4-methoxybenzylamine supplier

Name
4-Methoxybenzylamine
EINECS 219-247-2
CAS No. 2393-23-9
Article Data204
CAS DataBase
Density 1.028 g/cm³
Solubility It is highly soluble in water.
Melting Point -10 °C
Formula C₈H₁₁NO
Boiling Point 236.499 °C at 760 mmHg
Molecular Weight 137.181
Flash Point 98.8 °C
Transport Information UN 2735 8/PG 2
Appearance clear colorless to slightly yellow liquid
Safety 26-36/37/39-45-27
Risk Codes 34-37-22
Molecular Structure
Hazard Symbols C
Synonyms Benzylamine,p-methoxy- (6CI,7CI,8CI);(4-Methoxyphenyl)methanamine;1-(4-Methoxyphenyl)methanamine;1-Aminomethyl-4-methoxybenzene;4-Methoxybenzenemethanamine;4-Methoxyphenylmethylamine;Anisylamine;Para-methoxybenzylamine;p-Methoxybenzylamine;
PSA 35.25000
LogP 1.85420

Synthetic route

: 874-90-8
4-methoxybenzonitrile

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With hydrogen; aluminum oxide; silica gel; nickel In methanol; ammonia at 120℃; under 7600 Torr; for 6h;	100%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 24h;	100%
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); potassium tert-butylate; hydrogen bromide; hydrogen; 2-((di-iso-propylphosphino)methyl)-1-methyl-1H-imidazole In tetrahydrofuran; water; acetone; toluene at 20℃; under 37503.8 Torr; for 5.5h; Inert atmosphere; Schlenk technique; Autoclave;	98%

: 21244-24-6
2-[(4-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With hydrazine hydrate In tetrahydrofuran for 16h; Reflux;	99%
With hydrazine hydrate In 1,4-dioxane at 110℃; Gabriel Amine Synthesis; Inert atmosphere;	90%
With sodium hydroxide und anschliessend mit verd.Salzsaeure;

: 3717-21-3, 3717-22-4, 140461-28-5, 140461-29-6, 3235-04-9
p-methoxyl benzaldoxime

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With sodium tetrahydroborate at 20℃; for 0.0333333h; neat (no solvent, solid phase);	98%
With sodium hydrogensulfate monohydrate; molybdenum(V) chloride; sodium cyanoborohydride In ethanol for 1.1h; Reflux;	95%
With ammonium formate; zinc In methanol for 0.05h; Heating;	92%

: N-(4-Methoxybenzyl)-2,4-dinitrobenzenesulfonamide

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With 2-hydroxyethanethiol In N,N-dimethyl-formamide at 20℃; for 1h;	98%

: 123-11-5
4-methoxy-benzaldehyde

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With nickel(II) tetrafluoroborate hexahydrate; ammonia; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine In 2,2,2-trifluoroethanol at 100℃; for 24h; chemoselective reaction;	97%
With ammonium hydroxide; hydrogen In ethanol at 130℃; under 7500.75 Torr; for 12h; Autoclave;	93.4%
With ammonia; hydrogen In methanol at 30℃; for 15h; Autoclave;	92%

: 171414-16-7
N-(4-methoxybenzyl)-2-nitro-N-(prop-2-yn-1-yl)benzenesulfonamide

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With polystyrene-thiophenol; caesium carbonate; triphenylphosphine In tetrahydrofuran at 20℃; for 24h;	96%
With potassium carbonate; thiophenol In acetonitrile at 50℃;	93%
With caesium carbonate; thiophenol In N,N-dimethyl-formamide at 20℃; for 0.5h;	88%

: 824-94-2
p-methoxybenzyl chloride

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; ammonium hydroxide In PEG1000-DIL; methyl cyclohexane at 60℃; for 3h;	96%
With ammonia at 25℃; Kinetics; Activation energy; Temperature; Reagent/catalyst;
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 18 h / Reflux 2: hydrazine hydrate / tetrahydrofuran / 16 h / Reflux View Scheme

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With hydrogenchloride; indium In tetrahydrofuran at 20℃; for 3h;	95%
With 1,3-diphenyl-disiloxane; triphenylphosphine In toluene at 23℃; for 24h; Reagent/catalyst; Solvent; Staudinger Azide Reduction;	93%
With cerium(III) chloride; sodium iodide In acetonitrile for 24h; Heating;	80%

: 68090-03-9
4-methoxy-selenobenzamide

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With samarium diiodide; water In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	94%

: N-(2-(4-methoxyphenyl)-2-oxoethyl)picolinamide

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
Stage #1: N-(2-(4-methoxyphenyl)-2-oxoethyl)picolinamide With hydrogenchloride In water at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With zinc In water at 20℃; for 16h; Inert atmosphere;	91%

: 99075-91-9
methyl N-(4'-methoxybenzyl)carbamate

A: 67-56-1
methanol

B: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With C25H19BrMnN2O2P; potassium tert-butylate; hydrogen In toluene at 130℃; under 15001.5 Torr; for 48h;	A 87 %Spectr. B 91%

: 105-13-5
4-Methoxybenzyl alcohol

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With ammonia In toluene at 110℃; under 5250.53 Torr; for 30h;	89%
With ammonium hydroxide; C19H37IrN4(2+)*2I(1-) at 170℃; for 100h; Sealed tube;	45%
Stage #1: 4-Methoxybenzyl alcohol With N-Boc-o-nitrobenzenesulfonamide-aminomethyl polystyrene res; triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; Stage #3: With mercaptoethyl alcohol; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃;

: 1312299-36-7
N-(4-methoxybenzyl)-2-methylpropane-2-sulfinamide

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; methanol at 25℃; for 0.5h; Inert atmosphere;	89%

: 921-01-7, 3374-22-9, 4371-52-2, 40143-64-4, 40143-66-6, 40143-69-9, 52-90-4
rac-cysteine

: N-(4-methoxybenzyl)-2,4-dinitro-benzenesulfonamide

A: 3165-76-2
S-(2,4-Dinitrophenyl)-cystein

B: 7446-09-5
sulfur dioxide

C: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
In aq. phosphate buffer for 0.5h; pH=7.4;	A n/a B 84% C n/a

...Expand

: 3424-93-9
4-methoxyphenylacetamide

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With titanium tetrachloride; magnesium In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	80%
With 1,10-Phenanthroline; diethoxymethylane; iron(II) acetate In toluene at 100℃; for 28h; Inert atmosphere; chemoselective reaction;	60%
With benzo[b]thiophene-2-boronic acid; phenylsilane In toluene at 130℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	42%

: N-(9-fluorenylmethoxycarbonyl)-4-methoxybenzylamine

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate In neat (no solvent) at 25℃; for 0.133333h; Green chemistry;	80%
With piperidine In N,N-dimethyl-formamide at 25℃; for 0.166667h;
With piperidine In N,N-dimethyl-formamide at 20℃; for 2h;

: 1-(4-methoxybenzyl)-3,4-di(naphthalene-2-yl)-1H-pyrrole-2,5-dione

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With methanol; sodium hydroxide at 80℃; for 0.166667h; Microwave irradiation;	80%

: 17061-62-0
N,N-bis(p-methoxybenzyl)amine

A: 123-11-5
4-methoxy-benzaldehyde

B: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With sodium periodate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; acetic acid In water; acetonitrile for 20h;	A 80% B 8%

: 16712-16-6, 64165-14-6, 65387-22-6, 70179-79-2, 540-69-2
ammonium formate

: 123-11-5
4-methoxy-benzaldehyde

A: 17061-63-1
N-(4-methoxybenzyl)formamide

B: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl] In methanol at 37℃; for 15h; chemoselective reaction;	A 21 %Spectr. B 79%

...Expand

: 592-41-6
1-hexene

: 105-13-5
4-Methoxybenzyl alcohol

A: 69287-13-4
1-(4-methoxyphenyl)-1-heptanone

B: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With 2-Amino-4-methylpyridine; Wilkinson's catalyst; polystyrene-based diphenylphosphine In toluene at 130℃; for 72h; Addition; dehydrogenation;	A 68% B 2%

...Expand

: 874-90-8
4-methoxybenzonitrile

A: 17061-62-0
N,N-bis(p-methoxybenzyl)amine

B: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With sodium tetrahydroborate; nickel dichloride In ethanol at 20℃; for 0.0833333h;	A 6% B 64%
With hydrogen In carbon dioxide at 50℃; under 90009 Torr; for 4h; chemoselective reaction;

: 67-56-1
methanol

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

A: 15175-54-9
N,N-dimethyl-4-methoxylbenzylamine

B: 702-24-9
4-methoxy-N-methylbenzylamine

C: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With trans-RuCl(phenpyra-Me)(PPh3)2PF6; sodium hydroxide at 125℃; for 2.5h; Sealed tube; Inert atmosphere; Glovebox;	A 17 %Chromat. B 62% C 6 %Chromat.

...Expand

: 50289-28-6, 40462-63-3
4-methoxybenzylidenediphenylmethylamine

A: 101-81-5
Diphenylmethane

B: 60996-87-4
(diphenylmethyl)[(4-methoxyphenyl)methyl]amine

C: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With sodium In 1,4-dioxane a. 10h, reflux, b. 6h, RT;	A 26% B 39% C 27%
With sodium In 1,4-dioxane a. 10h, reflux, b. 6h, RT; other educts;	A 26% B 39% C 27%

...Expand

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

A: 2393-23-9
4-methoxy-benzylamine

B: 5961-59-1
N-methyl-N-(4-methoxyphenyl)amine

C: (4-methoxy-benzyl)-(4-methoxy-phenyl)-methyl-amine

Conditions

Conditions	Yield
With triethylsilane; tin(IV) chloride In dichloromethane at 0 - 5℃; Rearrangement; Reduction; Addition;	A 13% B 8% C 34%

...Expand

: 41097-47-6
N,N'-Bis-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine

A: 58520-45-9
(1R,2S)/(1S,2R)-1,2-diamino-1,2-bis(4-methoxyphenyl)ethane

B: 2393-23-9
4-methoxy-benzylamine

: d,l-1,2-diamino-1,2-bis(4-methoxyphenyl)ethane

Conditions

Conditions	Yield
With titanium tetrachloride; zinc In tetrahydrofuran at 25℃; for 8h; reduction;	A 13% B 26% C n/a
With methanesulfonic acid; zinc In tetrahydrofuran at 25℃; for 8h; reduction;	A n/a B 13% C n/a

...Expand

: 3717-21-3, 3717-22-4, 140461-28-5, 140461-29-6, 3235-04-9
p-methoxyl benzaldoxime

A: 58520-45-9
(1R,2S)/(1S,2R)-1,2-diamino-1,2-bis(4-methoxyphenyl)ethane

B: 2393-23-9
4-methoxy-benzylamine

: d,l-1,2-diamino-1,2-bis(4-methoxyphenyl)ethane

Conditions

Conditions	Yield
With methanesulfonic acid; zinc In acetonitrile at 25℃; reduction;	A n/a B 17% C n/a

...Expand

: 104-93-8
4-Methylanisole

: 2393-23-9
4-methoxy-benzylamine

Conditions

Conditions	Yield
With C5H11NO*CHF3O3S In ethanol; water at 10℃; for 12h; pH=7.4; Inert atmosphere; Sealed tube; Enzymatic reaction;	17%

: 3424-93-9
4-methoxyphenylacetamide

A: 2393-23-9
4-methoxy-benzylamine

B: 105-13-5
4-Methoxybenzyl alcohol

Conditions

Conditions	Yield
With sulfuric acid at 35 - 40℃; bei der elektrolytischen Reduktion;

: 100-52-7
benzaldehyde

: 2393-23-9
4-methoxy-benzylamine

: 31490-38-7
N-(4-methoxybenzyl)benzaldimine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%
With magnesium sulfate In dichloromethane for 3h; Reflux;	100%
In dichloromethane for 18h; Molecular sieve;	92%

: 123-11-5
4-methoxy-benzaldehyde

: 2393-23-9
4-methoxy-benzylamine

: 3261-60-7
N-(4-methoxybenzylidene)-4-methoxybenzylamine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane for 3h; Reflux;	100%
In toluene for 24h; Condensation; Heating;	95%

: 79027-28-4
(2S)-3-(benzyloxy)-2-methylpropanal

: 143-33-9
sodium cyanide

: 2393-23-9
4-methoxy-benzylamine

: 130533-04-9
(3R)-2-(4-methoxybenzylamino)-3-benzyloxymethylbutyronitrile

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 2h; Ambient temperature;	100%

...Expand

: 2393-23-9
4-methoxy-benzylamine

: 3261-60-7
N-(4-methoxybenzylidene)-4-methoxybenzylamine

Conditions

Conditions	Yield
With oxygen; methylene blue; potassium carbonate In acetonitrile at 20℃; for 10h; Irradiation; Green chemistry;	100%
With cobalt nanoparticles encapsulated within nitrogen doped graphitic shells prepared via pyrolysis of poly([1,3-bis(4-vinylbenzyl)imidazolium]CoCl4) at 800 oC In toluene at 120℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; Sealed tube;	99%
With 2',3',4'-trihydroxyacetophenone In water at 20℃; for 24h;	98%

: 2393-23-9
4-methoxy-benzylamine

: 530-62-1
1,1'-carbonyldiimidazole

: N-(1H-imidazol-1-ylcarbonyl)-4-methoxybenzylamine

Conditions

Conditions	Yield
Stage #1: 4-methoxy-benzylamine With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 0.166667h; Stage #2: 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 0℃; for 0.116667h;	100%
Stage #1: 4-methoxy-benzylamine With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide for 2h; Inert atmosphere;	98%
Stage #1: 4-methoxy-benzylamine With hydrogenchloride In dichloromethane; isopropyl alcohol Stage #2: 1,1'-carbonyldiimidazole In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol at 20℃; for 1.5h;	87%

: 60933-68-8
2,3,5-tri-O-benzyl-β-D-arabinofuranoside

: 2393-23-9
4-methoxy-benzylamine

: (3S,4S,5S)-3,4-Bis-benzyloxy-5-hydroxy-1-(4-methoxy-benzyl)-pyrrolidin-2-one

Conditions

Conditions	Yield
With 4 A molecular sieve In benzene Heating;	100%

: 616-02-4
citraconic acid anhydride

: 2393-23-9
4-methoxy-benzylamine

: 215871-89-9
1-(4-Methoxy-benzyl)-3-methyl-pyrrole-2,5-dione

Conditions

Conditions	Yield
With acetic acid at 100℃; for 5h;	100%
In toluene for 13h; Heating;	80%

: 2393-23-9
4-methoxy-benzylamine

: 2-phenylthioacetimidic acid phenyl ester hydrobromide

: N-(4-methoxy-benzyl)-2-phenyl-acetamidine; hydrobromide

Conditions

Conditions	Yield
In methanol for 5h; Ambient temperature;	100%

: 2393-23-9
4-methoxy-benzylamine

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 124455-21-6, 124455-24-9
[1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-(4-methoxy-benzyl)-amine

Conditions

Conditions	Yield
With magnesium sulfate In diethyl ether at 0℃; for 3h;	100%
With magnesium sulfate In diethyl ether at 0℃; Condensation;
With magnesium sulfate In dichloromethane for 0.5h;

: 160549-10-0
2,3,5-tri-O-benzyl-D-arabinofuranose

: 2393-23-9
4-methoxy-benzylamine

: 157831-24-8
((3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-(4-methoxy-benzyl)-amine

Conditions

Conditions	Yield
With 4 A molecular sieve In chloroform; benzene Substitution; Heating;	100%
With MS 4 Angstroem In chloroform; benzene Condensation; reflux;	100%

: 2393-23-9
4-methoxy-benzylamine

: 305324-44-1
N-[(tert-butoxy)carbonyl]-N-(2-oxo-4-phenylbutyl)glycine

: 305324-53-2
4-[(tert-butoxy)carbonyl]-1-[(4-methoxyphenyl)methyl]-6-(2-phenylethyl)piperazin-2-one

Conditions

Conditions	Yield
Stage #1: 4-methoxy-benzylamine; N-[(tert-butoxy)carbonyl]-N-(2-oxo-4-phenylbutyl)glycine With sodium tris(acetoxy)borohydride; acetic acid at 25℃; Condensation; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; Cyclization;	100%

: 2393-23-9
4-methoxy-benzylamine

: 107-13-1
acrylonitrile

: 55383-76-1
3-(4-methoxybenzylamino)propanenitrile

Conditions

Conditions	Yield
With aluminum oxide In neat (no solvent) at 90℃; for 4h; Michael Addition; Green chemistry;	100%
aza-Michael reaction;	84%
at 20℃; for 45h;	81%

: 2393-23-9
4-methoxy-benzylamine

: 76014-80-7
4-Oxo-1-(3-pyridyl)-1-butanone

: 3-[1-(4-methoxybenzyl)pyrrol-2-yl]pyridine

Conditions

Conditions	Yield
In methanol; dichloromethane at 20℃; for 1h;	100%

: 2393-23-9
4-methoxy-benzylamine

: 401809-94-7
6-(5-benzyloxycarbonylamino-5-methoxycarbonyl-pentylcarbamoyl)-1,3-dihydro-isoindole-2,5-dicarboxylic acid 2-tert-butyl ester

: 5-(5-benzyloxycarbonylamino-5-methoxycarbonyl-pentylcarbamoyl)-6-(4-methoxy-benzylcarbamoyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 16h;	100%

: 2393-23-9
4-methoxy-benzylamine

polymer; monomer(s): 2-methyl-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione; 2-{4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzyl}-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione: polymer; monomer(s): 2-methyl-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione; 2-{4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzyl}-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

polymer; monomer(s): 2-methyl-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione; 2-{4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzyl}-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione; 4-methoxybenzylamine: polymer; monomer(s): 2-methyl-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione; 2-{4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzyl}-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione; 4-methoxybenzylamine

Conditions

Conditions	Yield
With poly(vinylpyridine) In 1,2-dichloro-ethane at 90℃; for 42h;	100%

: 2393-23-9
4-methoxy-benzylamine

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 74-88-4
methyl iodide

: 3-(4-methoxy-benzylthiocarbamoyl)-1-methyl-3H-imidazol-1-ium; iodide

Conditions

Conditions	Yield
Stage #1: 4-methoxy-benzylamine; 1,1'-Thiocarbonyldiimidazole In acetonitrile at 20℃; for 1h; Stage #2: methyl iodide In acetonitrile at 20℃;	100%

...Expand

: 2393-23-9
4-methoxy-benzylamine

: 498543-07-0
[6-benzylsulfonyl-9-(tetrahydropyran-2-yl)-9H-purin-2-yl]-3-methyl-pent-1-yn-3-ol

: (3RS)-1-[6-(4-methoxybenzylamino)-9-(tetrahydropyran-2-yl)-9H-purin-2-yl]-3-methyl-pent-1-yn-3-ol

Conditions

Conditions	Yield
In tert-butyl alcohol at 20℃; for 0.416667h;	100%

: 32315-10-9
bis(trichloromethyl) carbonate

: 2393-23-9
4-methoxy-benzylamine

: 56651-60-6
4-methoxybenzyl isocyanate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -80℃;
With sodium hydrogencarbonate In dichloromethane; water at 0℃; for 2.5h;

: 2393-23-9
4-methoxy-benzylamine

: 32365-96-1, 68702-74-9, 86462-82-0
methyl 3-(R)-methyl-5-hydroxypentanoate

: 234447-80-4
(3R)-5-hydroxy-N-(4-methoxybenzyl)-3-methylpentanamide

Conditions

Conditions	Yield
In toluene at 105 - 110℃; for 4h;	100%
In toluene for 3h; Heating;	97%

: 2393-23-9
4-methoxy-benzylamine

: 2946-89-6
3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine

: N-nitro-N'-(4-methoxy-benzyl)guanidine

Conditions

Conditions	Yield
In methanol at 20℃;	100%

: 2393-23-9
4-methoxy-benzylamine

: 690634-05-0
benzotriazole-1-carbothioic acid (1,5-dimethylhexyl)amide

: 1-(1,5-dimethylhexyl)-3-(4-methoxybenzyl)thiourea

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	100%

: 2393-23-9
4-methoxy-benzylamine

: N,N'-di(tert-butoxycarbonyl)-N''-trifluoromethanesulfonylguanidine

: N,N''-bis(tert-butoxycarbonyl)-N'-(4-methoxybenzyl)guanidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	100%

: 100-52-7
benzaldehyde

: 2393-23-9
4-methoxy-benzylamine

: 206768-78-7
(E)-N-benzylidene-1-(4-methoxyphenyl)methanamine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%
With sodium sulfate In dichloromethane at 20℃; for 24h;	95%
Stage #1: 4-methoxy-benzylamine In dichloromethane for 0.0833333h; Molecular sieve; Stage #2: benzaldehyde In dichloromethane at 20℃;	95%

: 653-37-2
perfluorobenzaldehyde

: 2393-23-9
4-methoxy-benzylamine

: 730992-49-1
(E)-4-methoxy-N-(pentafluorobenzylidene)benzylamine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	100%

: 98-01-1
furfural

: 2393-23-9
4-methoxy-benzylamine

: N-(furan-2-ylmethylene)-1-(4-methoxyphenyl)methanamine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Darkness;	100%
In methanol at 20℃;	88%
In benzene Heating;

: 16838-89-4, 17073-88-0, 60933-68-8, 60933-69-9, 73068-66-3, 89361-52-4, 89615-42-9, 89615-45-2, 96192-07-3
2,3,5-tri-O-benzyl-L-xylofuranose

: 2393-23-9
4-methoxy-benzylamine

: ((3S,4R,5S)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-(4-methoxy-benzyl)-amine

Conditions

Conditions	Yield
With 4 A molecular sieve In dichloromethane at 50℃; for 15h;	100%

: 2393-23-9
4-methoxy-benzylamine

: 292638-85-8
acrylic acid methyl ester

: 55383-92-1
methyl 3-((4-methoxybenzyl)amino)propanoate

Conditions

Conditions	Yield
In methanol at 0℃; for 15.5h;	100%
With aluminum oxide In neat (no solvent) at 75℃; for 3.5h; Michael Addition; Green chemistry;	91%
aza-Michael reaction;	89%
With CLEA Pseudomonas stutzeri lipase (PSL) In hexane at 60℃; for 96h; Michael Addition; Sealed tube; Enzymatic reaction;	74%
With Pseudomonas fluorescence lipase immobilized on hyroxypropyl methyl cellulose support In toluene at 50℃; for 3h; Reagent/catalyst; Michael Addition; Enzymatic reaction; chemoselective reaction;

: 17347-61-4
2,2-dimethylsuccinic anhydride

: 2393-23-9
4-methoxy-benzylamine

: 322642-40-0
1-(4-methoxybenzyl)-3,3-dimethylpyrrolidine-2,5-dione

Conditions

Conditions	Yield
In toluene for 11h; Heating;	100%
With dmap; acetic acid Autoclave; Inert atmosphere;	99%

4-methoxybenzylamine Chemical Properties

Molecular Structure of 4-methoxybenzylamine (CAS NO.2393-23-9):

IUPAC Name: (4-methoxyphenyl)methanamine
Empirical Formula: C₈H₁₁NO
Molecular Weight: 137.179
EINECS: 219-247-2
Melting point: -10°C
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 3
Polar Surface Area: 12.47 Å²
Index of Refraction: 1.532
Molar Refractivity: 41.38 cm³
Molar Volume: 133.4 cm³
Surface Tension: 37.3 dyne/cm
Density: 1.028 g/cm³
Flash Point: 98.8 °C
Enthalpy of Vaporization: 47.33 kJ/mol
Boiling Point: 236.5 °C at 760 mmHg
Vapour Pressure: 0.0472 mmHg at 25°C
Sensitive: Air Sensitive
BRN: 508206
InChI
InChI=1/C8H11NO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3
Smiles
O(c1ccc(cc1)CN)C
Product Categories: Anilines, Aromatic Amines and Nitro Compounds; Amine; Amines; API intermediates; C8; Nitrogen Compounds

4-methoxybenzylamine Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34-37-22
R34:Causes burns.
R37:Irritating to respiratory system
R22:Harmful if swallowed.
Safety Statements: 26-36/37/39-45-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S27:Take off immediately all contaminated clothing.
RIDADR: UN 2735 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29222900

4-methoxybenzylamine Specification

4-methoxybenzylamine , with CAS number of 2393-23-9, can be called (4-Methoxyphenyl)methanamine ; 1-(4-Methoxyphenyl)methanamine ; 1-Aminomethyl-4-methoxybenzene ; 4-Methoxybenzylamine ; 4-Methoxyphenylmethylamine ; Anisylamine ; p-Methoxybenzylamine . It is a clear colorless to slightly yellow liquid. For the synthesis of pharmaceutical intermediates.

Product Name

4-Methoxybenzylamine

Synthetic route

4-methoxybenzylamine Chemical Properties

4-methoxybenzylamine Safety Profile

4-methoxybenzylamine Specification

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