenol

: 57835-36-6
2-bromo-4-octylphenol

Conditions

Conditions	Yield
With bromine; sodium hydrogencarbonate In chloroform at 0℃;	80%
With bromine; 1,2-dichloro-ethane

: 1806-26-4
p-Octylphenol

: 57044-25-4
(R)-oxiranemethanol

: 925706-88-3
(S)-2-(4-octylphenoxymethyl)oxirane

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 24h; Mitsunobu reaction;	80%

: 50-00-0
formaldehyd

: 1806-26-4
p-Octylphenol

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 7,16-bis(2-hydroxy-5-octylbenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Conditions

Conditions	Yield
In toluene at 110℃; for 20h;	78%

...Expand

: 376642-29-4
3-[2-(4-benzyloxyphenyl)-5-methyl-1H-pyrrol-1-yl]propan-1-ol

: 1806-26-4
p-Octylphenol

: 10465-81-3
1,1'-(Azodicarbonyl)dipiperidin

: 376642-30-7
2-(4-benzyloxyphenyl)-5-methyl-1-[3-(4-octyloxyphenyl)propyl]-1H-pyrrole

Conditions

Conditions	Yield
With triphenylphosphine In toluene	77.4%

...Expand

: 1806-26-4
p-Octylphenol

: 107-30-2
chloromethyl methyl ether

: 123914-95-4
1-methoxymethoxy-4-octyl-benzene

Conditions

Conditions	Yield
With sodium hydroxide; Aliquat 336 In dichloromethane; water at -10℃; for 0.5h;	74%

: 1806-26-4
p-Octylphenol

: 1452822-15-9
C21H23BrF4O

: 1452822-24-0
(Z)-4-(hexyloxy)-4'-(2,3,3-trifluoro-3-(4-octylphenoxy)prop-1-enyl)biphenyl

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 80℃; Schlenk technique; Inert atmosphere; stereoselective reaction;	74%

: 22094-18-4
1,3-dibromo-2,2-dimethoxypropane

: 1806-26-4
p-Octylphenol

: 1-(3-bromo-2,2-dimethoxypropoxy)-4-octylbenzene

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide for 10h; Reflux;	74%

: 1806-26-4
p-Octylphenol

: 1586018-38-3
tert-butyl 1-(oxiran-2-ylmethyl)indazole-5-carboxylate

: 1586018-39-4
tert-butyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indazole-5-carboxylate

Conditions

Conditions	Yield
With dmap at 120℃; for 2h;	73%

: 50-00-0
formaldehyd

: 1806-26-4
p-Octylphenol

: 112921-43-4
2,6-Bis(bromomethyl)-p-octylphenol

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid for 0.333333h;	71%

: 1806-26-4
p-Octylphenol

: 24801-88-5
3-(triethoxypropyl) isocyanate

: 1314704-83-0
4-octylphenyl-3-(triethoxysilyl)propylcarbamate

Conditions

Conditions	Yield
With DBDU In tetrahydrofuran at 75℃; for 24h;	71%

: 1806-26-4
p-Octylphenol

: 82885-98-1
C16H39N3O6P(1+)*F6P(1-)

: 51437-93-5
Igepal CO-520

Conditions

Conditions	Yield
With potassium carbonate; formamide In 1,4-dioxane at 95℃; for 24h;	70%

: 1806-26-4
p-Octylphenol

: 74-88-4
methyl iodide

: 3307-19-5
1-(4-methoxyphenyl)octane

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 40℃;	70%

4-OCTYLPHENOL Chemical Properties

MF: C₁₄H₂₂O
MW: 206.32
EINECS: 217-302-5
mp： 44-45 °C(lit.)
bp： 150 °C4 mm Hg(lit.)
density： 0.961 g/mL at 25 °C(lit.)
Fp： >230 °F
CAS DataBase Reference： 1806-26-4(CAS DataBase Reference)
The structure of 4-OCTYLPHENOL is:

4-OCTYLPHENOL Toxicity Data With Reference

1、RTECS#: CAS# 1806-26-4: SM5787000
2、LD50/LC50: RTECS: Not available.
3、Carcinogenicity: 4-Octylphenol - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.

4-OCTYLPHENOL Consensus Reports

4-OCTYLPHENOL is reported in EPA TSCA Inventory.

4-OCTYLPHENOL Safety Profile

Hazard Codes： Xi
RIDADR： UN 2430 8/PG 2
WGK Germany： 3
HazardClass： 8
Risk Statements： Irritating to the eyes；Irritating to the skin
Safety Statements： In case of contact with eyes, rinse immediately with plenty of water and seek medical advice；Wear suitable protective clothing
PackingGroup： III Experimental reproductive effects.
When heated to decomposition it emits acrid smoke and irritating vapors.

4-OCTYLPHENOL Specification

1、Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
2、Handling and Storage
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

4-N-OCTYLPHENOL

Synthetic route

4-OCTYLPHENOL Chemical Properties

4-OCTYLPHENOL Toxicity Data With Reference

4-OCTYLPHENOL Consensus Reports

4-OCTYLPHENOL Safety Profile

4-OCTYLPHENOL Specification

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