5-Bromovaleryl chloride supplier

Name
5-Bromovaleryl chloride
EINECS 629-364-4
CAS No. 4509-90-4
Article Data72
CAS DataBase
Density 1.502 g/cm³
Solubility Reacts with water.
Melting Point
Formula C₅H₈BrClO
Boiling Point 214.1 °C at 760 mmHg
Molecular Weight 199.475
Flash Point 107.2 °C
Transport Information UN 3265
Appearance clear colorless to slightly yellow liquid
Safety S26; S27; S36/37/39; S45; S28
Risk Codes R34; R36/37
Molecular Structure
Hazard Symbols C
Synonyms Valerylchloride, 5-bromo- (7CI,8CI);5-Bromovaleric acid chloride;5-Bromovaleroylchloride;5-Bromovaleryl chloride, 98%;pentanoyl chloride, 5-bromo-;
PSA 17.07000
LogP 2.31700

Synthetic route

: 2067-33-6
5-bromopentanoic acid

: 4509-90-4
5-bromovaleroyl chloride

Conditions

Conditions	Yield
With thionyl chloride	100%
With oxalyl dichloride In benzene at 20 - 50℃; Inert atmosphere;	98%
With oxalyl dichloride In benzene at 50℃; for 3h;	97%

: 71250-83-4
5-Bromvaleriansaeuretrimethylsilylester

: 4509-90-4
5-bromovaleroyl chloride

Conditions

Conditions	Yield
With thionyl chloride

δ-bromo-n-valeric acid: δ-bromo-n-valeric acid

: 4509-90-4
5-bromovaleroyl chloride

Conditions

Conditions	Yield
With thionyl chloride

: 542-28-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 4509-90-4
5-bromovaleroyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: SOCl2 View Scheme

: 79-37-8
oxalyl dichloride

: 2067-33-6
5-bromopentanoic acid

: 4509-90-4
5-bromovaleroyl chloride

Conditions

Conditions	Yield
In N-methyl-acetamide; dichloromethane
In N-methyl-acetamide; dichloromethane

: 2067-33-6
5-bromopentanoic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 4509-90-4
5-bromovaleroyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride In dichloromethane at 20℃;

: 4509-90-4
5-bromovaleroyl chloride

: 100-66-3
methoxybenzene

: 69287-12-3
5-bromo-1-(4-methoxyphenyl)pentan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 2h;	100%
With aluminium trichloride Friedel-Crafts acylation;	85%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; for 2h; Friedel-Crafts Acylation;
With metallic chloride at 50℃; Friedel-Crafts Acylation;
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Inert atmosphere;

: 107-10-8
propylamine

: 4509-90-4
5-bromovaleroyl chloride

: 442913-00-0
5-Bromo-pentanoic acid propylamide

Conditions

Conditions	Yield
With pyridine In dichloromethane	100%
In N,N-dimethyl-formamide
In N,N-dimethyl-formamide

: 2859-67-8
3-(3-pyridyl)propan-1-ol

: 4509-90-4
5-bromovaleroyl chloride

: 5-bromo-pentanoic acid 3-pyridin-3-yl-propyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane	100%

: 4509-90-4
5-bromovaleroyl chloride

: 100-51-6
benzyl alcohol

: 60343-28-4
Benzyl 5-bromovalerate

Conditions

Conditions	Yield
With pyridine In dichloromethane	100%
With triethylamine In dichloromethane at 0 - 20℃; for 16.5h;	100%
With triethylamine In dichloromethane at 0 - 20℃;

: 4509-90-4
5-bromovaleroyl chloride

: 118-31-0
(naphth-1-yl)methylamine

: 5-bromo-pentanoic acid (naphthalen-1-ylmethyl)-amide

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 1h;	100%

: 4509-90-4
5-bromovaleroyl chloride

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 130250-58-7
5-bromo-N-methoxy-N-methylpentanamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 12h;	100%

: 4509-90-4
5-bromovaleroyl chloride

: 149246-81-1
3-(3-bromophenyl)-1H-pyrazol-5-amine

: 1040724-62-6
5-bromo-pentanoic acid [5-(3-bromo-phenyl)-2H-pyrazol-3-yl]-amide

Conditions

Conditions	Yield
In ISOPROPYLAMIDE at 0℃; for 1h;	100%
In ISOPROPYLAMIDE at 0℃; for 1h;

: 4509-90-4
5-bromovaleroyl chloride

: 5339-85-5
2-aminophenethyl alcohol

: 1430091-95-4
5-bromo-N-[2-(2-hydroxyethyl)phenyl]pentanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -5 - 0℃;	100%
With triethylamine In dichloromethane at -5 - 0℃;	100%

: 87876-05-9
4-chloro-2-butyn-1-amine

: 4509-90-4
5-bromovaleroyl chloride

: 5-bromo-N-(4-chlorobut-2-ynyl)pentanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -5 - 20℃; for 2h;	100%

: 50541-93-0
4-amino-1-benzylpiperidine

: 4509-90-4
5-bromovaleroyl chloride

: N-(1-benzylpiperidin-4-yl)-5-bromopentanamide

Conditions

Conditions	Yield
With potassium carbonate In water; ethyl acetate for 1h;	99%
With triethylamine In dichloromethane at 20℃;	61%
With aq. KCO3 In ethyl acetate at 20℃; for 1h;

: 4509-90-4
5-bromovaleroyl chloride

: 106-40-1
4-bromo-aniline

: 948883-07-6
5-bromo-N-(4-bromophenyl)pentanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 3h;	99%
With triethylamine In dichloromethane at 0℃; for 1h;	86%
With triethylamine In DCE at 20℃;

: 497-25-6
dimethylenecyclourethane

: 4509-90-4
5-bromovaleroyl chloride

: 1330681-59-8
3-(5-bromopentanoyl)oxazolidin-2-one

Conditions

Conditions	Yield
Stage #1: dimethylenecyclourethane With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; Stage #2: 5-bromovaleroyl chloride In tetrahydrofuran; hexane at -78 - 20℃; for 1.5h; Inert atmosphere;	99%

: 4509-90-4
5-bromovaleroyl chloride

: C21H20F3N3O2

: C26H27BrF3N3O3

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h; Cooling with ice;	99%

: 4509-90-4
5-bromovaleroyl chloride

: 3081-24-1
H-Phe-OEt

: 170798-06-8
(S)-2-(5-Bromo-pentanoylamino)-3-phenyl-propionic acid ethyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h; Ambient temperature;	98%

: 4509-90-4
5-bromovaleroyl chloride

: 619-45-4
4-methoxycarbonyl aniline

: 195191-89-0
4-(5-Bromo-pentanoylamino)-benzoic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃; for 1.5h;	98%

: 121-30-2
chloraminophenamide

: 4509-90-4
5-bromovaleroyl chloride

: 907625-19-8
N-[2,4-bis(aminosulfonyl)-5-chlorophenyl]-5-bromo-pentanamide

Conditions

Conditions	Yield
In 1,4-dioxane for 2h; Heating / reflux;	98%

: 4509-90-4
5-bromovaleroyl chloride

: C51H101NO4

: C56H108BrNO5

Conditions

Conditions	Yield
With dmap; triethylamine In benzene at 20℃;	98%

: 4509-90-4
5-bromovaleroyl chloride

: 6290-05-7
Diethyl iminodiacetate

: 1132801-02-5
C13H22BrNO5

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 0 - 20℃; for 2h;	97.7%

: 4509-90-4
5-bromovaleroyl chloride

: (-)-N-{2-[3-acetyl-5-(2-oxopiperidino)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl]ethyl}methanesulfonamide

Conditions

Conditions	Yield
With pyridine; sodium acetate	97%

: 4509-90-4
5-bromovaleroyl chloride

: 34403-48-0
methyl-4-cyanobenzylamine

: 633699-38-4
5-bromo-N-[(4-cyanophenyl)methyl]-N-methylpentanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 5h;	97%

: 4509-90-4
5-bromovaleroyl chloride

: 55289-36-6
3-bromo-2-methylaniline

: 1231891-49-8
1-(3-bromo-2-methylphenyl)piperidin-2-one

Conditions

Conditions	Yield
Stage #1: 5-bromovaleroyl chloride; 3-bromo-2-methylaniline With triethylamine In dichloromethane at 20℃; for 0.5h; Stage #2: With sodium hydride In tetrahydrofuran at 20℃; Stage #3: With hydrogenchloride; water In tetrahydrofuran	97%

: 4509-90-4
5-bromovaleroyl chloride

: 100-01-6
4-nitro-aniline

: 38560-30-4
1-(4-nitrophenyl)piperidine-2-one

Conditions

Conditions	Yield
Stage #1: 5-bromovaleroyl chloride; 4-nitro-aniline With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; Stage #2: With potassium tert-butylate In tetrahydrofuran at 0 - 20℃;	96%
With pyridine; dmap In tetrahydrofuran at 0 - 100℃; for 1h;	96.82%
Stage #1: 5-bromovaleroyl chloride; 4-nitro-aniline In tetrahydrofuran; water at 20℃; for 1h; Green chemistry; Stage #2: In tetrahydrofuran; water at 20℃; for 4h; Green chemistry;	90%
Stage #1: 5-bromovaleroyl chloride; 4-nitro-aniline With triethylamine In tetrahydrofuran at 0 - 20℃; Stage #2: With potassium tert-butylate In tetrahydrofuran at 0 - 20℃;

: 4509-90-4
5-bromovaleroyl chloride

: C11H12Cl2N2O

: 5-bromo-N-[4-(3,3-dichloro-2-oxopiperidin-1-yl)phenyl]valeroyl amide

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20℃; for 0.5h;	96.04%

: 4509-90-4
5-bromovaleroyl chloride

: 57-88-5
cholesterol

: 86689-84-1
cholest-5-en-3-β-yl 5-bromopentanoate

Conditions

Conditions	Yield
With pyridine for 1h;	96%
With pyridine In dichloromethane at 0 - 24℃; for 1h;	96%
With pyridine In tetrahydrofuran at 0 - 20℃; for 12h;	84%

: 4509-90-4
5-bromovaleroyl chloride

: 41632-04-6
methyl 6-chloroanthranilate

: 864387-30-4
methyl 2-(5-bromopentanoylamino)-6-chlorobenzoate

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 0 - 20℃; for 1h;	96%

: 4509-90-4
5-bromovaleroyl chloride

: 1075282-08-4
tert-butyl N-(2-amino-6-methyl-phenyl)-N-(4-cyano-phenyl)-hydrazinocarboxylate

: 1075282-10-8
tert-butyl N-[2-(5-bromo-pentanoylamino)-6-methylphenyl]-N-(4-cyano-phenyl)-hydrazinocarboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	96%

: 4509-90-4
5-bromovaleroyl chloride

: 142350-85-4
benzyl N-[(1R,2R)-2-aminocyclohexyl]carbamate

: 1438415-81-6
benzyl (1R,2R)-2-(5-bromopentanamido)cyclohexylcarbamate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 5 - 20℃; for 2h;	96%

: 4509-90-4
5-bromovaleroyl chloride

: tert-butyl (3S,4S)-3-amino-4-hydroxypiperidine-1-carboxylate

: 1510832-71-9
C15H27BrN2O4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	96%

: 69082-94-6
5-(2-aminophenyl)-10,15,20-triphenylporphyrinate

: 4509-90-4
5-bromovaleroyl chloride

: 80441-46-9
meso-triphenylporphyrin

Conditions

Conditions	Yield
With ammonium hydroxide In tetrahydrofuran at 0℃; for 0.5h;	95%
Stage #1: 5-(2-aminophenyl)-10,15,20-triphenylporphyrinate; 5-bromovaleroyl chloride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With ammonia In tetrahydrofuran; water	95%
With pyridine In dichloromethane for 10h; Ambient temperature;	65%

5-Bromovaleryl chloride Chemical Properties

Molecular Structure of 5-Bromovaleryl chloride (CAS NO.4509-90-4):

IUPAC Name: 5-bromopentanoyl chloride
Empirical Formula: C₅H₈BrClO
Molecular Weight: 199.4734
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 4
Polar Surface Area: 17.07 Å²
Index of Refraction: 1.481
Molar Refractivity: 37.82 cm³
Molar Volume: 132.7 cm³
Surface Tension: 36.6 dyne/cm
Density: 1.502 g/cm³
Flash Point: 107.2 °C
Enthalpy of Vaporization: 45.04 kJ/mol
Boiling Point: 214.1 °C at 760 mmHg
Vapour Pressure: 0.158 mmHg at 25°C
Sensitive: Moisture Sensitive/Lachrymatory
SMILES: BrCCCCC(Cl)=O
InChI: InChI=1/C5H8BrClO/c6-4-2-1-3-5(7)8/h1-4H2
Product Categories: Acid Halides; Carbonyl Compounds; Organic Building Blocks

5-Bromovaleryl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34-36/37
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system.
Safety Statements: 26-27-28-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
Hazard Note: Harmful/Corrosive/Lachrymatory/Moisture Sensitive
HazardClass: 8
PackingGroup: II

5-Bromovaleryl chloride Specification

5-Bromovaleryl chloride , with CAS number of 4509-90-4, can be called Valerylchloride, 5-bromo- (7CI,8CI) ; 5-Bromovaleric acid chloride ; 5-Bromovaleroylchloride ; 5-Bromovaleryl chloride, 98% ; pentanoyl chloride, 5-bromo- .

Product Name

5-Bromovaleryl chloride

Synthetic route

5-Bromovaleryl chloride Chemical Properties

5-Bromovaleryl chloride Safety Profile

5-Bromovaleryl chloride Specification

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