Product Name

  • Name

    5-ACETYL-2-METHYLPYRIDINE

  • EINECS 252-995-8
  • CAS No. 36357-38-7
  • Article Data29
  • CAS DataBase
  • Density 1.036 g/cm3
  • Solubility Partly miscible with water.
  • Melting Point 129-133°C(lit.)
  • Formula C8H9NO
  • Boiling Point 233.608 °C at 760 mmHg
  • Molecular Weight 135.166
  • Flash Point 103.889 °C
  • Transport Information
  • Appearance pale-yellow oil
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 36357-38-7 (5-ACETYL-2-METHYLPYRIDINE)
  • Hazard Symbols
  • Synonyms Ketone,methyl 6-methyl-3-pyridyl (6CI,7CI);1-(6-Methyl-3-pyridyl)-1-ethanone;1-(6-Methylpyridin-3-yl)ethanone;2-Methyl-5-acetylpyridine;3-Acetyl-6-methylpyridine;5-Acetyl-2-picoline;NSC27972;
  • PSA 29.96000
  • LogP 1.59260

Synthetic route

2-methyl-5-pyridylacetylene
1945-85-3

2-methyl-5-pyridylacetylene

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
With sulfuric acid In toluene at 80℃; for 3h; Inert atmosphere;92%
With sulfuric acid In toluene at 50℃;91%
Stage #1: 2-methyl-5-pyridylacetylene With sulfuric acid In toluene at 50℃;
Stage #2: With sodium hydrogencarbonate In toluene		91%
Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Stage #1: Methyl 6-methylnicotinate With sodium hydride In ethyl acetate; N,N-dimethyl-formamide; toluene at 80℃; for 10h;
Stage #2: With sulfuric acid In water at 110℃; for 2h;
Stage #3: With potassium carbonate In water pH=9;		65%
Multi-step reaction with 2 steps
1: NaH / dimethylformamide; toluene / 2.5 h / 80 °C
2: 10percent aq. H2SO4 / 2 h / Heating
View Scheme
Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

ethyl acetate
141-78-6

ethyl acetate

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Stage #1: Methyl 6-methylnicotinate; ethyl acetate With sodium hydride In N,N-dimethyl-formamide; toluene at 80℃; for 10h;
Stage #2: With sulfuric acid In water at 110℃; for 2h;
Stage #3: With potassium carbonate In water pH=9;		65%
Stage #1: Methyl 6-methylnicotinate; ethyl acetate With lithium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl-formamide at -50 - 20℃; for 1h;
Stage #2: With sulfuric acid In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 4h; Reflux;
1-amino-1-buten-3-one
2976-86-5

1-amino-1-buten-3-one

A

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

B

1-(4-methyl-pyridin-3-yl)-ethanone
51227-30-6

1-(4-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
for 15h; heating on water bath;A 47%
B n/a
for 15h; heating on water bath;
5-ethyl-2-methyl-pyridine
104-90-5

5-ethyl-2-methyl-pyridine

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Stage #1: 5-ethyl-2-methyl-pyridine With sulfuric acid; acetic anhydride; acetic acid
Stage #2: With chromium(VI) oxide at 10 - 20℃;
Stage #3: With sodium carbonate In water		31%
Stage #1: 5-ethyl-2-methyl-pyridine With chromium(VI) oxide; sulfuric acid; acetic anhydride In acetic acid at 20 - 30℃; for 24h;
Stage #2: With sodium carbonate In water
2-hydroxy-2-(6-methyl-[3]pyridyl)-propionitrile

2-hydroxy-2-(6-methyl-[3]pyridyl)-propionitrile

A

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

B

hydrogen cyanide
74-90-8

hydrogen cyanide

Conditions
ConditionsYield
beim Aufbewahren an der Luft;
acetylacetaldehyde dimethyl acetal
5436-21-5

acetylacetaldehyde dimethyl acetal

1-amino-1-buten-3-one
2976-86-5

1-amino-1-buten-3-one

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
With ammonium acetate; acetic acid
1-amino-1-buten-3-one
2976-86-5

1-amino-1-buten-3-one

(E)-4-chloro-3-buten-2-one
4643-20-3

(E)-4-chloro-3-buten-2-one

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

ethyl 3-(2-methyl-5-pyridinyl)-3-oxopropanoate
21683-58-9

ethyl 3-(2-methyl-5-pyridinyl)-3-oxopropanoate

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
With sulfuric acid for 2h; Heating; Yield given;
With sulfuric acid; water for 2h; Product distribution / selectivity; Heating / reflux;
methylmagnesium chloride
676-58-4

methylmagnesium chloride

N-methoxy-N-methyl-6-methylnicotinamide
221615-71-0

N-methoxy-N-methyl-6-methylnicotinamide

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
In tetrahydrofuran Substitution;
2-methyl-5-<α-oxy-ethyl>-pyridine

2-methyl-5-<α-oxy-ethyl>-pyridine

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
With chromic acid; acetic acid
3-(1-hydroxyethyl)-6-methylpyridine
56019-64-8, 100189-16-0, 110338-86-8

3-(1-hydroxyethyl)-6-methylpyridine

acetic acid
64-19-7

acetic acid

chromic acid

chromic acid

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

...Expand
sodium salt of oxymethylenacetone

sodium salt of oxymethylenacetone

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
With ammonium acetate; diethyl ether; acetic acid
With ammonium acetate; diethyl ether; acetic acid
6-methyl-nicotinoyl chloride
51598-76-6

6-methyl-nicotinoyl chloride

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2
2: tetrahydrofuran
View Scheme
ethyl 6-methylnicotinate
21684-59-3

ethyl 6-methylnicotinate

ethyl acetate
141-78-6

ethyl acetate

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Stage #1: ethyl 6-methylnicotinate; ethyl acetate With sodium hydride In N,N-dimethyl-formamide; toluene at 80℃; for 2.5h;
Stage #2: With sulfuric acid; water for 2h; Heating / reflux;
Stage #3: With water; potassium carbonate at 0℃; Product distribution / selectivity;
methylmagnesium bromide
75-16-1

methylmagnesium bromide

N-methoxy-N-methyl-6-methylnicotinamide
221615-71-0

N-methoxy-N-methyl-6-methylnicotinamide

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
In tetrahydrofuran; hexane at 0 - 20℃; for 16h;
Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Stage #1: Methyl 6-methylnicotinate; N,N-dimethyl-formamide With lithium hexamethyldisilazane In tetrahydrofuran; ethyl acetate at -50 - 20℃; for 1h;
Stage #2: With sulfuric acid In tetrahydrofuran; ethyl acetate at 0℃; for 4h; Reflux;
(6-methylpyridin-3-yl)trifluoromethanesulfonate
111770-91-3

(6-methylpyridin-3-yl)trifluoromethanesulfonate

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: piperidine; Tri(p-tolyl)phosphine / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / Inert atmosphere
1.2: 40 °C
1.3: 2 h / Reflux
2.1: sulfuric acid / toluene / 50 °C
View Scheme
Multi-step reaction with 2 steps
1.1: piperidine / palladium diacetate; Tri(p-tolyl)phosphine / toluene; 1-methyl-pyrrolidin-2-one / 40 °C / Inert atmosphere
1.2: 2 h / Reflux
2.1: sulfuric acid / toluene / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: piperidine; palladium diacetate; Tri(p-tolyl)phosphine / toluene; 1-methyl-pyrrolidin-2-one / 16 h / 40 °C / Inert atmosphere
2: sodium hydroxide / toluene / 2 h / Inert atmosphere; Reflux
3: sulfuric acid / toluene / 3 h / 80 °C / Inert atmosphere
View Scheme
5-Hydroxy-2-methylpyridine
1121-78-4

5-Hydroxy-2-methylpyridine

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridine / dichloromethane / 1.5 h / 0 °C
2.1: piperidine; Tri(p-tolyl)phosphine / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / Inert atmosphere
2.2: 40 °C
2.3: 2 h / Reflux
3.1: sulfuric acid / toluene / 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / dichloromethane / 1.5 h / 0 °C
2.1: piperidine / palladium diacetate; Tri(p-tolyl)phosphine / toluene; 1-methyl-pyrrolidin-2-one / 40 °C / Inert atmosphere
2.2: 2 h / Reflux
3.1: sulfuric acid / toluene / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere
2: piperidine; palladium diacetate; Tri(p-tolyl)phosphine / toluene; 1-methyl-pyrrolidin-2-one / 16 h / 40 °C / Inert atmosphere
3: sodium hydroxide / toluene / 2 h / Inert atmosphere; Reflux
4: sulfuric acid / toluene / 3 h / 80 °C / Inert atmosphere
View Scheme
2-methyl-4-(6-methylpyridin-3-yl)but-3-yn-2-ol
52535-35-0

2-methyl-4-(6-methylpyridin-3-yl)but-3-yn-2-ol

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / toluene / 2 h / Inert atmosphere; Reflux
2: sulfuric acid / toluene / 3 h / 80 °C / Inert atmosphere
View Scheme
5-bromo-2-methylpyridine
3430-13-5

5-bromo-2-methylpyridine

1-(trimethylsilyl)ethanone
13411-48-8

1-(trimethylsilyl)ethanone

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In 1,2-dichloro-ethane at 75℃; for 6h; Inert atmosphere; Sealed tube;73 %Spectr.
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C
2: tetrahydrofuran; hexane / 16 h / 0 - 20 °C
View Scheme
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

2,2,2-trideuterio-1-(6-methylpyridin-3-yl)ethanone

2,2,2-trideuterio-1-(6-methylpyridin-3-yl)ethanone

Conditions
ConditionsYield
With chloroform-d1; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine at 22℃; for 0.5h;99%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

lithium (Z)-1-ethoxy-4-(6-methylpyridin-3-yl)-1,4-dioxobut-2-en-2-olate

lithium (Z)-1-ethoxy-4-(6-methylpyridin-3-yl)-1,4-dioxobut-2-en-2-olate

Conditions
ConditionsYield
Stage #1: 1-(6-methyl-pyridin-3-yl)-ethanone With lithium hexamethyldisilazane In tetrahydrofuran for 1h; Cooling;
Stage #2: oxalic acid diethyl ester In tetrahydrofuran at 20℃; for 4h; Cooling;		94%
morpholine
110-91-8

morpholine

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

4-[(6-methyl-pyridin-3-yl)-thioacetyl]-morpholine
19733-95-0

4-[(6-methyl-pyridin-3-yl)-thioacetyl]-morpholine

Conditions
ConditionsYield
With sulfur for 17h; Reflux;93.3%
With sulfur In water; ethyl acetate at 110℃; for 7h;
With sulfur at 110℃; for 7h;
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

ethylene glycol
107-21-1

ethylene glycol

3-(2-methyl-1,3-dioxolan-2-yl)-6-methylpyridine
184766-45-8

3-(2-methyl-1,3-dioxolan-2-yl)-6-methylpyridine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 8h; Heating;92%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

4-bromoohenyl methyl sulfone
3466-32-8

4-bromoohenyl methyl sulfone

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

Conditions
ConditionsYield
With potassium phosphate; palladium(II) acetylacetonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1-methyl-pyrrolidin-2-one at 100℃; for 18h; Product distribution / selectivity; Inert atmosphere;91%
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate In toluene for 5h; Concentration; Inert atmosphere; Reflux;75%
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate In toluene for 4h; Concentration; Inert atmosphere; Reflux;75%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

3-(1-hydroxyethyl)-6-methylpyridine
56019-64-8, 100189-16-0, 110338-86-8

3-(1-hydroxyethyl)-6-methylpyridine

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 0℃; for 1.5h;90%
With sodium tetrahydroborate In ethanol for 0.5h;76%
With water; platinum Hydrogenation;
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

3-dimethylamino-1-(6-methyl-pyridin-3-yl)-2-propen-1-one

3-dimethylamino-1-(6-methyl-pyridin-3-yl)-2-propen-1-one

Conditions
ConditionsYield
for 18h; Heating / reflux;90%
morpholine
110-91-8

morpholine

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

6-methyl-3-pyridylthioacetmorpholide hydrochloride

6-methyl-3-pyridylthioacetmorpholide hydrochloride

Conditions
ConditionsYield
Stage #1: morpholine; 1-(6-methyl-pyridin-3-yl)-ethanone With sulfur for 16h; Reflux;
Stage #2: With hydrogenchloride In tetrahydrofuran; water		87.9%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

1-(6-methyl-[3]pyridyl)-ethanone oxime
5470-72-4

1-(6-methyl-[3]pyridyl)-ethanone oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In ethanol at 25℃; for 7h;85%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

C8H13NO
1613133-67-7

C8H13NO

Conditions
ConditionsYield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C40H38I2N4(2+)*2CF3O3S(1-) In dichloromethane at 20℃; for 48h; Inert atmosphere;83%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

Conditions
ConditionsYield
With nitric acid for 5h; Heating;75.4%
With nitric acid
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

α-bromoacetophenone
70-11-1

α-bromoacetophenone

5-Acetyl-2-methyl-1-(2-oxo-2-phenyl-ethyl)-pyridinium; bromide
111861-59-7

5-Acetyl-2-methyl-1-(2-oxo-2-phenyl-ethyl)-pyridinium; bromide

Conditions
ConditionsYield
In butanone for 15h; Heating;72%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

4-bromoohenyl methyl sulfone
3466-32-8

4-bromoohenyl methyl sulfone

1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]-ethanone hydrochloride
1456699-02-7

1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]-ethanone hydrochloride

Conditions
ConditionsYield
Stage #1: 1-(6-methyl-pyridin-3-yl)-ethanone; 4-bromoohenyl methyl sulfone With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate In toluene at 60℃; for 3h; Inert atmosphere; Reflux;
Stage #2: With hydrogenchloride In water; toluene at 25℃;		70%
Stage #1: 1-(6-methyl-pyridin-3-yl)-ethanone; 4-bromoohenyl methyl sulfone With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate In toluene for 3h; Inert atmosphere; Reflux;
Stage #2: With hydrogenchloride Reflux;		70%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

4-bromoohenyl methyl sulfone
3466-32-8

4-bromoohenyl methyl sulfone

1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)-phenyl]-ethanone hydrochloride salt

1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)-phenyl]-ethanone hydrochloride salt

Conditions
ConditionsYield
Stage #1: 1-(6-methyl-pyridin-3-yl)-ethanone; 4-bromoohenyl methyl sulfone With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate In toluene at 60℃; Inert atmosphere; Reflux;
Stage #2: With hydrogenchloride In water; toluene Reflux;		70%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

4-chlorophenyl methyl sulfone
98-57-7

4-chlorophenyl methyl sulfone

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
221615-75-4

1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone

Conditions
ConditionsYield
With palladium(II) acetylacetonate; potassium phosphate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In dimethyl sulfoxide at 150℃; for 16h; Inert atmosphere;69%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

ethyl Pentafluoropropionate
426-65-3

ethyl Pentafluoropropionate

4,4,5,5,5-pentafluoro-3-hydroxy-1-(6-methyl-3-pyridyl)pent-2-en-1-one

4,4,5,5,5-pentafluoro-3-hydroxy-1-(6-methyl-3-pyridyl)pent-2-en-1-one

Conditions
ConditionsYield
With lithium hydride In tetrahydrofuran Claisen Condensation;69%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

cyclohexylhydrazine
6498-34-6

cyclohexylhydrazine

ethyl 1-cyclohexyl-5-(6-methylpyridin-3-yl)-1H-pyrazole-3-carboxylate

ethyl 1-cyclohexyl-5-(6-methylpyridin-3-yl)-1H-pyrazole-3-carboxylate

Conditions
ConditionsYield
In ethanol at 90℃; for 5h;62%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

(S)-2-methylpropane-2-sulfinamide
343338-28-3

(S)-2-methylpropane-2-sulfinamide

(S)-2-methyl-N-[(1R)-1-(6-methylpyridin-3-yl)ethyl]propane-2-sulfinamide

(S)-2-methyl-N-[(1R)-1-(6-methylpyridin-3-yl)ethyl]propane-2-sulfinamide

Conditions
ConditionsYield
Stage #1: 1-(6-methyl-pyridin-3-yl)-ethanone; (S)-2-methylpropane-2-sulfinamide In tetrahydrofuran at 80℃; for 2h;
Stage #2: With L-Selectride In tetrahydrofuran at -78 - -70℃; for 1.5h;		34%
Dimethyl oxalate
553-90-2

Dimethyl oxalate

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

2-hydroxy-4-(6-methylpyridin-3-yl)-4-oxo-but-2-enoic acid methyl ester
1276115-80-0

2-hydroxy-4-(6-methylpyridin-3-yl)-4-oxo-but-2-enoic acid methyl ester

Conditions
ConditionsYield
Stage #1: Dimethyl oxalate With sodium methylate In methanol for 0.25h; Claisen condensation;
Stage #2: 1-(6-methyl-pyridin-3-yl)-ethanone In methanol at 30℃; for 0.0833333h; Claisen condensation; Microwave irradiation;		16%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

1-[6-(bromomethyl)-3-pyridinyl]ethanone

1-[6-(bromomethyl)-3-pyridinyl]ethanone

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane at 90℃; for 12h;16%
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

2-(6-methyl-pyridin-3-yl)-acetamide
19733-98-3

2-(6-methyl-pyridin-3-yl)-acetamide

Conditions
ConditionsYield
Stage #1: 1-(6-methyl-pyridin-3-yl)-ethanone With pyridine; ammonia for 0.5h;
Stage #2: With sulfur at 160℃; for 17h;		15%
furfural
98-01-1

furfural

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

3-furan-2-yl-1-(6-methyl-pyridin-3-yl)-propenone
91718-59-1

3-furan-2-yl-1-(6-methyl-pyridin-3-yl)-propenone

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

methyl magnesium iodide
917-64-6

methyl magnesium iodide

2-(6-methylpyridin-3-yl)propan-2-ol
40472-90-0

2-(6-methylpyridin-3-yl)propan-2-ol

Conditions
ConditionsYield
With diethyl ether
1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

hydrogen cyanide
74-90-8

hydrogen cyanide

2-hydroxy-2-(6-methyl-[3]pyridyl)-propionitrile

2-hydroxy-2-(6-methyl-[3]pyridyl)-propionitrile

1-(6-methyl-pyridin-3-yl)-ethanone
36357-38-7

1-(6-methyl-pyridin-3-yl)-ethanone

hydrogen cyanide
74-90-8

hydrogen cyanide

2-hydroxy-2-(6-methyl-[3]pyridyl)-propionic acid

2-hydroxy-2-(6-methyl-[3]pyridyl)-propionic acid

5-Acetyl-2-methylpyridine Chemical Properties

Molecular Structure of 5-Acetyl-2-methylpyridine (CAS NO.36357-38-7):

IUPAC Name: 1-(6-methylpyridin-3-yl)ethanone
Empirical Formula: C8H9NO
Molecular Weight: 135.1632
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 29.96 Å2
Index of Refraction: 1.512
Molar Refractivity: 39.19 cm3
Molar Volume: 130.4 cm3
Surface Tension: 38.1 dyne/cm
Density: 1.036 g/cm3
Flash Point: 103.9 °C
Enthalpy of Vaporization: 47.03 kJ/mol
Boiling Point: 233.6 °C at 760 mmHg
Vapour Pressure: 0.0553 mmHg at 25°C
EINECS: 252-995-8
Product Categories: Pyridine; Heterocyclic Compounds; Nucleotides and Nucleosides; Bases & Related Reagents; Nucleotides; Pyridines
InChI
InChI=1/C8H9NO/c1-6-3-4-8(5-9-6)7(2)10/h3-5H,1-2H3
Smiles
n1cc(C(=O)C)ccc1C

5-Acetyl-2-methylpyridine Specification

  5-Acetyl-2-methylpyridine , with CAS number of 36357-38-7, can be called 1-(6-methylpyridin-3-yl)ethan-1-one ; 1-(6-Methyl-3-pyridinyl)-ethanone ; 2-Methyl-5-acetylpyridine ; 5-Acetyl-2-picoline ; Methyl 6-Methyl-3-pyridyl Ketone ; Ethanone, 1-(6-methyl-3-pyridinyl)- ; 5-Acetyl-2-methylpyridine . It is a pale-yellow oil.

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