5-Bromo-2-chlorophenol supplier

Name
5-Bromo-2-chlorophenol
EINECS
CAS No. 183802-98-4
Article Data11
CAS DataBase
Density 1.788 g/cm³
Solubility
Melting Point 46-47 ºC
Formula C₆H₄BrClO
Boiling Point 234.9 ºC at 760 mmHg
Molecular Weight 207.454
Flash Point 95.9 ºC
Transport Information
Appearance Light yellow to White crystals
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Chloro-5-Bromophenol;3-Bromo-6-chlorophenol;
PSA 20.23000
LogP 2.80810

Synthetic route

: 16817-43-9
5-Bromo-2-chloroanisole

: 183802-98-4
5-bromo-2-chlorophenol

Conditions

Conditions	Yield
Stage #1: 5-Bromo-2-chloroanisole With boron tribromide In dichloromethane at 0 - 20℃; for 20.6667h; Stage #2: With water In dichloromethane at 0℃; for 0.5h;	98%
Stage #1: 5-Bromo-2-chloroanisole With boron tribromide In dichloromethane at 0 - 20℃; for 14h; Stage #2: With potassium carbonate In water at 0℃; Stage #3: With hydrogenchloride In water	96%
Stage #1: 5-Bromo-2-chloroanisole With boron tribromide In dichloromethane at 0 - 20℃; for 14h; Stage #2: With water; potassium carbonate In dichloromethane Stage #3: With hydrogenchloride In water	96%
Stage #1: 5-Bromo-2-chloroanisole With boron tribromide In dichloromethane at 0 - 20℃; for 4h; Stage #2: With sodium hydroxide; water In dichloromethane Stage #3: With hydrogenchloride In water	95%
With boron tribromide In dichloromethane at 0 - 20℃; for 7h;

: 591-20-8
3-Bromophenol

A: 13659-24-0
3-bromo-4-chlorophenol

B: 183802-98-4
5-bromo-2-chlorophenol

C: 863870-87-5
3 -bromo-2-chlorophenol

Conditions

Conditions	Yield
With N-chloro-succinimide; (R)-[1,1′-binaphthalene]-2,2′-diylbis-(diphenylphosphine sulfide) In chloroform-d1 at 20℃; for 2h; regioselective reaction;	A 72% B n/a C n/a
With N-chloro-succinimide; C24H20F12N4OS In chloroform-d1 at 20℃; for 3h; regioselective reaction;	A n/a B 48% C 14%
With 1,3-dichloro-5,5-dimethylhydantoin; diisopropylamine hydrochloride In toluene at 0℃; for 4h; Darkness; Overall yield = 57 %; regioselective reaction;

...Expand

: 591-20-8
3-Bromophenol

A: 13659-24-0
3-bromo-4-chlorophenol

B: 183802-98-4
5-bromo-2-chlorophenol

Conditions

Conditions	Yield
With N-chloro-succinimide; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2S)-2-(mesitylselanyl)-2,3-dihydro-1H-inden-1-yl)thiourea In chloroform-d1 at 20℃; for 12h; regioselective reaction;	A n/a B 60%

: 18282-59-2
4-bromo-1,2-dichlorobenzene

: 124-41-4
sodium methylate

: 183802-98-4
5-bromo-2-chlorophenol

Conditions

Conditions	Yield
With methanol at 180℃;

: 60811-17-8
5-bromo-2-chloroaniline

: 183802-98-4
5-bromo-2-chlorophenol

Conditions

Conditions	Yield
With sulfuric acid Diazotization.Erhitzen der Diazoniumsalz-Loesung;

: 876487-15-9
2,3,4-tribromo-6-chloro-phenol

: 71-43-2
benzene

A: 108-86-1
bromobenzene

B: 183802-98-4
5-bromo-2-chlorophenol

Conditions

Conditions	Yield
With aluminium trichloride

...Expand

: 7446-70-0
aluminium trichloride

: 876487-15-9
2,3,4-tribromo-6-chloro-phenol

: 71-43-2
benzene

A: 108-86-1
bromobenzene

B: 183802-98-4
5-bromo-2-chlorophenol

...Expand

: 95-76-1
m,p-dichloroaniline

: 183802-98-4
5-bromo-2-chlorophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuBr und HBr 2: methanol / 180 °C View Scheme

: 16817-43-9
5-Bromo-2-chloroanisole

A: 183802-98-4
5-bromo-2-chlorophenol

B: 108-95-2
phenol

Conditions

Conditions	Yield
With boron tribromide In dichloromethane

: 183802-98-4
5-bromo-2-chlorophenol

: 52334-81-3
2-chloro-5-trifluoromethylpyridine

: 1020330-54-4
2-(5-bromo-2-chlorophenoxy)-5-(trifluoromethyl)pyridine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃; for 12h;	100%

: 183802-98-4
5-bromo-2-chlorophenol

: 100-39-0
benzyl bromide

: 903579-12-4
2-benzyloxy-4-bromo-1-chloro-benzene

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; for 16h;	100%

: 36865-41-5
3-bromopropanol methyl ether

: 183802-98-4
5-bromo-2-chlorophenol

: 897954-59-5
4-bromo-1-chloro-2-(3-methoxypropoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃; for 15h; Solvent;	99.44%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 16h;	91%
With potassium carbonate at 20℃; for 16h;	89.1%

: 183802-98-4
5-bromo-2-chlorophenol

: 75-03-6
ethyl iodide

: 900174-61-0
1-bromo-4-chloro-3-ethoxybenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 55℃; for 3h;	99%
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 3h;	99%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 3h;	94%
With potassium carbonate In acetone at 55℃; for 18h; Sealed tube;

: 748101-41-9
zinc cyanide

: 183802-98-4
5-bromo-2-chlorophenol

: 4-chloro-3-hydroxybenzonitrile

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide	94%

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 183802-98-4
5-bromo-2-chlorophenol

: tert-butyl (2-(5-bromo-2-chlorophenoxy)ethyl)carbamate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 6h;	91%

: 4333-56-6
cyclopropyl bromide

: 183802-98-4
5-bromo-2-chlorophenol

: 1201196-54-4
4-bromo-1-chloro-2-(cyclopropoxy)benzene

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl acetamide at 150℃; for 47h;	87%
With caesium carbonate In dimethyl sulfoxide at 170℃; for 48h; High pressure;

: 7748-36-9
oxetan-3-ol

: 183802-98-4
5-bromo-2-chlorophenol

: 3-(5-bromo-2-chlorophenoxy)oxetane

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;	87%

: 89598-96-9
(3-bromophenyl)boronic acid

: 183802-98-4
5-bromo-2-chlorophenol

: C12H8BrClO

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 90℃; for 5h; Inert atmosphere;	85.42%

: 183802-98-4
5-bromo-2-chlorophenol

: 48125-11-7
5-bromo-2-chloro-4-nitrophenol

Conditions

Conditions	Yield
With nitric acid In chloroform at 0 - 5℃; for 1.16667h;	82%

: 183802-98-4
5-bromo-2-chlorophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 5-(tert-butyldimethylsilyl)-2-chlorophenol

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-chlorophenol; tert-butyldimethylsilyl chloride With triethylamine In dichloromethane at 0℃; for 4h; Stage #2: tert-butyldimethylsilyl chloride With n-butyllithium In tetrahydrofuran at -78 - 60℃; Inert atmosphere; Stage #3: With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃; for 0.5h;	82%

: 183802-98-4
5-bromo-2-chlorophenol

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1198422-80-8
4'-chloro-3'-hydroxy[1,1'-biphenyl]-4-carboxylate

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In ethanol; water; toluene for 0.5h; Suzuki coupling; Reflux; Inert atmosphere;	81%

: 23605-23-4
2-Chloro-N-cyclohexylacetamide

: 183802-98-4
5-bromo-2-chlorophenol

: (5-bromo-2-chlorophenoxy)-N-cyclohexylacetamide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; for 4.5h;	80%

: 1188329-66-9
(6S)-2-nitro-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

: 183802-98-4
5-bromo-2-chlorophenol

: 1198422-57-9
4-chloro-40-({[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b]-[1,3]oxazin-6-yl]oxy}methyl)[1,10-biphenyl]-3-ol

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In ethanol; water; toluene for 1h; Suzuki coupling; Inert atmosphere; Reflux;	76%

: 212127-83-8
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydropyrrole-1-carboxylate

: 183802-98-4
5-bromo-2-chlorophenol

: 1-tert-butoxycarbonyl-3-(3-hydroxy-4-chlorophenyl)-2,5-dihydropyrrole

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In N,N-dimethyl-formamide at 100℃; Inert atmosphere;	76%

: 183802-98-4
5-bromo-2-chlorophenol

: 130745-64-1
cis-4-(tert-butyl-diphenylsilyloxy)-cyclohexanol

: 874650-36-9
1-bromo-3-[cis-4-(tert-butyl-diphenylsilyloxy)-cyclohexyloxy]-4-chloro-benzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 55℃; for 48h;	72%

: 183802-98-4
5-bromo-2-chlorophenol

: 130745-65-2
trans-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]cyclohexanol

: 874650-36-9
1-bromo-3-[cis-4-(tert-butyl-diphenylsilyloxy)-cyclohexyloxy]-4-chloro-benzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 55℃; for 48h;	72%

: 183802-98-4
5-bromo-2-chlorophenol

: 141699-57-2
3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester

: tert-butyl 3-(5-bromo-2-chlorophenoxy)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;	72%

: 183802-98-4
5-bromo-2-chlorophenol

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

: 740806-61-5
O-5-bromo-2-chlorophenyl N,N-dimethylcarbamothioate

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-chlorophenol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Stage #2: N,N-Dimethylthiocarbamoyl chloride In tetrahydrofuran; mineral oil at 20℃;	70%
With potassium carbonate In tetrahydrofuran; water

: 183802-98-4
5-bromo-2-chlorophenol

: 121238-27-5
2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl trichloroimidate

: 1259428-86-8
5-bromo-2-chlorophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In toluene at 20℃; for 5h; Inert atmosphere;	67%

: 383-62-0
ethyl 2-chloro-2,2-difluoroacetate

: 183802-98-4
5-bromo-2-chlorophenol

: 1000575-20-1
4-Bromo-1-chloro-2-(difluoromethoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	67%

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 183802-98-4
5-bromo-2-chlorophenol

: 4-bromo-1-chloro-2-(difluoromethoxy-d1)benzene

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-chlorophenol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: With water-d2 In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Stage #3: diethyl (bromodifluoromethyl)phosphonate In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere;	65%

: 183802-98-4
5-bromo-2-chlorophenol

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 4-bromo-1-chloro-2-(2,2-diethoxyethoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 18h;	64%
With potassium carbonate In N,N-dimethyl-formamide at 135℃; for 7h;
With potassium carbonate In N,N-dimethyl-formamide at 135℃; for 7h;

: 183802-98-4
5-bromo-2-chlorophenol

: 548482-49-1
5-methylene-1,3,2-dioxathiane 2-oxide

: 2-((5-bromo-2-chlorophenoxy)methyl)prop-2-en-1-ol

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-chlorophenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: 5-methylene-1,3,2-dioxathiane 2-oxide In N,N-dimethyl-formamide; mineral oil at 55℃; for 4h;	60%

: 13154-24-0
triisopropylsilyl chloride

: 183802-98-4
5-bromo-2-chlorophenol

: 874650-34-7
1-bromo-4-chloro-3-(tri-isopropyl-silyloxy)-benzene

Conditions

Conditions	Yield
With triethylamine; dmap In dichloromethane at 0 - 20℃; for 18h;	59%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 18h;

: 183802-98-4
5-bromo-2-chlorophenol

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: tert-butyl 4-(5-bromo-2-chlorophenoxy)piperidine-1-carboxylate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;	57%

: 183802-98-4
5-bromo-2-chlorophenol

: 874650-39-2
3-hydroxycyclopentyl 4-methylbenzenesulfonate

: 1-bromo-3-(cis-3-hydroxy-cyclopent-1-yloxy)-4-chloro-benzene

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-chlorophenol With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: 3-hydroxycyclopentyl 4-methylbenzenesulfonate In DMF (N,N-dimethyl-formamide) at 65℃; for 16h;	50%

5-Bromo-2-chlorophenol Specification

The 5-Bromo-2-chlorophenol is an organic compound with the formula C₆H₄BrClO. The IUPAC name of this chemical is 5-bromo-2-chlorophenol. With the CAS registry number 183802-98-4, it is also named as 2-Chloro-5-Bromophenol. The product's categories are Phenol & Thiophenol & Mercaptan; Bromine Compounds; Chlorine Compounds; Phenols. Besides, it is a light yellow to white crystals, which should be stored in closed cool and ventilated place.

Physical properties about 5-Bromo-2-chlorophenol are: (1)ACD/LogP: 3.13; (2)#H bond acceptors: 1; (3)#H bond donors: 1; (4)#Freely Rotating Bonds: 1; (5)Polar Surface Area: 9.23 Å²; (6)Index of Refraction: 1.619; (7)Molar Refractivity: 40.71 cm³; (8)Molar Volume: 115.9 cm³; (9)Polarizability: 16.14×10^-24cm³; (10)Surface Tension: 50.1 dyne/cm; (11)Density: 1.788 g/cm³; (12)Flash Point: 95.9 °C; (13)Enthalpy of Vaporization: 49.08 kJ/mol; (14)Boiling Point: 234.9 °C at 760 mmHg; (15)Vapour Pressure: 0.0337 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1c(O)cc(Br)cc1
(2)InChI: InChI=1/C6H4BrClO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H
(3)InChIKey: UEVFFMZHGNYDKM-UHFFFAOYAU
(4)Std. InChI: InChI=1S/C6H4BrClO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H
(5)Std. InChIKey: UEVFFMZHGNYDKM-UHFFFAOYSA-N

Product Name

5-Bromo-2-chlorophenol

Synthetic route

5-Bromo-2-chlorophenol Specification

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